Dennis
Middle Name
T.
Villareal, MD
Middle Name
T.
Picture
Positions
- Professor
-
Medicine-Endocrinology, Diabetes and Metabolism
Baylor College of Medicine
Houston, Texas United States
- Staff Physician
-
Medical Care and Research Service Lines
Michael E. DeBakey VA Medical Center
Houston, Texas United States
Addresses
- Michael E. DeBakey VA Medical Center (Office)
-
Bldg 110, Rm 264
2002 Holcombe Blvd
Houston, TX 77030
United States
Education
- Fellowship at St Louis University School of Medicine
- 03/1994 - St Louis, Missouri United States
- Geriatric Medicine
- Fellowship at Washington University - Barnes-Jewish Hospital
- 06/1991 - St Louis, Missouri United States
- Endocrinology, Diabetes, and Metabolism
- Residency at Washington University - Barnes-Jewish Hospital
- 06/1993 - St Louis, Missouri United States
- Internal Medicine
- MD from Cebu Institute of Medicine
- Cebu City, Philippines
Certifications
- Endocrinology, Diabetes, and Metabolism
- American Board of Internal Medicine
- Geriatric Medicine
- American Board of Internal Medicine
Honors & Awards
- Michael E. DeBakey M.D. Excellence in Research Award
- Baylor College of Medicine (05/2020)
- Clinical Trials Advisory Panel (CTAP) to the National Institute on Aging
- NIH - National Advisory Council on Aging (11/2016)
- Clinical Integrative Diabetes and Obesity (CIDO) Study Section
- NIH - Scientific Review Panel Standing Member (01/2010 - 12/2014)
- Inducted to Fellowship
- Gerontological Society of America (11/2013)
- Most Outstanding Cebu Institute of Medicine Alumni (MOCA)
- 12/2007
- K23 Patient-Oriented Research Career Development Award
- National Institute of Health (01/2001 - 12/2005)
- Inducted to Fellowship
- American College of Physicians (01/2001)
- Inducted to Fellowship
- American College of Endocrinology (01/1996)
- John M Kinney International Award for Nutrition and Metabolism
- 01/1992
Professional Interests
- Lifestyle, hormonal, and anabolic interventions to ameliorate sarcopenic obesity and frailty
Professional Statement
I am a physician-scientist with specialty training in geriatrics and endocrinology. I have extensive clinical and research experience in examining the impact of lifestyle interventions in reversing frailty in older adults with obesity. My clinical and translational laboratories involve hormonal, nutritional, and behavioral/lifestyle interventions to retard or reverse the metabolic and physical complications of aging, including sarcopenic obesity and type 2 diabetes. I am dedicated to research designed to inform practice guidelines with respect to optimal treatment strategies for older adults with obesity.Websites
Selected Publications
- Armamento-Villareal R, Aguirre L, Waters DL, Napoli N, Qualls C, Villareal DT "Effect of Aerobic or Resistance Exercise, or Both, on Bone Mineral Density and Bone Metabolism in Obese Older Adults While Dieting: A Randomized Controlled Trial." J Bone Miner Res. 2020 March ; 35 : 430-439. Pubmed PMID: 31797417
- Colleluori G, Aguirre L, Phadnis U, Fowler K, Armamento-Villareal R, Sun X, Brunetti L, Hyoung Park J, Kaipparettu BA, Purluri N, Auetumrongsawat V, Yarasheski K, Qualls C, Villareal DT "Aerobic Plus Resistance Exercise in Obese Older Adults Improves Muscle Protein Synthesis and Preserves Myocellular Quality Despite Weight Loss." Cell Metab. 2019 August 6; 30 (2): 261-273. Pubmed PMID: 31279675
- Batsis JA, Villareal DT "Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies." Nat Rev Endocrinol. 2018 September ; 14 (9): 513-537. Pubmed PMID: 30065268
- Villareal DT, Aguirre L, Gurney AB, Waters DL, Sinacore DR, Colombo E, Armamento-Villareal R, Qualls C "Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults." N Engl J Med. 2017 May 18; 376 : 1943-55. Pubmed PMID: 28514618
- Villareal DT, Chode S, Parimi N, Sinacore DR, Hilton T, Armamento-Villareal R, Napoli N, Qualls C, Shah K "Weight Loss, Exercise, or Both and Physical Function in Obese Older Adults." N Engl J Med. 2011 364 : 1219-1229. Pubmed PMID: 21449785
- Colleluori G, Napoli H, Phadnis U, Armamento-Villareal R, Villareal DT "Effect of Weight Loss, Exercise, or Both on Undercarboxylated Osteocalcin and Insulin Secretion in Frail, Obese Older Adults." Oxid Med Cell Longev. 2017 August 23; (1): 1-13. Pubmed PMID: 28951766
