Positions

Vice Chair for Research

Baylor College of Medicine

Professor of Psychiatry and Behavioral Sciences

Marjorie Bintliff Johnson and Raleigh White Johnson, Jr. Chair for Research in Psychiatry
Menninger Department of Psychiatry & Behavioral Sciences
Baylor College of Medicine
Houston, TX, US

Director

Mood and Anxiety Disorders Program
Baylor College of Medicine
Houston, Texas, United States

Staff Physician

Michael E. DeBakey VA Medical Center

Addresses

Veterans Affairs Medical Center (Hospital)

Room: VAMC-MHCL
Houston, TX, 77030
United States

Jamail Specialty Building (Clinic)

1977 Butler Blvd
Suite E4.207
Houston, TX, 77030
United States
Phone: (713) 798-5877
sjmathew@bcm.edu

Education

Fellowship at Columbia University College Of Physicians And Surgeons

06/2004 - New York, New York, United States

Residency at New York State Psychiatric Institute

06/2001 - New York, New York, United States

MD from Baylor College Of Medicine

05/1997 - Houston, Texas, United States

AB from Dartmouth College

06/1991 - Hanover, New Hampshire, United States

Certifications

Board Certified

American Board of Psychiatry and Neurology

#N5849

State of Texas Medical License

Professional Interests

• Psychopharmacology
• Treatment-resistant depression and anxiety
• Biomarker research

