Jason M. Karch

Assistant Professor

Email

karch@bcm.edu

Positions

Assistant Professor: Integrative Physiology
Baylor College of Medicine
Houston, TX, US

Education

PhD from University of Cincinnati: 11/2012 - Cincinnati, Ohio, United States; Cell and Cancer Biology

BA from Dakota Wesleyan University: 05/2005 - Mitchell, South Dakota, United States; Biology

Professional Statement

Aberrant cell death is a common thread that binds various human diseases such as ischemic injuries, degenerative diseases, many types of cancer, and aging. Further mechanistic detail of the cell death pathways during these disease states is needed to identify efficacious novel therapeutic targets to prevent or induce cell death as needed. Specifically, we are interested in defining the regulated necrotic cell death pathway that leads to cardiomyocyte death during an ischemic event.

Websites

Lab Website

X/Twitter

Selected Publications

Jason Karch, Michael J Bround, Hadi Khalil, Michelle A Sargent, Nadina Latchman, Naohiro Terada, Pablo M Peixoto, Jeffery D Molkentin. " Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD " Science Advances. 2019 Aug 1;
Pubmed PMID: 31489369.
Jason Karch, Jennifer Q Kwong, Adam R Burr, Michelle A Sargent, John W Elrod, Pablo M Peixoto, Sonia Martinez-Caballero, Hanna Osinska, Emily HY Cheng, Jeffrey Robbins, Kathleen W Kinnally, Jeffery D Molkentin. " Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice " ELife. 2013 Aug 27; 2
Pubmed PMID: 23991283.
Jason Karch, Jeffery D Molkentin. " Regulated necrotic cell death: the passive aggressive side of Bax and Bak " Circulation Research. 2015 May 22; 116
Pubmed PMID: 25999420.
Jason Karch, Onur Kanisicak, Matthew J Brody, Michelle A Sargent, Demetria M Michael, Jeffery D Molkentin. " Necroptosis interfaces with MOMP and the MPTP in mediating cell death " PloS one. 2015 Jun 10; 10
Pubmed PMID: 26061004.
Jason Karch, Tobias G Schips, Bryan D Maliken, Matthew J Brody, Michelle A Sargent, Onur Kanisicak, Jeffery D Molkentin. " Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak " Elife. 2017 Nov 17; 6
Pubmed PMID: 29148970.
Robichaux DJ, Harata M, Murphy E, Karch J. " Mitochondrial permeability transition pore-dependent necrosis. " JMCC. 2022 ;
Mendoza A, Karch J. " Keeping the beat against time: mitochondrial fitness in the aging heart.. " Frontiers in Aging. 2023 ;
Patel P, Mendoza A, Robichaux DJ, Wang MC, Wehrens XH, Karch J. " Inhibition of the anti-apoptotic Bcl-2 family by BH3 mimetics sensitize the mitochondrial permeability transition pore through Bax and Bak.. " 2021 ;