- Assistant Professor
Department of Neuroscience
Baylor College of Medicine
Houston, TX US
- BS from University of Notre Dame
- 05/1997 - Notre Dame, Indiana United States
- PhD from University of California, Berkeley
- 12/2002 - Berkeley, California United States
- Post-Doctoral Fellowship at University of Washington
- 06/2007 - Seattle, Washington United States
- Post-Doctoral Fellowship at Baylor College of Medicine
- 02/2013 - Houston, Texas United States
Professional StatementI am a molecular and cellular neuroscientist with broad interests in neuronal development and injury. I specialize in microscopy and biochemistry using rodent model systems. Currently, my efforts fall into two main categories:
1. I am studying the role of the brain-specific angiogenesis inhibitors (BAIs), an adhesion-GPCR subfamily, on neuronal development. These cell surface receptors contain a number of ligand-binding domains and couple to multiple intracellular signaling pathways. We hypothesize that they serve as molecular signal integrators, thereby coordinating multiple aspects of neuronal development.
2. I also study the effects of radiation on terminally differentiated cells in the brain. Brain cancer is relatively common in children, but recent clinical advances have greatly increased long-term survival and cure rates. Unfortunately, these children experience long-lasting damage to multiple cognitive domains. With our collaborators in the Department of Radiation Oncology at The University of Texas MD Anderson Cancer Center, we have uncovered evidence that the decades-long prevailing hypothesis that radiation-mediated damage is restricted to undifferentiated cells is incorrect and that radiation directly damages terminally differentiated neurons. We are extending these investigations in order to fully understand the nature of radiation-mediated injuries to neurons and to develop strategies for clinical intervention.
I am resident in Kim Tolias' laboratory, and perform all of my research in collaboration with Dr. Tolias. I share her commitment to graduate education and participate primarily through practical teaching.
- Y-K Tu, JG Duman and KF Tolias "The adhesion-GPCR BAI1 promotes excitatory synaptogenesis by coordinating bidirectional trans-synaptic signaling." J. Neuroscience.. 2018 38 : 8388-3406.
- K Um, S Niu, JG Duman, JX Cheng, Y-K Tu, B Schwechter, F Liu, L Hiles, AS Narayanan, RT Ash, S Mulherkar, K Alpadi, SM Smirnakis and KF Tolias "Dynamic Control of Excitatory Synapse Development by a Rac1 GEF/GAP Regulatory Complex." Dev. Cell. 2014 29 : 701-715.
- JG Duman, J Dinh, W Zhou, H Cham, VC Mavratsas, M Pacešković, S Mulherkar, SL McGovern, KF Tolias and DR Grosshans "Memantine prevents acute radiation-induced toxicities at hippocampal excitatory synapses." Neuro-Oncol. 2018 20 : 655-665.
- JG Duman, CP Tzeng, Y-K Tu, T Munjal, B Schwechter, TS Ho and KF Tolias "The Adhesion-GPCR BAI1 Regulates Synaptogenesis by Controlling the Recruitment of the Par3/Tiam1 Polarity Complex to Synaptic Sites.." J. Neurosci.. 2013 April 17; 33 (16): 6964-78. Pubmed PMID: 23595754
- JG Duman, S Mulherkar, Y-K Tu, KC Erikson, CP Tzeng, VC Mavratsas, TS-Y Ho and KF Tolias "The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest." eLife. 2019 8 : e47566.
- International Society for Neurochemistry
- Member (06/2011)
- Society for Neuroscience
- Member (07/2012)
- Adhesion-GPCR Consortium
- Associate member (03/2017)
- (PQ9) Directed and unbiased studies of synaptic injuries as sequelae of radiotherapy: mapping, sex-dependence, and reversal - #R01CA219667
- $2,191,796.00 (09/01/2017 - 08/31/2022) Grant funding from NIH-NCI
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