Reina Villareal, M.D.

Professor

Email

reina.villareal@bcm.edu

Positions

Professor: Medicine-Endocrinology
Baylor College of Medicine
Houston, TX, US

Staff Physician: Medical Care Line
Michael E. DeBakey VA Medical Center
Houston, TX

Core Faculty: Center for Translational Research on Inflammatory Diseases (CTRID)
Baylor College of Medicine
Michael E. DeBakey VA Medical Center
Houston, TX

Addresses

Michael E. DeBakey VA Medical Center (Hospital): 2002 Holcombe
Building 100, Room 240
Houston, TX, 77030
United States
Phone: (713) 794-7534

Education

Fellowship at Washington University School of Medicine: St. Louis, Missouri, United States

Residency at Texas Tech University: Amarillo, Texas, United States

MD from Cebu Institute of Medicine: Cebu, Philippines

Certifications

American Board of Internal Medicine-Endocrinology and Diabetes

Diabetes, Endocrinology and Metabolism

Honors & Awards

MD

Professional Interests

CYP450 enzyme genes in gonadal hormone and bone metabolism
Aromatase inhibitors and weight loss in severely obese men with hypogonadism
Bone quality in men with type 2 diabetes mellitus and hypogonadism

Professional Statement

I am an endocrinologist with interest in the interaction between genetics, gonadal hormones and bone.

Websites

VIICTR Publications List

Section of Endocrinology, Diabetes and Metabolism

Center for Translational Research on Inflammatory Diseases (CTRID)

