Hazem El Osta

El Osta

Hazem El Osta, MD, FACP

Assistant Professor

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Email

Hazem.elosta@bcm.edu

Positions

Assistant Professor: Medicine
Hematology & Oncology
Baylor College of Medicine
Houston, TX, US

Addresses

Baylor College of Medicine Medical Center McNair Campus (Office): Dan L Duncan Comprehensive Cancer Center
7200 Cambridge St, 7B
Houston, TX, 77030
United States
Phone: (713) 798-3750

Baylor College of Medicine Medical Center McNair Campus (Clinic): Dan L Duncan Comprehensive Cancer Center
7200 Cambridge St, 7B
Houston, TX, 77030
United States
Phone: (713) 798-3750

Education

MD from Saint-Joseph University School of Medicine: 07/2004 - Beirut, Lebanon

Residency at Kansas University School of Medicine: 08/2009 - Wichita, Kansas, United States

Research Fellowship at MD Anderson Cancer Center: 08/2010 - Houston, Texas, United States

Clinical Fellowship at Louisiana State University: 08/2013 - Shreveport, Louisiana, United States

Certifications

Board certified-Medical Oncology: American Board of Medical Specialities

Board certified-Hematology: American Board of Medical Specialities

Board certified- Internal Medicine: American Board of Internal Medicine

Honors & Awards

ASCO merit award (2011)

