Email

jakeefe@bcm.edu

Positions

Medical Scientist Training Program (MD/PhD)

Baylor College of Medicine
Houston, TX US

GS4

Development, Disease Models & Therapeutics
Baylor College of Medicine
Houston, Texas United States
Mentor - Xander Wehrens, M.D., Ph.D.

Education

BS from University of California-Los Angeles

06/2017 - Los Angeles, California United States

Biomedical Engineering

PhD from Baylor College of Medicine

12/2024 - Houston, Texas United States

Cardiovascular inflammation and arrhythmia

Selected Publications

• Jian Wang, Jangling Song, Li Ni, Xander Wehrens "Immune Cells and Arrhythmias." Cardiovasc Res.. 2025 Feb 12; Pubmed PMID: 39937651
• Keefe, Joshua Anthony. Huang, Shih-Jen. Huan, Tianxao. Mendelson, Michael. Yao, Chen. Madhur, Meena S. Levy, Daniel "Evidence for a Causal Role of the SH2B3-B2M Axis in Blood Pressure Regulation." Hypertension. 2019;73:497-503. Pubmed PMID: 30624993
• Keefe J, Yao C, Hwang SJ, Courchesne P, Lee GY, Dupuis J, Mizgerd JP, O'Connor G, Washko GR, Cho MH, Silverman EK, Levy D "An Integrative Genomic Strategy Identifies sRAGE as a Causal and Protective Biomarker of Lung Function." Chest. 2022 Jan;161(1):76-84. Pubmed PMID: 34237330
• "Macrophage-mediated interleukin-6 signaling drives ryanodine receptor-2 calcium leak in postoperative atrial fibrillation." J Clin Invest.. 2025 Mar 6; Pubmed PMID: 40048254

Funding

McNair MD/PhD Scholar

McNair Medical Institute at The Robert and Janice McNair Foundation

Macrophage-Mediated Interleukin-6 Signaling Drives Ryanodine Receptor-2 Calcium Leak in Postoperative Atrial Fibrillation - #1F30HL172431

Grant funding from NIH/NHLBI

Intellectual Property

Design Patent #62/483,221 (Approved)

Co Inventors: Kamei, Daniel Takashi. Wu, Benjamin Ming. Pereira, David Yuan. Wu, Chloe Michelle. Yee, Matthew Foosing. Keefe, Joshua Anthony. Pearce, Christina Caroline. Dailamy, Amir Adam. Wong, Vincent K. Le, Nguyen Khoi