Richard
Middle Name
Louis
Hurwitz, M.D.
Middle Name
Louis
Picture
Positions
- Associate Professor
-
Pediatrics-Oncology
Baylor College of Medicine
Houston, TX US
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
Addresses
- Feigin Center (Office)
-
Suite C0730
1102 Bates Street
Houston, TX 77030
United States
Phone: (832) 824-4260
rhurwitz@bcm.edu
- Texas Children's Hospital, Clinical Care Center (Clinic)
-
6701 Fannin St., 14th floor
Houston, TX 77030
United States
Phone: (832) 822-4242
Education
- BS from Rensselaer Polytechnic Institute
- 05/1975 - Troy, New York United States
- MD from Albany Medical College of Union University
- 05/1975 - Albany, New York United States
- Residency at University Of Minnesota Affiliate Hospitals
- Minneapolis, Minnesota United States
- Pediatrics
- Clinical Fellowship at University of Minnesota Medical School
- Minneapolis, Minnesota United States
- Pediatric Hematology-Oncology
- Postdoctoral Fellowship at University Of Washington
- Seattle, Washington United States
Professional Interests
- Gene therapy
- Retinoblastoma
- Retinal degeneration
Websites
Selected Publications
- Bond, W.S., Akinfenwa, P.Y., Perlaky, L., Hurwitz, MY., Hurwitz, R.L.*, Chévez-Barrios, P.* "Tumorspheres but Not Adherent Cells Derived from Retinoblastoma Tumors Are of Malignant Origin." PLoS ONE. 2013 : Pubmed PMID: 23658322
- Wadhwa L, Bond WS, Perlaky L, Overbeek PA, Hurwitz MY, Chévez-Barrios P, Hurwitz RL "Embryonic Retinal Tumors in SV40 T-Ag Transgenic Mice Contain CD133+ Tumor-Initiating Cells.." Invest. Ophthalmol. Vis. Sci.. 2012 53 (7): 3454-62. Pubmed PMID: 22562503
- Ildefonso CJ, Kong L, Leen A, Chai SJ, Petrochelli V, Chintagumpala M, Hurwitz MY, Chévez-Barrios P, Hurwitz RL "Absence of systemic immune response to adenovectors after intraocular administration to children with retinoblastoma.." Mol. Ther.. 2010 October ; 18 (10): 1885-90. Pubmed PMID: 20606647
- Ildefonso CJ, Bond WS, Al-Tawashi AR, Hurwitz MY, Hurwitz RL "The Liberation of CD44 Intracellular Domain Modulates Adenoviral Vector Transgene Expression.." J. Biol. Chem.. 2012 September 21; 287 (39): 32697-707. Pubmed PMID: 22865879
- Chévez-Barrios P, Chintagumpala M, Mieler W, Paysse E, Boniuk M, Kozinetz C, Hurwitz MY, Hurwitz RL "Response of retinoblastoma with vitreous tumor seeding to adenovirus-mediated delivery of thymidine kinase followed by ganciclovir.." J. Clin. Oncol.. 2005 November 1; 23 (31): 7927-35. Pubmed PMID: 16258092
- Chaudhuri SR, Mallam JN, Chévez-Barrios P, Wadhwa L, Ng P, Hurwitz MY, Hurwitz RL "Modulation of adenoviral transduction in vitro and in vivo by hyaluronan and its receptor CD44.." Mol. Ther.. 2007 March ; 15 (3): 566-70. Pubmed PMID: 17180120
- Bond WS, Wadhwa L, Perlaky L, Penland RL, Hurwitz MY, Hurwitz RL, Chèvez-Barrios P "Establishment and propagation of human retinoblastoma tumors in immune deficient mice.." J Vis Exp. 2011 (54): Pubmed PMID: 21847079