2011 Pfizer Fellowships in Oncology Award

Professional Interests

Thoracic medical oncology
Head and neck cancer

Websites

PubMed

Selected Publications

Circu ML, Dykes SS, Carroll J, Kelly K, Galiano F, Greer A, Cardelli J, El-Osta H. " A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion. " PLoS One. 2016 Jan ; 11 (1) : e0146931.
Pubmed PMID: 26784896.
El-Osta H, Falchook G, Tsimberidou A, Hong D, Naing A, Kim K, Wen S, Janku F, Kurzrock R. " BRAF mutations in advanced cancers: clinical characteristics and outcomes. " PLoS One. 2011 ; 6 (10) : e25806.
Pubmed PMID: 22039425.
El-Osta HE, Kurzrock R.. " Castleman's disease: from basic mechanisms to molecular therapeutics. " Oncologist. 2011 ; 16 (4) : 497-511.
Pubmed PMID: 21441298.
El-Osta H, Salyers WJ Jr.. " Delayed splenic rupture: myth or reality? " Ann Intern Med. 2009 Feb ; 150 (3) : 224-5.
Pubmed PMID: 19189923.
El-Osta H, Jani P, Mansour A, Rascoe P, Jafri S. " Endobronchial Ultrasound for Nodal Staging of Patients with Non-Small-Cell Lung Cancer with Radiologically Normal Mediastinum. A Meta-Analysis. " Ann Am Thorac Soc. 2018 Jul ; 15 (7) : 864-874.
Pubmed PMID: 29684288.
Ansari J, Shackelford RE, El-Osta H. " Epigenetics in non-small cell lung cancer: from basics to therapeutics. " Transl Lung Cancer Res.. 2016 Apr ; 5 (2) : 155-71.
Pubmed PMID: 27186511.
Peddi P, Paryani B, Takalkar A, Bundrick P, Ponugupati J, Nair B, El-Osta H.. " Exceptional response to cetuximab monotherapy in a patient with metastatic oropharyngeal squamous cell carcinoma: a molecular insight. " Onco Targets Ther.. 2016 Feb ; 9 : 705-9.
Pubmed PMID: 26929641.
El-Osta H, Shahid K, Mills GM, Peddi P. " Immune checkpoint inhibitors: the new frontier in non-small-cell lung cancer treatment. " Onco Targets Ther. 2016 Aug ; 16 (9) : 5101-16.
Pubmed PMID: 27574451.
El-Osta H, El-Haddad P, Nabbout N. " Lung carcinoma associated with excessive eosinophilia. " J Clin Oncol.. 2008 Jul ; 26 (20) : 3456-7.
Pubmed PMID: 18612162.
Circu M, Cardelli J, Barr MP, O'Byrne K, Mills G, El-Osta H. " Modulating lysosomal function through lysosome membrane permeabilization or autophagy suppression restores sensitivity to cisplatin in refractory non-small-cell lung cancer cells. " PLoS One. 2017 Sep ; 12 (9) : e0184922.
Pubmed PMID: 28945807.
El-Osta H, Hong D, Wheler J, Fu S, Naing A, Falchook G, Hicks M, Wen S, Tsimberidou AM, Kurzrock R.. " Outcomes of research biopsies in phase I clinical trials: the MD anderson cancer center experience. " Oncologist. 2011 ; 16 (9) : 1292-8.
Pubmed PMID: 21859821.
Peddi P, Ajit NE, Burton GV, El-Osta H.. " Regression of a glioblastoma multiforme: spontaneous versus a potential antineoplastic effect of dexamethasone and levetiracetam. " BMJ Case Rep.. 2016 ;
Pubmed PMID: 28011886.
El-Osta HE, Yammine YS, Chehab BM, Fields AS, Moore DF Jr, Mattar BI. " Unexplained hemopericardium as a presenting feature of primary cardiac angiosarcoma: a case report and a review of the diagnostic dilemma. " J Thorac Oncol. 2008 Jul ; 3 (7) : 800-2.
Pubmed PMID: 18594329.
El-Osta HE, Salyers WJ Jr, Palko W, Hagan ME, El-Haddad B, Schulz TK. " Anaplastic large-cell lymphoma with leukemoid reaction. " J Clin Oncol.. 2008 Sep ; 26 (26) : 4356-8.
Pubmed PMID: 18779625.
El-Osta H, Janku F, Kurzrock R. " Successful treatment of Castleman's disease with interleukin-1 receptor antagonist (Anakinra). " Mol Cancer Ther. 2010 Jun ; 9 (6) : 1485-8.
Pubmed PMID: 20501803.
El-Osta H, Jafri S. " Predictors for clinical benefit of immune checkpoint inhibitors in advanced non-small-cell lung cancer: a meta-analysis " Immunotherapy. 2019 Feb ; 11 (3)
Pubmed PMID: 30730276.
El-Osta H, Shackelford R. " Personalized treatment options for ALK-positive metastatic non-small-cell lung cancer: potential role for Ceritinib. " Pharmgenomics Pers Med. 2015 Sep ; 8 : 145-54.
Pubmed PMID: 26622190.
El-Osta H, Nair B. " Rituximab-induced acute thrombocytopenia: an underappreciated entity. " Leuk Lymphoma. 2013 Dec ; 54 (12) : 2736-7..
Pubmed PMID: 23488605.
Ansari J, Naqash AR, Munker R, El-Osta H, Master S, Cotelingam JD, Griffiths E, Greer AH, Yin H, Peddi P, Shackelford RE. " Histiocytic sarcoma as a secondary malignancy: pathobiology, diagnosis, and treatment. " Eur J Haematol. 2016 Jul ; 97 (1) : 9-16.
Pubmed PMID: 26990812.
El-Osta H, Reddy P, Deutsch JM.. " Acquired factor VIII inhibitors: case reports of paclitaxel and penicillin-induced entities. " Blood Coagul Fibrinolysis. 2009 Dec ; 20 (8) : 719-21.
Pubmed PMID: 19696661.
Su J, Veillon D, Shackelford R, Cotelingam J, El-Osta H, Mills G, Munker R, Devarakonda S.. " Acute Promyelocytic Leukemia and Chronic Lymphocytic Leukemia: Concomitant Presentation of Two Molecularly Distinct Entities. " J La State Med Soc. 2017 May ; 169 (3) : 68-70.
Pubmed PMID: 28644154.
El Osta L, El Osta N, El Osta H. " Benefits and potential risks of bisphosphonate therapy A narrative review. " J Med Liban. 2016 Oct ; 64 (4) : 228-37.
Pubmed PMID: 29845849.
El-Osta H, Jafri S. " Predictors for clinical benefit of immune checkpoint inhibitors in advanced non-small-cell lung cancer: a meta-analysis " Immunotherapy. 2019 Feb ; 11 (3) : 189-199.
Pubmed PMID: 30730276.
Azar RR, Kassab R, Zoghbi A, Aboujaoudé S, El-Osta H, Ghorra P, Germanos M, Salamé E. " Effects of clopidogrel on soluble CD40 ligand and on high-sensitivity C-reactive protein in patients with stable coronary artery disease. " Am Heart J. 2006 Feb ; 151 (2) : 521.e1-521.e4.
Pubmed PMID: 16442924.
El-Osta H, Mott F, Burt B, Wang DY, Sabichi A. " Predictors of benefits from frontline chemoimmunotherapy in stage IV non-small-cell lung cancer: a meta-analysis " Oncoimmunology. 2019 Sep 20; e1665974-2.
Master S, Kallam D, El-Osta H, Peddi P. " Clinical review: management of adult Kasabach-Merritt syndrome associated with hemangiomas. " J Blood Disord Transfus. 2017 Dec ; 8 (5) : 397.

Memberships

Fellow of the American College of Physicians

American Society of Clinical Oncology

American Association for Cancer Research

Languages

Arabic, French

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