Professional Statement

Websites

Selected Publications

• Wilkinson ST, Farmer C, Ballard E, Mathew SJ, Grunebaum MF, Murrough JW, Sos P, Wang G, Gueorguieva R, Zarate CA Jr.. " Impact of midazolam vs. saline on effect size estimates in controlled trials of ketamine as a rapid-acting antidepressant. " Neuropsychopharmacology. 2019 Jan 17;
  Pubmed PMID: 30653192.
• Fava M, Freeman MP, Flynn M, Judge H, Hoeppner BB, Cusin C, Ionescu DF, Mathew SJ, Chang LC, Iosifescu DV, Murrough J, Debattista C, Schatzberg AF, Trivedi MH, Jha MK, Sanacora G, Wilkinson ST, Papakostas GI.. " Correction: Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD) " Mol Psychiatry. 2019 Jan 7;
  Pubmed PMID: 30617276.
• Salloum NC, Fava M, Freeman MP, Flynn M, Hoeppner B, Hock RS, Cusin C, Iosifescu DV, Trivedi MH, Sanacora G, Mathew SJ, Debattista C, Ionescu DF, Papakostas GI.. " Efficacy of intravenous ketamine treatment in anxious versus nonanxious unipolar treatment-resistant depression. " Depress Anxiety. 2018 Dec 30;
  Pubmed PMID: 30597688.
• Krystal AD, Pizzagalli DA, Mathew SJ, Sanacora G, Keefe R, Song A, Calabrese J, Goddard A, Goodman W, Lisanby SH, Smoski M, Weiner R, Iosifescu D, Nurnberger J Jr, Szabo S, Murrough J, Shekhar A, Potter W.. " The first implementation of the NIMH FAST-FAIL approach to psychiatric drug development. " Nat Rev Drug Discov. 2018 Dec 28; 18 (1) : 82-84.
  Pubmed PMID: 30591715.
• Mathew SJ, Wilkinson ST, Altinay M, Asghar-Ali A, Chang LC, Collins KA, Dale RM, Hu B, Krishnan K, Kellner CH, Malone DA, Murrough JW, Ostroff RB, Sanacora G, Shao M, Anand A.. " ELEctroconvulsive therapy (ECT) vs. Ketamine in patients with Treatment-resistant Depression: The ELEKT-D study protocol. " Contemp Clin Trials. 2019 Feb ; 77 : 19-26.
  Pubmed PMID: 30572160.
• Pape JC, Carrillo-Roa T, Rothbaum BO, Nemeroff CB, Czamara D, Zannas AS, Iosifescu D, Mathew SJ, Neylan TC, Mayberg HS, Dunlop BW, Binder EB.. " DNA methylation levels are associated with CRF(1) receptor antagonist treatment outcome in women with post-traumatic stress disorder " Clin Epigenetics. 2018 Nov 3; 10 (1) : 136.
  Pubmed PMID: 30390684.
• Fava M, Freeman MP, Flynn M, Judge H, Hoeppner BB, Cusin C, Ionescu DF, Mathew SJ, Chang LC, Iosifescu DV, Murrough J, Debattista C, Schatzberg AF, Trivedi MH, Jha MK, Sanacora G, Wilkinson ST, Papakostas GI.. " Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD). " Mol Psychiatry. 2018 Oct 3;
  Pubmed PMID: 30283029.
• Wilkinson ST, Kiselycznyk C, Banasr M, Webler RD, Haile C, Mathew SJ.. " Serum and plasma brain-derived neurotrophic factor and response in a randomized controlled trial of riluzole for treatment resistant depression. " J Affect Disord. 2018 Dec 1; 241 : 514-518.
  Pubmed PMID: 30153634.
• Gould F, Dunlop BW, Rosenthal JB, Iosifescu DV, Mathew SJ, Neylan TC, Rothbaum BO, Nemeroff CB, Harvey PD.. " Temporal Stability of Cognitive Functioning and Functional Capacity in Women with Posttraumatic Stress Disorder. " Arch Clin Neuropsychol.. 2018 Aug 15;
  Pubmed PMID: 30124744.
• Coplan JD, Lu D, El Sehamy AM, Tang C, Jackowski AP, Abdallah CG, Nemeroff CB, Owens MJ, Mathew SJ, Gorman JM.. " Early Life Stress Associated With Increased Striatal N-Acetyl-Aspartate: Cerebrospinal Fluid Corticotropin-Releasing Factor Concentrations, Hippocampal Volume, Body Mass and Behavioral Correlates. " Chronic Stress (Thousand Oaks).. 2018 Jan ; 2
  Pubmed PMID: 29963652.
• Hodgins GE, Blommel JG, Dunlop BW, Iosifescu D, Mathew SJ, Neylan TC, Mayberg HS, Harvey PD.. " Placebo Effects Across Self-Report, Clinician Rating, and Objective Performance Tasks Among Women With Post-Traumatic Stress Disorder: Investigation of Placebo Response in a Pharmacological Treatment Study of Post-Traumatic Stress Disorder. " J Clin Psychopharmacol. 2018 Jun ; 38 (3) : 200-206.
  Pubmed PMID: 29505471.
• Patriquin MA, Mathew SJ.. " The Neurobiological Mechanisms of Generalized Anxiety Disorder and Chronic Stress. " Chronic Stress (Thousand Oaks).. 2017 Jan ; 1
  Pubmed PMID: 29503978.
• Coplan JD, Webler R, Gopinath S, Abdallah CG, Mathew SJ.. " Neurobiology of the dorsolateral prefrontal cortex in GAD: Aberrant neurometabolic correlation to hippocampus and relationship to anxiety sensitivity and IQ. " J Affect Disord.. 2018 Mar 15; 229 : 1-13.
  Pubmed PMID: 29288871.
