Philip J. Lupo, Ph.D.

Professor

(713) 798-2960

Email

philip.lupo@bcm.edu

Positions

Professor: Pediatrics
Hematology-Oncology
Baylor College of Medicine
Houston, TX, US

Co-Leader, Cancer Prevention & Population Sciences Program: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Addresses

Baylor Clinic (Office): 6620 Main Street
BCLN-11D.26
Houston, TX, 77030
United States

Education

Post-Doctoral Fellowship at University of Texas Health Science Center: 08/2010 - Houston, Texas, United States; Genetic Epidemiology

PhD from University of Texas Health Science Center: 08/2009 - Houston, Texas, United States; Epidemiology

MPH from University of Texas Health Science Center: 08/2004 - Houston, Texas, United States; Disease Control

BS from Houston Baptist University: 05/1996 - Houston, Texas, United States; Biology, Political Science

Honors & Awards

Delta Omega, Honorary Society in Public Health: (05/2010)

Pediatric Loan Repayment Program: National Institutes of Health (10/2011 - 09/2015)

Research Mentoring Award: University of Texas School of Public Health (08/2012)

Kurt Groten Family Research Scholars Award: (07/2012 - 06/2015)

Annual Investigator Meeting Travel Award: Childhood Cancer Survivor Study (06/2013)

Invited participant, Integrative Molecular Epidemiology Workshop: American Association for Cancer Research (07/2013)

“Top Abstracts” recipient: American Society of Preventive Oncology (03/2014)

Best Poster: National Birth Defects Prevention Network 18th Annual Meeting (10/2015)

Top Scoring Abstracts Award: 49th Congress of the International Society of Paediatric Oncology (10/2017)

Best Poster: National Birth Defects Prevention Network 21st Annual Meeting (03/2018)

F. Clarke Fraser New Investigator Award: Teratology Society (06/2018)

Professional Interests

Cancer epidemiology
Genetic epidemiology
Childhood cancer
Overlap between birth defects and childhood cancer
Epidemiology of birth defects

Professional Statement

The ultimate goal of my research is to discover factors that can be used in childhood cancer prevention efforts and targeted interventions to limit the adverse consequences of childhood cancer treatment.

