Email

kearney@bcm.edu

Positions

Associate Professor

Pathology & Immunology
Baylor College of Medicine
Houston, TX, US

Education

Advanced Training from Baylor College Of Medicine

01/1989 - Houston, TX, United States

Advanced Training from Mayo Clinic (Rochester)

01/1984 - Rochester, MN, United States

Advanced Training from Baylor College Of Medicine

01/1984 - Houston, TX, United States

M.D. from Northwestern University Medical School

01/1980 - Chicago, IL, United States

Websites

Selected Publications

• Seeborg FO, Paul ME, Abramson SL, Kearney DL, Dorfman SR, Holland SM, Shearer WT. " A 5-week-old HIV-1-exposed girl with failure to thrive and diffuse nodular pulmonary infiltrates. " J. Allergy Clin. Immunol.. 2004 Apr ; 113 (4) : 627-34.
  Pubmed PMID: 15100665.
• O'Doherty RM, Jensen PB, Anderson P, Jones JG, Berman HK, Kearney D, Newgard CB. " Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen. " J. Clin. Invest.. 2000 Feb ; 105 (4) : 479-88.
  Pubmed PMID: 10683377.
• Martin AB, Webber S, Fricker FJ, Jaffe R, Demmler G, Kearney D, Zhang YH, Bodurtha J, Gelb B, Ni J. " Acute myocarditis. Rapid diagnosis by PCR in children. " Circulation. 1994 Jul ; 90 (1) : 330-9.
  Pubmed PMID: 8026015.
• Browne LP, Kearney D, Taylor MD, Chung T, Slesnick TC, Nutting AC, Krishnamurthy R. " ALCAPA: the role of myocardial viability studies in determining prognosis. " Pediatr Radiol. 2010 Feb ; 40 (2) : 163-7.
  Pubmed PMID: 19795113.
• Siu BL, Kovalchin JP, Kearney DL, Fraser CD, Fenrich AL. " Aneurysmal dilatation of the ductus arteriosus in a neonate. " Pediatr Cardiol. ; 22 (5) : 403-5.
  Pubmed PMID: 11526417.
• Schowengerdt KO, Ni J, Denfield SW, Gajarski RJ, Bowles NE, Rosenthal G, Kearney DL, Price JK, Rogers BB, Schauer GM, Chinnock RE, Towbin JA. " Association of parvovirus B19 genome in children with myocarditis and cardiac allograft rejection: diagnosis using the polymerase chain reaction. " Circulation. 1997 Nov 18; 96 (10) : 3549-54.
  Pubmed PMID: 9396454.
• Grifka RG, Vick GW, O'Laughlin MP, Myers TJ, Morrow WR, Nihill MR, Kearney DL, Mullins CE. " Balloon expandable intravascular stents: aortic implantation and late further dilation in growing minipigs. " Am. Heart J.. 1993 Oct ; 126 (4) : 979-84.
  Pubmed PMID: 8213458.
• Park P, Khawly JA, Kearney DL, Altman CA, Yen KG. " Bilateral endogenous endophthalmitis secondary to endocarditis with negative transesophageal echocardiogram. " Am. J. Ophthalmol.. 2004 Jul ; 138 (1) : 151-3.
  Pubmed PMID: 15234302.
• Desai MS, Zainuer S, Kennedy C, Kearney D, Goss J, Karpen SJ. " Cardiac structural and functional alterations in infants and children with biliary atresia, listed for liver transplantation. " Gastroenterology. 2011 Oct ; 141 (4) : 1264-1272.e4.
  Pubmed PMID: 21762660.
• Ladd AN, Taffet G, Hartley C, Kearney DL, Cooper TA. " Cardiac tissue-specific repression of CELF activity disrupts alternative splicing and causes cardiomyopathy. " Mol. Cell. Biol.. 2005 Jul ; 25 (14) : 6267-78.
  Pubmed PMID: 15988035.
• Carr M, Kearney DL, Eidem BW. " Congenital aneurysm of the muscular interventricular septum. " J Am Soc Echocardiogr. 2008 Nov ; 21 (11) : 1282.e1-6.
  Pubmed PMID: 18313262.
• Angelini P, de la Cruz MV, Valencia AM, Sánchez-Gómez C, Kearney DL, Sadowinski S, Real GR. " Coronary arteries in transposition of the great arteries. " Am. J. Cardiol.. 1994 Nov 15; 74 (10) : 1037-41.
