Email

Positions

Instructor

Mol. & Human Genetics/P. Liu
Baylor College of Medicine
Houston, US

Selected Publications

• Clinical validation of RNA sequencing for Mendelian disorder diagnostics " AJHG. 2025 ;
  Pubmed PMID: 40043707.
• The clinical utility and diagnostic implementation of human subject cell transdifferentiation followed by RNA sequencing " AJHG. 2024 ;
  Pubmed PMID: 38593811.
• The utility of ultra-deep RNA sequencing in Mendelian disorder diagnostics " AJHG. 2025 ;
  Pubmed PMID: 41075783.
• One-step piggyBac transposon-based CRISPR/Cas9 activation of multiple genes " Mol Ther Nucleic Acids .. 2017 ;
  Pubmed PMID: 28918057.
• piggyBac mediates efficient in vivo CRISPR library screening for tumorigenesis in mice " Proc Natl Acad Sci U S A .. 2017 ;
  Pubmed PMID: 28062688.
• Human Induced Pluripotent Stem Cell NEUROG2 Dual Knockin Reporter Lines Generated by the CRISPR/Cas9 System " Stem Cells Dev .. 2015 ;
  Pubmed PMID: 26414932.
• Cell Stem Cell .. " OLIG2 drives abnormal neurodevelopmental phenotypes in human iPSC-based organoid and chimeric mouse models of down syndrome " 2019 ;
  Pubmed PMID: 31130512.
• RNA m6A modification orchestrates a LINE-1–host interaction that facilitates retrotransposition and contributes to long gene vulnerability " Cell Res .. 2021 ;
  Pubmed PMID: 4108665.
• Efficient Generation of hiPSC Neural Lineage Specific Knockin Reporters Using the CRISPR/Cas9 and Cas9 Double Nickase System " J Vis Exp .. 2015 ;
  Pubmed PMID: 26065872.
• Role of astroglia in Down’s syndrome revealed by patient-derived human-induced pluripotent stem cells " Nat Commun .. 2014 ;
  Pubmed PMID: 25034944.