Richard Louis Hurwitz, M.D.

Associate Professor

(832) 824-4259

Email

rhurwitz@bcm.edu

Positions

Associate Professor: Pediatrics-Oncology
Baylor College of Medicine
Houston, TX, US

Member: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Addresses

Feigin Center (Office): Suite C0730
1102 Bates Street
Houston, TX, 77030
United States
Phone: (832) 824-4260
rhurwitz@bcm.edu

Texas Children's Hospital, Clinical Care Center (Clinic): 6701 Fannin St., 14th floor
Houston, TX, 77030
United States
Phone: (832) 822-4242

Education

BS from Rensselaer Polytechnic Institute: 05/1975 - Troy, New York, United States

MD from Albany Medical College of Union University: 05/1975 - Albany, New York, United States

Residency at University Of Minnesota Affiliate Hospitals: Minneapolis, Minnesota, United States; Pediatrics

Clinical Fellowship at University of Minnesota Medical School: Minneapolis, Minnesota, United States; Pediatric Hematology-Oncology

Postdoctoral Fellowship at University Of Washington: Seattle, Washington, United States

Professional Interests

Gene therapy
Retinoblastoma
Retinal degeneration

Websites

VIICTR Publications List

Selected Publications

Bond, W.S., Akinfenwa, P.Y., Perlaky, L., Hurwitz, MY., Hurwitz, R.L.*, Chévez-Barrios, P.*. " Tumorspheres but Not Adherent Cells Derived from Retinoblastoma Tumors Are of Malignant Origin " PLoS ONE. 2013 ;
Pubmed PMID: 23658322.
Wadhwa L, Bond WS, Perlaky L, Overbeek PA, Hurwitz MY, Chévez-Barrios P, Hurwitz RL. " Embryonic Retinal Tumors in SV40 T-Ag Transgenic Mice Contain CD133+ Tumor-Initiating Cells. " Invest. Ophthalmol. Vis. Sci.. 2012 ; 53 (7) : 3454-62.
Pubmed PMID: 22562503.
Ildefonso CJ, Kong L, Leen A, Chai SJ, Petrochelli V, Chintagumpala M, Hurwitz MY, Chévez-Barrios P, Hurwitz RL. " Absence of systemic immune response to adenovectors after intraocular administration to children with retinoblastoma. " Mol. Ther.. 2010 Oct ; 18 (10) : 1885-90.
Pubmed PMID: 20606647.
Ildefonso CJ, Bond WS, Al-Tawashi AR, Hurwitz MY, Hurwitz RL. " The Liberation of CD44 Intracellular Domain Modulates Adenoviral Vector Transgene Expression. " J. Biol. Chem.. 2012 Sep 21; 287 (39) : 32697-707.
Pubmed PMID: 22865879.
Chévez-Barrios P, Chintagumpala M, Mieler W, Paysse E, Boniuk M, Kozinetz C, Hurwitz MY, Hurwitz RL. " Response of retinoblastoma with vitreous tumor seeding to adenovirus-mediated delivery of thymidine kinase followed by ganciclovir. " J. Clin. Oncol.. 2005 Nov 1; 23 (31) : 7927-35.
Pubmed PMID: 16258092.
Chaudhuri SR, Mallam JN, Chévez-Barrios P, Wadhwa L, Ng P, Hurwitz MY, Hurwitz RL. " Modulation of adenoviral transduction in vitro and in vivo by hyaluronan and its receptor CD44. " Mol. Ther.. 2007 Mar ; 15 (3) : 566-70.
Pubmed PMID: 17180120.
Bond WS, Wadhwa L, Perlaky L, Penland RL, Hurwitz MY, Hurwitz RL, Chèvez-Barrios P. " Establishment and propagation of human retinoblastoma tumors in immune deficient mice. " J Vis Exp. 2011 ; (54)
Pubmed PMID: 21847079.