- Wadhwa L, Hurwitz MY, Chévez-Barrios P, Hurwitz RL "Treatment of invasive retinoblastoma in a murine model using an oncolytic picornavirus.." Cancer Res.. 2007 November 15; 67 (22): 10653-6. Pubmed PMID: 18006805
- Suber ML, Hurwitz MY, Chévez-Barrios P, Hurwitz RL "Immune consequences of intraocular administration of modified adenoviral vectors.." Hum. Gene Ther.. 2001 May 1; 12 (7): 833-8. Pubmed PMID: 11339899
- Mallam JN, Hurwitz MY, Mahoney T, Chévez-Barrios P, Hurwitz RL "Efficient gene transfer into retinal cells using adenoviral vectors: dependence on receptor expression.." Invest. Ophthalmol. Vis. Sci.. 2004 June ; 45 (6): 1680-7. Pubmed PMID: 15161826
- Chévez-Barrios P, Hurwitz MY, Louie K, Marcus KT, Holcombe VN, Schafer P, Aguilar-Cordova CE, Hurwitz RL "Metastatic and nonmetastatic models of retinoblastoma.." Am. J. Pathol.. 2000 October ; 157 (4): 1405-12. Pubmed PMID: 11021842
- Hurwitz RL, Bogenmann E, Font RL, Holcombe V, Clark D "Expression of the functional cone phototransduction cascade in retinoblastoma.." J. Clin. Invest.. 1990 June ; 85 (6): 1872-8. Pubmed PMID: 2161431
- Hurwitz RL, Bunt-Milam AH, Chang ML, Beavo JA "cGMP phosphodiesterase in rod and cone outer segments of the retina.." J. Biol. Chem.. 1985 January 10; 260 (1): 568-73. Pubmed PMID: 2981219
- Suber ML, Pittler SJ, Qin N, Wright GC, Holcombe V, Lee RH, Craft CM, Lolley RN, Baehr W, Hurwitz RL "Irish setter dogs affected with rod/cone dysplasia contain a nonsense mutation in the rod cGMP phosphodiesterase beta-subunit gene.." Proc. Natl. Acad. Sci. U.S.A.. 1993 May 1; 90 (9): 3968-72. Pubmed PMID: 8387203
- Yu L, Baxter PA, Zhao X, Liu Z, Wadhwa L, Zhang Y, Su JM, Tan X, Yang J, Adesina A, Perlaky L, Hurwitz M, Idamakanti N, Police SR, Hallenbeck PL, Blaney SM, Chintagumpala M, Hurwitz RL, Li XN "A single intravenous injection of oncolytic picornavirus SVV-001 eliminates medulloblastomas in primary tumor-based orthotopic xenograft mouse models.." Neuro-oncology. 2011 January ; 13 (1): 14-27. Pubmed PMID: 21075780
- Hurwitz RL "A new vision of mesenchymal stromal cells.." Mol. Ther.. 2012 November ; 20 (11): 2017-8. Pubmed PMID: 23131854
- Hurwitz R, Holcombe V "Affinity purification of the photoreceptor cGMP-gated cation channel.." J. Biol. Chem.. 1991 May 5; 266 (13): 7975-7. Pubmed PMID: 1850731
- Takahashi S, Rousseau RF, Yotnda P, Mei Z, Dotti G, Rill D, Hurwitz R, Marini F, Andreeff M, Brenner MK "Autologous antileukemic immune response induced by chronic lymphocytic leukemia B cells expressing the CD40 ligand and interleukin 2 transgenes.." Hum. Gene Ther.. 2001 April 10; 12 (6): 659-70. Pubmed PMID: 11426465
- LeBien TW, Hurwitz RL, Kersey JH "Characterization of a xenoantiserum produced against three molar KCl-solubilized antigens obtained from a non-T, non-B (pre-B) acute lymphoblastic leukemia cell line.." J. Immunol.. 1979 January ; 122 (1): 82-8. Pubmed PMID: 310838
- Kersey JH, LeBien TW, Hurwitz R, Nesbit ME, Gajl-Peczalska KJ, Hammond D, Miller DR, Coccia PF, Leikin S "Childhood leukemia-lymphoma. Heterogeneity of phenotypes and prognoses.." Am. J. Clin. Pathol.. 1979 October ; 72 (4): 746-52. Pubmed PMID: 291337
