Positions
- Assistant Professor
-
Pediatrics-Nutrition
Baylor College of Medicine
Houston, TX US
Education
- Advanced Training from Baylor College Of Medicine
- 01/2002 - Houston, TX United States
- Advanced Training from Noble Foundation
- 01/2000 - Ardmore, OK United States
- Ph.D. from Nanjing Agricultural University
- 01/1994 - China, People's Rep
Websites
Selected Publications
- Cheng NH, Zhang W, Chen WQ, Jin J, Cui X, Butte NF, Chan L, Hirschi KD "A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis.." FEBS J.. 2011 July ; 278 (14): 2525-39. Pubmed PMID: 21575136
- Qu Y, Wang J, Ray PS, Guo H, Huang J, Shin-Sim M, Bukoye BA, Liu B, Lee AV, Lin X, Huang P, Martens JW, Giuliano AE, Zhang N, Cheng NH, Cui X "Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-?B signaling.." J. Clin. Invest.. 2011 January 4; 121 (1): 212-25. Pubmed PMID: 21123948
- Liu X, Liu S, Feng Y, Liu JZ, Chen Y, Pham K, Deng H, Hirschi KD, Wang X, Cheng N. "Structural insights into the N-terminal GIY-YIG endonuclease activity of Arabidopsis glutaredoxin AtGRXS16 in chloroplasts." Proc Natl Acad Sci U S A.. 2013 June 4; 110 (23): 9565-70.. Pubmed PMID: 23690600
- Yang SJ, Carter SA, Cole AB, Cheng NH, Nelson RS "A natural variant of a host RNA-dependent RNA polymerase is associated with increased susceptibility to viruses by Nicotiana benthamiana.." Proc. Natl. Acad. Sci. U.S.A.. 2004 April 20; 101 (16): 6297-302. Pubmed PMID: 15079073
- Ding XS, Liu J, Cheng NH, Folimonov A, Hou YM, Bao Y, Katagi C, Carter SA, Nelson RS "The Tobacco mosaic virus 126-kDa protein associated with virus replication and movement suppresses RNA silencing.." Mol. Plant Microbe Interact.. 2004 June ; 17 (6): 583-92. Pubmed PMID: 15195941
- Cheng NH, Pittman JK, Zhu JK, Hirschi KD "The protein kinase SOS2 activates the Arabidopsis H(+)/Ca(2+) antiporter CAX1 to integrate calcium transport and salt tolerance.." J. Biol. Chem.. 2004 January 23; 279 (4): 2922-6. Pubmed PMID: 14583601
- Cheng NH, Pittman JK, Barkla BJ, Shigaki T, Hirschi KD "The Arabidopsis cax1 mutant exhibits impaired ion homeostasis, development, and hormonal responses and reveals interplay among vacuolar transporters.." Plant Cell. 2003 February ; 15 (2): 347-64. Pubmed PMID: 12566577
- Shigaki T, Cheng NH, Pittman JK, Hirschi K "Structural determinants of Ca2+ transport in the Arabidopsis H+/Ca2+ antiporter CAX1.." J. Biol. Chem.. 2001 November 16; 276 (46): 43152-9. Pubmed PMID: 11562366
- Mei H, Cheng NH, Zhao J, Park S, Escareno RA, Pittman JK, Hirschi KD "Root development under metal stress in Arabidopsis thaliana requires the H+/cation antiporter CAX4.." New Phytol.. 2009 183 (1): 95-105. Pubmed PMID: 19368667
- Li XB, Cai L, Cheng NH, Liu JW "Molecular characterization of the cotton GhTUB1 gene that is preferentially expressed in fiber.." Plant Physiol.. 2002 October ; 130 (2): 666-74. Pubmed PMID: 12376634
- Pittman JK, Shigaki T, Cheng NH, Hirschi KD "Mechanism of N-terminal autoinhibition in the Arabidopsis Ca(2+)/H(+) antiporter CAX1.." J. Biol. Chem.. 2002 July 19; 277 (29): 26452-9. Pubmed PMID: 12006570
- Zhao J, Shigaki T, Mei H, Guo YQ, Cheng NH, Hirschi KD "Interaction between Arabidopsis Ca2+/H+ exchangers CAX1 and CAX3.." J. Biol. Chem.. 2009 February 13; 284 (7): 4605-15. Pubmed PMID: 19098009
- Park S, Cheng NH, Pittman JK, Yoo KS, Park J, Smith RH, Hirschi KD "Increased calcium levels and prolonged shelf life in tomatoes expressing Arabidopsis H+/Ca2+ transporters.." Plant Physiol.. 2005 November ; 139 (3): 1194-206. Pubmed PMID: 16244156
