Katerina Cermakova

Assistant Professor

Email

cermakov@bcm.edu

Positions

Assistant Professor: Department of Biochemistry and Molecular Pharmacology
Baylor College of Medicine
Houston, Texas, United States

Addresses

1 Baylor Plz. (Lab): N1317 Alkek Building
Houston, TX, 77030
United States
katerina.cermakova@bcm.edu

Education

PhD from KU Leuven: Leuven, Belgium

Postdoctoral Training at Institute of Organic Chemistry and Biochemistry: Prague, Czech Republic

Postdoctoral Training at Baylor College of Medicine: Houston, United States

Professional Interests

Structural biology
Intrinsically disordered protein
Transcription and chromatin
Biomolecular NMR
Cancer biology

Selected Publications

Cermakova K*, Demeulemeester J*, Lux V*, Nedomova M, Goldman SR, Smith EA, Srb P, Hexnerova R, Fabry M, Madlikova M, Horejsi M, De Rijck J, Debyser Z, Adelman K, Hodges HC, Veverka V.. " A ubiquitous disordered protein interaction module orchestrates transcription elongation. " Science. 2021 Nov 26; 374 (6571) : 1113-1121.
Pubmed PMID: 34822292.
Sharma S*, Cermakova K*, De Rijck J*, Demeulemeester J, Fábry M, El Ashkar S, Lepsik M, Tesina P, Duchoslav V, Novak P, Hubalek M, Srb P, Christ F, Rezacova P, Hodges HC, Debyser Z, Veverka V.. " Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation. " PNAS. 2018 Jul 24; 115 (30) : E7053-E7062.
Pubmed PMID: 29997176.
Hodges HC*, Stanton BZ*, Cermakova K, Chang CY, Miller EL, Kirkland JG, Ku WL, Veverka V, Zhao K, Crabtree GR.. " Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers. " Nature Structural and Molecular Biology. 2017 Dec 11; 25 (1) : 61-72.
Pubmed PMID: 29323272.
Mereau H*, De Rijck J*, Cermakova K, Kutz A, Juge S, Demeulemeester J, Gijsbers R, Christ F, Debyser Z, Schwaller J.. " Impairing MLL-fusion gene mediated transformation by dissecting critical interactions with the lens epithelial-derived growth factor (LEDGF/p75). " Leukemia. 2013 Jan 15; 27 (6) : 1245-53.
Pubmed PMID: 23318960.
Cermakova K, Hodges HC.. " Interaction modules that impart specificity to disordered protein. " Trends in Biochemical Sciences. 2023 Feb 6; 48 (5) : 477-490.
Pubmed PMID: 36754681.
Tesina P*, Cermakova K*, Horejsi M, Prochazkova K, Fabry M, Sharma S, Christ F, Demeulemeester J, Debyser Z, De Rijck J, Veverka V, Rezacova P.. " Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif. " Nature Communications. 2015 Aug 5; 6 (7968)
Pubmed PMID: 26245978.
Cermakova K, Hodges HC.. " Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation. " Molecules. 2018 Aug 6; 23 (8) : 1958.
Pubmed PMID: 30082609.
Chambers C, Cermakova K, Chan YS, Kurtz K, Wohlan K, Lewis AH, Wang C, Pham A, Dejmek M, Sala M, Loeza Cabrera M, Aguilar R, Nencka R, Lacorazza D, Rau RE, Hodges HC.. " SWI/SNF blockade disrupts PU.1-directed enhancer programs in normal hematopoietic cells and acute myeloid leukemia " Cancer Research. 2023 Apr 4; 83 (7) : 983-996.
Pubmed PMID: 36662812.
Cermakova K, Tesina P, Demeulemeester J, El Ashkar S, Mereau H, Schwaller J, Rezacova P, Veverka V, De Rijck J.. " Validation and Structural Characterisation of the LEDGF/p75-MLL Interface as a New Target for the Treatment of MLL-Dependent Leukaemia. " Cancer Research. 2014 Sep 15; 74 (18) : 5139-51.
Pubmed PMID: 25082813.
Cermakova K, Tao L, Dejmek M, Sala M, Montierth MD, Chan YS, Patel I, Chambers C, Loeza Cabrera M, Hoffman D, Parchem RJ, Wang W, Nencka R, Barbieri E, Hodges HC.. " Reactivation of the G1 enhancer landscape underlies core circuitry addiction to SWI/SNF. " Nucleic Acids Res.. 2024 Jan 11; 52 (1) : 4-21.
Pubmed PMID: 37993417.

Languages

English, Czech, Dutch