Dennis T. Villareal, MD, FACP, FGSA
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Dennis T. Villareal, MD, FACP, FGSA
Professor
Positions
- Professor
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Medicine-Endocrinology, Diabetes and Metabolism
Baylor College of Medicine
Houston, Texas United States
- Staff Physician
-
Medical Care and Research Service Lines
Michael E. DeBakey VA Medical Center
Houston, Texas United States
- Core Faculty
-
Center for Translational Research on Inflammatory Diseases (CTRID)
Michael E. DeBakey VA Medical Center
Baylor College of Medicine
Houston, Texas United States
Addresses
- Michael E. DeBakey VA Medical Center (Office)
-
Bldg 110, Rm 264
2002 Holcombe Blvd
Houston, TX 77030
United States
Education
- Fellowship at St Louis University School of Medicine
- 03/1994 - St Louis, Missouri United States
- Geriatric Medicine
- Residency at Washington University - Barnes-Jewish Hospital
- 06/1993 - St Louis, Missouri United States
- Internal Medicine
- Fellowship at Washington University - Barnes-Jewish Hospital
- 06/1991 - St Louis, Missouri United States
- Endocrinology, Diabetes, and Metabolism
- MD from Cebu Institute of Medicine
- Cebu City, Philippines
Certifications
- Endocrinology, Diabetes, and Metabolism
- American Board of Internal Medicine
Honors & Awards
- Academic Excellence in Clinical Research
- Physician Enterprise Vision Award (07/2023)
- Michael E. DeBakey M.D. Excellence in Research Award
- Baylor College of Medicine (05/2020)
- Clinical Trials Advisory Panel (CTAP) to the National Institute on Aging
- NIH - National Advisory Council on Aging (11/2016 - 10/2020)
- Clinical Integrative Diabetes and Obesity (CIDO) Study Section
- NIH - Scientific Review Panel Standing Member (01/2010 - 12/2014)
- Most Outstanding Cebu Institute of Medicine Alumni (MOCA)
- 12/2007
- K23 Patient-Oriented Research Career Development Award
- National Institute of Health (01/2001 - 12/2005)
- Elected Fellow
- Gerontological Society of America (2013) American College of Physicians (2001) American College of Endocrinology (1996)
- John M Kinney International Award for Nutrition and Metabolism
- 01/1992
Professional Interests
- Lifestyle, hormonal, and anabolic interventions to prevent or reverse sarcopenic obesity and frailty in older adults.
Professional Statement
I am a physician-scientist with specialized training in geriatrics and endocrinology. My research focuses on lifestyle interventions to reverse frailty and improve health outcomes in older adults with obesity. In my clinical and translational laboratories, I investigate hormonal, nutritional, and behavioral strategies to slow or reverse the complications of aging, including sarcopenic obesity and type 2 diabetes. I am committed to conducting research that informs clinical practice and advances optimal treatment strategies for older adults with obesity.Websites
Selected Publications
- Gregori G, Mediwala S, Liebschner M, Kim D, Bryant MS, Klonis N, Armamento-Villareal R, Qualls C, Villareal DT "Bone Quality Response to Lifestyle Intervention in Older Adults with Obesity (LIMB-Q Trial): a Randomized Controlled Trial." Lancet Healthy Longev. 2026 Sep 30; Pubmed PMID: 40976254
- Villareal DT, Aguirre L, Gurney AB, Waters DL, Sinacore DR, Colombo E, Armamento-Villareal R, Qualls C "Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults." N Engl J Med. 2017 18;376:1943-55. Pubmed PMID: 28514618
- Villareal DT, Chode S, Parimi N, Sinacore DR, Hilton T, Armamento-Villareal R, Napoli N, Qualls C, Shah K "Weight Loss, Exercise, or Both and Physical Function in Obese Older Adults." N Engl J Med. 2011;364:1219-1229. Pubmed PMID: 21449785
- Colleluori G, Aguirre L, Phadnis U, Fowler K, Armamento-Villareal R, Sun X, Brunetti L, Hyoung Park J, Kaipparettu BA, Purluri N, Auetumrongsawat V, Yarasheski K, Qualls C, Villareal DT "Aerobic Plus Resistance Exercise in Obese Older Adults Improves Muscle Protein Synthesis and Preserves Myocellular Quality Despite Weight Loss." Cell Metab. 2019;30(2):261-273. Pubmed PMID: 31279675
- Viola V, Samanta T, Nava M, Celli A, Armamento-Villareal R, Nguyen N, Colleluori G, Barnouin Y, Napoli N, Qualls C, Kaipparettu B, Villareal DT "Testosterone Modulation of Muscle Transcriptomic Profile During Lifestyle Therapy in Older Men with Obesity and Hypogonadism." J Cachexia Sarcopenia Muscle. 2025 Feb 16;1:e13697. Pubmed PMID: 40035362
- Gonzales-Gil A, Barnouin Y, Celli A, Viola V, Villarreal M, Nava M, Sciuk A, Qualls C, Armamento-Villareal R, Villareal DT "Metabolic effects of testosterone added to intensive lifestyle intervention in older men with obesity and hypogonadism." J Clin Endocrinol Metab. 2024 Apr 12; Pubmed PMID: 38606934
- Celli A, Barnouin Y, Jiang B, Blevins D, Colleluori G, Mediwala S, Armamento-Villareal R, Qualls C, Villareal DT "Lifestyle Intervention Strategy to Treat Diabetes in Older Adults: A Randomized Controlled Trial." Diabetes Care. 2022;45(9):1943-1952. Pubmed PMID: 35880801
- Panda S, Maier G, and Villareal DT "Targeting Energy Intake and Circadian Biology to Engage Mechanisms of Aging in Older Adults With Obesity: Calorie Restriction and Time-Restricted Eating." J Gerontol A Biol Sci Med. 2023 Jun 16;78:79-85. Pubmed PMID: 37325958
- Batsis JA, Villareal DT "Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies." Nat Rev Endocrinol. 2018 Sep;14(9):513-537. Pubmed PMID: 30065268
- Villareal DT, Apovian CM, Kushner RF, Klein S "Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society." Am J Clin Nutr. 2005 Nov;82(5):923-934. Pubmed PMID: 16280421
Funding
- Does Lifestyle Intervention in Obese Older Adults Improve Bone Quality? - #R01 DK109950 Grant funding from NIH - NIDDK
- Lifestyle Intervention plus Metformin to Treat Frailty in Older Veterans with Obesity - #101 CX002161 Grant funding from VA Merit Review
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