Email

meenakshi.anurag@bcm.edu

Positions

Assistant Professor

Department of Medicine
Baylor College of Medicine
Houston, TX

Addresses

Baylor College of Medicine, 1 Baylor Plaza, BCM-Jewish Institute for Research (Lab)

Room 645D,
Houston, TX 77030
United States
Phone: (713) 798-4298

Education

PhD from Institute of Genomics & Integrative Biology

10/2014 - New Delhi, Delhi India

Postdoctoral Fellowship at Baylor College of Medicine

Houston

Professional Interests

• Cancer multi-omics analysis
• Immune informatics
• Breast cancer

Professional Statement

The primary goal of my research is to improve disease diagnosis, treatment and survival by precision data science.
Since my PhD in Bioinformatics, have 7+ years of bioinformatics and data science experience in Cancer research. Cancer is a diverse and heterogeneous disease, hence one therapy will not be uniformly beneficial to all patients. I am also working on rare cancers like Male breast cancer. To dissect the molecular level heterogeneity of these tumors, we employ multi-omics and big data analysis on patient’s next generation sequencing and proteomics data. I implement bioinformatics to understand the role of mutations, structural variations, gene expressions, copy number variations, proteomics and genomic aberrations in promoting cancer.
In the past, I have shown role of DNA damage repair defects as a new class of endocrine treatment resistance driver in breast cancer. Exploring the cause and effect relationship further, we are trying to understanding the contribution of immune-checkpoint and other immune-tolerance factors in therapeutic resistant and advancement of estrogen-receptor positive disease. This warrants for integration of patient genome, transcriptome and metabolome with clinical data.

Websites

Selected Publications

• "Comprehensive profiling of DNA repair defects in breast cancer identifies a novel class of endocrine therapy resistance drivers." Clinical Cancer Research. 2018 May; Pubmed PMID: 29793947
• "Immune Checkpoint Profiles in Luminal B Breast Cancer (Alliance)." 2019 Oct 30; Pubmed PMID: 31665365
• "The prognostic effects of somatic mutations in ER-positive breast cancer." Nature Communications. 2018 Sep; Pubmed PMID: 30181556
• "Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy." 2020; Pubmed PMID: 33212010

Skills

Bioinformatics

NGS-data analysis

Cancer genomics

Immune-informatics

Transcriptomics