- Pittman JK, Cheng NH, Shigaki T, Kunta M, Hirschi KD "Functional dependence on calcineurin by variants of the Saccharomyces cerevisiae vacuolar Ca2+/H+ exchanger Vcx1p.." Mol. Microbiol.. 2004 November ; 54 (4): 1104-16. Pubmed PMID: 15522090
- Cheng NH, Pittman JK, Shigaki T, Lachmansingh J, LeClere S, Lahner B, Salt DE, Hirschi KD "Functional association of Arabidopsis CAX1 and CAX3 is required for normal growth and ion homeostasis.." Plant Physiol.. 2005 August ; 138 (4): 2048-60. Pubmed PMID: 16055687
- Pittman JK, Shigaki T, Marshall JL, Morris JL, Cheng NH, Hirschi KD "Functional and regulatory analysis of the Arabidopsis thaliana CAX2 cation transporter.." Plant Mol. Biol.. 2004 December ; 56 (6): 959-71. Pubmed PMID: 15821993
- Sze H, Padmanaban S, Cellier F, Honys D, Cheng NH, Bock KW, Conéjéro G, Li X, Twell D, Ward JM, Hirschi KD "Expression patterns of a novel AtCHX gene family highlight potential roles in osmotic adjustment and K+ homeostasis in pollen development.." Plant Physiol.. 2004 September ; 136 (1): 2532-47. Pubmed PMID: 15347787
- Wu Q, Lin J, Liu JZ, Wang X, Lim W, Oh M, Park J, Rajashekar CB, Whitham SA, Cheng NH, Hirschi KD, Park S "Ectopic expression of Arabidopsis glutaredoxin AtGRXS17 enhances thermotolerance in tomato.." Plant Biotechnol. J.. 2012 October ; 10 (8): 945-55. Pubmed PMID: 22762155
- Cheng NH, Hirschi KD "Cloning and characterization of CXIP1, a novel PICOT domain-containing Arabidopsis protein that associates with CAX1.." J. Biol. Chem.. 2003 February 21; 278 (8): 6503-9. Pubmed PMID: 12480930
- Cheng NH, Liu JZ, Nelson RS, Hirschi KD "Characterization of CXIP4, a novel Arabidopsis protein that activates the H+/Ca2+ antiporter, CAX1.." FEBS Lett.. 2004 February 13; 559 (41277): 99-106. Pubmed PMID: 14960315
- Cheng NH, Pittman JK, Shigaki T, Hirschi KD "Characterization of CAX4, an Arabidopsis H(+)/cation antiporter.." Plant Physiol.. 2002 April ; 128 (4): 1245-54. Pubmed PMID: 11950973
- Conn SJ, Gilliham M, Athman A, Schreiber AW, Baumann U, Moller I, Cheng NH, Stancombe MA, Hirschi KD, Webb AA, Burton R, Kaiser BN, Tyerman SD, Leigh RA "Cell-Specific Vacuolar Calcium Storage Mediated by CAX1 Regulates Apoplastic Calcium Concentration, Gas Exchange, and Plant Productivity in Arabidopsis.." Plant Cell. 2011 January ; 23 (1): 240-57. Pubmed PMID: 21258004
- Cheng NH, Liu JZ, Brock A, Nelson RS, Hirschi KD "AtGRXcp, an Arabidopsis chloroplastic glutaredoxin, is critical for protection against protein oxidative damage.." J. Biol. Chem.. 2006 September 8; 281 (36): 26280-8. Pubmed PMID: 16829529
- Cheng NH "AtGRX4, an Arabidopsis chloroplastic monothiol glutaredoxin, is able to suppress yeast grx5 mutant phenotypes and respond to oxidative stress.." FEBS Lett.. 2008 March 19; 582 (6): 848-54. Pubmed PMID: 18275854
- Zhao J, Cheng NH, Motes CM, Blancaflor EB, Moore M, Gonzales N, Padmanaban S, Sze H, Ward JM, Hirschi KD "AtCHX13 is a plasma membrane K+ transporter.." Plant Physiol.. 2008 October ; 148 (2): 796-807. Pubmed PMID: 18676662
- Cheng NH, Liu JZ, Liu X, Wu Q, Thompson SM, Lin J, Chang J, Whitham SA, Park S, Cohen JD, Hirschi KD "Arabidopsis Monothiol Glutaredoxin, AtGRXS17, Is Critical for Temperature-dependent Postembryonic Growth and Development via Modulating Auxin Response.." J. Biol. Chem.. 2011 June 10; 286 (23): 20398-406. Pubmed PMID: 21515673
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