Jesus G Vallejo, M.D.

Professor

Email

jesus.vallejo@bcm.edu

Positions

Professor: Pediatrics and Medicine
Infectious Diseases
Baylor College of Medicine
Houston, Texas, United States

Dean - Temple Regional Campus: Baylor College of Medicine
Houston, Texas, United States

Education

Clinical Fellowship at Baylor College Of Medicine Affiliate Hospitals: 06/1996 - Houston, Texas, United States; Pediatric Infectious Diseases

Residency at Baylor College Of Medicine Affiliate Hospitals: 06/1992 - Houston, Texas, United States; Pediatrics

Internship at Baylor College Of Medicine Affiliate Hospitals: 06/1990 - Houston, Texas, United States; Pediatrics

MD from Baylor College Of Medicine: 05/1989 - Houston, Texas, United States

BS from University Of Texas At San Antonio: 01/1985 - San Antonio, Texas, United States; Biology

Certifications

(11/01/1997 - 10/31/2004)

American Board of Pediatrics-Infectious Diseases

(11/01/2004 - 10/31/2014)

American Board of Pediatrics-Infectious Diseases

(11/01/2014 - 10/31/2024)

American Board of Pediatrics-Infectious Diseases

Honors & Awards

Medical Faculty Development Award: Robert Wood Johnson Foundation (07/1996 - 06/2000)

Young Investigator Award: Pediatric Infectious Diseases Society (05/2003)

Fulbright & Jaworski L.L.P. Faculty Excellence Award in Teaching/Evaluation: Baylor College of Medicine (05/2012)

Research Mentor Award: Dept. of Pediatrics, Baylor College of Medicine (08/2013)

