Ping Yi, Ph.D., B.S.

Assistant Professor

Email

pyi@bcm.edu

Positions

Assistant Professor: Mol & Cell Biology-Mol.Regulation
Baylor College of Medicine
Houston, TX, US

Member: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Education

Advanced Training from Baylor College Of Medicine: 01/2008 - Houston, TX, United States

Ph.D. from University Of Rochester: 01/2002 - Rochester, NY, United States

Professional Interests

Cancer Biology, Nuclear receptor structure and function, Cell signaling

Professional Statement

My lab research has been focused on molecular regulation of oncogene activation in cancer, with a particular focus on post-translational modification and signal transduction pathways, and nuclear receptor structural studies. Current studies aim to explore the role of non-proteolytic ubiquitination in prostate and lung cancer development and progression. We employ diverse tools for the studies, including transgenic mouse models, PDX tumor models and a variety of molecular biology and cell biology tools. Another interest of the lab is to understand the structure and function of nuclear receptor-coregulator complexes. We are the first group to use cryo electron microscopy (Cryo-EM) to determine the quaternary structure of DNA-bound estrogen receptor alpha, Steroid Receptor Coactivator (SRC-3) and a secondary coactivator (p300) complex. Combining cryo-EM structural approach and biochemical analysis, we have elucidated a series of nuclear receptor complex structures.

Websites

VIICTR Publications List

Selected Publications

Yu, W., Singh, R., Wang, Z., O'Malley, B. W., Yi, P.. " The E3 ligase TRAF4 promotes IGF signaling by mediating atypical ubiquitination of IRS-1. " J. Biol. Chem.. 2021 ; 296 : 100739.
Pubmed PMID: 33991522.
Yi, P., Wang, Z., Feng, Q., Pintilie, G. D., Foulds, C. E., Lanz, R. B., Ludtke, S. J., Schmid, M. F., Chiu, W., O’Malley, B. W.. " The Structure of a Biological Active Estrogen Receptor-Coactivator Complex on DNA. " Mol. Cell. 2015 ; 57 : 1047-1058.
Pubmed PMID: 25728767.
Singh, R., Karri, D., Shen, H., Shao, J., Dasgupta, S., Huang, S., Edwards, D.P., Ittmann, M.M., O'Malley, B.W., Yi, P.. " TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis. " J. Clin. Invest.. 2018 ; 128 : 3129-3143.
Pubmed PMID: 29715200.
Yi, P., Wang, Z., Feng, Q., Chou C. K., Pintilie, G. D., Shen, H., Foulds, C. E., Fan, G., Serysheva, I., Ludtke, S. J., Schmid, M. F., Hung, M. C., Chiu, W., O'Malley, B. W.. " Structural and Functional Impacts of ER Coactivator Sequential Recruitment. " Mol. Cell. 2017 ; 67 : 733-743.
Pubmed PMID: 28844863.
Yi P, Xia W, Wu RC, Lonard DM, Hung MC, O'Malley BW. " SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization. " Genes Dev.. 2013 Feb 1; 27 (3) : 274-87.
Pubmed PMID: 23388826.
Dasgupta, S., Rajapakshe, K., Zhu, B., Nikolai, B. C., Yi, P., Putluri, N., Choi, J. M., Jung, S. Y., Coarfa, C., Westbrook, T. F., Zhang, X. H., Foulds, C. E., Tsai, S. Y., Tsai M. J., O'Malley, B. W.. " Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. " Nature. 2018 ; 556 : 249-254.
Pubmed PMID: 29615789.
Yu, X*., Yi, P*., Hamilton, R. A., Shen, H., Chen, M., Foulds, C. E., Mancini, M. A., Ludtke, S. J., Wang, Z., O’Malley, B. W.. " Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes. " Mol. Cell. 2020 ; 79 : 812-823.
Pubmed PMID: 32668201.
Yi P, Feng Q, Amazit L, Lonard DM, Tsai SY, Tsai MJ, O'Malley BW. " Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1. " Mol. Cell. 2008 Feb 29; 29 (4) : 465-76.
Pubmed PMID: 18313384.