Karen R. Rabin, M.D., Ph.D.

Professor

(832) 824-4213

Email

krrabin@bcm.edu

Positions

Professor: Pediatrics-Oncology
Baylor College of Medicine
Houston, TX, US

Member: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Addresses

Texas Children's Hospital, Clinical Care Center (Clinic): 6701 Fannin St., 14th floor
Houston, TX, 77030
United States
Phone: (832) 822-4242

Education

M.D. from University Of California, San Francisco School Of Medicine: 01/1998 - San Francisco, CA, United States

PhD from Baylor College of Medicine: 12/2010 - Houston, Texas, United States

Fellowship at Stanford University School of Medicine: Stanford, CA; Pediatric Hematology and Oncology

Residency at University of California - San Francisco: San Francisco, CA; Pediatrics

Certifications

Board certified in Pediatrics: American Board of Pediatrics

Board certified in Pediatric Hematology/Oncology: American Board of Pediatrics

Honors & Awards

Member, COG ALL Executive Committee: Children's Oncology Group

Director: Texas Children's Hospital Leukemia Program

Professional Interests

childhood leukemia

Professional Statement

Dr. Rabin’s research interests include molecular genetics and risk-directed therapy for acute lymphoblastic leukemia (ALL) in children. She has a particular interest in biology and clinical management of ALL in children with Down syndrome.