Professional Interests

Sepsis, Myocarditis, LVAD infections, Clinical trials

Websites

VIICTR Publications List

School of Medicine Admissions

Selected Publications

Gorbea C, Makar KA, Pauschinger M, Pratt G, Bersola JLF, Varela J, David RM, Banks L, Huang CH, Schultheiss HP, Towbin JA, Vallejo JG, Bowles NE. " A role for Toll-Like Receptor 3 variants in host susceptibility to enteroviral myocarditis and dilated cardiomyopathy " J Biol Chem.. 2010 ; 285 (30) : 23208-23.
Pubmed PMID: 20472559.
Vallejo J, Mann DL. " Antiinflammatory therapy in myocarditis. " Curr. Opin. Cardiol.. 2003 May ; 18 (3) : 189-93.
Pubmed PMID: 12826819.
Desai MS, Mariscalco MM, Tawil A, Vallejo JG, Smith CW. " Atherogenic diet-induced hepatitis is partially dependent on murine TLR4. " J. Leukoc. Biol.. 2008 Jun ; 83 (6) : 1336-44.
Pubmed PMID: 18334542.
Knuefermann P, Nemoto S, Baumgarten G, Misra A, Sivasubramanian N, Carabello BA, Vallejo JG. " Cardiac inflammation and innate immunity in septic shock: is there a role for toll-like receptors? " Chest. 2002 Apr ; 121 (4) : 1329-36.
Pubmed PMID: 11948070.
Knuefermann P, Nemoto S, Misra A, Nozaki N, Defreitas G, Goyert SM, Carabello BA, Mann DL, Vallejo JG. " CD14-deficient mice are protected against lipopolysaccharide-induced cardiac inflammation and left ventricular dysfunction. " Circulation. 2002 Nov 12; 106 (20) : 2608-15.
Pubmed PMID: 12427659.
Vallejo JG, Ong LT, Starke JR. " Clinical features, diagnosis, and treatment of tuberculosis in infants. " Pediatrics. 1994 Jul ; 94 (1) : 41281.
Pubmed PMID: 8008511.
Vallejo JG, Baker CJ, Edwards MS. " Demonstration of circulating group B streptococcal immune complexes in neonates with meningitis. " J. Clin. Microbiol.. 1994 Sep ; 32 (9) : 2041-5.
Pubmed PMID: 7814522.
Gorbea C, Rechsteiner M, Vallejo JG, Bowles NE.. " Depletion of the 26S proteasome adaptor Ecm29 increases Toll-like receptor 3 signaling " Sci Signal. 2013 Oct 1; 6 (295) : ra86.
Pubmed PMID: 24084648.
Ghose R, Guo T, Vallejo JG, Gandhi A. " Differential role of toll-interleukin 1 receptor domain-containing adaptor protein in toll-like receptor 2-mediated regulation of gene expression of hepatic cytokines and drug-metabolizing enzymes. " Drug Metab. Dispos.. 2011 May ; 39 (5) : 874-81.
Pubmed PMID: 21303924.
Nemoto S, Vallejo JG, Knuefermann P, Misra A, Defreitas G, Carabello BA, Mann DL. " Escherichia coli LPS-induced LV dysfunction: role of toll-like receptor-4 in the adult heart. " Am. J. Physiol. Heart Circ. Physiol.. 2002 Jun ; 282 (6) : H2316-23.
Pubmed PMID: 12003842.
Vallejo JG, Nemoto S, Ishiyama M, Yu B, Knuefermann P, Diwan A, Baker JS, Defreitas G, Tweardy DJ, Mann DL. " Functional significance of inflammatory mediators in a murine model of resuscitated hemorrhagic shock. " Am. J. Physiol. Heart Circ. Physiol.. 2005 Mar ; 288 (3) : H1272-7.
Pubmed PMID: 15706046.
Vallejo JG, Englund JA, Garcia-Prats JA, Demmler GJ. " Ganciclovir treatment of steroid-associated cytomegalovirus disease in a congenitally infected neonate. " Pediatr. Infect. Dis. J.. 1994 Mar ; 13 (3) : 239-41.
Pubmed PMID: 8177639.
Vallejo JG, Knuefermann P, Mann DL, Sivasubramanian N. " Group B Streptococcus induces TNF-alpha gene expression and activation of the transcription factors NF-kappa B and activator protein-1 in human cord blood monocytes. " J. Immunol.. 2000 Jul 1; 165 (1) : 419-25.
