Email

kworley@bcm.edu

Positions

Professor

DMHG:Faculty-General/Basic
Baylor College of Medicine
Houston, TX US

Chair Elect - Faculty Senate

Baylor College of Medicine
Houston, Texas United States

Vice Chair for Research Affairs - Basic and Translational

Department of Molecular and Human Genetics
Baylor College of Medicine

Addresses

BCM-Margaret M. Alkek Building for Biomedical Research (Office)

Room: BCM ABBR-R717
Houston, TX 77030
United States
Phone: (713) 798-8292
kworley@bcm.edu

Education

Postdoctoral Fellowship at Baylor College Of Medicine

08/1997 - Houston, TX United States

Bioinformatics

PhD from Baylor College Of Medicine

10/1993 - Houston, TX United States

Molecular and Human Genetics

BS from Massachusetts Institute Of Technology

06/1984 - Cambridge, MA United States

Chemical Engineering

Professional Statement

My research interests center on building, annotating, understanding and making use of genomes. I have coordinated research in large multi-institutional international research consortia, including analysis and publication of research results for the Human Genome Project, Human Microbiome Project and comparative genomics projects for over 40 animal species. For these projects, I had a role creating genome representations through de novo genome assembly, improving genome representation through targeted sequencing and structural variation analysis, and contributing to the understanding genome function through analysis, annotation and computational methods. The number of sequenced human genomes has increased, and genomes representative of diverse humans have become available, but the challenge of interpreting the impact of personal variation and applying this knowledge in a way that serves individual patients and improves the practice of medicine remains an analytical frontier. Ongoing research interests include projects related to Alzheimer’s Disease, undiagnosed diseases and strategic initiatives related to data science at BCM.

Websites

Selected Publications

• Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J "Initial sequencing and analysis of the human genome.." Nature. 2001 February 15; 409 (6822): 860-921. Pubmed PMID: 11237011
• International Human Genome Sequencing Consortium "Finishing the euchromatic sequence of the human genome." Nature. 2004 431 : 931-45.
• Margulies EH, Cooper GM, Asimenos G, Thomas DJ, Dewey CN, Siepel A, Birney E, Keefe D, Schwartz AS, Hou M, Taylor J, Nikolaev S, Montoya-Burgos JI, Löytynoja A, Whelan S, Pardi F, Massingham T, Brown JB, Bickel P, Holmes I, Mullikin JC, Ureta-Vidal A, Pat "Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome.." Genome Res.. 2007 June ; 17 (6): 760-74. Pubmed PMID: 17567995
• "Structure, function and diversity of the healthy human microbiome.." Nature. 2012 June 14; 486 (7402): 207-14. Pubmed PMID: 22699609