Websites

Research Profile

PubMed

Texas Children's Cancer Center

My Bibliography at NCBI

Lab Page

Selected Publications

Lupo PJ, Nousome D, Kamdar KY, Okcu MF, Scheurer ME. " A case-parent triad assessment of folate metabolic genes and the risk of childhood acute lymphoblastic leukemia. " Cancer Causes Control. 2012 Nov ; 23 (11) : 1797-803.
Pubmed PMID: 22941668.
Lupo PJ, Symanski E. " A comparative analysis of modeled and monitored ambient hazardous air pollutants in Texas: a novel approach using concordance correlation. " J Air Waste Manag Assoc. 2009 Nov ; 59 (11) : 1278-86.
Pubmed PMID: 19947109.
Lupo PJ, Chapa C, Nousome D, Duhon C, Canfield MA, Shaw GM, Finnell RH, Zhu H. " A GCH1 haplotype and risk of neural tube defects in the National Birth Defects Prevention Study. " Mol. Genet. Metab.. 2012 Nov ; 107 (3) : 592-5.
Pubmed PMID: 23059057.
Lupo PJ, Lee LJ, Okcu MF, Bondy ML, Scheurer ME. " An exploratory case-only analysis of gene-hazardous air pollutant interactions and the risk of childhood medulloblastoma. " Pediatr Blood Cancer. 2012 Oct ; 59 (4) : 605-10.
Pubmed PMID: 22389292.
Gilboa SM, Desrosiers TA, Lawson C, Lupo PJ, Riehle-Colarusso TJ, Stewart PA, van Wijngaarden E, Waters MA, Correa A. " Association between maternal occupational exposure to organic solvents and congenital heart defects, National Birth Defects Prevention Study, 1997-2002. " 2012 Jul 17;
Pubmed PMID: 22811060.
Lee LJ, Canfield MA, Hashmi SS, Moffitt KB, Marengo L, Agopian AJ, Belmont JW, Freedenberg D, Tanksley SM, Mitchell LE, Lupo PJ. " Association between thyroxine levels at birth and choanal atresia or stenosis among infants in Texas, 2004-2007. " Birth Defects Res. Part A Clin. Mol. Teratol.. 2012 Nov ; 94 (11) : 951-4.
Pubmed PMID: 23125093.
Agopian AJ, Lupo PJ, Canfield MA, Langlois PH. " Case-control study of maternal residential atrazine exposure and male genital malformations. " Am. J. Med. Genet. A. 2013 May ; 161 (5) : 977-82.
Pubmed PMID: 23494929.
Sexton K, Linder SH, Marko D, Bethel H, Lupo PJ. " Comparative assessment of air pollution-related health risks in Houston. " Environ. Health Perspect.. 2007 Oct ; 115 (10) : 1388-93.
Pubmed PMID: 17938725.
Lupo PJ, Langer-Curry RC, Robinson M, Okhuysen PC, Chappell CL. " Cryptosporidium muris in a Texas canine population. " Am. J. Trop. Med. Hyg.. 2008 Jun ; 78 (6) : 917-21.
Pubmed PMID: 18541769.
Roessler E, Pei W, Ouspenskaia MV, Karkera JD, Veléz JI, Banerjee-Basu S, Gibney G, Lupo PJ, Mitchell LE, Towbin JA, Bowers P, Belmont JW, Goldmuntz E, Baxevanis AD, Feldman B, Muenke M. " Cumulative ligand activity of NODAL mutations and modifiers are linked to human heart defects and holoprosencephaly. " Mol. Genet. Metab.. ; 98 (41276) : 225-34.
Pubmed PMID: 19553149.
Lupo PJ, Canfield MA, Chapa C, Lu W, Agopian AJ, Mitchell LE, Shaw GM, Waller DK, Olshan AF, Finnell RH, Zhu H. " Diabetes and obesity-related genes and the risk of neural tube defects in the national birth defects prevention study. " Am. J. Epidemiol.. 2012 Dec 15; 176 (12) : 1101-9.
Pubmed PMID: 23132673.
Lupo PJ, Symanski E, Chan W, Mitchell LE, Waller DK, Canfield MA, Langlois PH. " Differences in exposure assignment between conception and delivery: the impact of maternal mobility. " Paediatr Perinat Epidemiol. 2010 Mar ; 24 (2) : 200-8.
Pubmed PMID: 20415777.
Agopian AJ, Lupo PJ, Herdt-Losavio ML, Langlois PH, Rocheleau CM, Mitchell LE. " Differences in folic acid use, prenatal care, smoking, and drinking in early pregnancy by occupation. " Prev Med. 2012 Jul 27;
Pubmed PMID: 22846503.
Badgwell B, Cormier JN, Krishnan S, Yao J, Staerkel GA, Lupo PJ, Pisters PW, Feig B, Mansfield P. " Does neoadjuvant treatment for gastric cancer patients with positive peritoneal cytology at staging laparoscopy improve survival? " Ann. Surg. Oncol.. 2008 Oct ; 15 (10) : 2684-91.
Pubmed PMID: 18649106.
Lupo PJ, Langlois PH, Mitchell LE. " Epidemiology of Ebstein anomaly: prevalence and patterns in Texas, 1999-2005. " Am. J. Med. Genet. A. 2011 May ; 155 (5) : 1007-14.
Pubmed PMID: 21465650.
Long J, Lupo PJ, Goldmuntz E, Mitchell LE. " Evaluation of heterogeneity in the association between congenital heart defects and variants of folate metabolism genes: conotruncal and left-sided cardiac defects. " Birth Defects Res. Part A Clin. Mol. Teratol.. 2011 Oct ; 91 (10) : 879-84.
Pubmed PMID: 21987465.
Lupo PJ, Goldmuntz E, Mitchell LE. " Gene-gene interactions in the folate metabolic pathway and the risk of conotruncal heart defects. " J. Biomed. Biotechnol.. 2010 ; 2010 : 630940.
Pubmed PMID: 20111745.
Rountree SD, Waring SC, Chan WC, Lupo PJ, Darby EJ, Doody RS. " Importance of subtle amnestic and nonamnestic deficits in mild cognitive impairment: prognosis and conversion to dementia. " Dement Geriatr Cogn Disord. 2007 ; 24 (6) : 476-82.
Pubmed PMID: 17992015.
Swartz MD, Peterson CB, Lupo PJ, Wu X, Forman MR, Spitz MR, Hernandez LM, Vannucci M, Shete S. " Investigating multiple candidate genes and nutrients in the folate metabolism pathway to detect genetic and nutritional risk factors for lung cancer. " PLoS ONE. 2013 ; 8 (1) : e53475.
Pubmed PMID: 23372658.