Pubmed PMID: 10861080.
Vallejo JG, Stevens AM, Dutton RV, Kaplan SL. " Hepatosplenic abscesses due to Brucella melitensis: report of a case involving a child and review of the literature. " Clin. Infect. Dis.. 1996 Mar ; 22 (3) : 485-9.
Pubmed PMID: 8852967.
Baumgarten G, Knuefermann P, Nozaki N, Sivasubramanian N, Mann DL, Vallejo JG. " In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: the role of toll-like receptor-4. " J. Infect. Dis.. 2001 Jun 1; 183 (11) : 1617-24.
Pubmed PMID: 11343210.
Cabrera AG, Khan MS, Morales DL, Chen DW, Moffett BS, Price JF, Dreyer WJ, Denfield SW, Jeewa A, Fraser CD, Vallejo JG. " Infectious complications and outcomes in children supported with left ventricular assist devices. " J. Heart Lung Transplant.. 2013 May ; 32 (5) : 518-24.
Pubmed PMID: 23489988.
Dong JW, Vallejo JG, Tzeng HP, Thomas JA, Mann DL. " Innate immunity mediates myocardial preconditioning through Toll-like receptor 2 and TIRAP-dependent signaling pathways. " Am. J. Physiol. Heart Circ. Physiol.. 2010 Mar ; 298 (3) : H1079-87.
Pubmed PMID: 20061547.
Vallejo JG, Baker CJ, Edwards MS. " Interleukin-6 production by human neonatal monocytes stimulated by type III group B streptococci. " J. Infect. Dis.. 1996 Aug ; 174 (2) : 332-7.
Pubmed PMID: 8699063.
Vallejo JG, Starke JR. " Intrathoracic tuberculosis in children. " Semin Respir Infect. 1996 Sep ; 11 (3) : 184-95.
Pubmed PMID: 8883176.
Breinholt JP, Vallejo JG, Gates CM, Clunie SK, Kearney DL, Dreyer WJ, Towbin JA, Bowles NE. " Myocardial pro-inflammatory cytokine expression and cellular rejection in pediatric heart transplant recipients. " J. Heart Lung Transplant.. 2008 Mar ; 27 (3) : 317-24.
Pubmed PMID: 18342755.
Tzeng HP, Fan J, Vallejo JG, Dong JW, Chen X, Houser SR, Mann DL. " Negative inotropic effects of high-mobility group box 1 protein in isolated contracting cardiac myocytes. " Am. J. Physiol. Heart Circ. Physiol.. 2008 Mar ; 294 (3) : H1490-6.
Pubmed PMID: 18223193.
Albanyan EA, Vallejo JG, Smith CW, Edwards MS. " Nonopsonic binding of type III Group B Streptococci to human neutrophils induces interleukin-8 release mediated by the p38 mitogen-activated protein kinase pathway. " Infect. Immun.. 2000 Apr ; 68 (4) : 2053-60.
Pubmed PMID: 10722601.
Misra A, Haudek SB, Knuefermann P, Vallejo JG, Chen ZJ, Michael LH, Sivasubramanian N, Olson EN, Entman ML, Mann DL. " Nuclear factor-kappaB protects the adult cardiac myocyte against ischemia-induced apoptosis in a murine model of acute myocardial infarction. " Circulation. 2003 Dec 23; 108 (25) : 3075-8.
Pubmed PMID: 14676146.
Syed FM, Hahn HS, Odley A, Guo Y, Vallejo JG, Lynch RA, Mann DL, Bolli R, Dorn GW. " Proapoptotic effects of caspase-1/interleukin-converting enzyme dominate in myocardial ischemia. " Circ. Res.. 2005 May 27; 96 (10) : 1103-9.
Pubmed PMID: 15845887.
Ghose R, White D, Guo T, Vallejo J, Karpen SJ. " Regulation of hepatic drug-metabolizing enzyme genes by Toll-like receptor 4 signaling is independent of Toll-interleukin 1 receptor domain-containing adaptor protein. " Drug Metab. Dispos.. 2008 Jan ; 36 (1) : 95-101.
Pubmed PMID: 17932222.
Huang CH, Vallejo JG, Kollias G, Mann DL. " Role of the innate immune system in acute viral myocarditis. " Basic Res. Cardiol.. 2009 May ; 104 (3) : 228-37.
Pubmed PMID: 19159057.
Vallejo JG. " Role of Toll-like receptors in cardiovascular diseases. " Clin. Sci.. 2011 Jul 1; 121 (1) : 41284.