Selected Publications

Colleluori G, Chen R, Turin CG, Vigevano F, Qualls C, Johnson B, Mediwala S, Villareal DT, Armamento-Villareal R. " Aromatase inhibitors and weight loss improves hormonal profile of obese hypogonadal men without causing major side effects. " Front Endocrinol (Lausanne). 2020 May 15; 11 : 277.
Pubmed PMID: 32499757.
Armamento-Villareal R, Aguirre L, Waters DL, Napoli N, Qualls C, Villareal DT. " Effect of Aerobic or Resistance Exercise, or Both on Bone Mineral Density and Bone Metabolism in Obese Older Adults While Dieting: A Randomized Controlled Trial " J Bone Miner Res. 2020 Mar ; 35 (3) : 430-439.
Pubmed PMID: 31797417.
Aguirre L, Colleluori G, Robbins D, Dorin R, Shah VO, Chen R, Jan I, Qualls C, Villareal DT, Armamento-Villareal R. " Bone and Body composition response to testosterone therapy vary according to polymorphisms in the CYP19A1 " Endocrine. 2019 Sep ; 65 (3) : 692-706.
Pubmed PMID: 31325085.
Colleluori G, Aguirre L, Phadnis U, Fowler K, Armamento-Villareal R, Sun Z, Brunetti L, Hyoung Park J, Abraham Kaipparettu B, Putluri N, Auetumrongsawat V, Yarasheski K, Qualls C, Villareal DT. " Aerobic Plus Resistance Exercise in Obese Older Adults Improves Muscle Protein Synthesis and Preserves Myocellular Quality Despite Weight Loss " Cell Metab. 2019 Aug 28; 30 (2) : 261-273.
Pubmed PMID: 31279675.
Colleluori G, Aguirre LE, Qualls C, Chen R, Napoli N, Villareal DT, Armamento-Villareal R. " Adipocytes ESR1 Expression, Body Fat and Response to Testosterone Therapy in hypogonadal Men Vary According to Estradiol Levels " Nutrients.. 2018 Sep 4; 10 (9) : E1226..
Pubmed PMID: 30181488.
Georgia Colleluori, Rui Chen, Nicola Napoli, Lina E. Aguirre, Clifford Qualls, Dennis T. Villareal and Reina Armamento-Villareal. " Fat Mass Follows a U-Shaped Distribution Based on Estradiol Levels in Postmenopausal Women " Front Endocrinol (Lausanne). 2018 Jul 2; 9 : 315.
Pubmed PMID: 30013511.
Effect of Weight Loss, Exercise, or Both on Undercarboxylated Osteocalcin and Insulin Secretion in Frail, Obese Older Adults " Oxid Med Cell Longev.. 2017 ;
Pubmed PMID: 28951766.
Aguirre LE, Colleluori G, Dorin R, Robbins D, Chen R, Jiang B, Qualls C, Villareal DT, Armamento-Villareal R. Hypogonadal Men with Higher Body Mass Index have Higher Bone Density and Better Bone Quality but Reduced Muscle Density. " Hypogonadal Men with Higher Body Mass Index have Higher Bone Density and Better Bone Quality but Reduced Muscle Density " Calcif Tissue Int.. 2017 Dec ; 101 (6) : 602-611.
Pubmed PMID: 28856390.
Villareal DT, Aguirre L, Gurney AB, Waters DL, Sinacore DR, Colombo E, Armamento-Villareal R, Qualls C. " Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults. " N Engl J Med. 2017 May 18; 376 (20) : 1943-1955.
Pubmed PMID: 28514618.
Colleluori G, Aguirre L, Dorin R, Robbins D, Blevins D, Barnouin Y, Chen R, Qualls C, Villareal DT, Armamento-Villareal R. " Hypogonadal men with type 2 diabetes mellitus have smaller bone size and lower bone turnover " Bone.. 2017 Mar 16; 99 : 14-19.
Pubmed PMID: 28323146.
Armamento-Villareal R, Shah VO, Aguirre LE, Meisner AL, Qualls C, Royce ME. " The rs4646 and rs12592697 Polymorphisms in CYP19A1 Are Associated with Disease Progression among Patients with Breast Cancer from Different Racial/Ethnic Backgrounds " Front Genet.. 2016 Dec 2; 7 : 211.
Pubmed PMID: 27994616.
. Armamento-Villareal R, Aguirre LE, Qualls C, Villareal DT. " Effect of Lifestyle Intervention on the Hormonal Profile of Frail Obese Older Men. J Nutr Health Aging " J Nutr Health Aging. 2016 ; 20 (3) : 334-40.
Pubmed PMID: 26892583.
Armamento-Villareal R, Wingkun N, Aguirre LE, Kulkarny V, Napoli N, Colleluori G, Qualls C, Villareal DT. " The FTO gene is associated with a paradoxically favorable cardiometabolic risk profile in frail, obese older adults " Pharmacogenet Genomics. 2015 Dec ;
Pubmed PMID: 26709911.
Lina E. Aguirre, Georgia Colleluori, Kenneth E. Fowler, Irum Zeb Jan, Kenneth Villareal, Clifford Qualls, David Robbins, Dennis T. Villareal, Reina Armamento-Villareal. " High Aromatase Activity in Hypogonadal Men is Associated with Higher Spine BMD, Increased Truncal Fat and Reduced Lean Mass, In Press. " European Journal of Endocrinology. 2015 ;
Napoli N, Rastelli A, Ma C, Colleluori G, Vattikuti S, Armamento-Villareal R.. " Genetic polymorphism at Val80 (rs700518) of the CYP19A1 gene is associated with body composition changes in women on aromatase inhibitors for ER (+) breast cancer " Pharmacogenet Genomics. 2015 Jun ;
Pubmed PMID: 26049585.
Aguirre L, Napoli N, Waters D, Qualls C, Villareal DT, Armamento-Villareal R. " Increasing adiposity is associated with higher adipokine levels and lower bone mineral density in obese older adults " J Clin Endocrinol Metab. 2014 Sep ; 99 (9) : 3290-7.
