Email

barbieri@bcm.edu

Positions

Associate Professor

Pediatrics
Hematology/Oncology
Baylor College of Medicine
Houston, TX US

Faculty Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States

Faculty Member

Graduate Program in Cancer and Cell Biology
Baylor College of Medicine
Houston, Texas United States

Addresses

1102 Bates Street (Lab)

Feigin Center
TXFC-C75003
Houston, TX 77030
United States
Phone: (832) 824-4747
barbieri@bcm.edu

Education

PhD from University of Bologna

04/2010 - Bologna, Italy

Oncology and Experimental Pathology

MD from University of Bologna

09/2005 - Bologna, Italy

Pediatrics- Hematology Oncology

MD from University of Bologna

03/1999 - Bologna, Italy

Honors & Awards

American Cancer Society Scholar

ACS

St. Baldrick's Scholar

St. Baldrick's Foundation

Hyundai Hope on Wheels Scholar

Hyundai Hope on Wheels

Young Investigator Award

Department of Pediatrics

High Impact Publication Award (senior author)

Department of Pediatrics

Professional Interests

• Neuroblastoma
• Cancer Metabolism
• Developmental Therapeutics
• Tumor Microenvironment and Immunometabolism

Professional Statement

My research goals and interests lie at the intersection between the study of the molecular mechanisms driving neuroblastoma oncogenesis, tumor metabolism, and translational oncology. Amplification of the MYCN oncogene is the most common genetic aberration in high-risk neuroblastoma and is associated with poor prognosis and chemoresistance. The long-term goal of my laboratory is to elucidate the MYCN-dependent pathways that serve as targets for neuroblastoma treatment. Toward this goal, my focus is to understand how MYCN drives undifferentiated, chemorefractory, and metabolically distinct tumors and develop novel approaches to intervention for high-risk MYCN-amplified disease.

Websites

Selected Publications

• Tao L, Moreno-Smith M, Ibarra-García-Padilla R, Milazzo G, Drolet NA, Hernandez BE, Oh YS, Patel I, Kim JJ, Zorman B, Patel T, Kamal AHM, Zhao Y, Hicks J, Vasudevan SA, Putluri N, Coarfa C, Sumazin P, Perini G, Parchem RJ, Uribe RA, Barbieri E. "CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming.." Adv Sci (Weinh). 2021; Pubmed PMID: 34365742
• Tao L, Mohammad MA, Milazzo G, Moreno-Smith M, Patel TD, Zorman B, Badachhape A, Hernandez BE, Wolf AB, Zeng Z, Foster JH, Aloisi S, Sumazin P, Zu Y, Hicks J, Ghaghada KB, Putluri N, Perini G, Coarfa C, Barbieri E. "MYCN-driven Fatty Acid Uptake is a Metabolic Vulnerability in Neuroblastoma.." Nat Commun.. 2022; Pubmed PMID: 35764645
• Moreno-Smith M, Milazzo G, Tao L, Fekry B, Zhu B, Mohammad MA, Di Giacomo S, Borkar R, Reddy KRK, Capasso M, Vasudevan SA, Sumazin P, Hicks J, Putluri N, Perini G, Eckel-Mahan K, Burris TP, Barbieri E. "Restoration of the molecular clock is tumor suppressive in neuroblastoma.." Nat Commun.. 2021; Pubmed PMID: 34183658
• Myrthala Moreno-Smith, Anna Lakoma, Zaowen Chen, Ling Tao...and Eveline Barbieri "p53 Nongenotoxic Activation and mTORC1 Inhibition Lead to Effective Combination for Neuroblastoma Therapy." Clin Cancer Res. 2017; Pubmed PMID: 28821555

Languages

Italian