Mihail G. Chelu, M.D., Ph.D.
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Mihail G. Chelu, M.D., Ph.D.
Associate Professor
Positions
- Associate Professor
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Medicine - Cardiology
Baylor College of Medicine
Houston, Texas United States
- Director of Electrophysiology
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Baylor Heart Clinic
Baylor College of Medicine
Houston, Texas United States
- Director of Clinical Electrophysiology Research
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Baylor College of Medicine
Houston, Texas United States
- Medical Director
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Inherited Arrhythmia and Cardiomyopathy Clinic
Baylor College of Medicine
Houston, Texas United States
- Associate Program Director
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Electrophysiology Fellowship
Baylor College of Medicine
Addresses
- Baylor Heart Clinic (Clinic)
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6620 Main Street, Suite 1225
Houston, TX 77030
United States
Phone: (713) 798-2545
Education
- MD from Iuliu Hatieganu University of Medicine and Pharmacy
- 09/2000 - Cluj-Napoca, Romania
- PhD from Baylor College of Medicine
- 09/2006 - Houston, Texas United States
- Molecular Physiology and Biophysics
- Clinical Fellowship at Texas Heart Institute at St Luke's Episcopal Hospital/Baylor College of Medicine
- 06/2013 - Houston, Texas United States
- Cardiac Electrophysiology
- Clinical Fellowship at Texas Heart Institute at St Luke's Episcopal Hospital/Baylor College of Medicine
- 06/2012 - Houston, Texas United States
- Cardiovascular Disease
- Postdoctoral Fellowship at Baylor College of Medicine
- 03/2009 - Houston, Texas United States
- Internal Medicine/Clinical Investigator Pathway
- Residency at University of Texas Health Science Center
- 03/2009 - Houston, Texas United States
- Internal Medicine/Clinical Investigator Pathway
- Internship at University of Texas Health Science Center
- 03/2006 - Houston, Texas United States
- Internal Medicine
- MS from Babes-Bolyai University
- 06/1997 - Cluj-Napoca, Romania
- Theoretical Physics
- BS from Babes-Bolyai University
- 06/1996 - Cluj-Napoca, Romania
- Physics
Certifications
- Clinical Cardiac Electrophysiology
- American Board of Internal Medicine
- Cardiovascular Disease
- American Board of Internal Medicine
- Adult Echocardiography
- National Board of Echocardiography
- Nuclear Cardiology
- Certification Board of Nuclear Cardiology
- Internal Medicine
- American Board of Internal Medicine
Professional Interests
- Inherited cardiac arrhythmias and cardiomyopathies
- Sudden cardiac death
- Ablation of complex atrial flutters and fibrillation
- Ablation of ventricular arrhythmias
- Implantation of pacemakers, defibrillators, cardiac resynchronization therapy devices
Professional Statement
Dr. Chelu’s research interests include: 1. molecular mechanisms and genetics of cardiac arrhythmias and cardiomyopathies; 2. developing magnetic resonance imaging protocols to image left atrial scar and characterize biophysics of ablation; and 3. integration of sensors and mobile platforms to monitor, identify disease signatures, and determine impact on quality of life. 4. cybersecurity of cardiac electrophysiology devices.Selected Publications
- Steinberg BA, Turner J, Lyons A, Biber J, Chelu MG, Fang JC, Freedman RA, Han FT, Hardisty B, Marrouche NF, Ranjan R, Shah RU, Spertus JA, Stehlik J, Zenger B, Piccini JP, Hess R "Systematic collection of patient-reported outcomes in atrial fibrillation: feasibility and initial results of the Utah mEVAL AF programme." Europace. 2019 Nov 8;pii: euz293(doi: 10.1093/europace/euz293) Pubmed PMID: 31702780