• : Abdallah CG, Averill CL, Salas R, Averill LA, Baldwin PR, Krystal JH, Mathew SJ, Mathalon DH.. " Prefrontal Connectivity and Glutamate Transmission: Relevance to Depression Pathophysiology and Ketamine Treatment. " Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Oct ; 2 (7) : 566-574.
  Pubmed PMID: 29034354.
• Wilkinson ST, Ballard ED, Bloch MH, Mathew SJ, Murrough JW, Feder A, Sos P, Wang G, Zarate CA Jr, Sanacora G.. " The Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation: A Systematic Review and Individual Participant Data Meta-Analysis. " Am J Psychiatry. 2018 Feb 1; 175 (2) : 150-158.
  Pubmed PMID: 28969441.
• Dunlop BW, Binder EB, Iosifescu D, Mathew SJ, Neylan TC, Pape JC, Carrillo-Roa T, Green C, Kinkead B, Grigoriadis D, Rothbaum BO, Nemeroff CB, Mayberg HS.. " Corticotropin-Releasing Factor Receptor 1 Antagonism Is Ineffective for Women With Posttraumatic Stress Disorder. " Biol Psychiatry. 2017 Dec 15; 82 (12) : 866-874.
  Pubmed PMID: 28793974.
• : Mathew SJ, Gueorguieva R, Brandt C, Fava M, Sanacora G.. " A Randomized, Double-Blind, Placebo-Controlled, Sequential Parallel Comparison Design Trial of Adjunctive Riluzole for Treatment-Resistant Major Depressive Disorder. " Neuropsychopharmacology.. 2017 Dec ; 42 (13) : 2567-2574.
  Pubmed PMID: 28553836.
• Murrough JW, Abdallah CG, Mathew SJ.. " Targeting glutamate signalling in depression: progress and prospects. " Nat Rev Drug Discov.. 2017 Jul ; 16 (7) : 472-486.
  Pubmed PMID: 28303025.
• Abdallah CG, Jackowski A, Salas R, Gupta S, Sato JR, Mao X, Coplan JD, Shungu DC, Mathew SJ.. " The Nucleus Accumbens and Ketamine Treatment in Major Depressive Disorder. " Neuropsychopharmacology.. 2017 Jul ; 42 (8) : 1739-1746.
  Pubmed PMID: 28272497.
• Sanacora G, Frye MA, McDonald W, Mathew SJ, Turner MS, Schatzberg AF, Summergrad P, Nemeroff CB; American Psychiatric Association (APA) Council of Research Task Force on Novel Biomarkers and Treatments.. " A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders. " JAMA Psychiatry. 2017 Apr 1; 74 (4) : 399-405.
  Pubmed PMID: 28249076.
• Mathew SJ, Lijffijt M.. " Neurometabolic Abnormalities in Treatment-Resistant Depression " Am J Psychiatry. 2017 Jan 1; 174 (1) : 3-5.
  Pubmed PMID: 28041002.
• Sanacora G, Johnson MR, Khan A, Atkinson SD, Riesenberg RR, Schronen JP, Burke MA, Zajecka JM, Barra L, Su HL, Posener JA, Bui KH, Quirk MC, Piser TM, Mathew SJ, Pathak S.. " Adjunctive Lanicemine (AZD6765) in Patients with Major Depressive Disorder and History of Inadequate Response to Antidepressants: A Randomized, Placebo-Controlled Study " Neuropsychopharmacology. 2017 Mar ; 42 (4) : 844-853.
  Pubmed PMID: 27681442.
• Lijffijt M, Lane SD, Mathew SJ, Stanford MS, Swann AC. " Heightened early-attentional stimulus orienting and impulsive action in men with antisocial personality disorder. " Eur Arch Psychiatry Clin Neurosci. 2017 Oct ; 267 (7) : 697-707.
  Pubmed PMID: 27662886.
• Sanacora G, Heimer H, Hartman D, Mathew SJ, Frye M, Nemeroff C, Robinson Beale R.. " Balancing the Promise and Risks of Ketamine Treatment for Mood Disorders. " Neuropsychopharmacology. 2017 May ; 42 (6) : 1179-1181.
  Pubmed PMID: 27640324.
• Coplan JD, Kolavennu V, Abdallah CG, Mathew SJ, Perera TD, Pantol G, Carpenter D, Tang C.. " Patterns of anterior versus posterior white matter fractional anistotropy concordance in adult nonhuman primates: Effects of early life stress. " J Affect Disord. 2016 Mar 1; 192 : 167-75.
  Pubmed PMID: 26735328.
• Raparia E, Coplan JD, Abdallah CG, Hof PR, Mao X, Mathew SJ, Shungu DC. " Impact of childhood emotional abuse on neocortical neurometabolites and complex emotional processing in patients with generalized anxiety disorder " J Affect Disord. 2016 Jan 15; 190 : 414-423.
  Pubmed PMID: 26551399.
• Al Jurdi RK, Swann A, Mathew SJ.. " Psychopharmacological Agents and Suicide Risk Reduction: Ketamine and Other Approaches " Curr Psychiatry Rep. 2016 Oct ; 17 (10) : 81.
  Pubmed PMID: 26307033.
• Abdallah CG, Jackowski A, Sato JR, Mao X, Kang G, Cheema R, Coplan JD, Mathew SJ, Shungu DC. " Prefrontal cortical GABA abnormalities are associated with reduced hippocampal volume in major depressive disorder " Eur Neuropsychopharmacol. 2015 Aug ; 25 (8) : 1082-90.
  Pubmed PMID: 25983019.
