Email

dlwagner@bcm.edu

Positions

Assistant Professor

Center for Gene Therapy
Baylor College of Medicine

Addresses

BCM/CAGT - Feigin Center (Office)

1102 BATES AVE
Houston, TX, 77030
United States

Education

MD-PhD from Charité - Universitätsmedizin Berlin

06/2021 - Berlin, Germany

MD from Charité - Universitätsmedizin Berlin

12/2019 - Berlin, Germany

Research Fellowship at Baylor College of Medicine

12/2016 - Houston

Selected Publications

• Integration of ζ-deficient CARs into the CD3-zeta gene conveys potent cytotoxicity in T and NK cells " Blood. 2024 ;
  Pubmed PMID: 38493479.
• Combining different CRISPR nucleases for simultaneous knock-in and base editing prevents translocations in multiplex-edited CAR T cells " Genome Biol. 2023 ;
  Pubmed PMID: 37095570.
• Pharmacological interventions enhance virus-free generation of TRAC-replaced CAR T cells " Mol Ther Methods Clin Dev. 2022 ;
  Pubmed PMID: 35573047.
• High prevalence of Streptococcus pyogenes Cas9-reactive T cells within the adult human population " Nat Med. 2019 ;
  Pubmed PMID: 30374197.
• Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours " Nat Rev Clin Oncol. 2023 ;
  Pubmed PMID: 36418477.
• Immunogenicity of CAR T cells in cancer therapy " Nat Rev Clin Oncol. 2021 ;
  Pubmed PMID: 33633361.

Show 2 more publications

Memberships

American Society for Gene and Cell Therapy

Member (03/2027)

American Society for Gene and Cell Therapy

Committee Member 'Genome Editing' (06/2019 - 05/2025)

American Society for Gene and Cell Therapy

Committee Member 'Immune Responses to Gene Therapy' (06/2019 - 05/2025)

European Society for Gene and Cell Therapy

Academic Member (07/2017)

German Society for Gene Therapy (DG-GT e.V.)

Academic Member (01/2020)

Federation of Clinical Immunology Societies

Scientific Program Committee (08/2023 - 07/2026)

Dan L Duncan Comprehensive Cancer Center

Research Member (04/2024)

American Society for Gene and Cell Therapy

Editorial Board MTMCD (01/2024)

Languages

German