Badgwell BD, Chang GJ, Rodriguez-Bigas MA, Smith K, Lupo PJ, Frankowski RF, Delclos G, Du XL, Cormier J. " Management and outcomes of anorectal infection in the cancer patient. " Ann. Surg. Oncol.. 2009 Oct ; 16 (10) : 2752-8.
Pubmed PMID: 19649556.
Nousome D, Lupo PJ, Okcu MF, Scheurer ME. " Maternal and offspring xenobiotic metabolism haplotypes and the risk of childhood acute lymphoblastic leukemia. " Leuk. Res.. 2013 May ; 37 (5) : 531-5.
Pubmed PMID: 23433810.
Lupo PJ, Symanski E, Waller DK, Chan W, Langlois PH, Canfield MA, Mitchell LE. " Maternal exposure to ambient levels of benzene and neural tube defects among offspring: Texas, 1999-2004. " Environ. Health Perspect.. 2011 Mar ; 119 (3) : 397-402.
Pubmed PMID: 20923742.
Lupo PJ, Symanski E, Langlois PH, Lawson CC, Malik S, Gilboa SM, Lee LJ, Agopian AJ, Desrosiers TA, Waters MA, Romitti PA, Correa A, Shaw GM, Mitchell LE. " Maternal occupational exposure to polycyclic aromatic hydrocarbons and congenital heart defects among offspring in the national birth defects prevention study. " Birth Defects Res. Part A Clin. Mol. Teratol.. 2012 Nov ; 94 (11) : 875-81.
Pubmed PMID: 22945317.
Langlois PH, Hoyt AT, Lupo PJ, Lawson CC, Waters MA, Desrosiers TA, Shaw GM, Romitti PA, Lammer EJ. " Maternal occupational exposure to polycyclic aromatic hydrocarbons and risk of neural tube defect-affected pregnancies. " 2012 Jul 17;
Pubmed PMID: 22807044.
Langlois PH, Hoyt AT, Lupo PJ, Lawson CC, Waters MA, Desrosiers TA, Shaw GM, Romitti PA, Lammer EJ. " Maternal Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Risk of Oral Cleft-Affected Pregnancies. " Cleft Palate Craniofac. J.. 2012 Nov 8;
Pubmed PMID: 23136939.
Lupo PJ, Langlois PH, Reefhuis J, Lawson CC, Symanski E, Desrosiers TA, Khodr ZG, Agopian AJ, Waters MA, Duwe KN, Finnell RH, Mitchell LE, Moore CA, Romitti PA, Shaw GM. " Maternal Occupational Exposure to Polycyclic Aromatic Hydrocarbons: Effects on Gastroschisis among Offspring in the National Birth Defects Prevention Study. " Environ. Health Perspect.. 2012 Jun ; 120 (6) : 910-5.
Pubmed PMID: 22330681.
Agopian AJ, Langlois PH, Cai Y, Canfield MA, Lupo PJ. " Maternal Residential Atrazine Exposure and Gastroschisis by Maternal Age. " Matern Child Health J. 2012 Nov 25;
Pubmed PMID: 23184502.
Agopian AJ, Cai Y, Langlois PH, Canfield MA, Lupo PJ. " Maternal Residential Atrazine Exposure and Risk for Choanal Atresia and Stenosis in Offspring. " J. Pediatr.. 2012 Oct 1;
Pubmed PMID: 23036484.
Lee LJ, Lupo PJ. " Maternal Smoking During Pregnancy and the Risk of Congenital Heart Defects in Offspring: A Systematic Review and Metaanalysis. " Pediatr Cardiol. 2012 Aug 12;
Pubmed PMID: 22886364.
Lupo PJ, Nousome D, Okcu MF, Chintagumpala M, Scheurer ME. " Maternal Variation in EPHX1, a Xenobiotic Metabolism Gene, Is Associated with Childhood Medulloblastoma: An Exploratory Case-Parent Triad Study. " Pediatr Hematol Oncol. 2012 Nov ; 29 (8) : 679-85.
Pubmed PMID: 22994552.
Lupo PJ, Mitchell LE, Goldmuntz E. " NAT1, NOS3, and TYMS genotypes and the risk of conotruncal cardiac defects. " Birth Defects Res. Part A Clin. Mol. Teratol.. 2011 Jan ; 91 (1) : 61-5.
Pubmed PMID: 21254360.
Cantu MA, Lupo PJ, Bilgi M, Hicks MJ, Allen CE, McClain KL. " Optimal therapy for adults with langerhans cell histiocytosis bone lesions. " PLoS ONE. 2012 ; 7 (8) : e43257.
Pubmed PMID: 22916233.
Lupo PJ, Symanski E, Waller DK, Chan W, Canfield MA, Langlois PH, Mitchell LE. " Polytomous logistic regression as a tool for exploring heterogeneity across birth defect subtypes: an example using anencephaly and spina bifida. " Birth Defects Res. Part A Clin. Mol. Teratol.. 2010 Aug ; 88 (8) : 701-5.
Pubmed PMID: 20740595.
Agopian AJ, Tinker SC, Lupo PJ, Canfield MA, Mitchell LE. " Proportion of neural tube defects attributable to known risk factors. " Birth Defects Res. Part A Clin. Mol. Teratol.. 2013 Jan ; 97 (1) : 42-6.
Pubmed PMID: 23427344.
Agopian AJ, Canfield MA, Olney RS, Lupo PJ, Ramadhani T, Mitchell LE, Shaw GM, Moore CA. " Spina bifida subtypes and sub-phenotypes by maternal race/ethnicity in the National Birth Defects Prevention Study. " Am. J. Med. Genet. A. 2011 Dec 2;
Pubmed PMID: 22140002.
O'Bryant SE, Waring SC, Cullum CM, Hall J, Lacritz L, Massman PJ, Lupo PJ, Reisch JS, Doody R. " Staging dementia using Clinical Dementia Rating Scale Sum of Boxes scores: a Texas Alzheimer's research consortium study. " Arch. Neurol.. 2008 Aug ; 65 (8) : 1091-5.
Pubmed PMID: 18695059.
Hashmi SS, Canfield MA, Marengo L, Moffitt KB, Belmont JW, Freedenberg D, Tanksley SM, Lupo PJ. " The association between neonatal thyroxine and craniosynostosis, Texas, 2004-2007. " Birth Defects Res. Part A Clin. Mol. Teratol.. 2012 Dec ; 94 (12) : 1004-9.
Pubmed PMID: 23109112.
Goldmuntz E, Woyciechowski S, Renstrom D, Lupo PJ, Mitchell LE. " Variants of folate metabolism genes and the risk of conotruncal cardiac defects. " Circ Cardiovasc Genet. 2008 Dec ; 1 (2) : 126-32.
Pubmed PMID: 20031554.
Agopian AJ, Lupo PJ, Tinker SC, Canfield MA, Mitchell LE. " Working towards a risk prediction model for neural tube defects. " Birth Defects Res. Part A Clin. Mol. Teratol.. 2012 Mar ; 94 (3) : 141-6.
Pubmed PMID: 22253139.