Websites

VIICTR Publications List

http://www.txch.org/molecular-leukemia-rabin/

Rabin Laboratory Home Page

Selected Publications

Rabin KR, Gramatges MM, Borowitz MJ, Palla SL, Shi X, Margolin JF, Zweidler-McKay PA. " Absolute lymphocyte counts refine minimal residual disease-based risk stratification in childhood acute lymphoblastic leukemia. " Pediatr Blood Cancer. 2012 Sep ; 59 (3) : 468-74.
Pubmed PMID: 22102553.
Rabin KR. " Attacking remaining challenges in childhood leukemia. " N. Engl. J. Med.. 2012 Apr 12; 366 (15) : 1445-6.
Pubmed PMID: 22494125.
Rabin KR, Man TK, Yu A, Folsom MR, Zhao YJ, Rao PH, Plon SE, Naeem RC. " Clinical utility of array comparative genomic hybridization for detection of chromosomal abnormalities in pediatric acute lymphoblastic leukemia. " Pediatr Blood Cancer. 2008 Aug ; 51 (2) : 171-7.
Pubmed PMID: 18253961.
Giuriato S, Rabin K, Fan AC, Shachaf CM, Felsher DW. " Conditional animal models: a strategy to define when oncogenes will be effective targets to treat cancer. " Semin. Cancer Biol.. 2004 Feb ; 14 (1) : 41344.
Pubmed PMID: 14757531.
Valle M, Plon SE, Rabin KR. " Differential in vitro cytotoxicity does not explain increased host toxicities from chemotherapy in Down syndrome acute lymphoblastic leukemia. " Leuk. Res.. 2009 Feb ; 33 (2) : 336-9.
Pubmed PMID: 18718659.
Blink M, Buitenkamp TD, van den Heuvel-Eibrink MM, Danen-van Oorschot AA, de Haas V, Reinhardt D, Klusmann JH, Zimmermann M, Devidas M, Carroll AJ, Basso G, Pession A, Hasle H, Pieters R, Rabin KR, Izraeli S, Zwaan CM. " Frequency and prognostic implications of JAK 1-3 aberrations in Down syndrome acute lymphoblastic and myeloid leukemia. " Leukemia. 2011 Aug ; 25 (8) : 1365-8.
Pubmed PMID: 21537335.
G Weber, U Gerdemann, I Caruana, B Savoldo, KR Rabin, EJ Shpall, NF Hensel, JJ Melenhorst, AM. Leen, AJ Barrett, CM. Bollard. " Generation of multi-leukemia antigen-specific T cells to enhance the graft-versus-leukemia effect after allogeneic stem cell transplant " Leukemia. 2013 Jul ;
Pubmed PMID: 23528871.
G Weber, I Caruana, RH Rouce, AJ Barrett, AM Leen, KR Rabin, CM Bollard. " Generation of tumor antigen-specific T cell lines from pediatric patients with acute lymphoblastic leukemia - implications for immunotherapy " Clin Cancer Res. 2013 ;
Pubmed PMID: 23838315.
Loudin MG, Wang J, Eastwood Leung HC, Gurusiddappa S, Meyer J, Condos G, Morrison D, Tsimelzon A, Devidas M, Heerema NA, Carroll AJ, Plon SE, Hunger SP, Basso G, Pession A, Bhojwani D, Carroll WL, Rabin KR. " Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles. " Leukemia. 2011 Oct ; 25 (10) : 1555-63.
Pubmed PMID: 21647151.
Rabin KR, Whitlock JA. " Malignancy in children with trisomy 21. " Oncologist. 2009 Feb ; 14 (2) : 164-73.
Pubmed PMID: 19176633.
Rabin KR, Poplack DG. " Management strategies in acute lymphoblastic leukemia. " Oncology (Williston Park, N.Y.). 2011 Apr 15; 25 (4) : 328-35.
Pubmed PMID: 21618954.
Rabin KR, Smith J, Kozinetz CA. " Myelosuppression and infectious complications in children with down syndrome and acute lymphoblastic leukemia. " Pediatr Blood Cancer. 2012 Apr ; 58 (4) : 633-5.
Pubmed PMID: 22106003.
Rathore N, Eissa HM, Margolin JF, Liu H, Wu MF, Horton T, Kamdar K, Dreyer Z, Steuber P, Rabin KR, Redell M, Allen CE, McClain KL, Guillerman RP, Bollard CM. " Pediatric Hodgkin Lymphoma: Are We Over-scanning Our Patients? " Pediatr Hematol Oncol. 2012 Aug ; 29 (5) : 415-23.
Pubmed PMID: 22632168.
Rabin K, Man TK, Lau CC. " Personalized care of pediatric cancer patients. " 2008 ; 62 : 173-85; discuss.
Pubmed PMID: 18626200.
Gaikwad A, Rye CL, Devidas M, Heerema NA, Carroll AJ, Izraeli S, Plon SE, Basso G, Pession A, Rabin KR. " Prevalence and clinical correlates of JAK2 mutations in Down syndrome acute lymphoblastic leukaemia. " Br. J. Haematol.. 2009 Mar ; 144 (6) : 930-2.
Pubmed PMID: 19120350.
Mullighan CG, Collins-Underwood JR, Phillips LA, Loudin MG, Liu W, Zhang J, Ma J, Coustan-Smith E, Harvey RC, Willman CL, Mikhail FM, Meyer J, Carroll AJ, Williams RT, Cheng J, Heerema NA, Basso G, Pession A, Pui CH, Raimondi SC, Hunger SP, Downing JR, Ca. " Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia. " Nat. Genet.. 2009 Nov ; 41 (11) : 1243-6.
Pubmed PMID: 19838194.
Gramatges MM, Rabin KR. " The Adolescent and Young Adult with Cancer: State of the Art – Acute Leukemias " Curr Oncol Rep. 2013 Aug ;
Pubmed PMID: 23757222.
Junco JJ, Zorman B, Gant VU Jr, Muñoz J, Lacorazza HD, Sumazin P, Rabin KR. " CRLF2 overexpression results in reduced B-cell differentiation and upregulated E2F signaling in the Dp16 mouse model of Down syndrome " Exp Hematol. 2022 Mar 17;
Pubmed PMID: 35306048.
Muñiz JP, Woodhouse JP, Hughes AE, Pruitt SL, Rabin KR, Scheurer ME, Lupo PJ, Schraw JM. " Residence in a Latinx enclave and end-induction minimal residual disease positivity among children with acute lymphoblastic leukemia " Pediatr Hematol Oncol. 2022 Mar 9;
Pubmed PMID: 35262447.
Gupta S, Teachey DT, Chen Z, Rabin KR, Dunsmore KP, Larsen EC, Maloney KW, Mattano LA Jr, Winter SS, Carroll AJ, Heerema NA, Borowitz MJ, Wood BL, Carroll WL, Raetz EA, Winick NJ, Loh ML, Hunger SP, Devidas M. " Sex-based disparities in outcome in pediatric acute lymphoblastic leukemia: a Children's Oncology Group report " Cancer. 2022 May 1;
Pubmed PMID: 35201611.
Rabin KR. " Genetic Ancestry and Childhood Acute Lymphoblastic Leukemia Subtypes and Outcomes in the Genomic Era " JAMA Oncol.. 2022 Mar 1;
Pubmed PMID: 35084428.
Yi JS, Chambers TM, Getz KD, Miller TP, Burrows E, Daves MH, Lupo PJ, Scheurer ME, Aplenc R, Rabin KR, Gramatges MM. " A report from the Leukemia Electronic Abstraction of Records Network on risk of hepatotoxicity during pediatric acute lymphoblastic leukemia treatment " Haematologica. 2022 Jan 27;
Pubmed PMID: 35081687.
Rabin KR. " Risk stratification for Down syndrome and acute lymphocytic leukaemia: one size does not fit all " Lancet Haematol.. 2021 Oct ;
Pubmed PMID: 34560009.
Gant VU, Junco JJ, Terrell M, Rashid R, Rabin KR. " Enhancer polymorphisms at the IKZF1 susceptibility locus for acute lymphoblastic leukemia impact B-cell proliferation and differentiation in both Down syndrome and non-Down syndrome genetic backgrounds " PLoS ONE. 2021 Jan 7;
Pubmed PMID: 33411777.
Junco JJ, Chen T, Rashid R, Terrell M, Gant VU Jr, Miller M, Rau R, Lacorazza HD, Rabin KR. " An Mb1-Cre-driven oncogenic Kras mutation results in a mouse model of T-acute lymphoblastic leukemia/lymphoma with short latency and high penetrance " Leukemia. 2021 Jun ;
Pubmed PMID: 32918044.
Brown AL,... Lupo PJ, Rabin KR. " Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome " Blood. 2019 Oct 19;
Pubmed PMID: 31350265.
Outcomes in Children, Adolescents, and Young Adults With Down Syndrome and ALL: A Report From the Children's Oncology Group " ;
Pubmed PMID: 37890117.
Children's Oncology Group blueprint for research: Acute lymphoblastic leukemia " ;
Pubmed PMID: 37489549.
Management of Down Syndrome-Associated Leukemias: A Review " ;
Pubmed PMID: 37440251.
Genomic landscape of Down syndrome-associated acute lymphoblastic leukemia " ;
Pubmed PMID: 37001051.

Memberships

American Society of Hematology: Member

American Society of Pediatric Hematology-Oncology

Children's Oncology Group

American Academy of Pediatrics

Funding

Molecular epidemiology of acute lymphoblastic leukemia in children with Down syndrome #1R01CA249867-01: (08/01/2020 - 07/31/2025); Grant funding from National Cancer Institute

Improving Outcome Disparities for Latino Children and Adolescents with Acute Lymphoblastic Leukemia #P20CA262733: (08/01/2021 - 07/31/2024); Grant funding from National Cancer Institute

Chronic Health Conditions in Survivors of Down Syndrome-Associated Leukemia #1R01CA263000: (06/20/2022 - 05/31/2027); Grant funding from National Cancer Institute

Skills

childhood leukemia

Languages

Spanish