Michael D Taylor, M.D., PhD.
Professor
Positions
- Professor
-
Department of Pediatrics
Section of Hematology-Oncology
Baylor College of Medicine
Houston, Texas, United States
- Director
-
Pediatric Brain Tumor Research Program
Texas Children’s Hospital
Houston, Texas, United States
- Member
-
Baylor College of Medicine
Dan L Duncan Comprehensive Cancer Center
- The Cyvia and Melvyn Wolff Chair of Pediatric Neuro-Oncology
-
Texas Children's Cancer and Hematology Center
Section of Hematology-Oncology
Texas Children's Hospital
- Scholar
-
Cancer Prevention and Research Institute of Texas (CPRIT)
Houston, Texas, United States
- Professor
-
Department of Neurosurgery
Baylor College of Medicine
Houston, Texas, United States
- Staff Neurosurgeon
-
Neurosurgery
Texas Children's Hospital
Houston, Texas, United States
Addresses
- Feigin Center (Office)
-
TX CHILDS FEIGIN CTR (TXFC)
1102 Bates Avenue
Houston, TX, 77030
United States
Phone: (832) 824-4032
michael.taylor@bcm.edu
Education
- MD from University of Western Ontario
- 06/1994 - London, Ontario, Canada
- PhD from University of Toronto
- 06/2002 - Toronto, Ontario, Canada
- Residency at University of Toronto
- 06/2003 - Toronto, Ontario, Canada
- Neurosurgery
- Postdoctoral Fellowship at St Jude Children’s Research Hospital
- 06/2004 - Memphis, Tennessee, United States
- Cancer Genomics
- Postdoctoral Fellowship at University of Toronto
- 07/2005 - Toronto, Ontario, Canada
- Functional Genomics
Professional Interests
- Brain Tumors
Professional Statement
I am a Pediatric Neurosurgeon and Scientist at the Baylor College of Medicine affiliated Texas Children’s Hospital. I am also Director of the Texas Children’s Pediatric Brain Tumor Research Program and the Cyvia and Melvyn Wolff Chair of Pediatric Neuro-Oncology. My laboratory and the Program are located in the Feigin Center in Houston, Texas. My research centers on the molecular genetics of medulloblastoma and ependymoma, two of the most common malignant pediatric brain tumors.
My team have published over 400 peer-reviewed publications, many in high-impact journals such as Nature, Science, Cell, Cancer Cell, and Lancet Oncology. These publications have been cited over 70,000 times and the findings adopted to improve clinical practice for children with brain cancer.
My group demonstrated that medulloblastoma is comprised of at least four distinct diseases (Journal Clinical Oncology, 2011; Cancer Cell, 2017; Nature, 2017) and that there is clinically significant heterogeneity in metastatic medulloblastomas (Nature, 2012; Nature, 2016; Nature Genetics, 2017). My team recently showed that these cerebellar tumors are a disorder of early brain development, a finding which provides a proximate explanation for the peak incidence of cerebellar tumors in early childhood (Nature, 2019; Nature, 2022; Cell, 2024).
People often note my quick wit and strong collaboration skills. Nearly every member of the lab has at some point been “Taylorized” — if you’re wondering what that is then please email me for current opportunities so you can come and join the adventure!
My team have published over 400 peer-reviewed publications, many in high-impact journals such as Nature, Science, Cell, Cancer Cell, and Lancet Oncology. These publications have been cited over 70,000 times and the findings adopted to improve clinical practice for children with brain cancer.
My group demonstrated that medulloblastoma is comprised of at least four distinct diseases (Journal Clinical Oncology, 2011; Cancer Cell, 2017; Nature, 2017) and that there is clinically significant heterogeneity in metastatic medulloblastomas (Nature, 2012; Nature, 2016; Nature Genetics, 2017). My team recently showed that these cerebellar tumors are a disorder of early brain development, a finding which provides a proximate explanation for the peak incidence of cerebellar tumors in early childhood (Nature, 2019; Nature, 2022; Cell, 2024).
People often note my quick wit and strong collaboration skills. Nearly every member of the lab has at some point been “Taylorized” — if you’re wondering what that is then please email me for current opportunities so you can come and join the adventure!
Selected Publications
-
Vladoiu MC, El-Hamamy I, Donovan LK, et. al.,.....Stein L, Taylor MD.. " Childhood cerebellar tumours mirror conserved fetal transcriptional programs " Nature. 2019 Aug 1; 572 ((7767)) : 67-73.
Pubmed PMID: 31043743. -
Suzuki H, Kumar SA, Shuai S, et al. ...Stein L, Taylor MD. " Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma " Nature. 2019 Oct 1; 574 ((7780)) : 707-711.
Pubmed PMID: 31664194. -
Michealraj KA, Kumar SA, Kim LJY, et al. ....Taylor MD. " Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma " Cell. 2020 Jun 11; 181 ((6)) : 1329-1345.
Pubmed PMID: 32445698. -
Hendrikse LD, Haldipur P, Saulnier O, et. al., ....Taylor MD. " Failure of human rhombic lip differentiation underlies medulloblastoma formation " Nature. 2022 Sep 21; 609 ((7929)) : 1021-1028.
Pubmed PMID: 36131014.
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