Joshua Anthony Keefe

Medical Scientist Training Program (MD/PhD)

jakeefe@bcm.edu

Medical Scientist Training Program (MD/PhD): Baylor College of Medicine
Houston, TX, US

GS4: Development, Disease Models & Therapeutics
Baylor College of Medicine
Houston, Texas, United States
Mentor - Xander Wehrens, M.D., Ph.D.

BS from University of California-Los Angeles: 06/2017 - Los Angeles, California, United States; Biomedical Engineering

PhD from Baylor College of Medicine: 12/2024 - Houston, Texas, United States; Cardiovascular inflammation and arrhythmia

Jian Wang, Jangling Song, Li Ni, Xander Wehrens. " Immune Cells and Arrhythmias " Cardiovasc Res.. 2025 Feb 12;
Pubmed PMID: 39937651.
Keefe, Joshua Anthony. Huang, Shih-Jen. Huan, Tianxao. Mendelson, Michael. Yao, Chen. Madhur, Meena S. Levy, Daniel. " Evidence for a Causal Role of the SH2B3-B2M Axis in Blood Pressure Regulation " Hypertension. 2019 ; 73 : 497-503.
Pubmed PMID: 30624993.
Keefe J, Yao C, Hwang SJ, Courchesne P, Lee GY, Dupuis J, Mizgerd JP, O'Connor G, Washko GR, Cho MH, Silverman EK, Levy D. " An Integrative Genomic Strategy Identifies sRAGE as a Causal and Protective Biomarker of Lung Function " Chest. 2022 Jan ; 161 (1) : 76-84.
Pubmed PMID: 34237330.
Macrophage-mediated interleukin-6 signaling drives ryanodine receptor-2 calcium leak in postoperative atrial fibrillation " J Clin Invest.. 2025 Mar 6;
Pubmed PMID: 40048254.
Joshua A. Keefe, Jose Alberto Navarro Garcia, Shuai Zhao, Mihail G Chelu, Xander HT Wehrens. " Atrial fibroblast–derived macrophage migration inhibitory factor promotes atrial macrophage accumulation in postoperative atrial fibrillation " JCI Insight. 2025 Aug 14; 10 (18) : e190756.
Pubmed PMID: 40811033.

McNair MD/PhD Scholar: McNair Medical Institute at The Robert and Janice McNair Foundation

Macrophage-Mediated Interleukin-6 Signaling Drives Ryanodine Receptor-2 Calcium Leak in Postoperative Atrial Fibrillation #1F30HL172431: Grant funding from NIH/NHLBI

Hydrogel Platform for Aqueous Two-Phase Concentration of a Target to Enhance its Detection: Design Patent #62/483,221 (Approved); Co Inventors: Kamei, Daniel Takashi. Wu, Benjamin Ming. Pereira, David Yuan. Wu, Chloe Michelle. Yee, Matthew Foosing. Keefe, Joshua Anthony. Pearce, Christina Caroline. Dailamy, Amir Adam. Wong, Vincent K. Le, Nguyen Khoi