- Chintagumpala MM, Hurwitz RL, Moake JL, Mahoney DH, Steuber CP "Chronic relapsing thrombotic thrombocytopenic purpura in infants with large von Willebrand factor multimers during remission.." J. Pediatr.. 1992 January ; 120 (1): 49-53. Pubmed PMID: 1731024
- Kylmä T, Paulin L, Hurwitz MY, Hurwitz RL, Kommonen B "Cloning and analysis of the cDNA encoding the rod G-protein transduction alpha, beta1 and gamma1 subunits from the canine retina.." Gene. 1997 July 1; 193 (1): 41278. Pubmed PMID: 9249060
- Kylmä T, Paulin L, Hurwitz MY, Hurwitz RL, Kommonen B "Cloning of the cDNA encoding rod photoreceptor cGMP-phosphodiesterase alpha and gamma subunits from the retinal degenerate Labrador retriever dog.." Res. Vet. Sci.. 62 (3): 293-6. Pubmed PMID: 9300552
- Kazazian HH, Dowling CE, Hurwitz RL, Coleman M, Stopeck A, Adams JG "Dominant thalassemia-like phenotypes associated with mutations in exon 3 of the beta-globin gene.." Blood. 1992 June 1; 79 (11): 3014-8. Pubmed PMID: 1586746
- Srivastava D, Fox DA, Hurwitz RL "Effects of magnesium on cyclic GMP hydrolysis by the bovine retinal rod cyclic GMP phosphodiesterase.." Biochem. J.. 1995 June 1; 308 : 653-8. Pubmed PMID: 7772055
- Kommonen B, Kylma T, Cohen RJ, Penn JS, Paulin L, Hurwitz M, Hurwitz RL "Elevation of cGMP with normal expression and activity of rod cGMP-PDE in photoreceptor degenerate labrador retrievers.." Ophthalmic Res.. 1996 28 (1): 19-28. Pubmed PMID: 8726673
- Chong EM, Coffee RE, Chintagumpala M, Hurwitz RL, Hurwitz MY, Chévez-Barrios P "Extensively necrotic retinoblastoma is associated with high-risk prognostic factors.." Arch. Pathol. Lab. Med.. 2006 November ; 130 (11): 1669-72. Pubmed PMID: 17076529
- Morad AB, Steuber CP, Mahoney DH, Hurwitz RL "Hypoplastic anemia in an infant with human immunodeficiency virus (HIV) infection.." Am. J. Hematol.. 1993 February ; 42 (2): 236. Pubmed PMID: 8438892
- Beavo JA, Hansen RS, Harrison SA, Hurwitz RL, Martins TJ, Mumby MC "Identification and properties of cyclic nucleotide phosphodiesterases.." Mol. Cell. Endocrinol.. 28 (3): 387-410. Pubmed PMID: 6185373
- Hurwitz RL, Hansen RS, Harrison SA, Martins TJ, Mumby MC, Beavo JA "Immunologic approaches to the study of cyclic nucleotide phosphodiesterases.." Adv Cyclic Nucleotide Protein Phosphorylation. 1984 16 : 89-106. Pubmed PMID: 6326539
- Hurwitz RL, Bunt-Milam AH, Beavo JA "Immunologic characterization of the photoreceptor outer segment cyclic GMP phosphodiesterase.." J. Biol. Chem.. 1984 July 10; 259 (13): 8612-8. Pubmed PMID: 6330115
- Hurwitz RL, Beavo JA "Immunotitration analysis of the rod outer segment phosphodiesterase.." Adv Cyclic Nucleotide Protein Phosphorylation. 1984 17 : 239-48. Pubmed PMID: 6203341
- Hurwitz RL, Hirsch KM, Clark DJ, Holcombe VN, Hurwitz MY "Induction of a calcium/calmodulin-dependent phosphodiesterase during phytohemagglutinin-stimulated lymphocyte mitogenesis.." J. Biol. Chem.. 1990 May 25; 265 (15): 8901-7. Pubmed PMID: 2160471
