Jack Meng Fen Su, M.D.

Assistant Professor

(832) 822-4306

Email

msu@bcm.edu

Positions

Assistant Professor: Pediatrics
Hematology-Oncology
Baylor College of Medicine
Houston, Texas, United States

Clinical Instructor: Pediatrics
Hematology-Oncology
Baylor College of Medicine
Houston, Texas, United States

Member: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Addresses

Baylor College of Medicine (Office): 6701 Fannin Street, CC1510
Houston, TX, 77030
United States

Education

BS from Stanford University: 05/1986 - Palo Alto, California, United States; Chemistry

MD from University Of California, San Francisco School Of Medicine: 05/1990 - San Francisco, California, United States

Residency at University Of California, San Francisco School Of Medicine: 06/1997 - San Francisco, California, United States; Pediatrics

MS from Baylor College of Medicine: 06/2007 - Houston, Texas, United States; Clinical Investigation

Clinical Fellowship at Baylor College Of Medicine: 06/2006 - Houston, Texas, United States; Pediatric Oncology Clinical Resaerch

Clinical Fellowship at Baylor College of Medicine: 06/2001 - Houston, Texas, United States; Pediatric Hematology-Oncology

Certifications

Pediatrics: (10/01/1997 - 12/31/2016); American Board of Pediatrics

Pediatric Hematology-Oncology: (11/07/2000 - 11/30/2016); American Board of Pediatrics

Texas Medical Licensure: #L3150 (08/31/2014 - 08/31/2017); Texas Medical Board

DEA: #BA756552 (02/05/2014 - 02/28/2017); Drug Enforcement Administration

California Licensure of Physicians and Surgeons: (03/28/1996 - 03/28/2016); Medical Board of California

Texas Controlled Substances Registation Certification: #20122053 (02/28/2015 - 08/31/2016); Texas Department of Public Safety

Honors & Awards

Study Chair, A Phase I Study of Valproic Acid in Children with Recurrent/Progressive Solid Tumors, Including CNS Tumors (ADVL0419; NCT00107458): clinical trial completed accrual; Children's Oncology Group (01/2004 - 09/2008)

Study Chair, A Phase I Study of ABT-888, an Oral Inhibitor of Poly(ADP-ribose) Polymerase, and Temozolomide in Children with Recurrent/Progressive CNS Tumors (PBTC-027; NCT00946335): trial completed accrual; Pediatric Brain Tumor Consortium (01/2008 - 10/2012)

Co-Chair, New Agent and Pharmacology Committee: Pediatric Brain Tumor Consortium (03/2011 - 08/2014)

Scientific Committee: committee member; atric Brain Tumor Consortium (01/2011)

Central Nervous System Tumor Disease Committee: committee member; Children's Oncology Group (01/2009)

Study Co-Chair, A Phase II Study of Valproic Acid and Radiation, Followed by Maintenance Valproic Acid and Bevacizumab in Children with Newly Diagnosed High-Grade Gliomas or Brainstem Gliomas (NCT00879437): clinical trial ongoing; Texas Oklahoma Pediatric Neuro-Oncology Consortium (01/2009)

Study Chair, A Phase I/II Study of Suberoylanilide Hydroxamic Acid (SAHA; Vorinostat) and Local Irradiation, Followed by Maintenance SAHA in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma (ACNS0927; NCT01189266): trial enrollment completed; final data anlaysis pending; Children's Oncology Group (01/2010)

Study Co-Chair, A Phase I/II Study of ABT-888, an Oral Poly( ADP-ribose) Polymerase Inhibitor, and Concurrent Radiation Therapy, Followed by ABT-888 and Temozolomide, in Children with Newly Diagnosed Diffuse Pontine Gliomas (PBTC33, NCT01514201): clinical trial ongoing; Pediatric Brain Tumor Consortium (01/2011)

