Email

Positions

Senior Staff Scientist

Mass Spectrometry Proteomics Core
Advanced Technology Cores
Baylor College of Medicine
Houston, TX, US

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Websites

Selected Publications

• Leng M, Bessuso D, Jung SY, Wang Y, Qin J. " Targeting Plk1 to chromosome arms and regulating chromosome compaction by the PICH ATPase. " Cell Cycle. 2008 May 15; 7 (10) : 1480-9.
  Pubmed PMID: 18418076.
• Liu S, Chu J, Yucer N, Leng M, Wang SY, Chen BP, Hittelman WN, Wang Y. " RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response. " J. Biol. Chem.. 2011 Jun 24; 286 (25) : 22314-22.
  Pubmed PMID: 21558276.
• Ke Y, Huh JW, Warrington R, Li B, Wu N, Leng M, Zhang J, Ball HL, Li B, Yu H. " PICH and BLM limit histone association with anaphase centromeric DNA threads and promote their resolution. " EMBO J.. 2011 ; 30 (16) : 3309-21.
  Pubmed PMID: 21743438.
• Leng M, Chan DW, Luo H, Zhu C, Qin J, Wang Y. " MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability. " Proc. Natl. Acad. Sci. U.S.A.. 2006 Aug 1; 103 (31) : 11485-90.
  Pubmed PMID: 16864798.
• Lin Y, Leng M, Wan M, Wilson JH. " Convergent Transcription through a Long CAG Tract Destabilizes Repeats and Induces Apoptosis. " Mol. Cell. Biol.. 2010 Sep ; 30 (18) : 4435-51.
  Pubmed PMID: 20647539.
• Mu JJ, Wang Y, Luo H, Leng M, Zhang J, Yang T, Besusso D, Jung SY, Qin J. " A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. " J. Biol. Chem.. 2007 Jun 15; 282 (24) : 17330-4.
  Pubmed PMID: 17478428.
• Luo H, Chan DW, Yang T, Rodriguez M, Chen BP, Leng M, Mu JJ, Chen D, Songyang Z, Wang Y, Qin J. " A new XRCC1-containing complex and its role in cellular survival of methyl methanesulfonate treatment. " Mol. Cell. Biol.. 2004 Oct ; 24 (19) : 8356-65.
  Pubmed PMID: 15367657.
• Chen Y, Leng M, Gao Y, Zhan D, Choi J, Song L, Li K, Xia X, Zhang C, Liu M, Ji S, Jain A, Saltzman A, Malovannaya A, Qin J, Jung SY, Wang Y. " A Cross-Linking-Aided Immunoprecipitation/Mass Spectrometry Workflow Reveals Extensive Intracellular Trafficking in Time-Resolved, Signal-Dependent Epidermal Growth Factor Receptor Proteome " J Proteome Res. 2019 Oct 4; 18 (10) : 3715-3730.
  Pubmed PMID: 31442056.
• Saltzman A, Leng M, Bhatt B, Singh P, Chan D, Dobroleski L, Chandrasekaran H, Choi J, Jain A, Jung S, Lewis M, Ellis M, Malovannaya A. " gpGrouper: A Gene-Level Peptide Grouping and Quantitation Algorithm For Bottom-Up Proteomics Data. " Mol Cell Proteomics. 2018 Nov ; 17 (11) : 2270-2283.
  Pubmed PMID: 30093420.
• Alcott CE, Yalamanchili HK, Ji P, Heijden ME, Saltzman A, Elrod N, Lin A, Leng M, Bhatt B, Hao S, Wang Q, Saliba A, Tang J, Malovannaya A, Wagner EJ, Liu Z, Zoghbi HY. " Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation " eLife. 2020 Apr 22;
  Pubmed PMID: 32319885.