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Jean J. Kim, Ph.D.

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jean.kim@bcm.edu

Associate Professor: Molecular & Cellular Biology
Stem Cells and Regenerative Medicine Center
Baylor College of Medicine
Houston, Texas United States

Core Director: Advanced Technology Cores Unit
Office of Research
Human Stem Cell Core (HSCC)
Houston, Texas United States

Associate Professor: Education, Innovation & Technology
Baylor College of Medicine
Houston, Texas United States

Co-Leader of Shared Resource: Gene Modulation in Cancer Cell Models (GMCCM) Shared Resource
Dan L Duncan Comprehensive Cancer Center

The Gene Modulation in Cancer Cell Models (GMCCM) Shared Resource provides DLDCCC members with a versatile combination of cutting-edge technologies and genomic resources to facilitate mechanistic and exploratory investigations using cancer cells and cell lines as experimental models. GMCCM houses essential elements for single-gene analysis to whole-genome screens, including genome-wide libraries of short-hairpin RNAs (shRNAs), cDNAs, and CRISPR sgRNAs, as well as multiple automated robotic platforms for library manipulation. In addition, GMCCM provides highly customizable CRISPR/Cas9-mediated genome-editing services to create knock-in and knock-out cell lines derived from multiple cell types including primary cells, somatic cancer cell lines, human pluripotent stem cells (hPSCs) and cancer patient-derived induced PSCs. The ever-expanding functionalities of CRISPR/Cas9 promises to greatly benefit research of DLDCCC members that rely on cell lines as experimental systems. GMCCM represents a renaming and restructuring of the former Cell-Based Assay Screening Services (C-BASS) supported by the DLDCCC with an Institutional Human Stem Cell Core supported by BCM. By housing these resources in a single, cohesive Shared Resource allows investigators to employ myriad genomic and genetic platforms.