Websites

VIICTR Publications List

Selected Publications

Yu L, Baxter PA, Voicu H, Gurusiddappa S, Zhao Y, Adesina A, Man TK, Shu Q, Zhang YJ, Zhao XM, Su JM, Perlaky L, Dauser R, Chintagumpala M, Lau CC, Blaney SM, Rao PH, Leung HC, Li XN. " A clinically relevant orthotopic xenograft model of ependymoma that maintains the genomic signature of the primary tumor and preserves cancer stem cells in vivo. " Neuro-oncology. 2010 Jun ; 12 (6) : 580-94.
Pubmed PMID: 20511191.
Blaney SM, Tagen M, Onar-Thomas A, Berg SL, Gururangan S, Scorsone K, Su J, Goldman S, Kieran MW, Kun L, Boyett J, Stewart C. " A phase-1 pharmacokinetic optimal dosing study of intraventricular topotecan for children with neoplastic meningitis: A pediatric brain tumor consortium study. " Pediatr Blood Cancer. 2013 Apr ; 60 (4) : 627-32.
Pubmed PMID: 23002039.
Yu L, Baxter PA, Zhao X, Liu Z, Wadhwa L, Zhang Y, Su JM, Tan X, Yang J, Adesina A, Perlaky L, Hurwitz M, Idamakanti N, Police SR, Hallenbeck PL, Blaney SM, Chintagumpala M, Hurwitz RL, Li XN. " A single intravenous injection of oncolytic picornavirus SVV-001 eliminates medulloblastomas in primary tumor-based orthotopic xenograft mouse models. " Neuro-oncology. 2011 Jan ; 13 (1) : 14-27.
Pubmed PMID: 21075780.
Takei H, Dauser R, Su J, Chintagumpala M, Bhattacharjee MB, Jones J, Adesina AM. " Anaplastic ganglioglioma arising from a Lhermitte-Duclos-like lesion. Case report. " J. Neurosurg.. 2007 Aug ; 107 (2) : 137-42.
Pubmed PMID: 18459885.
Muscal JA, Jones JY, Paulino AC, Bertuch AA, Su J, Woo SY, Mahoney DH, Chintagumpala M. " Changes mimicking new leptomeningeal disease after intensity-modulated radiotherapy for medulloblastoma. " Int. J. Radiat. Oncol. Biol. Phys.. 2009 Jan 1; 73 (1) : 214-21.
Pubmed PMID: 18485616.
Su JM, Perlaky L, Li XN, Leung HC, Antalffy B, Armstrong D, Lau CC. " Comparison of ethanol versus formalin fixation on preservation of histology and RNA in laser capture microdissected brain tissues. " Brain Pathol.. 2004 Apr ; 14 (2) : 175-82.
Pubmed PMID: 15193030.
Cheung HC, Yatsenko SA, Kadapakkam M, Legay H, Su J, Lupski JR, Plon SE. " Constitutional tandem duplication of 9q34 that truncates EHMT1 in a child with ganglioglioma. " Pediatr Blood Cancer. 2012 May ; 58 (5) : 801-5.
Pubmed PMID: 21681934.
Hwang SW, Su JM, Jea A. " Diagnosis and management of brain and spinal cord tumors in the neonate. " Semin Fetal Neonatal Med. 2012 Aug ; 17 (4) : 202-6.
Pubmed PMID: 22465555.
Li XN, Shu Q, Su JM, Adesina AM, Wong KK, Perlaky L, Antalffy BA, Blaney SM, Lau CC. " Differential expression of survivin splice isoforms in medulloblastomas. " Neuropathol. Appl. Neurobiol.. 2007 Feb ; 33 (1) : 67-76.
Pubmed PMID: 17239009.
Shu Q, Wong KK, Su JM, Adesina AM, Yu LT, Tsang YT, Antalffy BC, Baxter P, Perlaky L, Yang J, Dauser RC, Chintagumpala M, Blaney SM, Lau CC, Li XN. " Direct orthotopic transplantation of fresh surgical specimen preserves CD133+ tumor cells in clinically relevant mouse models of medulloblastoma and glioma. " Stem Cells. 2008 Jun ; 26 (6) : 1414-24.
Pubmed PMID: 18403755.