Wadhwa L, Hurwitz MY, Chévez-Barrios P, Hurwitz RL. " Treatment of invasive retinoblastoma in a murine model using an oncolytic picornavirus. " Cancer Res.. 2007 Nov 15; 67 (22) : 10653-6.
Pubmed PMID: 18006805.
Suber ML, Hurwitz MY, Chévez-Barrios P, Hurwitz RL. " Immune consequences of intraocular administration of modified adenoviral vectors. " Hum. Gene Ther.. 2001 May 1; 12 (7) : 833-8.
Pubmed PMID: 11339899.
Mallam JN, Hurwitz MY, Mahoney T, Chévez-Barrios P, Hurwitz RL. " Efficient gene transfer into retinal cells using adenoviral vectors: dependence on receptor expression. " Invest. Ophthalmol. Vis. Sci.. 2004 Jun ; 45 (6) : 1680-7.
Pubmed PMID: 15161826.
Chévez-Barrios P, Hurwitz MY, Louie K, Marcus KT, Holcombe VN, Schafer P, Aguilar-Cordova CE, Hurwitz RL. " Metastatic and nonmetastatic models of retinoblastoma. " Am. J. Pathol.. 2000 Oct ; 157 (4) : 1405-12.
Pubmed PMID: 11021842.
Hurwitz RL, Bogenmann E, Font RL, Holcombe V, Clark D. " Expression of the functional cone phototransduction cascade in retinoblastoma. " J. Clin. Invest.. 1990 Jun ; 85 (6) : 1872-8.
Pubmed PMID: 2161431.
Hurwitz RL, Bunt-Milam AH, Chang ML, Beavo JA. " cGMP phosphodiesterase in rod and cone outer segments of the retina. " J. Biol. Chem.. 1985 Jan 10; 260 (1) : 568-73.
Pubmed PMID: 2981219.
Suber ML, Pittler SJ, Qin N, Wright GC, Holcombe V, Lee RH, Craft CM, Lolley RN, Baehr W, Hurwitz RL. " Irish setter dogs affected with rod/cone dysplasia contain a nonsense mutation in the rod cGMP phosphodiesterase beta-subunit gene. " Proc. Natl. Acad. Sci. U.S.A.. 1993 May 1; 90 (9) : 3968-72.
Pubmed PMID: 8387203.
Yu L, Baxter PA, Zhao X, Liu Z, Wadhwa L, Zhang Y, Su JM, Tan X, Yang J, Adesina A, Perlaky L, Hurwitz M, Idamakanti N, Police SR, Hallenbeck PL, Blaney SM, Chintagumpala M, Hurwitz RL, Li XN. " A single intravenous injection of oncolytic picornavirus SVV-001 eliminates medulloblastomas in primary tumor-based orthotopic xenograft mouse models. " Neuro-oncology. 2011 Jan ; 13 (1) : 14-27.
Pubmed PMID: 21075780.
Hurwitz RL. " A new vision of mesenchymal stromal cells. " Mol. Ther.. 2012 Nov ; 20 (11) : 2017-8.
Pubmed PMID: 23131854.
Hurwitz R, Holcombe V. " Affinity purification of the photoreceptor cGMP-gated cation channel. " J. Biol. Chem.. 1991 May 5; 266 (13) : 7975-7.
Pubmed PMID: 1850731.
Takahashi S, Rousseau RF, Yotnda P, Mei Z, Dotti G, Rill D, Hurwitz R, Marini F, Andreeff M, Brenner MK. " Autologous antileukemic immune response induced by chronic lymphocytic leukemia B cells expressing the CD40 ligand and interleukin 2 transgenes. " Hum. Gene Ther.. 2001 Apr 10; 12 (6) : 659-70.
Pubmed PMID: 11426465.
LeBien TW, Hurwitz RL, Kersey JH. " Characterization of a xenoantiserum produced against three molar KCl-solubilized antigens obtained from a non-T, non-B (pre-B) acute lymphoblastic leukemia cell line. " J. Immunol.. 1979 Jan ; 122 (1) : 82-8.
Pubmed PMID: 310838.
Kersey JH, LeBien TW, Hurwitz R, Nesbit ME, Gajl-Peczalska KJ, Hammond D, Miller DR, Coccia PF, Leikin S. " Childhood leukemia-lymphoma. Heterogeneity of phenotypes and prognoses. " Am. J. Clin. Pathol.. 1979 Oct ; 72 (4) : 746-52.
