Jizhong Cheng, M.D.

Associate Professor

(713) 798-2698

Email

jizhongc@bcm.edu

Positions

Associate Professor: Medicine-Nephrology
Baylor College of Medicine
Houston, TX, US

Addresses

Alkek Building for Biomedical Research (Lab): Room: ABBR-R702
Houston, TX, 77030
United States

Education

Advanced Training from University Of Texas Medical Branch: 01/2003 - Galveston, TX, United States

Advanced Training from University Of Texas Medical Branch: 01/2001 - Galveston, TX, United States

M.S. from Tongji Medical University: 01/1994 - Wuhan, China, People's Rep

M.D. from Tongji Medical University: 01/1991 - Wuhan, China, People's Rep

Professional Interests

Cellular and molecular mechanisms underlying arteriovenous fistula (AVF)
Chronic kidney diseases (CKD)

Websites

VIICTR Publications List

Selected Publications

Zhang L, Ma Y, Zhang J, Cheng J, Du J. " A new cellular signaling mechanism for angiotensin II activation of NF-kappaB: An IkappaB-independent, RSK-mediated phosphorylation of p65. " Arterioscler. Thromb. Vasc. Biol.. 2005 Jun ; 25 (6) : 1148-53.
Pubmed PMID: 15802625.
Qi G, Jia L, Li Y, Bian Y, Cheng J, Li H, Xiao C, Du J. " Angiotensin II infusion-induced inflammation, monocytic fibroblast precursor infiltration, and cardiac fibrosis are pressure dependent. " Cardiovasc. Toxicol.. 2011 Jun ; 11 (2) : 157-67.
Pubmed PMID: 21373977.
Ma Y, Zhang L, Peng T, Cheng J, Taneja S, Zhang J, Delafontaine P, Du J. " Angiotensin II stimulates transcription of insulin-like growth factor I receptor in vascular smooth muscle cells: role of nuclear factor-kappaB. " Endocrinology. 2006 Mar ; 147 (3) : 1256-63.
Pubmed PMID: 16322063.
Pan L, Li Y, Jia L, Qin Y, Qi G, Cheng J, Qi Y, Li H, Du J. " Cathepsin S Deficiency Results in Abnormal Accumulation of Autophagosomes in Macrophages and Enhances Ang II-Induced Cardiac Inflammation. " PLoS ONE. 2012 ; 7 (4) : e35315.
Pubmed PMID: 22558139.
Liang A, Wang Y, Han G, Truong L, Cheng J. " Chronic kidney disease accelerates endothelial barrier dysfunction in a mouse model of an arteriovenous fistula. " Am. J. Physiol. Renal Physiol.. 2013 Jun ; 304 (12) : F1413-20.
Pubmed PMID: 23576636.
Zhang L, Cheng J, Ma Y, Thomas W, Zhang J, Du J. " Dual pathways for nuclear factor kappaB activation by angiotensin II in vascular smooth muscle: phosphorylation of p65 by IkappaB kinase and ribosomal kinase. " Circ. Res.. 2005 Nov 11; 97 (10) : 975-82.
Pubmed PMID: 16224066.
Cheng J, Wang Y, Liang A, Jia L, Du J. " FSP-1 Silencing in Bone Marrow Cells Suppresses Neointima Formation in Vein Graft. " Circ. Res.. 2012 Jan 20; 110 (2) : 230-40.
Pubmed PMID: 22116816.
Li Y, Zhang C, Wu Y, Han Y, Cui W, Jia L, Cai L, Cheng J, Li H, Du J. " Interleukin-12p35 Deletion Promotes CD4 T-Cell-Dependent Macrophage Differentiation and Enhances Angiotensin II-Induced Cardiac Fibrosis. " Arterioscler. Thromb. Vasc. Biol.. 2012 Jul ; 32 (7) : 1662-74.
Pubmed PMID: 22556333.
Ma F, Li Y, Jia L, Han Y, Cheng J, Li H, Qi Y, Du J. " Macrophage-Stimulated Cardiac Fibroblast Production of IL-6 Is Essential for TGF ß/Smad Activation and Cardiac Fibrosis Induced by Angiotensin II. " PLoS ONE. 2012 ; 7 (5) : e35144.
Pubmed PMID: 22574112.
Cheng J, Zhang J, Merched A, Zhang L, Zhang P, Truong L, Boriek AM, Du J. " Mechanical stretch inhibits oxidized low density lipoprotein-induced apoptosis in vascular smooth muscle cells by up-regulating integrin alphavbeta3 and stablization of PINCH-1. " J. Biol. Chem.. 2007 Nov 23; 282 (47) : 34268-75.
Pubmed PMID: 17878168.
Cheng J, Du J. " Mechanical stretch simulates proliferation of venous smooth muscle cells through activation of the insulin-like growth factor-1 receptor. " Arterioscler. Thromb. Vasc. Biol.. 2007 Aug ; 27 (8) : 1744-51.
Pubmed PMID: 17541019.
