Kim
Middle Name
Carlyle
Worley, Ph.D.
Middle Name
Carlyle
Picture

Kim
Middle Name
Carlyle
Worley, Ph.D.
Middle Name
Carlyle
Professor
Positions
- Professor
-
DMHG:Faculty-General/Basic
Baylor College of Medicine
Houston, TX US
- Chair Elect - Faculty Senate
-
Baylor College of Medicine
Houston, Texas United States
- Vice Chair for Research Affairs - Basic and Translational
-
Department of Molecular and Human Genetics
Baylor College of Medicine
Addresses
- BCM-Margaret M. Alkek Building for Biomedical Research (Office)
-
Room: BCM ABBR-R717
Houston, TX 77030
United States
Phone: (713) 798-8292
kworley@bcm.edu
Education
- Postdoctoral Fellowship at Baylor College Of Medicine
- 08/1997 - Houston, TX United States
- Bioinformatics
- PhD from Baylor College Of Medicine
- 10/1993 - Houston, TX United States
- Molecular and Human Genetics
- BS from Massachusetts Institute Of Technology
- 06/1984 - Cambridge, MA United States
- Chemical Engineering
Professional Statement
My research interests center on building, annotating, understanding and making use of genomes. I have coordinated research in large multi-institutional international research consortia, including analysis and publication of research results for the Human Genome Project, Human Microbiome Project and comparative genomics projects for over 40 animal species. For these projects, I had a role creating genome representations through de novo genome assembly, improving genome representation through targeted sequencing and structural variation analysis, and contributing to the understanding genome function through analysis, annotation and computational methods. The number of sequenced human genomes has increased, and genomes representative of diverse humans have become available, but the challenge of interpreting the impact of personal variation and applying this knowledge in a way that serves individual patients and improves the practice of medicine remains an analytical frontier. Ongoing research interests include projects related to Alzheimer’s Disease, undiagnosed diseases and strategic initiatives related to data science at BCM.Websites
Selected Publications
- Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J "Initial sequencing and analysis of the human genome.." Nature. 2001 February 15; 409 (6822): 860-921. Pubmed PMID: 11237011
- International Human Genome Sequencing Consortium "Finishing the euchromatic sequence of the human genome." Nature. 2004 431 : 931-45.
- Margulies EH, Cooper GM, Asimenos G, Thomas DJ, Dewey CN, Siepel A, Birney E, Keefe D, Schwartz AS, Hou M, Taylor J, Nikolaev S, Montoya-Burgos JI, Löytynoja A, Whelan S, Pardi F, Massingham T, Brown JB, Bickel P, Holmes I, Mullikin JC, Ureta-Vidal A, Pat "Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome.." Genome Res.. 2007 June ; 17 (6): 760-74. Pubmed PMID: 17567995
- "Structure, function and diversity of the healthy human microbiome.." Nature. 2012 June 14; 486 (7402): 207-14. Pubmed PMID: 22699609
- Bradnam KR, Fass JN, (...), Worley KC, Yin S, Yiu SM, Yuan J, Zhang G, Zhang H, Zhou S, Korf IF "Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species.." Gigascience. 2013 2 : 10.
- English AC, Richards S, Han Y, Wang M, Vee V, Qu J, Qin X, Muzny DM, Reid JG, Worley KC, Gibbs RA "Mind the Gap: Upgrading Genomes with Pacific Biosciences RS Long-Read Sequencing Technology.." PLoS ONE. 2012 7 (11): e47768. Pubmed PMID: 23185243
- "The genome sequence of taurine cattle: a window to ruminant biology and evolution.." Science. 2009 April 24; 324 (5926): 522-8. Pubmed PMID: 19390049
- Marmoset Genome Sequencing and Analysis Consortium "The common marmoset genome provides insight into primate biology and evolution.." Nat. Genet.. 2014 46 : 850-7.
- Rogers J, Raveendran M, Harris RA, Mailund T, Leppälä K, (...), Zinner D, Roos C, Jolly CJ, Gibbs RA, Worley KC; Baboon Genome Analysis Consortium "The comparative genomics and complex population history of Papio baboons.." Sci Adv.. 2019 5 : eaau6947.
- Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R "Genome sequence of the Brown Norway rat yields insights into mammalian evolution.." Nature. 2004 April 1; 428 (6982): 493-521. Pubmed PMID: 15057822
- Honeybee Genome Sequencing Consortium "Insights into social insects from the genome of the honeybee Apis mellifera.." Nature. 2006 443 : 931-49.
Log In to edit your profile