Liang Xie, Ph.D.

Associate Professor

(713) 798-5985

Email

liang.xie@bcm.edu

Positions

Associate Professor: Medicine-Cardiovascular Research
Cardiovascular Research Institute (CVRI)
Baylor College of Medicine
Houston, TX, US

Addresses

Cardiovascular Research. Institute (Office): One Baylor Plaza
Room: 507D
Houston, TX, 77030
United States

Education

PhD from University of Rochester: 05/2004 - Rochester, New York, United States; Pharmacology

Post-Doctoral Fellowship at Duke University: 05/2009 - Durham, North Carolina, United States; Cardiovascular Research

MS from Wuhan University: 05/1995 - Wuhan, China; Biochemistry

BS from Wuhan University: 05/1992 - Wuhan, China; Biochemistry

Professional Statement

Dr. Xie studies the basic biochemistry of protein prolyl hydroxylation and its important roles of in cardiac function. His particular focuses include the understanding of the molecular mechanisms by which Prolyl Hydroxylase Domain Proteins (PHDs) regulate calcium cycling and cardiac contractile function and how their dysregulation contributes to the pathophysiological development of heart diseases such as cardiac hypertrophy and arrhythmia.

Websites

VIICTR Publications List

Publications

Selected Publications

Mao H, Li CM, Sun B, Ward C, Waich-Cohen A, Rosas IO, Huang HJ, Karmouty-Quintana H, Xie L, Pandit LM, Pi X.. " Inhibition of BMPER Mitigates Pulmonary Hypertension by Modulating LRP1-YAP Interaction in Smooth Muscle Cells. " Arterioscler Thromb Vasc Biol.. 2025 ; doi: 10.1161/ATVBAHA.124.322189..
Pubmed PMID: 40964716.
Mao H, Angelini A, Li S, Wang G, Li L, Patterson C, Pi X, Xie L.. " CRAT links cholesterol metabolism to innate immune responses in the heart. " Nat Metab.. 2023 ; 5 (8) : 1382-1394.
Pubmed PMID: 37443356.
Wang X, Song J, Yuan Y, Li L, Abu-Taha I, Heijman J, Sun L, Dobrev S, Kamler M, Xie L, Wehrens XHT, Horrigan FT, Dobrev D, Li N.. " Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis. " Circ Res.. 2023 ; 133 (1) : e1-e16.
Pubmed PMID: 37154033.
Angelini A, Pi X, Xie L.. " Evaluation of long-chain fatty acid respiration in neonatal mouse cardiomyocytes using SeaHorse instrument. " STAR Protoc.. 2022 ; 3 (2) : 101392.
Pubmed PMID: 35600933.
Song S, Tien CL, Cui H, Basil P, Zhu N, Gong Y, Li W, Li H, Fan Q, Min Choi J, Luo W, Xue Y, Cao R, Zhou W, Ortiz AR, Stork B, Mundra V, Putluri N, York B, Chu M, Chang J, Yun Jung S, Xie L, Song J, Zhang L, Sun Z.. " Myocardial Rev-erb-Mediated Diurnal Metabolic Rhythm and Obesity Paradox. " Circulation. 2022 ; 145 (6) : 448-464.
Pubmed PMID: 35034472.
Angelini A, Saha PK, Jain A, Jung SY, Mynatt RL, Pi X, Xie L.. " PHDs/CPT1B/VDAC1 axis regulates long-chain fatty acid oxidation in cardiomyocytes. " Cell Reports. 2021 ; 37 (1) : 109767.
Pubmed PMID: 34610308.
Mao H, Li L, Fan Q, Angelini A, Saha PK, Coarfa C, Rajapakshe K, Perera D, Cheng J, Wu H, Ballantyne CM, Sun Z, Xie L, Pi X.. " Endothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin. " Nat Commun.. 2021 ; 12 (1) : 5296.
Pubmed PMID: 34489478.
Mao H, Li L, Fan Q, Angelini A, Saha PK, Wu H, Ballantyne CM, Hartig SM, Xie L, Pi X.. " Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance. " Nat Commun.. 2021 ; 12 (1) : 1927.
Pubmed PMID: 33772019.
Fan Q, Mao H, Angelini A, Coarfa C, Robertson MJ, Lagor WR, Wehrens XHT, Martin JF, Pi X, Xie L.. " Depletion of endothelial prolyl hydroxylase domain protein 2 and 3 promotes cardiomyocyte proliferation and prevents ventricular failure induced by myocardial infarction. " Circulation. 2019 ; 140 (5) : 440-442.
Pubmed PMID: 31356139.
Fan Q, Mao H, Xie L, Pi X.. " Prolyl hydroxylase domain-2 protein regulates lipopolysaccharide-induced vascular inflammation. " Am J Pathol.. 2019 ; 189 (4) : 200-213.
Pubmed PMID: 30339838.
Pi X, Xie L, Patterson C.. " Emerging roles of vascular endothelium in metabolic homeostasis. " Circ Res.. 2018 ; 123 (4) : 477-494.
Pubmed PMID: 30355249.
Angelini A, Pi X, Xie L.. " Dioxygen and metabolism; dangerous liaisons in cardiac function and disease. " Front Physiol.. 2017 ; 8 : 1044.
Pubmed PMID: 29311974.
Lockyer P, Mao H, Fan Q, Li L, LYu-Lee L, Eissa NT, Patterson C, Xie L, Pi X.. " LRP1-dependent BMPER signaling regulates lipopolysaccharide-induced vascular inflammation. " Arterioscler Thromb Vasc Biol.. 2017 ; 37 (8) : 1524-1535.
Pubmed PMID: 28596374.
Mao H, Xie L, Pi X.. " LDL receptor related protein-1 signaling in angiogenesis. " Front Cardiovasc Med.. 2017 ; 4 : 34.
Pubmed PMID: 28589128.
Mao H, Lockyer P, Li L, Ballantyne CM, Patterson C, Xie L, Pi X.. " Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ. " Nat Commun.. 2017 ; 8 : 14960.
Pubmed PMID: 28393867.
Mao H, Lockyer P, Townley-Tilson WH, Xie L, Pi X.. " LRP1 Regulates Retinal Angiogenesis by Inhibiting PARP-1 Activity and Endothelial Cell Proliferation. " Arterioscler Thromb Vasc Biol.. 2016 ; 36 (2) : 350-360.
Pubmed PMID: 26634655.
Townley-Tilson WHD, Pi X, Xie L.. " The role of oxygen sensors, hydroxylases, and HIF in cardiac function and disease. " Oxid Med Cell Longev.. 2015 ; 2015 : 676893.
Pubmed PMID: 26491535.
Xie L, Pi X, Townley-Tilson WH, Li N, Wehrens XH, Entman ML, Taffet GE, Mishra A, Peng J, Schisler JC, Meissner G, Patterson C.. " PHD2/3-dependent hydroxylation tunes cardiac response to β-adrenergic stress via phospholamban. " J Clin Invest.. 2015 ; 125 (7) : 2759-71.
Pubmed PMID: 26075818.
Xie L, Pi X, Wang Z, Willis MS, Patterson C.. " Depletion of PHD3 protects hearts from injury induced by ischemia/reperfusion and inhibits cardiomyocyte apoptosis induced by oxidative stress. " J Mol Cell Cardiol.. 2015 ; 80 : 156-165.
Pubmed PMID: 25633836.

Memberships

American Heart Association: Member