Florante A Quiocho, Ph.D.

Distinguished Emeritus Professor

Email

faq@bcm.edu

Positions

Distinguished Emeritus Professor: Baylor College of Medicine
Houston, Texas

Member: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Addresses

BCM-Ben Taub Research Center (Office): Room: BCMT-T334A
Houston, TX, 77030
United States

Education

Advanced Training from Harvard University: 01/1972 - Cambridge, MA, United States

Advanced Training from Yale University: 01/1966 - New Haven, CT, United States

Ph.D. from Yale University: 01/1966 - New Haven, CT, United States

M.S. from Howard University: 01/1961 - Washington, DC, United States

B.S. from Central Philippine University: 01/1959 - Iloilo City, Philippines

Professional Interests

Biophysics and Computational Biology
Protein Structure-Function and Protein Folding
Structural Biology and Macromolecular Assemblies
Membrane Trafficking and Cytoskeleton
Signal Transduction
Membranes and Membrane Proteins
X-ray Crystallography of Proteins
Molecular Recognition and Protein-ligand Interactions

Professional Statement

Three-dimensional structures of biological macromolecules lie at the very core of understanding, at the atomic level, biological and biochemical processes. Our research interest is centered on the study of the three-dimensional structure and function of proteins and enzymes at atomic resolution. Although x-ray crystallography is the primary experimental approach to achieve this goal, other correlative studies employing biochemical, physical-chemical, and recombinant DNA techniques are also being pursued. The proteins under investigation cover the areas of signal transduction and cellular regulation, active transport, ligand and drug molecular recognition and vesicular trafficking and membrane fusion.

Websites

VIICTR Profile

Lab Page

Selected Publications

Wang D1, Epstein D, Khalaf O, Srinivasan S, Williamson WR, Fayyazuddin A, Quiocho FA, Hiesinger PR.. " Ca2+-Calmodulin regulates SNARE assembly and spontaneous neurotransmitter release via v-ATPase subunit V0a1. " J. Cell Biol.. 2014 Apr 14; 205 (1) : 21-31.
Pubmed PMID: 24733584.
Zheng F1, Quiocho FA.. " New structural insights into phosphorylation-free mechanism for full cyclin-dependent kinase (CDK)-cyclin activity and substrate recognition. " J. Biol. Chem.. 2013 18; 288 (42) : 30682-92.
Pubmed PMID: 24022486.
Alpadi K, Kulkarni A, Namjoshi S, Srinivasan S, Sippel KH, Ayscough K, Zieger M, Schmidt A, Mayer A, Evangelista M, Quiocho FA, Peters C. " Dynamin-SNARE interactions control trans-SNARE formation in intracellular membrane fusion. " Nat Commun. 2013 Apr 16; 4 : 1704.
Pubmed PMID: 23591871.
Huang Z, Srinivasan S, Zhang J, Chen K, Li Y, Li W, Quiocho FA, Pan X. " Discovering thiamine transporters as targets of chloroquine using a novel functional genomics strategy. " PLoS Genet.. 2012 Nov ; 8 (11) : e1003083.
Pubmed PMID: 23209439.
Finnigan GC, Cronan GE, Park HJ, Srinivasan S, Quiocho FA, Stevens TH. " Sorting of the Yeast Vacuolar-type, Proton-translocating ATPase Enzyme Complex (V-ATPase): IDENTIFICATION OF A NECESSARY AND SUFFICIENT GOLGI/ENDOSOMAL RETENTION SIGNAL IN Stv1p. " J. Biol. Chem.. 2012 Jun 1; 287 (23) : 19487-500.
Pubmed PMID: 22496448.
Zhang W, Chakravarty B, Zheng F, Gu Z, Wu H, Mao J, Wakil SJ, Quiocho FA. " Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-{gamma}-linolenic acid. " Proc. Natl. Acad. Sci. U.S.A.. 2011 Sep 20; 108 (38) : 15757-62.
Pubmed PMID: 21908709.
Srinivasan S, Vyas NK, Baker ML, Quiocho FA. " Crystal Structure of the Cytoplasmic N-Terminal Domain of Subunit I, a Homolog of Subunit a, of V-ATPase. " J. Mol. Biol.. 2011 Sep 9; 412 (1) : 14-21.
Pubmed PMID: 21787787.
Firozi P, Zhang W, Chen L, Quiocho FA, Worley KC, Templeton NS. " Identification and removal of colanic acid from plasmid DNA preparations: implications for gene therapy. " Gene Ther.. 2010 Dec ; 17 (12) : 1484-99.
Pubmed PMID: 20664542.
He B, Yu X, Margolis M, Liu X, Leng X, Etzion Y, Zheng F, Lu N, Quiocho FA, Danino D, Zhou Z. " Live-cell imaging in Caenorhabditis elegans reveals the distinct roles of dynamin self-assembly and guanosine triphosphate hydrolysis in the removal of apoptotic cells. " Mol. Biol. Cell. 2010 Feb 15; 21 (4) : 610-29.
Pubmed PMID: 20016007.
Vyas NK, Nickitenko A, Rastogi VK, Shah SS, Quiocho FA. " Structural insights into the dual activities of the nerve agent degrading organophosphate anhydrolase/prolidase. " Biochemistry. 2010 Jan 26; 49 (3) : 547-59.
Pubmed PMID: 20000741.

Memberships

Biophysical Society and Protein Society: Member

American Crystallographic Association: Member

American Society of Biochemistry and Molecular Biology: Member