Enrico Rey Barrozo, Ph.D.
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Enrico Rey Barrozo, Ph.D.
Assistant Professor
Positions
- Assistant Professor
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Obstetrics & Gynecology
Baylor College of Medicine
Houston, Texas US
- Faculty Member
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Development, Disease Models & Therapeutics Graduate Program
Baylor College of Medicine
Addresses
- Barrozo Lab (Office)
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One Baylor Plaza
203D
Houston, TX 77030
United States
Phone: (713) 798-7454
- Barrozo Lab (Lab)
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One Baylor Plaza
210D
Houston, TX 77030
United States
Professional Statement
At Baylor College of Medicine and Texas Children’s Hospital, I strive to understand the rules governing host-microbe interactions and early immune development. I have secured funding, including an NSF postdoctoral fellowship, an NIH Loan Repayment Award in Pediatrics, an R03 Maternal and Infant Environmental Health Riskscape (MIEHR) Pilot Award, and a $100,000 Career Development Award from the American Society for Gene & Cell Therapy (ASGCT). With this funding, we have pioneered spatial transcriptomics in human and mouse placenta tissue, identifying immune microenvironments in congenital ZIKV mouse models and placentae from human COVID-19 gravidae. We apply this approach to understand how environmental exposures, such as microplastic accumulation in the placenta, correlate with health disparities and developmental immunotoxicology. Additionally, we have conducted groundbreaking single-cell RNA-sequencing (scRNA-seq) studies on amniotic fluid and fetal cerebrospinal fluid (CSF) cells collected during laparoscopic fetoscopic repair of spina bifida. This research revealed clonal expansion and activation of fetal T cells as early as the second trimester in utero. Furthermore, we generated the first scRNA-seq data from pediatric RSV + SARS-CoV-2 co-infected subjects, uncovering synergistic and antagonistic innate immune responses. The combination of my training in multiomics, viral pathogenesis, and environmental exposures lend to a promising niche that aligns with the directives of the NICHD, NIAID, NIEHS, and NIMHD. Continued mentorship in maternal-fetal immunology and microbiome research will further enhance my capabilities. I am committed to leveraging Baylor's intellectual resources and Texas Children’s Hospital's facilities to explore genetic, environmental, and microbial molecular mechanisms driving perinatal and pediatric disease states.Websites
Selected Publications
- Barrozo ER, Seferovic MD, Castro ECC, Major AM, Moorshead DN, Jochum MD, Rojas RF, Shope CD, Aagaard KM "SARS-CoV-2 niches in human placenta revealed by spatial transcriptomics." Med. 2023 Jul 7; Pubmed PMID: 37423216
- Barrozo ER, Seferovic MD, Hamilton MP, Moorshead DN, Do T, O’Neil D, Aagaard KM "Zika virus co-opts microRNA networks to persist in placental niches detected by spatial transcriptomics." Am J Obstet Gynecol. 2023 Aug 18; Pubmed PMID: 37598997
- Barrozo ER, Aagaard KM "Human placental biology at single-cell resolution: a contemporaneous review." BJOG. 2021 Oct 15;
- Hunter R, Baird B, Garcia M, Begay J, Goitom S, Lucas S, Herbert G, Scieszka D, Padilla J, Brayer K, Ottens AK, Suter MA, Barrozo ER, Hines C, Bleske B, Campen MJ "Gestational Ozone Inhalation Elicits Maternal Cardiac Dysfunction and Transcriptional Changes to Placental Pericytes and Endothelial Cells." Toxicol Sci. 2023 Sep 11; Pubmed PMID: 37695302
- Hessami K, Norooznezhad AH, Monteiro S, Barrozo ER, Abdolmaleki AS, Arian SE, Zargarzadeh N, Shekerdemian LS, Aagaard KM, Shamshirsaz AA. "COVID-19 Pandemic and Infant Neurodevelopmental Impairment: A Systematic Review and Meta-analysis." JAMA Netw Open. 2022 Oct 3; Pubmed PMID: 36306133
- Hessami K, Aagaard KM, Castro EC, Arian SE, Nassr AA, Barrozo ER, Seferovic MD, Shamshirsaz AA "Placental Vascular and Inflammatory Findings from Pregnancies Diagnosed with Coronavirus Disease 2019: A Systematic Review and Meta-analysis." Am J Perinatol. 2022 Nov; Pubmed PMID: 35240710