- Weiss EP, Jordan RC, Frese EM, Albert SG, Villareal DT "Effects of Weight Loss on Lean Mass, Strength, Bone, and Aerobic Capacity." Med Sci Sports Exerc. 2017 January ; 49 : 206-217. Pubmed PMID: 27580151
- Villareal DT, Fontana L, Das SK, Redman L, Smith SR, Saltzman E, Bales C, Rochon J, Pieper C, Huang M, Lewis M, Schwartz AV; CALERIE Study Group "Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-Obese Younger Adults: a Randomized Clinical Trial." J Bone Miner Res. 2016 January ; : 40-51. Pubmed PMID: 26332798
- Armamento-Villareal R, Aguirre LE, Qualls C, Villareal DT "Effect of Lifestyle Intervention on the Hormonal Profile of Frail, Obese Older Men." J Nutr Health Aging. 2016 March ; 20 : 334-40. Pubmed PMID: 26892583
- Weiss, E. P., Albert, S. G., Reeds, D. N., Kress, K. S., Ezekiel, U. R., McDaniel, J. L., Patterson, B. W., Klein, S., and Villareal, D. T "Calorie Restriction and Matched Weight Loss from Exercise: Independent and Additive Effects on Glucoregulation and the Incretin System in Overweight Women and Men." Diabetes Care. 2015 : Pubmed PMID: 25877812
- Napoli N, Shah K, Waters D, Sinacore DR, Qualls C, Villareal DT. "Effect of Weight Loss, Exercise, or Both on Cognition and Quality of Life in Obese Older Adults." Am J Clin Nutr. 2014 100 : 189-198. Pubmed PMID: 24787497
- Bouchonville M, Armamento-Villareal R, Shah K, Napoli N, Sinacore DR, Qualls C, Villareal DT "Weight Loss, Exercise, or Both and Cardiometabolic Risk Factors in Obese Older Adults: Results of a Randomized Controlled Trial." Int J Obes. 2014 38 : 423-431. Pubmed PMID: 23823329
- Waters D, Vawter R, Qualls C, Chode S, Armamento-Villareal R, Villareal DT "Long-Term Maintenance of Weight Loss After Lifestyle Intervention in Frail, Obese Older Adults." J Nutr Health Aging. 2013 17 : 3-7. Pubmed PMID: 23299370
- Armamento-Villareal R, Aguirre L, Napoli N, Shah K, Hilton T, Sinacore D, Qualls C, Villareal DT "Changes in Thigh Muscle Volume predict Bone Mineral Density Response to Lifestyle Therapy in Frail, Obese Older Adults." Osteop Int. 2014 25 : 551-558. Pubmed PMID: 23892583
- Villareal DT, Smith G, Shah K, Mittendorfer, B "Effect of Weight Loss on the Rate of Muscle Protein Synthesis during Fasted and Fed Conditions in Obese Older Adults." Obesity. 2012 20 : 1780-1786. Pubmed PMID: 21938075
- Shah,K, Armamento-Villareal,R, Parimi,N, Chode,S, Sinacore,D.R, Hilton,T.N, Napoli,N, Qualls,C. and Villareal, DT "Exercise Training in Obese Older Adults Prevents Increase in Bone Turnover and Attenuates Decrease in Hip BMD Induced by Weight Loss Despite Decline in Bone-Active Hormones." J Am Bone Miner Res. 2011 12 : 2851-2859. Pubmed PMID: 21786319
- Villareal DT, Kotyk J, Armamento-Villareal R, Kenguva V, Seaman P, Shahar A, Wald M, Kleerekoper M, Fontana L "Reduced Bone Mineral Density is not associated with Significantly Reduced Bone Quality in Men and Women Practicing Long-Term Calorie Restriction with Adequate Nutrition." Aging Cell. 2011 10 : 96-102. Pubmed PMID: 20489691
- Villareal DT, Robertson H, Bell G, Patterson BW, Tran H, Wice B, and Polonsky KS "TCF7L2 Variant rs7903146 Affects the Risk of Type 2 Diabetes by Modulating Incretin Action." Diabetes. 2010 59 : 475-485. Pubmed PMID: 19934000
- Villareal DT, Koster J, Robertson H, Miyake K, Bell G, Patterson B, Nichols C, and Polonsky K. "Kir6.2 Variant E23K Increases ATP-Sensitive Potassium Channel Activity and is Associated with Impaired Insulin Release and Enhanced Insulin Sensitivity in Adults with Normal Glucose Tolerance." Diabetes. 2009 58 : 1869-1878. Pubmed PMID: 19491206
- Shah K, Stufflebam A, Hilton T, Sinacore D, Klein S, and Villareal DT "Diet and exercise interventions reduce intrahepatic fat content and improve insulin sensitivity in obese older adults." Obesity. 2009 December ; 17 : 2162-8. Pubmed PMID: 19390517
- Villareal DT, Smith GI, Sinacore DR, Shah K, Mittendorfer B "Regular Multicomponent Exercise Increases Physical Fitness and Muscle Protein Anabolism in Frail, Obese, Older Adults." Obesity. 2010 19 : 312-318. Pubmed PMID: 20489691
Funding
- Does Lifestyle Intervention in Obese Older Adults Improve Bone Quality? - #R01 DK109950 (06/01/2017 - 05/31/2023) Grant funding from NIH - NIDDK
- Lifestyle Intervention plus Metformin to Treat Frailty in Older Veterans with Obesity - #101 CX002161 (10/01/2020 - 09/30/2024) Grant funding from VA Merit Review
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