Jimmy Lloyd Holder Jr, M.D., Ph.D.

Assistant Professor

(832) 824-8957

Email

holder@bcm.edu

Positions

Assistant Professor: Pediatrics
Neurology and Developmental Neuroscience
Baylor College of Medicine
Houston, TX, US

Addresses

Blue Bird Circle Clinic for Pediatric Neurology (Hospital): TCH-Clinical Care Center
Room: TXCL-1250
Houston, TX, 77030
United States
Phone: (832) 822-1750

Jan and Dan Duncan Neurological Research Institute (Lab): 1250 Moursund St., Suite 925
Houston, TX, 77030
United States
Phone: (832) 824-8957
holder@bcm.edu
http://nri.texaschildrens.org/faculty/jimmy-l-holder-jr-md-phd

Jan and Dan Duncan Neurological Research Institute (Office): 1250 Moursund St., Suite 925
Houston, TX, 77030
United States
Phone: (832) 824-8957
holder@bcm.edu
http://nri.texaschildrens.org/faculty/jimmy-l-holder-jr-md-phd

Texas Children's Hospital, Clinical Care Center (Clinic): 6701 Fannin St. Ste 1250
Houston, TX, 77030
United States
Phone: (832) 822-1750

Education

BA from Johns Hopkins University: 05/1996 - Baltimore, Maryland, United States; Biology

MD from University Of Texas Southwestern: 06/2005 - Dallas, Texas, United States

PhD from University Of Texas Southwestern: 06/2005 - Dallas, Texas, United States; Genetics and Development

Residency at Baylor College Of Medicine: 06/2009 - Houston, Texas, United States; Pediatrics

Residency at Baylor College Of Medicine: 06/2012 - Houston, Texas, United States; Child Neurology

Post-Doctoral Fellowship at University of California San Francisco: 06/2007 - San Francisco, California, United States; Neurogenetics

Certifications

American Board of Psychiatry ad Neurology

Board certification in Neurology with Special Qualification in Child Neurology

#P5534 (02/08/2013 - 02/28/2016)

Texas Medical Board

Honors & Awards

Chao Physician-Scientist Award: Baylor College of Medicine (07/2013 - 06/2014)

Director, Medical Advisory Board: Bridge the Gap - SYNGAP education and research foundation (01/2015)

Philip R. Dodge Young Investigator Award: Child Neurology Society (10/2015)

Professional Statement

In the next 20 years, we will discover individualized therapies for neurodevelopmental disorders. This is the mission statement of my lab. We are using a spectrum of approaches to achieve this goal, from cell-based screens to mouse models of disease to neurons derived from in induced pluripotent stem cells (iPSCs). My ultimate goal is to translate the findings from the lab back to the clinic to improve quality of life for children with neurodevelopmental disorders.

Websites

VIICTR Publications List

NRI website

Professional Development

Co-organizer: Conference (Organizer, 2015); Sponsor: Phelan-McDermid Syndrome Foundation

Selected Publications

Han K, Holder JL Jr, Schaaf CP, Lu H, Chen H, Kang H, Tang J, Wu Z, Hao S, Cheung SW, Yu P, Sun H, Breman AM, Patel A, Lu HC, Zoghbi HY. " SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties " Nature. 2013 Nov 7; 503 (7474) : 72-7.
Pubmed PMID: 24153177.
He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder JL, Rossner MJ, Nishino S, Fu YH. " The transcriptional repressor DEC2 regulates sleep length in mammals. " Science. 2009 Aug 14; 325 (5942) : 866-70.
Pubmed PMID: 19679812.
Holder JL Jr, Butte NF, Zinn AR. " Profound obesity associated with a balanced translocation that disrupts the SIM1 gene " Hum Mol Genet.. 2000 Feb 1; 9 (1) : 101-8.
Pubmed PMID: 10587584.
Holder JL, Wilfong AA. " Zonisamide in the treatment of epilepsy. " Expert Opin Pharmacother. 2011 Nov ; 12 (16) : 2573-81.
Pubmed PMID: 21967409.
Holder JL Jr, Agadi S, Reese W, Rehder C, Quach MM. " Infantile spasms and hyperekplexia associated with isolated sulfite oxidase deficiency " JAMA Neurol.. 2014 Jun ; 71 (6) : 782-4.
Pubmed PMID: 24756183.
Holder JL Jr, Zhang L, Kublaoui BM, DiLeone RJ, Oz OK, Bair CH, Lee YH, Zinn AR. " Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice " Am J Physiol Endocrinol Metab. 2004 Jul ; 287 (1) : 105-13.
Pubmed PMID: 14982752.
Peddibhotla S, Nagamani SC, Erez A, Hunter JV, Holder Jr JL, Carlin ME, Bader PI, Perras HM, Allanson JE, Newman L, Simpson G, Immken L, Powell E, Mohanty A, Kang SH, Stankiewicz P, Bacino CA, Bi W, Patel A, Cheung SW. " Delineation of candidate genes responsible for structural brain abnormalities in patients with terminal deletions of chromosome 6q27 " Eur J Hum Genet.. 2014 Apr 16;
Pubmed PMID: 24736736.
A kinome-wide RNAi screen identifies ERK2 as a druggable regulator of Shank3 stability. " ;
Pubmed PMID: 30696942.
An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function. " ;
Pubmed PMID: 30610205.

Memberships

Child Neurology Society: Member

American Academy of Neurology: Member

American Academy of Pediatrics

Funding

Clinical Scientist Development Award: (07/01/2017 - 06/30/2021); Grant funding from Doris Duke Charitable Foundation; Identify genetic modifiers of SYNGAP1 and validate in human neurons.

Harnessing post-translational regulation of SHANK3 as a boosting strategy for Phelan-McDermid syndrome #R01NS120980: (05/31/2021 - 03/30/2026); Grant funding from NINDS (NIH)

Identifying genetic modifiers of Sulfamidase protein stability #R03NS120078: (10/01/2020 - 09/30/2022); Grant funding from NINDS (NIH)