Pubmed PMID: 291337.
Chintagumpala MM, Hurwitz RL, Moake JL, Mahoney DH, Steuber CP. " Chronic relapsing thrombotic thrombocytopenic purpura in infants with large von Willebrand factor multimers during remission. " J. Pediatr.. 1992 Jan ; 120 (1) : 49-53.
Pubmed PMID: 1731024.
Kylmä T, Paulin L, Hurwitz MY, Hurwitz RL, Kommonen B. " Cloning and analysis of the cDNA encoding the rod G-protein transduction alpha, beta1 and gamma1 subunits from the canine retina. " Gene. 1997 Jul 1; 193 (1) : 41278.
Pubmed PMID: 9249060.
Kylmä T, Paulin L, Hurwitz MY, Hurwitz RL, Kommonen B. " Cloning of the cDNA encoding rod photoreceptor cGMP-phosphodiesterase alpha and gamma subunits from the retinal degenerate Labrador retriever dog. " Res. Vet. Sci.. ; 62 (3) : 293-6.
Pubmed PMID: 9300552.
Kazazian HH, Dowling CE, Hurwitz RL, Coleman M, Stopeck A, Adams JG. " Dominant thalassemia-like phenotypes associated with mutations in exon 3 of the beta-globin gene. " Blood. 1992 Jun 1; 79 (11) : 3014-8.
Pubmed PMID: 1586746.
Srivastava D, Fox DA, Hurwitz RL. " Effects of magnesium on cyclic GMP hydrolysis by the bovine retinal rod cyclic GMP phosphodiesterase. " Biochem. J.. 1995 Jun 1; 308 : 653-8.
Pubmed PMID: 7772055.
Kommonen B, Kylma T, Cohen RJ, Penn JS, Paulin L, Hurwitz M, Hurwitz RL. " Elevation of cGMP with normal expression and activity of rod cGMP-PDE in photoreceptor degenerate labrador retrievers. " Ophthalmic Res.. 1996 ; 28 (1) : 19-28.
Pubmed PMID: 8726673.
Chong EM, Coffee RE, Chintagumpala M, Hurwitz RL, Hurwitz MY, Chévez-Barrios P. " Extensively necrotic retinoblastoma is associated with high-risk prognostic factors. " Arch. Pathol. Lab. Med.. 2006 Nov ; 130 (11) : 1669-72.
Pubmed PMID: 17076529.
Morad AB, Steuber CP, Mahoney DH, Hurwitz RL. " Hypoplastic anemia in an infant with human immunodeficiency virus (HIV) infection. " Am. J. Hematol.. 1993 Feb ; 42 (2) : 236.
Pubmed PMID: 8438892.
Beavo JA, Hansen RS, Harrison SA, Hurwitz RL, Martins TJ, Mumby MC. " Identification and properties of cyclic nucleotide phosphodiesterases. " Mol. Cell. Endocrinol.. ; 28 (3) : 387-410.
Pubmed PMID: 6185373.
Hurwitz RL, Hansen RS, Harrison SA, Martins TJ, Mumby MC, Beavo JA. " Immunologic approaches to the study of cyclic nucleotide phosphodiesterases. " Adv Cyclic Nucleotide Protein Phosphorylation. 1984 ; 16 : 89-106.
Pubmed PMID: 6326539.
Hurwitz RL, Bunt-Milam AH, Beavo JA. " Immunologic characterization of the photoreceptor outer segment cyclic GMP phosphodiesterase. " J. Biol. Chem.. 1984 Jul 10; 259 (13) : 8612-8.
Pubmed PMID: 6330115.
Hurwitz RL, Beavo JA. " Immunotitration analysis of the rod outer segment phosphodiesterase. " Adv Cyclic Nucleotide Protein Phosphorylation. 1984 ; 17 : 239-48.
Pubmed PMID: 6203341.
Hurwitz RL, Hirsch KM, Clark DJ, Holcombe VN, Hurwitz MY. " Induction of a calcium/calmodulin-dependent phosphodiesterase during phytohemagglutinin-stimulated lymphocyte mitogenesis. " J. Biol. Chem.. 1990 May 25; 265 (15) : 8901-7.