• Bhagwagar Z, Torbeyns A, Hennicken D, Zheng M, Dunlop BW, Mathew SJ, Khan A, Weisler R, Nelson C, Shelton R, Thase ME, Lane R.. " Assessment of the Efficacy and Safety of BMS-820836 in Patients With Treatment-Resistant Major Depression: Results From 2 Randomized, Double-Blind Studies " J Clin Psychopharmacol. 2015 Aug ; 35 (4) : 454-9.
  Pubmed PMID: 25961781.
• Ridgewell C, Bray A, Curtis K, Velasquez K, Baldwin PR, Fowler JC, Mathew SJ, Salas R.. " Enhanced Olfactory Cortex Connectivity in a Patient With PTSD With Olfactory Hallucinations " J Neuropsychiatry Clin Neurosci. 2015 ; 27 (2) : e170-1.
  Pubmed PMID: 25923873.
• Coplan J, Singh D, Gopinath S, Mathew SJ, Bulbena A.. " A Novel Anxiety and Affective Spectrum Disorder of Mind and Body-The ALPIM (Anxiety-Laxity-Pain-Immune-Mood) Syndrome: A Preliminary Report " J Neuropsychiatry Clin Neurosci. 2015 ; 27 (2) : 93-103.
  Pubmed PMID: 25923849.
• Price RB, Mathew SJ. " Does ketamine have anti-suicidal properties? Current status and future directions. " CNS Drugs. 2015 Mar ; 29 (3) : 181-8.
  Pubmed PMID: 25715884.
• Murrough JW, Collins KA, Fields J, DeWilde KE, Phillips ML, Mathew SJ, Wong E, Tang CY, Charney DS, Iosifescu DV. " Regulation of neural responses to emotion perception by ketamine in individuals with treatment-resistant major depressive disorder. " Transl Psychiatry. 2015 Feb 17; 5 : e509.
  Pubmed PMID: 25689570.
• DeWilde KE, Levitch CF, Murrough JW, Mathew SJ, Iosifescu DV. " The promise of ketamine for treatment-resistant depression: current evidence and future directions. " Ann N Y Acad Sci. 2015 May ; 1345 : 47-58.
  Pubmed PMID: 25649308.
• Coplan JD, Fulton SL, Reiner W, Jackowski A, Panthangi V, Perera TD, Gorman JM, Huang YY, Tang CY, Hof PR, Kaffman A, Dwork AJ, Mathew SJ, Kaufman J, Mann JJ.. " Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related function in mood and anxiety disorders " Front Behav Neurosci. 2014 Dec 23; 8 : 440.
  Pubmed PMID: 25566007.
• Murrough JW, Burdick KE, Levitch CF, Perez AM, Brallier JW, Chang LC, Foulkes A, Charney DS, Mathew SJ, Iosifescu DV. " Neurocognitive effects of ketamine and association with antidepressant response in individuals with treatment-resistant depression: a randomized controlled trial " Neuropsychopharmacology. 2015 Mar 13; 40 (5) : 1084-90.
  Pubmed PMID: 25374095.
• Coplan JD, Fathy HM, Jackowski AP, Tang CY, Perera TD, Mathew SJ, Martinez J, Abdallah CG, Dwork AJ, Pantol G, Carpenter D, Gorman JM, Nemeroff CB, Owens MJ, Kaffman A, Kaufman J. " Early life stress and macaque amygdala hypertrophy: preliminary evidence for a role for the serotonin transporter gene. " Front Behav Neurosci. 2014 Oct 6; 8 : 342.
  Pubmed PMID: 25339875.
• Wan LB, Levitch CF, Perez AM, Brallier JW, Iosifescu DV, Chang LC, Foulkes A, Mathew SJ, Charney DS, Murrough JW. " Ketamine safety and tolerability in clinical trials for treatment-resistant depression. " J Clin Psychiatry. 2015 Mar ; 76 (3) : 247-52.
  Pubmed PMID: 25271445.
• Abdallah CG, Salas R, Jackowski A, Baldwin P, Sato JR, Mathew SJ.. " Hippocampal volume and the rapid antidepressant effect of ketamine. " J Psychopharmacol. 2015 May ; 29 (5) : 591-5.
  Pubmed PMID: 25122038.
• Kaye JL, Dunlop BW, Iosifescu DV, Mathew SJ, Kelley ME, Harvey PD. Cognition, functional capacity, and self-reported disability in women with posttraumatic stress disorder: examining the convergence of performance-based measures and self-reports. " Cognition, functional capacity, and self-reported disability in women with posttraumatic stress disorder: examining the convergence of performance-based measures and self-reports. " J Psychiatr Res. 2014 Oct ; 57 : 51-7.
  Pubmed PMID: 24974001.
• Dunlop BW, Rothbaum BO, Binder EB, Duncan E, Harvey PD, Jovanovic T, Kelley ME, Kinkead B, Kutner M, Iosifescu DV, Mathew SJ, Neylan TC, Kilts CD, Nemeroff CB, Mayberg HS.. " Evaluation of a corticotropin releasing hormone type 1 receptor antagonist in women with posttraumatic stress disorder: study protocol for a randomized controlled trial. " Trials. 2014 Jun 21; 15 : 240.
  Pubmed PMID: 24950747.
• Lapidus KA, Gabbay V, Mao X, Johnson A, Murrough JW, Mathew SJ, Shungu DC. " In vivo (1)H MRS study of potential associations between glutathione, oxidative stress and anhedonia in major depressive disorder " Neurosci Lett. 2014 May 21; 569 : 74-9.
  Pubmed PMID: 24704328.