Wong KK, Chang YM, Tsang YT, Perlaky L, Su J, Adesina A, Armstrong DL, Bhattacharjee M, Dauser R, Blaney SM, Chintagumpala M, Lau CC. " Expression analysis of juvenile pilocytic astrocytomas by oligonucleotide microarray reveals two potential subgroups. " Cancer Res.. 2005 Jan 1; 65 (1) : 76-84.
Pubmed PMID: 15665281.
Wong KK, Tsang YT, Chang YM, Su J, Di Francesco AM, Meco D, Riccardi R, Perlaky L, Dauser RC, Adesina A, Bhattacharjee M, Chintagumpala M, Lau CC. " Genome-wide allelic imbalance analysis of pediatric gliomas by single nucleotide polymorphic allele array. " Cancer Res.. 2006 Dec 1; 66 (23) : 11172-8.
Pubmed PMID: 17145861.
Zhao X, Liu Z, Yu L, Zhang Y, Baxter P, Voicu H, Gurusiddappa S, Luan J, Su JM, Leung HC, Li XN. " Global gene expression profiling confirms the molecular fidelity of primary tumor-based orthotopic xenograft mouse models of medulloblastoma. " Neuro-oncology. 2012 May ; 14 (5) : 574-83.
Pubmed PMID: 22459127.
Paulino AC, Mazloom A, Teh BS, South M, Okcu MF, Su J, Butler EB, Chintagumpala M. " Local control after craniospinal irradiation, intensity-modulated radiotherapy boost, and chemotherapy in childhood medulloblastoma. " Cancer. 2011 Feb 1; 117 (3) : 635-41.
Pubmed PMID: 20845476.
Paulino AC, Lobo M, Teh BS, Okcu MF, South M, Butler EB, Su J, Chintagumpala M. " Ototoxicity after intensity-modulated radiation therapy and cisplatin-based chemotherapy in children with medulloblastoma. " Int. J. Radiat. Oncol. Biol. Phys.. 2010 Dec 1; 78 (5) : 1445-50.
Pubmed PMID: 20231075.
De Bortoli M, Castellino RC, Skapura DG, Shen JJ, Su JM, Russell HV, Hicks MJ, Man TK, Kim JY. " Patched haploinsufficient mouse rhabdomyosarcoma overexpress secreted phosphoprotein 1 and matrix metalloproteinases. " Eur. J. Cancer. 2007 May ; 43 (8) : 1308-17.
Pubmed PMID: 17467979.
Su JM, Li XN, Thompson P, Ou CN, Ingle AM, Russell H, Lau CC, Adamson PC, Blaney SM. " Phase 1 study of valproic acid in pediatric patients with refractory solid or CNS tumors: a children's oncology group report. " Clin. Cancer Res.. 2011 Feb 1; 17 (3) : 589-97.
Pubmed PMID: 21115653.
Li XN, Parikh S, Shu Q, Jung HL, Chow CW, Perlaky L, Leung HC, Su J, Blaney S, Lau CC. " Phenylbutyrate and phenylacetate induce differentiation and inhibit proliferation of human medulloblastoma cells. " Clin. Cancer Res.. 2004 Feb 1; 10 (3) : 1150-9.
Pubmed PMID: 14871995.
Muscal JA, Thompson PA, Giranda VL, Dayton BD, Bauch J, Horton T, McGuffey L, Nuchtern JG, Dauser RC, Gibson BW, Blaney SM, Su JM. " Plasma and cerebrospinal fluid pharmacokinetics of ABT-888 after oral administration in non-human primates. " Cancer Chemother. Pharmacol.. 2010 Feb ; 65 (3) : 419-25.
Pubmed PMID: 19526240.
Li XN, Shu Q, Su JM, Perlaky L, Blaney SM, Lau CC. " Valproic acid induces growth arrest, apoptosis, and senescence in medulloblastomas by increasing histone hyperacetylation and regulating expression of p21Cip1, CDK4, and CMYC. " Mol. Cancer Ther.. 2005 Dec ; 4 (12) : 1912-22.
Pubmed PMID: 16373706.
Shu Q, Antalffy B, Su JM, Adesina A, Ou CN, Pietsch T, Blaney SM, Lau CC, Li XN. " Valproic Acid prolongs survival time of severe combined immunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenografts. " Clin. Cancer Res.. 2006 Aug 1; 12 (15) : 4687-94.
Pubmed PMID: 16899619.

Languages

Chinese (Mandarin)