Pubmed PMID: 21413930.
Vallejo JG, Baker CJ, Edwards MS. " Roles of the bacterial cell wall and capsule in induction of tumor necrosis factor alpha by type III group B streptococci. " Infect. Immun.. 1996 Dec ; 64 (12) : 5042-6.
Pubmed PMID: 8945544.
Robinson P, Garza A, Moore J, Eckols TK, Parti S, Balaji V, Vallejo J, Tweardy DJ. " Substance P is required for the pathogenesis of EMCV infection in mice. " 2009 ; 2 (1) : 76-86.
Pubmed PMID: 19436834.
Ramabadran RS, Chancey A, Vallejo JG, Barger PM, Sivasubramanian N, Mann DL. " Targeted gene silencing of tumor necrosis factor attenuates the negative inotropic effects of lipopolysaccharide in isolated contracting cardiac myocytes. " Tex Heart Inst J. 2008 ; 35 (1) : 16-21.
Pubmed PMID: 18427645.
Knuefermann P, Vallejo J, Mann DL. " The role of innate immune responses in the heart in health and disease. " Trends Cardiovasc. Med.. 2004 Jan ; 14 (1) : 41281.
Pubmed PMID: 14720467.
Knuefermann P, Sakata Y, Baker JS, Huang CH, Sekiguchi K, Hardarson HS, Takeuchi O, Akira S, Vallejo JG. " Toll-like receptor 2 mediates Staphylococcus aureus-induced myocardial dysfunction and cytokine production in the heart. " Circulation. 2004 Dec 14; 110 (24) : 3693-8.
Pubmed PMID: 15569836.
Sakata Y, Dong JW, Vallejo JG, Huang CH, Baker JS, Tracey KJ, Tacheuchi O, Akira S, Mann DL. " Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury. " Am. J. Physiol. Heart Circ. Physiol.. 2007 Jan ; 292 (1) : H503-9.
Pubmed PMID: 16980352.
Hardarson HS, Baker JS, Yang Z, Purevjav E, Huang CH, Alexopoulou L, Li N, Flavell RA, Bowles NE, Vallejo JG. " Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury. " Am. J. Physiol. Heart Circ. Physiol.. 2007 Jan ; 292 (1) : H251-8.
Pubmed PMID: 16936008.
Moghimpour Bijani F, Vallejo JG, Rezaei N. " Toll-like Receptor Signaling Pathways in Cardiovascular Diseases: Challenges and Opportunities. " Int. Rev. Immunol.. 2012 Oct ; 31 (5) : 379-95.
Pubmed PMID: 23083347.
Vallejo JG, Kaplan SL, Mason EO. " Treatment of meningitis and other infections due to ampicillin-resistant Haemophilus influenzae type b in children. " Rev. Infect. Dis.. ; 13 (2) : 197-200.
Pubmed PMID: 2041948.
Vallejo JG, Starke JR. " Tuberculosis and pregnancy. " Clin. Chest Med.. 1992 Dec ; 13 (4) : 693-707.
Pubmed PMID: 1478028.
Vallejo JG, Ong LT, Starke JR. " Tuberculous osteomyelitis of the long bones in children. " Pediatr. Infect. Dis. J.. 1995 Jun ; 14 (6) : 542-6.
Pubmed PMID: 7667061.
Albanyan EA, Morad AB, Vallejo JG. " Vibrio vulnificus sepsis in a child with Diamond-Blackfan syndrome. " Pediatr. Infect. Dis. J.. 1997 Aug ; 16 (8) : 818-20.
Pubmed PMID: 9271048.
Bowles NE, Vallejo J. " Viral causes of cardiac inflammation. " Curr. Opin. Cardiol.. 2003 May ; 18 (3) : 182-8.
Pubmed PMID: 12826818.
Patel A, Mao KR, McNeil JC, Kaplan SL, Vallejo JG. " Fever and Reversible Laboratory Abnormalities Associated with Prolonged Use of Piperacillin-Tazobactam in Children " Pediatr Infect Disease J. 2015 Aug ; 34 (8) : 849-50.
Pubmed PMID: 25961892.
McNeil JC, Kok EY, Forbes A, Lamberth L, Hulten KG, Vallejo JG, Mason EO, Kaplan SL. " Healthcare-Associated Staphylococcus Aureus Bacteremia in Children: Evidence for Reverse Vancomycin Creep and Impact of Vancomycin Trough Values on Outcome " Pediatr Infect Dis J.. 2015 ;
Pubmed PMID: 26646549.