• Price RB, Iosifescu DV, Murrough JW, Chang LC, Al Jurdi RK, Iqbal SZ, Soleimani L, Charney DS, Foulkes AL, Mathew SJ.. " Effects of ketamine on explicit and implicit suicidal cognition: a randomized controlled trial in treatment-resistant depression " Depress Anxiety. 2014 Apr ; 31 (4) : 335-43.
  Pubmed PMID: 24668760.
• Coplan JD, Fathy HM, Abdallah CG, Ragab SA, Kral JG, Mao X, Shungu DC, Mathew SJ.. " Reduced hippocampal N-acetyl-aspartate (NAA) as a biomarker for overweight " Neuroimage Clin. 2014 Jan 9; 4 : 326-35.
  Pubmed PMID: 24501701.
• Dakwar E, Anerella C, Hart CL, Levin FR, Mathew SJ, Nunes EV. " Therapeutic infusions of ketamine: do the psychoactive effects matter? " Drug Alcohol Depend. 2014 Mar 1; 136 : 153-7.
  Pubmed PMID: 24480515.
• Mathew SJ. " Glycine transporter-I inhibitors: a new class of antidepressant? " Biol Psychiatry. 2013 Nov 15; 74 (10) : 710-1.
  Pubmed PMID: 24144323.
• Haile CN, Murrough JW, Iosifescu DV, Chang LC, Al Jurdi RK, Foulkes A, Iqbal S, Mahoney JJ 3rd, De La Garza R 2nd, Charney DS, Newton TF, Mathew SJ.. " Plasma brain derived neurotrophic factor (BDNF) and response to ketamine in treatment-resistant depression. " Int J Neuropsychopharmacol. 2014 Feb ; 17 (2) : 331-6.
  Pubmed PMID: 24103211.
• Murrough JW, Wan LB, Iacoviello B, Collins KA, Solon C, Glicksberg B, Perez AM, Mathew SJ, Charney DS, Iosifescu DV, Burdick KE. " Neurocognitive effects of ketamine in treatment-resistant major depression: association with antidepressant response " Psychopharmacology (Berl). 2013 Sep 11;
  Pubmed PMID: 24022236.
• Murrough JW, Iosifescu DV, Chang LC, Al Jurdi RK, Green CE, Perez AM, Iqbal S, Pillemer S, Foulkes A, Shah A, Charney DS, Mathew SJ. " Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial " Am J Psychiatry. 2013 Oct ; 170 (10) : 1134-42.
  Pubmed PMID: 23982301.
• Chang LC, Raty SR, Ortiz J, Bailard NS, Mathew SJ. " The emerging use of ketamine for anesthesia and sedation in traumatic brain injuries. " CNS Neurosci Ther. 2013 Jun ; 19 (6) : 390-5.
  Pubmed PMID: 23480625.
• Abdallah CG, Coplan JD, Jackowski A, Sato JR, Mao X, Shungu DC, Mathew SJ. " Riluzole effect on occipital cortex: A structural and spectroscopy pilot study. " Neurosci. Lett.. 2012 Nov 14; 530 (1) : 103-7.
  Pubmed PMID: 23043888.
• Murrough JW, Perez AM, Pillemer S, Stern J, Parides MK, aan het Rot M, Collins KA, Mathew SJ, Charney DS, Iosifescu DV. " Rapid and longer-term antidepressant effects of repeated ketamine infusions in treatment-resistant major depression. " Biol Psychiatry. 2013 Aug 15; 74 (4) : 250-6.
  Pubmed PMID: 22840761.
• Abdallah CG, Coplan JD, Jackowski A, Sato JR, Mao X, Shungu DC, Mathew SJ. " A pilot study of hippocampal volume and N-acetylaspartate (NAA) as response biomarkers in riluzole-treated patients with GAD. " Eur Neuropsychopharmacol. 2013 Apr ; 23 (4) : 276-84.
  Pubmed PMID: 22739126.
• Aan Het Rot M, Zarate CA, Charney DS, Mathew SJ. " Ketamine for depression: where do we go from here? " Biol. Psychiatry. 2012 Oct 1; 72 (7) : 537-47.
  Pubmed PMID: 22705040.
• Coplan JD, Hodulik S, Mathew SJ, Mao X, Hof PR, Gorman JM, Shungu DC. " The Relationship between Intelligence and Anxiety: An Association with Subcortical White Matter Metabolism. " Front Evol Neurosci. 2011 ; 3 : 8.
  Pubmed PMID: 22347183.
• Anand A, Gunn AD, Barkay G, Karne HS, Nurnberger JI, Mathew SJ, Ghosh S. " Early antidepressant effect of memantine during augmentation of lamotrigine inadequate response in bipolar depression: a double-blind, randomized, placebo-controlled trial. " Bipolar Disord. 2012 Feb ; 14 (1) : 64-70.
  Pubmed PMID: 22329473.
• Mathew SJ, Shah A, Lapidus K, Clark C, Jarun N, Ostermeyer B, Murrough JW. " Ketamine for treatment-resistant unipolar depression: current evidence. " CNS Drugs. 2012 Mar 1; 26 (3) : 189-204.
  Pubmed PMID: 22303887.
• Shungu DC, Weiduschat N, Murrough JW, Mao X, Pillemer S, Dyke JP, Medow MS, Natelson BH, Stewart JM, Mathew SJ. " Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. " NMR Biomed. 2012 Sep ; 25 (9) : 1073-87.
  Pubmed PMID: 22281935.
• Coplan JD, Abdallah CG, Mathew SJ, Shungu DC, Mao X, Smith EL, Kaufman D, Gorman JM, Owens MJ, Nemeroff CB, Banerji MA, Rosenblum LA, Kral JG. " Metabolic syndrome and neurometabolic asymmetry of hippocampus in adult bonnet monkeys. " Physiol. Behav.. 2011 Jul 6; 103 (5) : 535-9.