Memberships

American Association for Cancer Research: Member (01/2008)

Childhood Cancer and Leukemia International Consortium: Member (01/2011)

Children’s Oncology Group: Chair, Epidemiology Committee (07/2012)

International Society of Paediatric Oncology: Member (01/2015)

Advisory Committee to the Texas Cancer Registry: Member (07/2016)

Society for Birth Defects Research and Prevention: Member (09/2017)

National Birth Defects Prevention Network: Member (01/2008)

Funding

Epigenomic Profiling of Metabolic Outcomes in Childhood Leukemia Survivors #U24CASS727 (Parent grant ID): $20,000.00 (12/01/2013 - 11/30/2014); Grant funding from Childhood Cancer Survivor Study (CCSS)/NCI

Exploring the Intersection Between Childhood Cancer and Birth Defects to Identify Novel Cancer Predisposition Syndromes #Epidemiology Grant: $200,000.00 (07/01/2014 - 06/30/2016); Grant funding from Alex's Lemonade Stand Foundation

The Intersection between Childhood Cancer and Congenital Anomalies: Identifying Novel Cancer Predisposition Syndromes #RP140258: $874,964.00 (08/31/2014 - 08/30/2017); Grant funding from Cancer Prevention & Research Institute of Texas (CPRIT)

Genetic Epidemiology and Molecular Basis of Cancer Predisposition in Pediatric Rhabdomyosarcoma #RP170071: $1,488,105.00 (12/01/2016 - 11/30/2019); Grant funding from CPRIT

Molecular Epidemiology And Somatic Alterations Driving Acute Lymphoblastic Leukemia In Down Syndrome #RP170074: $1,200,000.00 (12/01/2016 - 11/30/2020); Grant funding from CPRIT

Reducing Ethnic Disparities in Acute Leukemia (REDIAL) Consortium: $2,000,000.00 (07/01/2017 - 06/30/2021); Grant funding from St. Baldrick's Foundation

The Early-Life Exposome and Risk of Pediatric Acute Lymphoblastic Leukemia #RP180755: $199,140.00 (08/31/2018 - 08/30/2020); Grant funding from CPRIT

A Multidisciplinary Approach for Identifying and Characterizing Novel Congenital Malformation Syndromes #R01HD093660: $1,662,692.00 (08/25/2018 - 06/30/2023); Grant funding from NIH/NICHD

Genomic Analysis of Congenital Heart Defects and Acute Lymphoblastic Leukemia in Children with Down Syndrome #X01HL145686: (10/01/2018 - 09/30/2019); Grant funding from NIH

Genomic Analysis of Pediatric Rhabdomyosarcoma #X01HD100852: (10/01/2019 - 09/30/2020); Grant funding from NIH

Molecular Epidemiology of Acute Lymphoblastic Leukemia in Children with Down Syndrome #R01CA249867: $2,130,791.00 (08/03/2020 - 07/31/2023); Grant funding from NIH/NCI

Identifying Novel Cancer Predisposition Syndromes: An Integrative Epidemiologic and Genomic Approach #CA190214: $1,000,000.00 (08/15/2020 - 08/14/2023); Grant funding from DOD