- Walker K, Kalra D, Lowdon R, Chen G, Molik D, Soto DC, Dabbaghie F, Khleifat AA, Mahmoud M, Paulin LF, Raza MS, Pfeifer SP, Agustinho DP, Aliyev E, Avdeyev P, Barrozo ER, et al., Sedlazeck FJ, Busby B. "The third international hackathon for applying insights into large-scale genomic composition to use cases in a wide range of organisms." F1000Res. 2022 May 16; Pubmed PMID: 36262335
- Beavis AC, Tran Kim, Barrozo ER, Phan SI, Teng M, He Biao "Phosphoprotein Residue S156 Plays a Role in Regulating Genome Replication." J Virol. 2021 Oct 6; Pubmed PMID: 34613802
- Barrozo ER, Nakayama S, Singh P, Neumann D, Bloom DC "Herpes Simplex Virus 1 miRNA miR-H8 is Dispensable for Latency and Reactivation In Vivo." 2020; Pubmed PMID: 33208453
- Barrozo ER, Nakayama S, Singh P, Vanni EAH, Arvin AM, Neumann D, Bloom DC "Deletion of Herpes Simplex Virus 1 miRNAs miR-H1 and miR-H6 Impairs Reactivation." 2020; Pubmed PMID: 32295910
- Phelan D, Barrozo ER, Bloom DC "HSV1 latent transcription and non-coding RNA: A critical retrospective." 2017; Pubmed PMID: 28363461
- Barrozo ER, Fowler DA, Beckman ML "Exposure to D2-like dopamine receptor agonists inhibits swimming in Daphnia magna." 2015; Pubmed PMID: 26296938
- Garcia MA, Liu R, Nihart A, El Hayek E, Castillo E, Barrozo ER, Suter MA, Bleske B, Scott J, Forsythe K, Gonzalez-Estrella J, Aagaard KM, Campen MJ "Quantitation and identification of microplastics accumulation in human placental specimens using pyrolysis gas chromatography mass spectrometry." Toxicol Sci. 2024; Pubmed PMID: 38366932
- Garcia MA, Liu R, Nihart A, El Hayek E, Castillo E, Barrozo ER, Suter MA, Bleske B, Scott J, Forsythe K, Gonzalez-Estrella J, Aagaard KM, Campen MJ "Quantitation and identification of microplastics accumulation in human placental specimens using pyrolysis gas chromatography mass spectrometry." Toxicol Sci. 2024 Feb; Pubmed PMID: 38366932
- Barrozo ER, Racusin DA, Jochum MD, Garcia BT, Suter MA, Delbeccaro M, Shope C, Antony K, Aagaard KM. "Discrete placental gene expression signatures accompany diabetic disease classifications during pregnancy." Am J Obstet Gynecol. 2024 May; Pubmed PMID: 38763341
- Bolte E, Dean T, Garcia B, Seferovic MD, Sauter K, Hummel G, Bucher M, Li F, Hicks J, Qin X, Suter MA, Barrozo ER, Jochum M, Shope C, Friedman JE, Gannon M, Weslowski SR, Mccurdy CE, Kievit P, Aagaard KM "Initiation of metformin in early pregnancy results in fetal bioaccumulation, growth restriction & renal dysmorphology in a primate model." Am J Obstet Gynecol. 2024 Jun; Pubmed PMID: 38871238
Memberships
- American Association for the Advancement of Science
- Member (07/2015)
- American Society for Virology
- Member (07/2017)
- Edward A. Bouchet Graduate Honor Society
- Member (11/2019)
- American Society of Gene & Cell Therapy
- Associate Member (07/2019)
- National Postdoc Association
- Member (12/2020)
- Society for Maternal-Fetal Medicine
- Member (01/2021)
- American Society for Microbiology
- Member (02/2021)
- 10x Genomics Clinical Translational Research Network
- Member (05/2021)
- Society for Reproductive Investigation (SRI)
- Member (01/2022)
Funding
- F31 NIH Predoctoral Fellowship - #F31AI140713 (08/08/2019 - 12/31/2020) Grant funding from NIAID
- Career Development Award in Immunological Aspects of Gene Therapy and Vaccines
- $100,000.00 (01/01/2022 - 01/01/2023) Grant funding from American Society for Gene & Cell Therapy
- Molecular Mechanisms of Immune Programming In Utero - #2208903
- $138,000.00 (06/01/2022 - 02/01/2024) Grant funding from NSF Postdoctoral Research Fellowship in Biology
- NIH Loan Repayment Program, Pediatric Research - #1L40AI171990-01
- $100,000.00 (07/01/2022 - 06/01/2024) Grant funding from NIAID
- Maternal and Infant Environmental Health Riskscape (MIEHR) Pilot Award
- $50,000.00 (04/01/2023 - 04/01/2024) Grant funding from NIEHS/NIMHD
- Disproportionate Bioaccumulation of Microplastics in the Placentae of Vulnerable Populations Correlated with Adverse Obstetrics Outcomes
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