Pubmed PMID: 2160471.
Hurwitz MY, Hurwitz RL, Edstrom RD. " Inhibition of human lymphocyte cyclic nucleotide phosphodiesterases by the chlorinated adenosine analog DTA-35. " J. Enzym. Inhib.. 1987 ; 1 (4) : 267-74.
Pubmed PMID: 2854846.
Srivastava D, Hurwitz RL, Fox DA. " Lead- and calcium-mediated inhibition of bovine rod cGMP phosphodiesterase: interactions with magnesium. " Toxicol. Appl. Pharmacol.. 1995 Sep ; 134 (1) : 43-52.
Pubmed PMID: 7676457.
Fox DA, Srivastava D, Hurwitz RL. " Lead-induced alterations in rod-mediated visual functions and cGMP metabolism: new insights. " Neurotoxicology. 1994 ; 15 (3) : 503-12.
Pubmed PMID: 7854584.
Murray JC, Hill RM, Hegemier S, Hurwitz RL. " Lymphoblastic lymphoma following prenatal exposure to phenytoin. " J. Pediatr. Hematol. Oncol.. 1996 May ; 18 (2) : 241-3.
Pubmed PMID: 8846150.
Booth DP, Hurwitz RL, Lolley RN. " Phosphodiesterase of cone photoreceptors from the lizard, Anolis carolinensis. " J. Neurochem.. 1991 Jun ; 56 (6) : 1949-56.
Pubmed PMID: 1851207.
Lee RH, Lieberman BS, Hurwitz RL, Lolley RN. " Phosphodiesterase-probes show distinct defects in rd mice and Irish setter dog disorders. " Invest. Ophthalmol. Vis. Sci.. 1985 Nov ; 26 (11) : 1569-79.
Pubmed PMID: 2997075.
Pittler SJ, Lee AK, Altherr MR, Howard TA, Seldin MF, Hurwitz RL, Wasmuth JJ, Baehr W. " Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel. " J. Biol. Chem.. 1992 Mar 25; 267 (9) : 6257-62.
Pubmed PMID: 1372902.
Hurwitz RL. " Re.:A Death in the Laboratory"." " Mol. Ther.. 2001 Jul ; 4 (1) : 4.
Pubmed PMID: 11472099.
Hurwitz RL, Brenner MK, Poplack DG, Horowitz MC. " Retinoblastoma treatment. " Science. 1999 Jul 30; 285 (5428) : 663-4.
Pubmed PMID: 10454919.
Hurwitz RL, Chévez-Barrios P, Boniuk M, Chintagumpala M, Hurwitz MY. " Retinoblastoma: from bench to bedside. " Expert Rev Mol Med. 2003 Jan ; 5 (1) : 41288.
Pubmed PMID: 14987394.
Chintagumpala M, Chevez-Barrios P, Paysse EA, Plon SE, Hurwitz R. " Retinoblastoma: review of current management. " Oncologist. 2007 Oct ; 12 (10) : 1237-46.
Pubmed PMID: 17962617.
Hurwitz RL, Mahoney DH, Armstrong DL, Browder TM. " Reversible encephalopathy and seizures as a result of conventional vincristine administration. " Med. Pediatr. Oncol.. 1988 ; 16 (3) : 216-9.
Pubmed PMID: 3164090.
Hayani A, Mahoney DH, Hawkins HK, Steuber CP, Hurwitz R, Fernbach DJ. " Soft-tissue sarcomas other than rhabdomyosarcoma in children. " Med. Pediatr. Oncol.. 1992 ; 20 (2) : 114-8.
Pubmed PMID: 1734215.
Hurwitz MY, Marcus KT, Chévez-Barrios P, Louie K, Aguilar-Cordova E, Hurwitz RL. " Suicide gene therapy for treatment of retinoblastoma in a murine model. " Hum. Gene Ther.. 1999 Feb 10; 10 (3) : 441-8.
Pubmed PMID: 10048396.
Carcamo B, Hurwitz MY, Craft CM, Hurwitz RL. " The mammalian pineal expresses the cone but not the rod cyclic GMP phosphodiesterase. " J. Neurochem.. 1995 Sep ; 65 (3) : 1085-92.
Pubmed PMID: 7643086.