  Pubmed PMID: 21459102.
• Murrough JW, Perez AM, Mathew SJ, Charney DS. " A case of sustained remission following an acute course of ketamine in treatment-resistant depression. " J Clin Psychiatry. 2011 Mar ; 72 (3) : 414-5.
  Pubmed PMID: 21450159.
• Jackowski A, Perera TD, Abdallah CG, Garrido G, Tang CY, Martinez J, Mathew SJ, Gorman JM, Rosenblum LA, Smith EL, Dwork AJ, Shungu DC, Kaffman A, Gelernter J, Coplan JD, Kaufman J. " Early-life stress, corpus callosum development, hippocampal volumetrics, and anxious behavior in male nonhuman primates. " Psychiatry Res. 2011 Apr 30; 192 (1) : 37-44.
  Pubmed PMID: 21377844.
• Feder A, Skipper J, Blair JR, Buchholz K, Mathew SJ, Schwarz M, Doucette JT, Alonso A, Collins KA, Neumeister A, Charney DS. " Tryptophan depletion and emotional processing in healthy volunteers at high risk for depression. " Biol. Psychiatry. 2011 Apr 15; 69 (8) : 804-7.
  Pubmed PMID: 21377656.
• Mathew SJ, Vythilingam M, Murrough JW, Zarate CA, Feder A, Luckenbaugh DA, Kinkead B, Parides MK, Trist DG, Bani MS, Bettica PU, Ratti EM, Charney DS. " A selective neurokinin-1 receptor antagonist in chronic PTSD: A randomized, double-blind, placebo-controlled, proof-of-concept trial. " Eur Neuropsychopharmacol. 2011 Mar ; 21 (3) : 221-9.
  Pubmed PMID: 21194898.
• Coplan JD, Mathew SJ, Abdallah CG, Mao X, Kral JG, Smith EL, Rosenblum LA, Perera TD, Dwork AJ, Hof PR, Gorman JM, Shungu DC. " Early-life stress and neurometabolites of the hippocampus. " Brain Res.. 2010 Oct 28; 1358 : 191-9.
  Pubmed PMID: 20713023.
• Murrough JW, Mao X, Collins KA, Kelly C, Andrade G, Nestadt P, Levine SM, Mathew SJ, Shungu DC. " Increased ventricular lactate in chronic fatigue syndrome measured by 1H MRS imaging at 3.0 T. II: comparison with major depressive disorder. " NMR Biomed. 2010 Jul ; 23 (6) : 643-50.
  Pubmed PMID: 20661876.
• Krystal JH, Mathew SJ, D'Souza DC, Garakani A, Gunduz-Bruce H, Charney DS. " Potential psychiatric applications of metabotropic glutamate receptor agonists and antagonists. " CNS Drugs. 2010 Aug 1; 24 (8) : 669-93.
  Pubmed PMID: 20658799.
• Coplan JD, Abdallah CG, Tang CY, Mathew SJ, Martinez J, Hof PR, Smith EL, Dwork AJ, Perera TD, Pantol G, Carpenter D, Rosenblum LA, Shungu DC, Gelernter J, Kaffman A, Jackowski A, Kaufman J, Gorman JM. " The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates. " Neurosci. Lett.. 2010 Aug 16; 480 (2) : 93-6.
  Pubmed PMID: 20541590.
• Abdallah CG, Tang CY, Mathew SJ, Martinez J, Hof PR, Perera TD, Shungu DC, Gorman JM, Coplan JD. " Diffusion tensor imaging in studying white matter complexity: a gap junction hypothesis. " Neurosci. Lett.. 2010 May 21; 475 (3) : 161-4.
  Pubmed PMID: 20371267.
• aan het Rot M, Collins KA, Murrough JW, Perez AM, Reich DL, Charney DS, Mathew SJ. " Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depression. " Biol. Psychiatry. 2010 Jan 15; 67 (2) : 139-45.
  Pubmed PMID: 19897179.
• Price RB, Nock MK, Charney DS, Mathew SJ. " Effects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression. " Biol. Psychiatry. 2009 Sep 1; 66 (5) : 522-6.
  Pubmed PMID: 19545857.
• Mathew SJ, Murrough JW, aan het Rot M, Collins KA, Reich DL, Charney DS. " Riluzole for relapse prevention following intravenous ketamine in treatment-resistant depression: a pilot randomized, placebo-controlled continuation trial. " Int. J. Neuropsychopharmacol.. 2010 Feb ; 13 (1) : 71-82.
  Pubmed PMID: 19288975.
• Mathew SJ, Price RB, Shungu DC, Mao X, Smith EL, Amiel JM, Coplan JD. " A pilot study of the effects of chronic paroxetine administration on hippocampal N-acetylaspartate in generalized anxiety disorder. " J. Psychopharmacol. (Oxford). 2010 Aug ; 24 (8) : 1175-81.
  Pubmed PMID: 19204062.
• aan het Rot M, Mathew SJ, Charney DS. " Neurobiological mechanisms in major depressive disorder. " CMAJ. 2009 Feb 3; 180 (3) : 305-13.
  Pubmed PMID: 19188629.
• Mathew SJ, Charney DS. " Publication bias and the efficacy of antidepressants. " Am J Psychiatry. 2009 Feb ; 166 (2) : 140-5.
  Pubmed PMID: 19188290.
• Price RB, Shungu DC, Mao X, Nestadt P, Kelly C, Collins KA, Murrough JW, Charney DS, Mathew SJ. " Amino acid neurotransmitters assessed by proton magnetic resonance spectroscopy: relationship to treatment resistance in major depressive disorder. " Biol. Psychiatry. 2009 May 1; 65 (9) : 792-800.