- Hurwitz MY, Hurwitz RL, Edstrom RD "Inhibition of human lymphocyte cyclic nucleotide phosphodiesterases by the chlorinated adenosine analog DTA-35.." J. Enzym. Inhib.. 1987 1 (4): 267-74. Pubmed PMID: 2854846
- Srivastava D, Hurwitz RL, Fox DA "Lead- and calcium-mediated inhibition of bovine rod cGMP phosphodiesterase: interactions with magnesium.." Toxicol. Appl. Pharmacol.. 1995 September ; 134 (1): 43-52. Pubmed PMID: 7676457
- Fox DA, Srivastava D, Hurwitz RL "Lead-induced alterations in rod-mediated visual functions and cGMP metabolism: new insights.." Neurotoxicology. 1994 15 (3): 503-12. Pubmed PMID: 7854584
- Murray JC, Hill RM, Hegemier S, Hurwitz RL "Lymphoblastic lymphoma following prenatal exposure to phenytoin.." J. Pediatr. Hematol. Oncol.. 1996 May ; 18 (2): 241-3. Pubmed PMID: 8846150
- Booth DP, Hurwitz RL, Lolley RN "Phosphodiesterase of cone photoreceptors from the lizard, Anolis carolinensis.." J. Neurochem.. 1991 June ; 56 (6): 1949-56. Pubmed PMID: 1851207
- Lee RH, Lieberman BS, Hurwitz RL, Lolley RN "Phosphodiesterase-probes show distinct defects in rd mice and Irish setter dog disorders.." Invest. Ophthalmol. Vis. Sci.. 1985 November ; 26 (11): 1569-79. Pubmed PMID: 2997075
- Pittler SJ, Lee AK, Altherr MR, Howard TA, Seldin MF, Hurwitz RL, Wasmuth JJ, Baehr W "Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel.." J. Biol. Chem.. 1992 March 25; 267 (9): 6257-62. Pubmed PMID: 1372902
- Hurwitz RL "Re.:A Death in the Laboratory"."." Mol. Ther.. 2001 July ; 4 (1): 4. Pubmed PMID: 11472099
- Hurwitz RL, Brenner MK, Poplack DG, Horowitz MC "Retinoblastoma treatment.." Science. 1999 July 30; 285 (5428): 663-4. Pubmed PMID: 10454919
- Hurwitz RL, Chévez-Barrios P, Boniuk M, Chintagumpala M, Hurwitz MY "Retinoblastoma: from bench to bedside.." Expert Rev Mol Med. 2003 January ; 5 (1): 41288. Pubmed PMID: 14987394
- Chintagumpala M, Chevez-Barrios P, Paysse EA, Plon SE, Hurwitz R "Retinoblastoma: review of current management.." Oncologist. 2007 October ; 12 (10): 1237-46. Pubmed PMID: 17962617
- Hurwitz RL, Mahoney DH, Armstrong DL, Browder TM "Reversible encephalopathy and seizures as a result of conventional vincristine administration.." Med. Pediatr. Oncol.. 1988 16 (3): 216-9. Pubmed PMID: 3164090
- Hayani A, Mahoney DH, Hawkins HK, Steuber CP, Hurwitz R, Fernbach DJ "Soft-tissue sarcomas other than rhabdomyosarcoma in children.." Med. Pediatr. Oncol.. 1992 20 (2): 114-8. Pubmed PMID: 1734215
- Hurwitz MY, Marcus KT, Chévez-Barrios P, Louie K, Aguilar-Cordova E, Hurwitz RL "Suicide gene therapy for treatment of retinoblastoma in a murine model.." Hum. Gene Ther.. 1999 February 10; 10 (3): 441-8. Pubmed PMID: 10048396
- Carcamo B, Hurwitz MY, Craft CM, Hurwitz RL "The mammalian pineal expresses the cone but not the rod cyclic GMP phosphodiesterase.." J. Neurochem.. 1995 September ; 65 (3): 1085-92. Pubmed PMID: 7643086
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