Email

Positions

Assistant Professor

Pediatrics-Hematology
Baylor College of Medicine
Houston, TX, US

Addresses

TX Childs Feigin Ctr (Lab)

Room: TXFC-C1030
Houston, TX, 77030
United States

TX Childs Feigin Ctr (Office)

Room: TXFC-C1030
Houston, TX, 77030
United States

Education

EdD from Royal College Of Surgeons In Ireland

01/2003 - Dublin, Ireland

Population Genetics

BA from Trinity College Dublin

07/1998 - Dublin, Ireland

Genetics

Websites

Selected Publications

• Flanagan JM, Peng H, Wang L, Gelbart T, Lee P, Johnson Sasu B, Beutler E. " Soluble transferrin receptor-1 levels in mice do not affect iron absorption. " Acta Haematol.. 2006 ; 116 (4) : 249-54.
  Pubmed PMID: 17119325.
• Truksa J, Lee P, Peng H, Flanagan J, Beutler E. " The distal location of the iron responsive region of the hepcidin promoter. " Blood. 2007 Nov 1; 110 (9) : 3436-7.
  Pubmed PMID: 17644736.
• Flanagan JM, Gerber AL, Cadet JL, Beutler E, Sipe JC. " The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addiction. " Hum. Genet.. 2006 Nov ; 120 (4) : 581-8.
  Pubmed PMID: 16972078.
• Flanagan JM, Beutler E. " The genetic basis of human erythrocyte pyridoxal kinase activity variation. " Haematologica. 2006 Jun ; 91 (6) : 801-4.
  Pubmed PMID: 16704963.
• Flanagan JM, Rhodes M, Wilson M, Beutler E. " The identification of a recurrent phosphoglycerate kinase mutation associated with chronic haemolytic anaemia and neurological dysfunction in a family from USA. " Br. J. Haematol.. 2006 Jul ; 134 (2) : 233-7.
  Pubmed PMID: 16740138.
• Flanagan JM, McMahon G, Brendan Chia SH, Fitzpatrick P, Tighe O, O'Neill C, Briones P, Gort L, Kozak L, Magee A, Naughten E, Radomyska B, Schwartz M, Shin JS, Strobl WM, Tyfield LA, Waterham HR, Russell H, Bertorelle G, Reichardt JK, Mayne PD, Croke DT. " The role of human demographic history in determining the distribution and frequency of transferase-deficient galactosaemia mutations. " Heredity. 2010 Feb ; 104 (2) : 148-54.
  Pubmed PMID: 19639008.
• Noel N, Flanagan JM, Flanagan J, Ramirez Bajo MJ, Kalko SG, Mañú Mdel M, Garcia Fuster JL, Perez de la Ossa P, Carreras J, Beutler E, Vives Corrons JL. " Two new phosphoglycerate kinase mutations associated with chronic haemolytic anaemia and neurological dysfunction in two patients from Spain. " Br. J. Haematol.. 2006 Feb ; 132 (4) : 523-9.
  Pubmed PMID: 16412025.
• Flanagan JM, Howard TA, Mortier N, Avlasevich SL, Smeltzer MP, Wu S, Dertinger SD, Ware RE. " Assessment of genotoxicity associated with hydroxyurea therapy in children with sickle cell anemia. " Mutat. Res.. 2010 Apr 30; 698 (41276) : 38-42.
  Pubmed PMID: 20230905.
• Bouchier-Hayes L, Oberst A, McStay GP, Connell S, Tait SW, Dillon CP, Flanagan JM, Beere HM, Green DR. " Characterization of cytoplasmic caspase-2 activation by induced proximity. " Mol. Cell. 2009 Sep 24; 35 (6) : 830-40.
  Pubmed PMID: 19782032.
• McGann PT, Howard TA, Flanagan JM, Lahti JM, Ware RE. " Chromosome damage and repair in children with sickle cell anaemia and long-term hydroxycarbamide exposure. " Br. J. Haematol.. 2011 Jul ; 154 (1) : 134-40.
  Pubmed PMID: 21542824.
• Flanagan JM, Peng H, Beutler E. " Effects of alcohol consumption on iron metabolism in mice with hemochromatosis mutations. " Alcohol. Clin. Exp. Res.. 2007 Jan ; 31 (1) : 138-43.
  Pubmed PMID: 17207112.
• Flanagan JM, Sheehan V, Linder H, Howard TA, Wang YD, Hoppe CC, Aygun B, Adams RJ, Neale GA, Ware RE. " Genetic mapping and exome sequencing identify two mutations associated with stroke protection in pediatric patients with sickle cell anemia. " Blood. 2013 Feb 19;
  Pubmed PMID: 23422753.
• Flanagan JM, Frohlich DM, Howard TA, Schultz WH, Driscoll C, Nagasubramanian R, Mortier NA, Kimble AC, Aygun B, Adams RJ, Helms RW, Ware RE. " Genetic predictors for stroke in children with sickle cell anemia. " Blood. 2011 Jun 16; 117 (24) : 6681-4.
  Pubmed PMID: 21515823.
• McGann PT, Flanagan JM, Howard TA, Dertinger SD, He J, Kulharya AS, Thompson BW, Ware RE. " Genotoxicity associated with hydroxyurea exposure in infants with sickle cell anemia: results from the BABY-HUG Phase III Clinical Trial. " Pediatr Blood Cancer. 2012 Aug ; 59 (2) : 254-7.
  Pubmed PMID: 22012708.
• Flanagan JM, Steward S, Howard TA, Mortier NA, Kimble AC, Aygun B, Hankins JS, Neale GA, Ware RE. " Hydroxycarbamide alters erythroid gene expression in children with sickle cell anaemia. " Br. J. Haematol.. 2012 Apr ; 157 (2) : 240-8.
  Pubmed PMID: 22360576.
• Flanagan JM, Truksa J, Peng H, Lee P, Beutler E. " In vivo imaging of hepcidin promoter stimulation by iron and inflammation. " Blood Cells Mol. Dis.. ; 38 (3) : 253-7.
  Pubmed PMID: 17331760.
• Miller ST, Rey K, He J, Flanagan J, Fish BJ, Rogers ZR, Wang WC, Ware RE. " Massive accidental overdose of hydroxyurea in a young child with sickle cell anemia. " Pediatr Blood Cancer. 2012 Jul 15; 59 (1) : 170-2.
  Pubmed PMID: 21744485.
• Flanagan JM, Steward S, Hankins JS, Howard TM, Neale G, Ware RE. " Microarray analysis of liver gene expression in iron overloaded patients with sickle cell anemia and beta-thalassemia. " Am. J. Hematol.. 2009 Jun ; 84 (6) : 328-34.
  Pubmed PMID: 19384939.
• Ware RE, Despotovic JM, Mortier NA, Flanagan JM, He J, Smeltzer MP, Kimble AC, Aygun B, Wu S, Howard T, Sparreboom A. " Pharmacokinetics, pharmacodynamics, and pharmacogenetics of hydroxyurea treatment for children with sickle cell anemia. " Blood. 2011 Nov 3; 118 (18) : 4985-91.
  Pubmed PMID: 21876119.