McNeil JC, Kok E, Vallejo JG, Campbell JR, Hulten KG, Mason EO, Kaplan SL. " Decreased susceptibility to chlorhexidine among nosocomial Staphylococcus aureus at Texas Children's Hospital: Clinical and Molecular Features " Antimicrob Agents Chemother. 2015 Dec ;
Pubmed PMID: 26666947.
38. Xu Z, Desai M, Philip J. Subramanian N, Bowles NE, Vallejo, JG. " Conditional Transgenic Expression of TIR-domain-containing adaptor-inducing interferon-β (TRIF) in the Adult Mouse Heart is Protective in Acute Viral Myocarditis.. " Basic Res Cardiol. 2011 ; 106 (6) : 1159-71.
Philip J. Xu Z, Bowles NE, Vallejo, JG. " Cardiac-Specific Overexpression of Melanoma Differentiation Associated Gene-5 Protects Mice from Lethal Viral Myocarditis.. " Circ Heart Fail.. 2013 ; 6 (2) : 326-34.
McNeil JC, Kaplan SL, Vallejo JG. " The influence of the route of antibiotic administration, methicillin-susceptibility, vancomycin duration and serum trough concentration on outcomes of pediatric Staphylococcus aureus bacteremic osteoarticular infection. " Pediatr Infect Dis J.. 2017 ; 36 (6) : 572-577.
Vallejo JG, Cain AN, Mason EO, Kaplan SL, Hulten KG. " Staphylococcus aureus central nervous system infections in children. " Pediatr Infect Dis J. 2017 ; 36 (10) : 947-951.
McNeil JC, Vallejo JG, Hulten KG, Kaplan SL. " Osteoarticular Infections Following Open or Penetrating Trauma in Children in the Post-Community-Acquired Methicillin-Resistant Staphylococcus aureus Era: The Impact of Enterobacter cloacae. " Pediatr Infect Dis J. 2018 ; 37 (12) : 1204-1210.
Kok EY, Vallejo JG, Sommer LM, Rosas L, Kaplan SL, Hulten KG, McNeil JC. " Association of vancomycin MIC and molecular characteristics with clinical outcomes in methicillin-susceptible Staphylococcus aureus acute hematogenous osteoarticular infections in children. " Antimicrob Agents Chemother.. 2018 ; 26 (62(5))
Gibson A, Kaplan SL, Vallejo JG. " Impact of Serum Vancomycin Trough Levels in the Treatment of Central Nervous System Shunt Infections caused by Coagulase Negative Staphylococci. " Pediatr Neurosurg. 2018 ; 53 (4) : 243-246.
Vallejo JG, McNeil JC, Hulten KG, Sommer LM, Dunn JJ, Kaplan SL. " Invasive Haemophilus influenzae disease at Texas Children’s Hospital, 2011-2018. " Pediatr Infect Dis J. 2019 ; 38 (9) : 900-905.
Kralik SF, Kukreja MK, Paldino MJ, Desai NK, Vallejo JG. " Comparison of CSF and MRI Findings among Neonates and Infants with E coli or Group B Streptococcal Meningitis. " AJNR Am J Neuroradiol. 2019 ; 40 (8) : 1413-1417.
Kaplan J, Ikeda S, McNeil JC, Kaplan SL, Vallejo JG. " Microbiology of Osteoarticular Infections in Patients with Sickle Hemoglobinopathies at Texas Children's Hospital, 2000-2018. " Pediatr Infect Dis J. 2019 ; 38 (12) : 1251-1253.
McNeil JC, Dunn JJ, Kaplan SL, Vallejo JG. " Complications of Otitis Media and Sinusitis Caused by Streptococcus anginosus Group Organisms in Children. " Pediatr Infect Dis J. 2020 ; 39 (2) : 108--113.
Orman G, Kukreja MK, Paladini MF, Vallejo JG, Desai N, Huisman T, Kralik S. " Accuracy of cochlear magnetic resonance imaging in predicting sensorineural hearing loss in infants with bacterial meningitis. " AJNR Am J Neuroradiol. 2020 ; 41 (6) : 1081-1086.

Memberships

Pediatric Infectious Diseases Society: Member

Infectious Diseases Society of America: Fellow

Society for Pediatric Research: Member

American Academy of Pediatrics: Fellow

Languages

Spanish