Pubmed PMID: 24878039.
Armamento-Villareal R, Aguirre L, Napoli N, Shah K, Hilton T, Sinacore DR, Qualls C, Villareal DT. " Changes in thigh muscle volume predict bone mineral density response to lifestyle therapy in frail, obese older adults " Osteoporos Int.. 2014 Feb ; 25 (2) : 551-8.
Pubmed PMID: 23892583.
Bouchonville M, Armamento-Villareal R, Shah K, Napoli N, Sinacore DR, Qualls C, Villareal DT. " Weight loss, exercise or both and cardiometabolic risk factors in obese older adults: results of a randomized controlled trial " Int J Obes (Lond). 2014 Mar ; 38 (3) : 423-31.
Pubmed PMID: 23823329.
Napoli N, Rastelli A, Ma C, Yarramaneni J, Vattikutti S, Moskowitz G, Giri T, Mueller C, Kulkarny V, Qualls C, Ellis M, Armamento-Villareal R. " Genetic polymorphism at Val80 (rs700518) of the CYP19A1 gene is associated with aromatase inhibitor associated bone loss in women with ER + breast cancer " Bone. 2013 Aug ; 55 (2) : 309-14.
Pubmed PMID: 23643682.
Armamento-Villareal R, Sadler C, Napoli N, Shah K, Chode S, Sinacore DR, Qualls C, Villareal DT. " Weight loss in obese older adults increases serum sclerostin and impairs hip geometry but both are prevented by exercise training " J Bone Miner Res. 2012 May ; 27 (5) : 1215-21.
Pubmed PMID: 22392834.
Napoli N, Vattikuti S, Yarramaneni J, Giri TK, Nekkalapu S, Qualls C, Armamento-Villareal RC. " Increased 2-hydroxylation of estrogen is associated with lower body fat and increased lean body mass in postmenopausal women " Maturitas. 2012 May ; 72 (1) : 66-71.
Pubmed PMID: 22385932.
Shah K, Armamento-Villareal R, Parimi N, Chode S, Sinacore DR, Hilton TN, Napoli N, Qualls C, Villareal DT. " Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bone mineral density induced by weight loss despite decline in bone-active hormones " J Bone Miner Res. 2011 Dec ; 26 (12) : 2851-9.
Pubmed PMID: 21786319.
Rastelli AL, Taylor ME, Gao F, Armamento-Villareal R, Jamalabadi-Majidi S, Napoli N, Ellis MJ. " Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial " Breast Cancer Res Treat. 2011 Aug ; 129 (1) : 107-16.
Pubmed PMID: 21691817.
Villareal DT, Chode S, Parimi N, Sinacore DR, Hilton T, Armamento-Villareal R, Napoli N, Qualls C, Shah K. " Weight loss, exercise, or both and physical function in obese older adults " N Engl J Med. 2011 Mar 31; 364 (13) : 1218-29.
Pubmed PMID: 21449785.
Armamento-Villareal R, Aguirre L, Waters D, Napoli N, Qualls C, Villareal DT. " Effect of Aerobic or Resistance Exercise, or Both on Bone Mineral Density and Bone Metabolism in Obese Older Adults While Dieting: A Randomized Controlled Trial. " J Bone Miner Res.. 2020 Mar ; 35 (3) : 430-439.
Pubmed PMID: 31797417.
Barnouin Y, Armamento-Villareal R, Celli A, Jiang B, Paudyal A, Nambi V, Bryant MS, Marcelli M, Garcia J, Qualls C and Villareal DT. " Testosterone Replacement Therapy added to Intensive Lifestyle Intervention in Older Men with Obesity and Hypogonadism " J Clin Endocrinol Metab. 2021 Mar 8; 106 (3) : e1096-e1110.
Pubmed PMID: 33351921.
Vigevano F, Gregori G, Colleluori G, Chen R, Autemrongsawat V, Napoli N, Qualls C, Villareal DT, Armamento-Villareal R.. " In Men With Obesity, T2DM Is Associated With Poor Trabecular Microarchitecture and Bone Strength, and Low Bone Turnover " J Clin Endocrinol Metab. 2021 Apr 23; 106 (5) : 1362-1376.
Pubmed PMID: 33537757.
Russo V, Chen R, Armamento-Villareal R. " Type-2 Diabetes Mellitus and Bone Health: A Review " Front Endocrinol (Lausanne). 2021 Jan 18; 11 : 607240.
Pubmed PMID: 33537757.
Colleluori G, Aguirre L, Napoli N, Qualls C, Villareal DT, Armamento-Villareal R. " Testosterone Therapy Effects on Bone Mass and Turnover in Hypogonadal Men with Type 2 Diabetes " J Clin Endocrinol Metab. 2021 Jul 13; 106 (8) : e3058-e3068.
Pubmed PMID: 33735389.
Russo V, Colleluori G, Chen R, Mediwala S, Qualls C, Liebschner M, Villareal DT, Armamento-Villareal R. " Testosterone therapy and bone quality in men with diabetes and hypogonadism: Study design and protocol " Contemp Clin Trials Commun. 2021. 2021 Jan 20; 21 : 100723.
Pubmed PMID: 33718653.

Memberships

Endocrine Society

American Society for Bone and Mineral Research

American Association of Clinical Endocrinologists

American College of Physicians

Funding

Testosterone Therapy and Bone Quality in Men with Diabetes Mellitus and Hypogonadism #1 I01 CX001665: (10/01/2019 - 03/31/2025); Grant funding from VA Merit Review

Aromatase inhibitors and weight loss in severely obese men with hypogonadism #1R01HD093047: (08/07/2017 - 06/30/2023); Grant funding from National Institutes of Health; This study is testing hypothesis that aromatase inhibitors in combination with weight loss will significantly improve hypogonadal symptoms among severely obese men.