Email

nader.el-mallawany@bcm.edu

Positions

Assistant Professor

Pediatrics
Hematology/Oncology
Baylor College of Medicine
Houston, TX US

Education

AB from Princeton University

Princeton, New Jersey United States

MD from University of Toledo College of Medicine

Toledo, Ohio United States

Residency at Brown University

Providence, Rhode Island United States

Fellowship at Columbia University

New York, New York United States

Professional Statement

With over ten years of experience caring for children and adolescents with cancer, Dr. Nader Kim El-Mallawany’s clinical niche is rooted in lymphomas/lymphoproliferative disorders, HIV-related malignancies (particularly Kaposi sarcoma), and the treatment of childhood cancer in low-income countries.

Dr. El-Mallawany is a member of the Lymphoma and Histiocytosis Team at the Texas Children’s Cancer and Hematology Centers with special interest in mature B-cell non-Hodgkin lymphomas (NHL), Epstein-Barr virus-associated lymphomas/lymphoproliferative disorders, as well as the rare NHL of childhood and adolescence. Over the years, his clinical research in lymphoma has focused on the role of viruses in the pathogenesis of lymphomas as well as the development of chemoimmunotherapy protocols for mature B-cell NHL.

He is also a member of the Global HOPE (Hematology-Oncology Pediatric Excellence) program, having spent four years working at the Baylor International Pediatric AIDS Initiative (BIPAI) Clinical Centre of Excellence and Kamuzu Central Hospital (KCH) in Malawi’s capital city, Lilongwe. During his time there, he pioneered the establishment of a comprehensive pediatric hematology/oncology treatment and care program at KCH, the referral hospital that serves nearly half of Malawi’s population of 15 million people. He also developed one of the world’s largest pediatric HIV-related malignancy programs at the BIPAI clinic, which has cared for over 200 children and adolescents with Kaposi sarcoma (KS) over the past decade.

Through his extensive clinical efforts in Malawi, Dr. El-Mallawany developed a research focus on pediatric KS, endemic Burkitt lymphoma, as well as the overall approach to treating childhood cancer and blood disorders in low-income settings. His work has helped define the unique clinical features that differentiate pediatric KS from adult disease and established evidence-based guidelines to develop risk-stratified and response-adapted treatment protocols for both pediatric KS and Burkitt lymphoma in endemic regions of sub-Saharan Africa. More recently, his research has expanded to characterize the biological underpinnings of pediatric KS linked with the causative virus, human herpesvirus-8. His ultimate career goal is to help bridge the massive disparity gap in curative outcomes for childhood cancer that unfortunately still prevails worldwide.

Selected Publications

• El-Mallawany NK, Kamiyango W, Villiera J, Peckham-Gregory EC, Scheurer ME, McAtee CL, Allen CE, Kovarik CL, Frank D, Eason AB, Caro-Vegas C, Chiao EY, Schutze GE, Ozuah NW, Mehta PS, Kazembe PN, Dittmer DP. "Kaposi Sarcoma Herpesvirus Inflammatory Cytokine Syndrome (KICS)-like Clinical Presentation in HIV-Infected Children in Malawi.." Clin Infect Dis. 2019; Pubmed PMID: 31102440
• El-Mallawany NK, Mehta PS, Kamiyango W, Villiera J, Peckham-Gregory EC, Kampani C, Krysiak R, Sanders MK, Caro-Vegas C, Eason AB, Ahmed S, Schutze GE, Martin SC,, Kazembe PN, Scheurer ME, Dittmer DP. "KSHV Viral Load and Interleukin-6 in HIVAssociated Pediatric Kaposi Sarcoma: Exploring the Role of Lytic Activation in Driving the Unique Clinical Features Seen in Endemic Regions.." Int J Cancer. 2019 Jan 1; Pubmed PMID: 30204240
• El-Mallawany NK, Villiera J, Kamiyango W, Peckham-Gregory EC, Scheurer ME, Allen CE, McAtee CL, Legarreta A, Dittmer DP, Kovarik CL, Chiao EY, Martin SC, Ozuah NW, Mehta PS, Kazembe PN. "Endemic Kaposi sarcoma in HIV-negative children and adolescents: an evaluation of overlapping and distinct clinical features in comparison with HIV-related disease.." Infect Agent Cancer. 2018 Nov; Pubmed PMID: 30455728
• El-Mallawany NK, McAtee CL, Campbell LR, Kazembe PN "Pediatric Kaposi sarcoma in context of the HIV epidemic in sub-Saharan Africa: current perspectives.." Pediatric Health Med Ther. 2018 Apr; Pubmed PMID: 29722363

Memberships

Dan L. Duncan Comprehensive Cancer Center

Member (02/2020)