Srinivas Chamakuri

Assistant Professor

Email

srinivas.chamakuri@bcm.edu

Positions

Assistant Professor: Pathology
Baylor College of Medicine
Houston, TX, USA

Education

MSc from Osmania University: 05/2008 - Hyderabad, India

PhD from University of Hyderabad: 01/2015 - Hyderabad, India

Postdoctoral Training at Baylor College of Medicine: 05/2020 - Houston, Texas, United States

Professional Interests

Synthetic Organic Chemistry
Medicinal Chemistry
DNA Encoded Library Technology
Fragment-based Drug Discovery
Diversity-Oriented Synthesis
Chemical Biology

Websites

Srinivas Chamakuri

ViiCTR Profile

Srinivas Chamakuri

Google Scholor

Srinivas Chamakuri

Selected Publications

Sunny Ann Tang, Afton Fults, Shelton R Boyd, Nikhil Gattu, Kevin A Tran, Jiayi Fan, Kevin R MacKenzie, Timothy Palzkill, Damian W Young, Srinivas Chamakuri*. " Expanding Complex Morpholines Using Systematic Chemical Diversity " Org. Lett. 2024 Mar 20;
Pubmed PMID: 38506470.
Ravikumar Jimmidi, Srinivas Chamakuri*, Shuo Lu, Reuben S Harris, Martin M Matzuk, Timothy Palzkill, Damian W Young. " DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors " 2023 Aug 4; 6 (1) : 164.
Pubmed PMID: 37542196.
Amol B Viveki, Timothy M Mansfield, Kevin A Tran, Evan Lenkeit, Kevin R MacKenzie, Damian W Young, Srinivas Chamakuri*. " Heterocyclic Merging of Stereochemically Diverse Chiral Piperazines and Morpholines with Indazoles " Chem. E .J. 2023 Jul 18; 29 (55) : e202301888.
Pubmed PMID: 37462979.
Damian W Young, Srinivas Chamakuri. " Trisubstituted triumph " Nature Chemistry volume 14, pages595–597 (2022). 2022 ; 14 : 595–597.
Pubmed PMID: 35668207.
Srinivas Chamakuri*, Sunny Ann Tang, Kevin A Tran, Shiva Krishna Reddy Guduru, Peter K Bolin, Kevin R MacKenzie, Damian W Young*. " A Concise Synthetic Method for Constructing 3-Substituted Piperazine-2-Acetic Acid Esters from 1, 2-Diamines " Molecules. 2022 ; 27 (11) : 3419.
Pubmed PMID: 35684357.
Chamakuri, S.; Lu, S.; Ucisik, M. N.; Bohren, K. M.; Chen, Y.-C.; Matzuk, M. M.; Palzkill, T.; Young, D. W.. " DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 M pro inhibitors " Proceedings of the National Academy of Sciences. 2021 ; 118 (36) : e2111172118.
Pubmed PMID: 34426525.
Chamakuri, S*.; Chung, M. -K.; Santini, C.; Matzuk, M. M.; Young, D.W*.. " Design and construction of a stereochemically diverse piperazine-based DNA-encoded chemical library " Bioorg Med Chem. 2021 ; 48 (15) : 116387.
Pubmed PMID: 34571488.
Jeffery A Erickson, Ravikumar Jimmidi, Prashanth Anamthathmakula, Xuan Qin, Jian Wang, Leyi Gong, Jaehyeon Park, Gary Koolpe, Caitlin Tan, Martin M Matzuk, Feng Li, Srinivas Chamakuri*, Wipawee Winuthayanon*. " Synthesis and Optimization of Small Molecule Inhibitors of Prostate Specific Antigen " Acs. Med. Chem. Lett.. 2024 Aug 5; 15 (9) : 1526-1532.
Pubmed PMID: 39291021.
Angela F Ku, Kiran L Sharma, Hai Minh Ta, Courtney M Sutton, Kurt M Bohren, Yong Wang, Srinivas Chamakuri, Ruihong Chen, Choel Kim, Martin M Matzuk et ak.,. " Reversible male contraception by targeted inhibition of serine/threonine kinase 33 " Science. 2024 May 23; 384 (6698) : 885-890.
Pubmed PMID: 38781365.