Email

Positions

Assistant Professor

Pathology & Immunology
Baylor College of Medicine
Houston, TX, US

Addresses

Office Feigin Center (Office)

TX Childs Feigin Tower
Room: 955.11
Houston, TX, 77030
United States
Phone: (832) 825-3798
Numan.Oezguen@bcm.edu

Education

PhD from RWTH

10/1999 - Aachen, Germany

MS from RWTH

10/1995 - Aachen, Germany

Websites

Selected Publications

• Oezguen N, Schein CH, Peddi SR, Power TD, Izumi T, Braun W. " A moving metal mechanism" for substrate cleavage by the DNA repair endonuclease APE-1." " Proteins. 2007 Jul 1; 68 (1) : 313-23.
  Pubmed PMID: 17427952.
• Oezguen N, Zhou B, Negi SS, Ivanciuc O, Schein CH, Labesse G, Braun W. " Comprehensive 3D-modeling of allergenic proteins and amino acid composition of potential conformational IgE epitopes. " Mol. Immunol.. 2008 Aug ; 45 (14) : 3740-7.
  Pubmed PMID: 18621419.
• Oezguen N, Kumar S, Hindupur A, Braun W, Muralidhara BK, Halpert JR. " Identification and analysis of conserved sequence motifs in cytochrome P450 family 2. Functional and structural role of a motif 187RFDYKD192 in CYP2B enzymes. " J. Biol. Chem.. 2008 Aug 1; 283 (31) : 21808-16.
  Pubmed PMID: 18495666.
• Navaratnarajah CK, Oezguen N, Rupp L, Kay L, Leonard VH, Braun W, Cattaneo R. " The heads of the measles virus attachment protein move to transmit the fusion-triggering signal. " Nat. Struct. Mol. Biol.. 2011 Feb ; 18 (2) : 128-34.
  Pubmed PMID: 21217701.
• Savidge TC, Urvil P, Oezguen N, Ali K, Choudhury A, Acharya V, Pinchuk I, Torres AG, English RD, Wiktorowicz JE, Loeffelholz M, Kumar R, Shi L, Nie W, Braun W, Herman B, Hausladen A, Feng H, Stamler JS, Pothoulakis C. " Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins. " Nat. Med.. 2011 Sep ; 17 (9) : 1136-41.
  Pubmed PMID: 21857653.
• Negi SS, Schein CH, Oezguen N, Power TD, Braun W. " InterProSurf: a web server for predicting interacting sites on protein surfaces. " Bioinformatics. 2007 Dec 15; 23 (24) : 3397-9.
  Pubmed PMID: 17933856.
• Kumar S, Qiu H, Oezguen N, Herlyn H, Halpert JR, Wojnowski L. " Ligand diversity of human and chimpanzee CYP3A4: activation of human CYP3A4 by lithocholic acid results from positive selection. " Drug Metab. Dispos.. 2009 Jun ; 37 (6) : 1328-33.
  Pubmed PMID: 19299527.
• Oezguen N, K Mantha A, Izumi T, H Schein C, Mitra S, Braun W. " MD simulation and experimental evidence for Mg binding at the b site in human AP endonuclease 1. " Bioinformation. 2011 ; 7 (4) : 184-98.
  Pubmed PMID: 22102776.
• Leonard VH, Sinn PL, Hodge G, Miest T, Devaux P, Oezguen N, Braun W, McCray PB, McChesney MB, Cattaneo R. " Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed. " J. Clin. Invest.. 2008 Jul ; 118 (7) : 2448-58.
  Pubmed PMID: 18568079.
• Murtazina D, Puchkaev AV, Schein CH, Oezguen N, Braun W, Nanavati A, Pikuleva IA. " Membrane-protein interactions contribute to efficient 27-hydroxylation of cholesterol by mitochondrial cytochrome P450 27A1. " J. Biol. Chem.. 2002 Oct 4; 277 (40) : 37582-9.
  Pubmed PMID: 12124390.