Wu X, Cheng J, Li P, Yang M, Qiu S, Liu P, Du J. " Mechano-sensitive transcriptional factor egr-1 regulates insulin-like growth factor-1 receptor expression and contributes to neointima formation in vein grafts. " Arterioscler. Thromb. Vasc. Biol.. 2010 Mar ; 30 (3) : 471-6.
Pubmed PMID: 19965784.
Haudek SB, Cheng J, Du J, Wang Y, Hermosillo-Rodriguez J, Trial J, Taffet GE, Entman ML. " Monocytic fibroblast precursors mediate fibrosis in angiotensin-II-induced cardiac hypertrophy. " J. Mol. Cell. Cardiol.. 2010 Sep ; 49 (3) : 499-507.
Pubmed PMID: 20488188.
Cheng J, Cui R, Chen CH, Du J. " Oxidized low-density lipoprotein stimulates p53-dependent activation of proapoptotic Bax leading to apoptosis of differentiated endothelial progenitor cells. " Endocrinology. 2007 May ; 148 (5) : 2085-94.
Pubmed PMID: 17289842.
Ren J, Yang M, Qi G, Zheng J, Jia L, Cheng J, Tian C, Li H, Lin X, Du J. " Proinflammatory protein CARD9 is essential for infiltration of monocytic fibroblast precursors and cardiac fibrosis caused by Angiotensin II infusion. " Am. J. Hypertens.. 2011 Jun ; 24 (6) : 701-7.
Pubmed PMID: 21436792.
Zhang L, Dong Y, Dong Y, Cheng J, Du J. " Role of Integrin-ß3 Protein in Macrophage Polarization and Regeneration of Injured Muscle. " J. Biol. Chem.. 2012 Feb 24; 287 (9) : 6177-86.
Pubmed PMID: 22210777.
Cheng J, Truong LD, Wu X, Kuhl D, Lang F, Du J. " Serum- and glucocorticoid-regulated kinase 1 is upregulated following unilateral ureteral obstruction causing epithelial-mesenchymal transition. " Kidney Int.. 2010 Oct ; 78 (7) : 668-78.
Pubmed PMID: 20631674.
Yang M, Zheng J, Miao Y, Wang Y, Cui W, Guo J, Qiu S, Han Y, Jia L, Li H, Cheng J, Du J. " Serum-Glucocorticoid Regulated Kinase 1 Regulates Alternatively Activated Macrophage Polarization Contributing to Angiotensin II-Induced Inflammation and Cardiac Fibrosis. " Arterioscler. Thromb. Vasc. Biol.. 2012 Jul ; 32 (7) : 1675-86.
Pubmed PMID: 22556335.
Cheng J, Wang Y, Ma Y, Chan BT, Yang M, Liang A, Zhang L, Li H, Du J. " The mechanical stress-activated serum-, glucocorticoid-regulated kinase 1 contributes to neointima formation in vein grafts. " Circ. Res.. 2010 Nov 12; 107 (10) : 1265-74.
Pubmed PMID: 20884880.
1. Luo J, Liang A, Liang M, Xia R, Rizvi Y, Wang Y, Cheng J.. " Serum Glucocorticoid-Regulated Kinase 1 Blocks CKD-Induced Muscle Wasting Via Inactivation of FoxO3a and Smad2/3. " J Am Soc Nephrol. 2016 Sep ; (2797) : 808.
2. Liang M, Wang Y, Liang A, Mitch, WE, Roy-Chaudhury P, Han G, Cheng J.. " Migration of smooth muscle cells from the arterial anastomosis of arteriovenous fistulas requires Notch activation to form neointima. " Kidney International. 2015 ; 88 : 490-502.
3. Luo, J., Liang, M., Mitch, W. E., Danesh, F., Yu, Z., Cheng, J.. " FSP-1 Impairs the function of Endothelium leading to Failure of Arteriovenous Grafts in Diabetic Mice.. " Endocrinology. 2015 ; (185) : 1234-50.
4. Liang, M., Woodard, L., Luo, J., Wilson, M., Mitch, W.E., Cheng, J.. " Protective Role of Insulin-Like Growth Factor-1 Receptor in Endothelial Cells against Unilateral Ureteral Obstruction-Induced Renal Fibrosis.. " Am J Pathol.. 2015 ; 5 (185) : 1234-50.

Funding

CHRONIC KIDNEY DISEASE ADVERSELY INFLUENCES VASCULAR FUNCTIONS #1R01DK095867: $217,000.00 (03/15/2013 - 02/01/2018); Grant funding from NIH/NIDDK; The major goals of this project are to study the role of Notch signaling in CKD-induced neointima formation in arteriovenous fistula.

Epigenetic alterations of GSTA4 regulate CKD-induced vascular remodeling #15GRNT25700209: $150,000.00 (07/01/2015 - 06/30/2017); Grant funding from American Heart Association; The goal of this project is to investigate the influence of the CKD on GSTA4 expression and neointima formation in arteriovenous fistula.