Katerina Cermakova
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Katerina Cermakova
Postdoctoral Associate
Positions
- Postdoctoral Associate
-
Center for Precision Environmental Health
Baylor College of Medicine
Houston, TX US
Addresses
- 1 Baylor Plz. (Lab)
-
N1317 Alkek Building
Houston, TX 77030
United States
katerina.cermakova@bcm.edu
Education
- PhD from KU Leuven
- Leuven, Belgium
- Postdoctoral Fellowship at Institute of Organic Chemistry and Biochemistry
- Prague, Czech Republic
Professional Interests
- Structural biology
- Intrinsically disordered protein
- Transcription and chromatin
- Biomolecular NMR
- Cancer biology
Selected Publications
- Cermakova K*, Demeulemeester J*, Lux V*, Nedomova M, Goldman SR, Smith EA, Srb P, Hexnerova R, Fabry M, Madlikova M, Horejsi M, De Rijck J, Debyser Z, Adelman K, Hodges HC, Veverka V. "A ubiquitous disordered protein interaction module orchestrates transcription elongation.." Science. 2021 Nov 26;374(6571):1113-1121. Pubmed PMID: 34822292
- Sharma S*, Cermakova K*, De Rijck J*, Demeulemeester J, Fábry M, El Ashkar S, Lepsik M, Tesina P, Duchoslav V, Novak P, Hubalek M, Srb P, Christ F, Rezacova P, Hodges HC, Debyser Z, Veverka V. "Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.." PNAS. 2018 Jul 24;115(30):E7053-E7062. Pubmed PMID: 29997176
- Hodges HC*, Stanton BZ*, Cermakova K, Chang CY, Miller EL, Kirkland JG, Ku WL, Veverka V, Zhao K, Crabtree GR. "Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers.." Nature Structural and Molecular Biology. 2017 Dec 11;25(1):61-72. Pubmed PMID: 29323272
- Mereau H*, De Rijck J*, Cermakova K, Kutz A, Juge S, Demeulemeester J, Gijsbers R, Christ F, Debyser Z, Schwaller J. "Impairing MLL-fusion gene mediated transformation by dissecting critical interactions with the lens epithelial-derived growth factor (LEDGF/p75).." Leukemia. 2013 Jan 15;27(6):1245-53. Pubmed PMID: 23318960
- Cermakova K, Hodges HC. "Interaction modules that impart specificity to disordered protein.." Trends in Biochemical Sciences. 2023 Feb 6;48(5):477-490. Pubmed PMID: 36754681
- Tesina P*, Cermakova K*, Horejsi M, Prochazkova K, Fabry M, Sharma S, Christ F, Demeulemeester J, Debyser Z, De Rijck J, Veverka V, Rezacova P. "Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif.." Nature Communications. 2015 Aug 5;6(7968) Pubmed PMID: 26245978
- Cermakova K, Hodges HC. "Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation.." Molecules. 2018 Aug 6;23(8):1958. Pubmed PMID: 30082609
- Chambers C, Cermakova K, Chan YS, Kurtz K, Wohlan K, Lewis AH, Wang C, Pham A, Dejmek M, Sala M, Loeza Cabrera M, Aguilar R, Nencka R, Lacorazza D, Rau RE, Hodges HC. "SWI/SNF blockade disrupts PU.1-directed enhancer programs in normal hematopoietic cells and acute myeloid leukemia." Cancer Research. 2023 Apr 4;83(7):983-996. Pubmed PMID: 36662812
- Cermakova K, Tesina P, Demeulemeester J, El Ashkar S, Mereau H, Schwaller J, Rezacova P, Veverka V, De Rijck J. "Validation and Structural Characterisation of the LEDGF/p75-MLL Interface as a New Target for the Treatment of MLL-Dependent Leukaemia.." Cancer Research. 2014 Sep 15;74(18):5139-51. Pubmed PMID: 25082813
Languages
English, Czech, Dutch
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