• Schein CH, Zhou B, Oezguen N, Mathura VS, Braun W. " Molego-based definition of the architecture and specificity of metal-binding sites. " Proteins. 2005 Jan 1; 58 (1) : 200-10.
  Pubmed PMID: 15505785.
• von Messling V, Oezguen N, Zheng Q, Vongpunsawad S, Braun W, Cattaneo R. " Nearby clusters of hemagglutinin residues sustain SLAM-dependent canine distemper virus entry in peripheral blood mononuclear cells. " J. Virol.. 2005 May ; 79 (9) : 5857-62.
  Pubmed PMID: 15827201.
• Bhavnani SK, Victor S, Calhoun WJ, Busse WW, Bleecker E, Castro M, Ju H, Pillai R, Oezguen N, Bellala G, Brasier AR. " How cytokines co-occur across asthma patients: From bipartite network analysis to a molecular-based classification. " J Biomed Inform. 2011 Dec ; 44 : S24-30.
  Pubmed PMID: 21986291.
• Schein CH, Oezguen N, van der Heden van Noort GJ, Filippov DV, Paul A, Kumar E, Braun W. " NMR solution structure of poliovirus uridylyated peptide linked to the genome (VPgpU). " Peptides. 2010 Aug ; 31 (8) : 1441-8.
  Pubmed PMID: 20441784.
• Schein CH, Oezguen N, Volk DE, Garimella R, Paul A, Braun W. " NMR structure of the viral peptide linked to the genome (VPg) of poliovirus. " Peptides. 2006 Jul ; 27 (7) : 1676-84.
  Pubmed PMID: 16540201.
• Schein CH, Volk DE, Oezguen N, Paul A. " Novel, structure-based mechanism for uridylylation of the genome-linked peptide (VPg) of picornaviruses. " Proteins. 2006 Jun 1; 63 (4) : 719-26.
  Pubmed PMID: 16498624.
• Vongpunsawad S, Oezgun N, Braun W, Cattaneo R. " Selectively receptor-blind measles viruses: Identification of residues necessary for SLAM- or CD46-induced fusion and their localization on a new hemagglutinin structural model. " J. Virol.. 2004 Jan ; 78 (1) : 302-13.
  Pubmed PMID: 14671112.
• Ivanciuc O, Schein CH, Garcia T, Oezguen N, Negi SS, Braun W. " Structural analysis of linear and conformational epitopes of allergens. " Regul. Toxicol. Pharmacol.. 2009 Aug ; 54 (3) : S11-9.
  Pubmed PMID: 19121639.
• Hegde ML, Tsutakawa SE, Hegde PM, Holthauzen LM, Li J, Oezguen N, Hilser VJ, Tainer JA, Mitra S. " The Disordered C-Terminal Domain of Human DNA Glycosylase NEIL1 Contributes to Its Stability via Intramolecular Interactions. " J. Mol. Biol.. 2013 Jul 10; 425 (13) : 2359-71.
  Pubmed PMID: 23542007.
• Schein CH, Ozgün N, Izumi T, Braun W. " Total sequence decomposition distinguishes functional modules, molegos" in apurinic/apyrimidinic endonucleases." " BMC Bioinformatics. 2002 Nov 25; 3 : 37.
  Pubmed PMID: 12445335.
• Mantha AK, Oezguen N, Bhakat KK, Izumi T, Braun W, Mitra S. " Unusual role of a cysteine residue in substrate binding and activity of human AP-endonuclease 1. " J. Mol. Biol.. 2008 May 23; 379 (1) : 28-37.
  Pubmed PMID: 18436236.
• Ivanciuc O, Oezguen N, Mathura VS, Schein CH, Xu Y, Braun W. " Using property based sequence motifs and 3D modeling to determine structure and functional regions of proteins. " Curr. Med. Chem.. 2004 Mar ; 11 (5) : 583-93.
  Pubmed PMID: 15032606.
• Izumi T, Schein CH, Oezguen N, Feng Y, Braun W. " Effects of backbone contacts 3' to the abasic site on the cleavage and the product binding by human apurinic/apyrimidinic endonuclease (APE1). " Biochemistry. 2004 Jan 27; 43 (3) : 684-9.