  Pubmed PMID: 19058788.
• Mathew SJ. " Treatment-resistant depression: recent developments and future directions. " Depress Anxiety. 2008 ; 25 (12) : 989-92.
  Pubmed PMID: 19058261.
• Mathew SJ, Mao X, Keegan KA, Levine SM, Smith EL, Heier LA, Otcheretko V, Coplan JD, Shungu DC. " Ventricular cerebrospinal fluid lactate is increased in chronic fatigue syndrome compared with generalized anxiety disorder: an in vivo 3.0 T (1)H MRS imaging study. " NMR Biomed. 2009 Apr ; 22 (3) : 251-8.
  Pubmed PMID: 18942064.
• Mathew SJ, Garakani A, Reinhard JF, Oshana S, Donahue S. " Short-term tolerability of a nonazapirone selective serotonin 1A agonist in adults with generalized anxiety disorder: a 28-day, open-label study. " Clin Ther. 2008 Sep ; 30 (9) : 1658-66.
  Pubmed PMID: 18840371.
• Hoffman EJ, Mathew SJ. " Anxiety disorders: a comprehensive review of pharmacotherapies. " Mt. Sinai J. Med.. ; 75 (3) : 248-62.
  Pubmed PMID: 18704983.
• Dumitriu D, Collins K, Alterman R, Mathew SJ. " Neurostimulatory therapeutics in management of treatment-resistant depression with focus on deep brain stimulation. " Mt. Sinai J. Med.. ; 75 (3) : 263-75.
  Pubmed PMID: 18704979.
• Mathew SJ, Price RB, Charney DS. " Recent advances in the neurobiology of anxiety disorders: implications for novel therapeutics. " Am J Med Genet C Semin Med Genet. 2008 May 15; 148 (2) : 89-98.
  Pubmed PMID: 18412102.
• Mathew SJ, Manji HK, Charney DS. " Novel drugs and therapeutic targets for severe mood disorders. " Neuropsychopharmacology. 2008 Aug ; 33 (9) : 2080-92.
  Pubmed PMID: 18172433.
• Mathew SJ, Price RB, Mao X, Smith EL, Coplan JD, Charney DS, Shungu DC. " Hippocampal N-acetylaspartate concentration and response to riluzole in generalized anxiety disorder. " Biol. Psychiatry. 2008 May 1; 63 (9) : 891-8.
  Pubmed PMID: 18028881.
• Amiel JM, Mathew SJ. " Glutamate and anxiety disorders. " Curr Psychiatry Rep. 2007 Aug ; 9 (4) : 278-83.
  Pubmed PMID: 17880858.
• Garakani A, Mathew SJ, Charney DS. " Neurobiology of anxiety disorders and implications for treatment. " Mt. Sinai J. Med.. 2006 Nov ; 73 (7) : 941-9.
  Pubmed PMID: 17195879.
• Mathew SJ, Ho S. " Etiology and neurobiology of social anxiety disorder. " J Clin Psychiatry. 2006 ; 67 : 41530.
  Pubmed PMID: 17092190.
• Coplan JD, Smith EL, Altemus M, Mathew SJ, Perera T, Kral JG, Gorman JM, Owens MJ, Nemeroff CB, Rosenblum LA. " Maternal-infant response to variable foraging demand in nonhuman primates: effects of timing of stressor on cerebrospinal fluid corticotropin-releasing factor and circulating glucocorticoid concentrations. " Ann. N. Y. Acad. Sci.. 2006 Jul ; 1071 : 525-33.
  Pubmed PMID: 16891612.
• Coplan JD, Mathew SJ, Mao X, Smith EL, Hof PR, Coplan PM, Rosenblum LA, Gorman JM, Shungu DC. " Decreased choline and creatine concentrations in centrum semiovale in patients with generalized anxiety disorder: relationship to IQ and early trauma. " Psychiatry Res. 2006 Jun 30; 147 (1) : 27-39.
  Pubmed PMID: 16797939.
• Mathew SJ, Amiel JM, Coplan JD, Fitterling HA, Sackeim HA, Gorman JM. " Open-label trial of riluzole in generalized anxiety disorder. " Am J Psychiatry. 2005 Dec ; 162 (12) : 2379-81.
  Pubmed PMID: 16330605.
• Mathew SJ, Keegan K, Smith L. " Glutamate modulators as novel interventions for mood disorders. " Rev Bras Psiquiatr. 2005 Sep ; 27 (3) : 243-8.
  Pubmed PMID: 16224615.
• Coplan JD, Altemus M, Mathew SJ, Smith EL, Sharf B, Coplan PM, Kral JG, Gorman JM, Owens MJ, Nemeroff CB, Rosenblum LA. " Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demand. " CNS Spectr. 2005 Jul ; 10 (7) : 530-6.
  Pubmed PMID: 16155510.
• Fallon BA, Mathew SJ. " Biological therapies for obsessive-compulsive disorder. " J Psychiatr Pract. 2000 May ; 6 (3) : 113-28.
  Pubmed PMID: 15990479.
• Coplan JD, Mathew SJ, Smith EL, Trost RC, Scharf BA, Martinez J, Gorman JM, Monn JA, Schoepp DD, Rosenblum LA. " Effects of LY354740, a novel glutamatergic metabotropic agonist, on nonhuman primate hypothalamic-pituitary-adrenal axis and noradrenergic function. " CNS Spectr. 2001 Jul ; 6 (7) : 607-12, 617.
  Pubmed PMID: 15573025.
• Mathew SJ, Coplan JD, Schoepp DD, Smith EL, Rosenblum LA, Gorman JM. " Glutamate-hypothalamic-pituitary-adrenal axis interactions: implications for mood and anxiety disorders. " CNS Spectr. 2001 Jul ; 6 (7) : 555-6, 561-4.
