Jason M. Karch

Assistant Professor

Email

karch@bcm.edu

Positions

Assistant Professor: Integrative Physiology
Baylor College of Medicine
Houston, TX, US

Education

PhD from University of Cincinnati: 11/2012 - Cincinnati, Ohio, United States; Cell and Cancer Biology

BA from Dakota Wesleyan University: 05/2005 - Mitchell, South Dakota, United States; Biology

Postdoctoral Fellowship at Cincinnati Children's Hospital Medical Center: 11/2018 - Cincinnati, Ohio, United States; Molecular Cardiology

Professional Interests

Cell Death
Heart Disease
Mitochondria
Necrosis
mPTP

Professional Statement

Aberrant cell death is a common thread that binds various human diseases such as ischemic injuries, degenerative diseases, many types of cancer, and aging. Further mechanistic detail of the cell death pathways during these disease states is needed to identify efficacious novel therapeutic targets to prevent or induce cell death as needed. Specifically, we are interested in defining the regulated necrotic cell death pathway that leads to cardiomyocyte death during an ischemic event.

Websites

Lab Website

X/Twitter

google scholar

Selected Publications

Patel P, Mendoza A, Robichaux DJ, Wang MC, Wehrens XH, Karch J. " Inhibition of the anti-apoptotic Bcl-2 family by BH3 mimetics sensitize the mitochondrial permeability transition pore through Bax and Bak. " 2021 ;
Pubmed PMID: 34926454.
Patel, P., Mendoza, A., Ramirez, D., Robichaux, D., Molkentin, J. D., & Karch, J.. " The adenine nucleotide translocase family underlies cardiac ischemia-reperfusion injury through the mitochondrial permeability pore independently of cyclophilin D " ;
Pubmed PMID: 39661674.
Mendoza, A., Patel, P., Robichaux, D., Ramirez, D., & Karch,. " Inhibition of the mPTP and lipid peroxidation is additively protective against I/R injury " ;
Pubmed PMID: 38618716.
Robichaux DJ, Harata M, Murphy E, Karch J. " Mitochondrial permeability transition pore-dependent necrosis " JMCC. 2022 ;
Pubmed PMID: 36410526.

Memberships

American Heart Association

Funding

Molecular Regulation of Mitochondrial Permeability Transition and its Role in Regulated Necrosis #R01HL150031: (07/01/2020 - 07/01/2030); Grant funding from NIH/NHLBI