  Pubmed PMID: 14730972.
• Navaratnarajah CK, Vongpunsawad S, Oezguen N, Stehle T, Braun W, Hashiguchi T, Maenaka K, Yanagi Y, Cattaneo R. " Dynamic interaction of the measles virus hemagglutinin with its receptor signaling lymphocytic activation molecule (SLAM, CD150). " J. Biol. Chem.. 2008 Apr 25; 283 (17) : 11763-71.
  Pubmed PMID: 18292085.
• Oezguen N, Power TD, Urvil P, Feng H, Pothoulakis C, Stamler JS, Braun W, Savidge TC. " Clostridial toxins: Sensing a target in a hostile gut environment. " Gut Microbes. 2012 Jan 1; 3 (1) : 35-41.
  Pubmed PMID: 22356854.
• Apte-Sengupta S, Negi S, Leonard VH, Oezguen N, Navaratnarajah CK, Braun W, Cattaneo R. " Base of the measles virus fusion trimer head receives the signal that triggers membrane fusion. " J. Biol. Chem.. 2012 Sep 21; 287 (39) : 33026-35.
  Pubmed PMID: 22859308.
• Oezguen N, Adamian L, Xu Y, Rajarathnam K, Braun W. " Automated assignment and 3D structure calculations using combinations of 2D homonuclear and 3D heteronuclear NOESY spectra. " J. Biomol. NMR. 2002 Mar ; 22 (3) : 249-63.
  Pubmed PMID: 11991354.
• Joffre E, von Mentzer A, Abd El Ghany M, Oezguen N, Savidge T, Dougan G, Svennerholm AM, Sjoling A. " Allele variants of enterotoxigenic Escherichia coli heat labile toxin are globally transmitted and associated with colonization factors " J Bacteriol. 2015 Jan ; 2 (197) : 392-304.
  Pubmed PMID: 25404692.
• Oezguen N, Kumar S.. " Analysis of Cytochrome P450 Conserved Sequence Motifs between Helices E and H: Prediction of Critical Motifs and Residues in Enzyme Functions " J. Drug Metabol. Toxicol.. 2011 Aug 30; 2 (110)
  Pubmed PMID: 25426333.
• Li S, Shi L, Yang Z, Zhang Y, Perez Cordon G, Huang T, Ramsey J, Oezguen N, Savidge TC, Feng H. " Critical Roles of Clostridium difficile Toxin B Enzymatic Activities in Pathogenesis " Infect Immum. 2015 Feb ; 83 (2) : 502-13.
  Pubmed PMID: 25404023.
• Pokusaeva K, Johnson C, Luk B, Uribe G, Fu Y, Oezguen N, Matsunami RK, Lugo M, Major A, Mori-Akiyama Y, Hollister EB, Dann SM, Shi XZ, Engler DA, Savidge T, Versalovic J. " GABA-producing Bifidobaterium dentium modulates visceral sensitivity in the intestine. " Neurogastroenterol Motil. 2016 ;
  Pubmed PMID: 27458085.
• Chumpitazi BP, Hollister EB, Oezguen N, Tsai CM, McMeans AR, Luna RA, Savidge TC, Versalovic J, Shulman RJ. " Gut microbiota influences low fermentable substrate diet efficacy in children with irritable bowel syndrome " Gut Microbes. 2014 Jan 27; 5 (2) : 165-75.
  Pubmed PMID: 24637601.
• Endsley MA, Somasunderam A, Li G, Oezguen N, Thiviyanathan V, Murray JL, Rubin DH, Hodge TW, O'Brien WA, Lewis B, Ferguson MR. " Nuclear trafficking of the HIV-1pre-integration complex depends on the ADAM10 intracellular domain " Virology. 2014 Apr ; 454-455.
  Pubmed PMID: 24725932.
• Chen D, Oezguen N, Urvil P, Ferguson C, Dann S, Savidge T,. " Regulation of Protein-Ligand Binding Affinity by Hydrogen Bond Pairing " Science Advances. 2016 Mar 26; 2 (3)
