Robert M Bryan Jr, Ph.D.

Vice Chair for Research, Professor of Anesthesiology, Medicine, and Cellular and Molecular Physiology

(713) 798-7720

Email

rbryan@bcm.edu

Positions

Vice Chair for Research, Professor of Anesthesiology, Medicine, and Cellular and Molecular Physiology: Anesthesiology
Baylor College of Medicine
Houston, TX, US

Education

Postdoctoral Fellowship at Duke University: 06/1981 - Durham, NC, United States

PhD from University Of British Columbia: 01/1980 - Vancouver, Canada

M.S. from University Of Alabama: 01/1974 - Tuscaloosa, AL, United States

BS from University Of Alabama: 05/1970 - Tuscaloosa, AL, United States

Professional Statement

Our laboratory studies communications between the gut bacteria, the gut, and the brain during normal and pathological states. These studies include hypertension, stroke, aging, Alzheimer’s disease, and cerebral small vessel disease.
A second line of investigation involves the control of cerebral circulation during normal and pathological states. Current projects involve the interaction between cerebrovascular endothelium and smooth muscle.

Websites

VIICTR - Publications

http://www.bcm.edu/anesthesiology/index.cfm?pmid=13110

Robert Bryan

Selected Publications

Blasco, M. P., Chauhan, A., Honarpisheh, P., Ahnstedt, H., d'Aigle, J., Ganesan, A., Ayyaswamy, S., Blixt, F., Venable, S., Major, A., Durgan, D., Haag, A., Kofler, J., Bryan, R., McCullough, L. D., Ganesh, B. P.. " Age-dependent involvement of gut mast cells and histamine in post-stroke inflammation. " J. Neuroinflammation. ; 17 : 160.
Spychala, M. S., Venna, V. R., Jandzinski, M., Doran, S. J., Durgan, D. J., Ganesh, B. P., Ajami, N. J., Putluri, N., Graf, J., Bryan, R. M., McCullough, L. D.. " Age-related changes in the gut microbiota influence systemic inflammation and stroke outcome. " Ann.Neurol.. 2018 ; 84 : 23-36.
Adnan S, Nelson JW, Ajami NJ, Venna VR, Petrosino JF, Bryan RM, Durgan DJ. " Alterations in the gut microbiota can elicit hypertension in rats. " Physiol Genomics. 2017 ; 49 : 96-104.
Durgan,D.J.; Lee,J.; McCullough,L.D.; Bryan,R.M.,Jr.. " Examining the Role of the Microbiota-Gut-Brain Axis in Stroke " Stroke. 2019 ; 50 (8) : 2270-2277.
Pubmed PMID: 31272315.
Lee, J., d'Aigle, J., Atadja, L., Quaicoe, V., Honarpisheh, P., Ganesh, B. P., Hassan, A., Graf, J., Petrosino, J. F., Putluri, N., Zhu, L., Durgan, D. J., Bryan, R. M., Jr., McCullough, L. D., Venna, V. R.. " Gut Microbiota-Derived Short-Chain Fatty Acids Promote Post-Stroke Recovery in Aged Mice. " Circ. Res.. 2020 ; 127 : 435-465.
Honarpisheh, P., Blixt, F. W., Blasco Conesa, M. P., Won, W., d'Aigle, J., Munshi, Y., Hudobenko, J., Furr, J. W., Mobley, A., Lee, J., Brannick, K. E., Zhu, L., Hazen, A. L., Bryan, R. M., McCullough, L. D., Ganesh, B. P.. " Peripherally-sourced myeloid antigen presenting cells increase with advanced aging. " Brain Behav.Immun.. 2020 ;
Ganesh,B.P.; Nelson,J.W.; Eskew,J.R.; Ganesan,A.; Ajami,N.J.; Petrosino,J.F.; Bryan,R.M.,Jr.; Durgan,D.J.. " Prebiotics, Probiotics, and Acetate Supplementation Prevent Hypertension in a Model of Obstructive Sleep Apnea " Hypertension. 2018 ; 72 (5) : 1141-1150.
Pubmed PMID: 30354816.
Durgan DJ, Ganesh BP, Cope JL, Ajami NJ, Phillips SC, Petrosino JF, Hollister EB, Bryan RM. " Role of the Gut Microbiome in Obstructive Sleep Apnea-Induced Hypertension. " Hypertension. 2016 ; 67 (2) : 469-474.
Nelson,J.W.; Phillips,S.C.; Ganesh,B.P.; Petrosino,J.F.; Durgan,D.J.; Bryan,R.M.. " The gut microbiome contributes to blood-brain barrier disruption in spontaneously hypertensive stroke prone rats " FASEB J. 2021 ; 35 (2) : e21201.
Pubmed PMID: 33496989.
Lee, J., Venna, V. R., Durgan, D. J., Shi, H., Hudobenko, J., Putluri, N., Petrosino, J., McCullough, L. D., Bryan, R. M.. " Young versus aged microbiota transplants to germ-free mice: increased short-chain fatty acids and improved cognitive performance. " Gut Microbes. 2020 ; 1-14.