- Kholmovski EG, Morris AK, Chelu MG "Cardiac MRI and Fibrosis Quantification." Card Electrophysiol Clin. 2019 Sep;11(3):537-549. Pubmed PMID: 31400877
- Chelu MG, Marrouche NF "Ablation of atrial fibrillation in patients with heart failure deserves more than a IIb guidelines recommendation." J Cardiovasc Electrophysiol. 2019 Sep;30(9):1412-1415. Pubmed PMID: 31120159
- Baher A, Kheirkhahan M, Rechenmacher SJ, Marashly Q, Kholmovski EG, Siebermair J, Acharya M, Aljuaid M, Morris AK, Kaur G, Han FT, Wilson BD, Steinberg BA, Marrouche NF, Chelu MG "High-Power Radiofrequency Catheter Ablation of Atrial Fibrillation: Using Late Gadolinium Enhancement Magnetic Resonance Imaging as a Novel Index of Esophageal Injury." JACC Clin Electrophysiol. 2018 Dec;4(12):1583-1594. Pubmed PMID: 30573123
- Chelu MG, King JB, Kholmovski EG, Ma J, Gal P, Marashly Q, AlJuaid MA, Kaur G, Silver MA, Johnson KA, Suksaranjit P, Wilson BD, Han FT, Elvan A, Marrouche NF "Atrial Fibrosis by Late Gadolinium Enhancement Magnetic Resonance Imaging and Catheter Ablation of Atrial Fibrillation: 5-Year Follow-Up Data." J Am Heart Assoc. 2018 Dec 4;7(23):e006313. Pubmed PMID: 30511895
- Chelu MG, Li N ""Sorting" SERCA2a: A novel therapeutic strategy in heart failure?." Int J Cardiol. 2018 Dec 1;(272:306-307):doi: 10.1016/j.ijcard.2018.08.053. Pubmed PMID: 30144996
- Chelu MG, Li N "Biomarkers (plasma trimethylamine-N-oxide) to predict atrial fibrillation: Are we there yet?." Int J Cardio. 2018 Sep 15;(267:116-117):doi: 10.1016/j.ijcard.2018.05.106. Epub 2018 May 30. Pubmed PMID: 29885821
- Chen G, Chelu MG, Dobrev D, Li N "Cardiomyocyte Inflammasome Signaling in Cardiomyopathies and Atrial Fibrillation: Mechanisms and Potential Therapeutic Implications." Front Physiol. 2018 Aug 13;9:1115:doi: 10.3389/fphys.2018.01115. Pubmed PMID: 30150941
- Chelu MG, Morris AK, Kholmovski EG, King JB, Kaur G, Silver MA, Cates JE, Han FT, Marrouche NF "Durable lesion formation while avoiding esophageal injury during ablation of atrial fibrillation: Lessons learned from late gadolinium MR imaging." J Cardiovasc Electrophysiol. 2018 Mar;29(3):385-392. doi: 10.1111/jce.13426. Epub 2018 Feb 1. Pubmed PMID: 29345381
- King JB, Azadani PN, Suksaranjit P, Bress AP, Witt DM, Han FT, Chelu MG, Silver MA, Biskupiak J, Wilson BD, Morris AK, Kholmovski EG, Marrouche N "Left Atrial Fibrosis and Risk of Cerebrovascular and Cardiovascular Events in Patients With Atrial Fibrillation." J Am Coll Cardiol. 2017 Sep 12;70(11):1311-1321. doi: 10.1016/j.jacc.2017.07.758. Pubmed PMID: 28882227
- Rizvi KA, Burgon NS, King JB, Akoum N, Vergara G, Anderson PA, Gardner GP, McGann CJ, Wilson B, Kholmovski EG, MacLeod RS, Chelu MG, Marrouche NF "Exercise Capacity Correlates With Left Atrial Structural Remodeling as Detected by Late Gadolinium-Enhanced Cardiac Magnetic Resonance in Patients With Atrial Fibrillation." JACC Clin Electrophysio. 2016 Nov;2(6):711-719. doi: 10.1016/j.jacep.2016.03.012. Epub 2016 May 25. Pubmed PMID: 29759749
- Chelu MG, Gunderson BD, Koehler J, Ziegler PD, Sears SF "Patient Activity Decreases and Mortality Increases After the Onset of Persistent Atrial Fibrillation in Patients With Implantable Cardioverter-Defibrillators." JACC Clin Electrophysiol. 2016 Aug;2(4):518-523. doi: 10.1016/j.jacep.2016.01.015. Epub 2016 Apr 6. Pubmed PMID: 29759876