  Pubmed PMID: 27051863.
• Oezguen, N., Nick, B., Jung, B., Wortmann, F.J., Hocker, H.. " Modeling of 0-conditions for bisphenol-A polycarbonate single chains. " Macromol. Symp. 1998 Feb ; 127 (1) : 151-159.
• Oezguen, N., Nick, B., Jung, B., Wortmann, F.J., Hocker, H.. " Molecular dynamic simulations with bisphenol-A polycarbonate under 0-conditions. " Jahresbericht DWI. 1998 ;
• Ruth Ann Luna, Numan Oezguen , Miriam Balderas, Alamelu Venkatachalam, Jessica K Runge, James Versalovic, Jeremy Veenstra-VanderWeele, George M Anderson, Tor Savidge, Kent C Williams. " Distinct Microbiome-Neuroimmune Signatures Correlate With Functional Abdominal Pain in Children With Autism Spectrum Disorder " Cell Mol Gastroenterol Hepatol. 2016 Dec 11; 3 (2) : 218-230.
  Pubmed PMID: 28275689.
• Hall AE, Engevik MA, Oezguen N, Haag A, Versalovic J. " CIC transporter activity modulates histidine catabolism in Lactobacillus reuteri by altering intracellular pH and membrane potential " Microb Cell Fact.. 2019 Dec 12; 18 (1) : 212.
  Pubmed PMID: 31830990.
• Labus JS, Hollister EB, Jacobs J, Kirbach K, Oezguen N, Gupta A, Acosta J, Luna RA, Aagaard K, Versalovic J, Savidge T, Hasiao E, Tillisch K, Mayer EA. " Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome " Microbiome. 2017 May 1; 5 (1) : 49.
  Pubmed PMID: 28457228.
• Hollister EB, Oezguen N, Chumpitazi BP, Luna RA, Weidler EM, Rubio-Gonzales M, Dahdouli M, Cope JL, Mistretta TA, Raza S, Metcalf GA, Muzny DM, Gibbs RA, Petrosino JF, Heitkemper M, Savidge TC, Shulman RJ, Versalovic J. " Leveraging Human Microbiome Features to Diagnose and Stratify Children with Irritable Bowel Syndrome " J Mol Diagn.. 2019 May 21; 1 (3) : 449-4661.
  Pubmed PMID: 31005411.
• Oezguen N, Yalcinkaya N, Kucukali CI, Dahdouli M, Hollister EB, Luna RA, Turkoglu R, Kurtuncu M, Eraksoy M, Savidge TC, Tuzun E. " Microbiota stratification identifies disease-specific alterations in neuro-Behcet's disease and multiple sclerosis " Clin Exp Rheumatol.. 2019 Nov ; 37 (6) : 58-66.
  Pubmed PMID: 31172918.
• Spinler JK, Auchtung J, Brown A, Boonma P, Oezguna N, Ross CL, Luna RA, Runge J, Versalovic J, Peniche A, Dann SM, Britton RA, Haag A, Savidge TC. " Next-Generation Probiotics Targeting Colstridium difficile through Precursor-Directed Antimicrobial Biosynthesis " Infect. Immun.. 2017 Sep 20; 85 (10) : 00303-17.
  Pubmed PMID: 28760934.
• Horvath, TD, Haidacher SJ, Oezguen N, Hoch KM, Auchtung JM, Haag AM. " Ruggedness testing of liquid chromatography-tandem mass spectrometry system components using microbiome-relevant methods and matrices. " J Microbiol Methods. 2020 Aug 11; 177 : 106020.
  Pubmed PMID: 32795635.
• Norsigian CJ, Danhof HA, Brand CK, Oezguen N, Midani FS, Palsson BO, Savidge TC, Britton RA, Spinler JK, Monk JM. " Systems biology analysis of the Clostridioides difficile core-genome contextualizes microenvironmental evolutionary pressures leading to genotypic and phenotypic divergence " NPJ Syst Biol Appl.. 2020 Oct 20; 6 (1) : 31.
  Pubmed PMID: 33082337.

Languages

German, Turkish