  Pubmed PMID: 15573019.
• Feder A, Coplan JD, Goetz RR, Mathew SJ, Pine DS, Dahl RE, Ryan ND, Greenwald S, Weissman MM. " Twenty-four-hour cortisol secretion patterns in prepubertal children with anxiety or depressive disorders. " Biol. Psychiatry. 2004 Aug 1; 56 (3) : 198-204.
  Pubmed PMID: 15271589.
• Mathew SJ, Mao X, Coplan JD, Smith EL, Sackeim HA, Gorman JM, Shungu DC. " Dorsolateral prefrontal cortical pathology in generalized anxiety disorder: a proton magnetic resonance spectroscopic imaging study. " Am J Psychiatry. 2004 Jun ; 161 (6) : 1119-21.
  Pubmed PMID: 15169704.
• Mathew SJ, Shungu DC, Mao X, Smith EL, Perera GM, Kegeles LS, Perera T, Lisanby SH, Rosenblum LA, Gorman JM, Coplan JD. " A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors. " Biol. Psychiatry. 2003 Oct 1; 54 (7) : 727-35.
  Pubmed PMID: 14512213.
• Mathew SJ, Coplan JD, Goetz RR, Feder A, Greenwald S, Dahl RE, Ryan ND, Mann JJ, Weissman MM. " Differentiating depressed adolescent 24 h cortisol secretion in light of their adult clinical outcome. " Neuropsychopharmacology. 2003 Jul ; 28 (7) : 1336-43.
  Pubmed PMID: 12784120.
• Kent JM, Mathew SJ, Gorman JM. " Molecular targets in the treatment of anxiety. " Biol. Psychiatry. 2002 Nov 15; 52 (10) : 1008-30.
  Pubmed PMID: 12437941.
• Mathew SJ, Coplan JD, Gorman JM. " Management of treatment-refractory panic disorder. " Psychopharmacol Bull. 2001 ; 35 (2) : 97-110.
  Pubmed PMID: 12397890.
• Mathew SJ, Coplan JD, Smith EL, Scharf BA, Owens MJ, Nemeroff CB, Mann JJ, Gorman JM, Rosenblum LA. " Cerebrospinal fluid concentrations of biogenic amines and corticotropin-releasing factor in adolescent non-human primates as a function of the timing of adverse early rearing. " Stress. 2002 Sep ; 5 (3) : 185-93.
  Pubmed PMID: 12186681.
• Mathew SJ, Coplan JD, Perko KA, Goetz RR, de la Neuz M, Hollander E, Liebowitz MR, Fallon BA. " Neuroendocrine predictors of response to intravenous clomipramine therapy for refractory obsessive-compulsive disorder. " Depress Anxiety. 2001 ; 14 (4) : 199-208.
  Pubmed PMID: 11754126.
• Mathew SJ, Coplan JD, Gorman JM. " Neurobiological mechanisms of social anxiety disorder. " Am J Psychiatry. 2001 Oct ; 158 (10) : 1558-67.
  Pubmed PMID: 11578981.
• Mathew SJ. " PANDAS variant and body dysmorphic disorder. " Am J Psychiatry. 2001 Jun ; 158 (6) : 963.
  Pubmed PMID: 11384911.
• Rickels K, Mathew S, Banov MD, Zimbroff DL, Oshana S, Parsons EC, Donahue SR, Kauffman M, Iyer GR, Reinhard JF. " Effects of PRX-00023, a novel, selective serotonin 1A receptor agonist on measures of anxiety and depression in generalized anxiety disorder: results of a double-blind, placebo-controlled trial. " J Clin Psychopharmacol. 2008 Apr ; 28 (2) : 235-9.
  Pubmed PMID: 18344738.
• Mathew SJ, Yudofsky SC, McCullough LB, Teasdale TA, Jankovic J. " Attitudes toward neurosurgical procedures for Parkinson's disease and obsessive-compulsive disorder. " J Neuropsychiatry Clin Neurosci. 1999 ; 11 (2) : 259-67.
  Pubmed PMID: 10333998.
• Mathew S, Charney D. " Anxiety and depression: leading edge of therapy. " Mt. Sinai J. Med.. ; 75 (3) : 171-3.
  Pubmed PMID: 18704975.

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Memberships

Society of Biological Psychiatry

Anxiety and Depression Association of America

American College of Neuropsychopharmacology

American Psychiatric Association

American Medical Association

American Society of Clinical Psychopharmacology

Funding

Ezogabine: Developing Neuronal KCNQ Channel Modulators for Mood Disorders
#H-40062

NIMH (National Institute of Mental Health)

Lanicemine: NMDA Receptor Modulation for Hyperarousal in PTSD

NIMH (National Institute of Mental Health)

ELEKT-D: Treatment Resistant Depression: ECT Versus Ketamine
#H-40701

Patient-Centered Outcomes Research Institute (PCORI)

Aug vs. Switch: Treatment Resistant Depression: Augmentation Versus Switch
#H-40432

Patient-Centered Outcomes Research Institute (PCORI)

VA-LLK: Ketamine for Treatment Resistant Late-Life Depression
#H-36574

Department of Veterans Affairs

AV101: Electrophysiological Biomarkers of Kynurenine Pathway Modulator AV-101 in Healthy Volunteers: Treating Suicidal Veterans
#H-41830

Michael E DeBakey VA Medical Center / VistaGen Therapeutics