- Mehra S, Chelu MG "Implantable Cardioverter-Defibrillator Shock after Stenting Across the Device Leads." Tex Heart Inst J. 2016 Feb 1;43(1):88-90. doi: 10.14503/THIJ-14-4759. eCollection 2016 Feb. Pubmed PMID: 27047295
- Siddiqui AM, Harris GS, Movahed A, Chiang KS, Chelu MG, Nekkanti R "Transhepatic venous approach to permanent pacemaker placement in a patient with limited central venous access." World J Clin Case. 2015 Sep 16;3(9):835-7. doi: 10.12998/wjcc.v3.i9.835. Pubmed PMID: 26380831
- Mehra S, DeAntonio HJ, Chelu MG "Occasional dropped ventricular pacing in a patient with no underlying rhythm and an Advisa® dual-chamber pacemaker." Europace. 2015 Aug;17(8):1250. doi: 10.1093/europace/euv077. Epub 2015 Apr 16. Pubmed PMID: 25883079
- Patel MB, Rasekh A, Shuraih M, Chelu MG, Bartlett T, Mathuria N, Naeini P, Strickland J, Massumi A, Razavi M, Cheng J "Safety and effectiveness of compassionate use of LARIAT® device for epicardial ligation of anatomically complex left atrial appendages." J Interv Card Electrophysiol. 2015 Jan;42(1):11-9. doi: 10.1007/s10840-014-9963-2. Epub 2015 Jan 17. Pubmed PMID: 25595627
- Chelu MG, Ibrahim Y, Shannoon F, Singh N, Saeed M, Razavi M "Incidence of arrhythmias during dialysis in intensive-care-unit patients with end-stage renal disease." Int J Cardiol. 2014 Jul 1;174(3):753-4. doi: 10.1016/j.ijcard.2014.04.085. Epub 2014 Apr 15. Pubmed PMID: 24774357
- Chelu MG, Leahey EW "Fatigue attributable to broken pacemaker header by baseball." Circ Arrhythm Electrophysiol. 2013 Oct;6(5):e77. Pubmed PMID: 24129211
- Massumi A, Chelu MG, Nazeri A, May SA, Afshar-Kharaghan H, Saeed M, Razavi M, Rasekh A "Initial experience with a novel percutaneous left atrial appendage exclusion device in patients with atrial fibrillation, increased stroke risk, and contraindications to anticoagulation." Am J Cardiol. 2013 Mar 15;111(6):869-73. Pubmed PMID: 23312129
- Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapura DG, Li N, Santonastasi M, Müller FU, Schmitz W, Schotten U, Anderson ME, Valderrábano M, Dobrev D, Wehrens XH "Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice." J Clin Invest. 2009 Jul;119(7):1940-51. Pubmed PMID: 19603549
- Sood S, Chelu MG, van Oort RJ, Skapura D, Santonastasi M, Dobrev D, Wehrens XH "Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation." Heart Rhythm. 2008 Jul;5(7):1047-54. doi: 10.1016/j.hrthm.2008.03.030. Epub 2008 Mar 27. Pubmed PMID: 18598963
- Chelu MG, Wehrens XH "Sarcoplasmic reticulum calcium leak and cardiac arrhythmias." Biochem Soc Trans. 2007 Nov;35(Pt 5):952-6. Review. Pubmed PMID: 17956253
- Kannankeril PJ, Mitchell BM, Goonasekera SA, Chelu MG, Zhang W, Sood S, Kearney DL, Danila CI, De Biasi M, Wehrens XH, Pautler RG, Roden DM, Taffet GE, Dirksen RT, Anderson ME, Hamilton SL "Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy." Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12179-84. Epub 2006 Jul 27. Pubmed PMID: 16873551
- Chelu MG, Goonasekera SA, Durham WJ, Tang W, Lueck JD, Riehl J, Pessah IN, Zhang P, Bhattacharjee MB, Dirksen RT, Hamilton SL "Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse." FASEB J. 2006 Feb;20(2):329-30. Epub 2005 Nov 11. Pubmed PMID: 16284304
- Chelu MG, Danila CI, Gilman CP, Hamilton SL "Regulation of ryanodine receptors by FK506 binding proteins." Trends Cardiovasc Med. 2004 Aug;14(6):227-34. Review. Pubmed PMID: 15451514
Memberships
- Heart Rhythm Society
- Fellow
- American College of Cardiology
- American Heart Association
- European Society of Cardiology
- European Heart Rhythm Association
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