Ping Yi, Ph.D., B.S.
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Ping Yi, Ph.D., B.S.
Assistant Professor
Positions
- Assistant Professor
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Mol & Cell Biology-Mol.Regulation
Baylor College of Medicine
Houston, TX US
- Member
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Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
Education
- Advanced Training from Baylor College Of Medicine
- 01/2008 - Houston, TX United States
- Ph.D. from University Of Rochester
- 01/2002 - Rochester, NY United States
Professional Interests
- Cancer Biology, Nuclear receptor structure and function, Cell signaling
Professional Statement
My lab research has been focused on molecular regulation of oncogene activation in cancer, with a particular focus on post-translational modification and signal transduction pathways, and nuclear receptor structural studies. Current studies aim to explore the role of non-proteolytic ubiquitination in prostate and lung cancer development and progression. We employ diverse tools for the studies, including transgenic mouse models, PDX tumor models and a variety of molecular biology and cell biology tools. Another interest of the lab is to understand the structure and function of nuclear receptor-coregulator complexes. We are the first group to use cryo electron microscopy (Cryo-EM) to determine the quaternary structure of DNA-bound estrogen receptor alpha, Steroid Receptor Coactivator (SRC-3) and a secondary coactivator (p300) complex. Combining cryo-EM structural approach and biochemical analysis, we have elucidated a series of nuclear receptor complex structures.Websites
Selected Publications
- Yu, W., Singh, R., Wang, Z., O'Malley, B. W., Yi, P. "The E3 ligase TRAF4 promotes IGF signaling by mediating atypical ubiquitination of IRS-1.." J. Biol. Chem.. 2021 296 : 100739. Pubmed PMID: 33991522
- Yi, P., Wang, Z., Feng, Q., Pintilie, G. D., Foulds, C. E., Lanz, R. B., Ludtke, S. J., Schmid, M. F., Chiu, W., O’Malley, B. W. "The Structure of a Biological Active Estrogen Receptor-Coactivator Complex on DNA.." Mol. Cell. 2015 57 : 1047-1058. Pubmed PMID: 25728767
- Singh, R., Karri, D., Shen, H., Shao, J., Dasgupta, S., Huang, S., Edwards, D.P., Ittmann, M.M., O'Malley, B.W., Yi, P. "TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis.." J. Clin. Invest.. 2018 128 : 3129-3143. Pubmed PMID: 29715200
- Yi, P., Wang, Z., Feng, Q., Chou C. K., Pintilie, G. D., Shen, H., Foulds, C. E., Fan, G., Serysheva, I., Ludtke, S. J., Schmid, M. F., Hung, M. C., Chiu, W., O'Malley, B. W. "Structural and Functional Impacts of ER Coactivator Sequential Recruitment.." Mol. Cell. 2017 67 : 733-743. Pubmed PMID: 28844863
- Yi P, Xia W, Wu RC, Lonard DM, Hung MC, O'Malley BW "SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization.." Genes Dev.. 2013 February 1; 27 (3): 274-87. Pubmed PMID: 23388826
- Dasgupta, S., Rajapakshe, K., Zhu, B., Nikolai, B. C., Yi, P., Putluri, N., Choi, J. M., Jung, S. Y., Coarfa, C., Westbrook, T. F., Zhang, X. H., Foulds, C. E., Tsai, S. Y., Tsai M. J., O'Malley, B. W. "Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer.." Nature. 2018 556 : 249-254. Pubmed PMID: 29615789
- Yu, X*., Yi, P*., Hamilton, R. A., Shen, H., Chen, M., Foulds, C. E., Mancini, M. A., Ludtke, S. J., Wang, Z., O’Malley, B. W. "Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes.." Mol. Cell. 2020 79 : 812-823. Pubmed PMID: 32668201
- Yi P, Feng Q, Amazit L, Lonard DM, Tsai SY, Tsai MJ, O'Malley BW "Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1.." Mol. Cell. 2008 February 29; 29 (4): 465-76. Pubmed PMID: 18313384
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