pyi

Ping Yi, Ph.D., B.S.

Picture

Ping Yi, Ph.D., B.S.

Assistant Professor

Email

pyi@bcm.edu

Positions

Assistant Professor: Mol & Cell Biology-Mol.Regulation
Baylor College of Medicine
Houston, TX US

Member: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States

Education

Advanced Training from Baylor College Of Medicine: 01/2008 - Houston, TX United States

Ph.D. from University Of Rochester: 01/2002 - Rochester, NY United States

Professional Interests

Cancer Biology, Nuclear receptor structure and function, Cell signaling

Professional Statement

My lab research has been focused on molecular regulation of oncogene activation in cancer, with a particular focus on post-translational modification and signal transduction pathways, and nuclear receptor structural studies. Current studies aim to explore the role of non-proteolytic ubiquitination in prostate and lung cancer development and progression. We employ diverse tools for the studies, including transgenic mouse models, PDX tumor models and a variety of molecular biology and cell biology tools. Another interest of the lab is to understand the structure and function of nuclear receptor-coregulator complexes. We are the first group to use cryo electron microscopy (Cryo-EM) to determine the quaternary structure of DNA-bound estrogen receptor alpha, Steroid Receptor Coactivator (SRC-3) and a secondary coactivator (p300) complex. Combining cryo-EM structural approach and biochemical analysis, we have elucidated a series of nuclear receptor complex structures.

Websites

VIICTR Publications List

Selected Publications

Yu, W., Singh, R., Wang, Z., O'Malley, B. W., Yi, P. "The E3 ligase TRAF4 promotes IGF signaling by mediating atypical ubiquitination of IRS-1.." J. Biol. Chem..2021;296:100739. Pubmed PMID: 33991522
Yi, P., Wang, Z., Feng, Q., Pintilie, G. D., Foulds, C. E., Lanz, R. B., Ludtke, S. J., Schmid, M. F., Chiu, W., O’Malley, B. W. "The Structure of a Biological Active Estrogen Receptor-Coactivator Complex on DNA.." Mol. Cell.2015;57:1047-1058. Pubmed PMID: 25728767
Singh, R., Karri, D., Shen, H., Shao, J., Dasgupta, S., Huang, S., Edwards, D.P., Ittmann, M.M., O'Malley, B.W., Yi, P. "TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis.." J. Clin. Invest..2018;128:3129-3143. Pubmed PMID: 29715200
Yi, P., Wang, Z., Feng, Q., Chou C. K., Pintilie, G. D., Shen, H., Foulds, C. E., Fan, G., Serysheva, I., Ludtke, S. J., Schmid, M. F., Hung, M. C., Chiu, W., O'Malley, B. W. "Structural and Functional Impacts of ER Coactivator Sequential Recruitment.." Mol. Cell.2017;67:733-743. Pubmed PMID: 28844863

Yi P, Xia W, Wu RC, Lonard DM, Hung MC, O'Malley BW "SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization.." Genes Dev.. 2013 February 1; 27 (3): 274-87. Pubmed PMID: 23388826
Dasgupta, S., Rajapakshe, K., Zhu, B., Nikolai, B. C., Yi, P., Putluri, N., Choi, J. M., Jung, S. Y., Coarfa, C., Westbrook, T. F., Zhang, X. H., Foulds, C. E., Tsai, S. Y., Tsai M. J., O'Malley, B. W. "Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer.." Nature. 2018 556 : 249-254. Pubmed PMID: 29615789
Yu, X*., Yi, P*., Hamilton, R. A., Shen, H., Chen, M., Foulds, C. E., Mancini, M. A., Ludtke, S. J., Wang, Z., O’Malley, B. W. "Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes.." Mol. Cell. 2020 79 : 812-823. Pubmed PMID: 32668201
Yi P, Feng Q, Amazit L, Lonard DM, Tsai SY, Tsai MJ, O'Malley BW "Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1.." Mol. Cell. 2008 February 29; 29 (4): 465-76. Pubmed PMID: 18313384