  Pubmed PMID: 7977043.
• Belton O, Byrne D, Kearney D, Leahy A, Fitzgerald DJ. " Cyclooxygenase-1 and -2-dependent prostacyclin formation in patients with atherosclerosis. " Circulation. 2000 Aug 22; 102 (8) : 840-5.
  Pubmed PMID: 10952950.
• Yang Z, McMahon CJ, Smith LR, Bersola J, Adesina AM, Breinholt JP, Kearney DL, Dreyer WJ, Denfield SW, Price JF, Grenier M, Kertesz NJ, Clunie SK, Fernbach SD, Southern JF, Berger S, Towbin JA, Bowles KR, Bowles NE. " Danon disease as an underrecognized cause of hypertrophic cardiomyopathy in children. " Circulation. 2005 Sep 13; 112 (11) : 1612-7.
  Pubmed PMID: 16144992.
• Yang Z, Bowles NE, Scherer SE, Taylor MD, Kearney DL, Ge S, Nadvoretskiy VV, DeFreitas G, Carabello B, Brandon LI, Godsel LM, Green KJ, Saffitz JE, Li H, Danieli GA, Calkins H, Marcus F, Towbin JA. " Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. " Circ. Res.. 2006 Sep 15; 99 (6) : 646-55.
  Pubmed PMID: 16917092.
• Bowles NE, Ni J, Kearney DL, Pauschinger M, Schultheiss HP, McCarthy R, Hare J, Bricker JT, Bowles KR, Towbin JA. " Detection of viruses in myocardial tissues by polymerase chain reaction. evidence of adenovirus as a common cause of myocarditis in children and adults. " J. Am. Coll. Cardiol.. 2003 Aug 6; 42 (3) : 466-72.
  Pubmed PMID: 12906974.
• Denfield SW, Kearney DL, Michael L, Gittenberger-de Groot A, Garson A. " Developmental differences in canine cardiac surgical scars. " Am. Heart J.. 1993 Aug ; 126 (2) : 382-9.
  Pubmed PMID: 8338009.
• Schowengerdt KO, Ni J, Denfield SW, Gajarski RJ, Radovancevic B, Frazier HO, Demmler GJ, Kearney D, Bricker JT, Towbin JA. " Diagnosis, surveillance, and epidemiologic evaluation of viral infections in pediatric cardiac transplant recipients with the use of the polymerase chain reaction. " J. Heart Lung Transplant.. 1996 Feb ; 15 (2) : 111-23.
  Pubmed PMID: 8672514.
• Huhta JC, Latson LA, Gutgesell HP, Cooley DA, Kearney DL. " Echocardiography in the diagnosis and management of symptomatic aortic valve stenosis in infants. " Circulation. 1984 Sep ; 70 (3) : 438-44.
  Pubmed PMID: 6744548.
• Wang GS, Kearney DL, De Biasi M, Taffet G, Cooper TA. " Elevation of RNA-binding protein CUGBP1 is an early event in an inducible heart-specific mouse model of myotonic dystrophy. " J. Clin. Invest.. 2007 Oct ; 117 (10) : 2802-11.
  Pubmed PMID: 17823658.
• Hauck AJ, Kearney DL, Edwards WD. " Evaluation of postmortem endomyocardial biopsy specimens from 38 patients with lymphocytic myocarditis: implications for role of sampling error. " Mayo Clin. Proc.. 1989 Oct ; 64 (10) : 1235-45.
  Pubmed PMID: 2593714.
• Stephens EH, Shangkuan J, Kuo JJ, Carroll JL, Kearney DL, Carberry KE, Fraser CD, Grande-Allen KJ. " Extracellular matrix remodeling and cell phenotypic changes in dysplastic and hemodynamically altered semilunar human cardiac valves. " Cardiovasc. Pathol.. ; 20 (5) : e157-67.
  Pubmed PMID: 20817569.
• Kearney DL, Towbin JA, Bricker JT, Radovancevic B, Frazier OH. " Familial right ventricular dysplasia (cardiomyopathy). " Pediatr Pathol Lab Med. ; 15 (1) : 181-9.
  Pubmed PMID: 8736609.
• Miller DJ, Maisch SA, Perez MD, Kearney DL, Feltes TF. " Fatal myocardial infarction in an 8-year-old girl with systemic lupus erythematosus, Raynaud's phenomenon, and secondary antiphospholipid antibody syndrome. " J. Rheumatol.. 1995 Apr ; 22 (4) : 768-73.
  Pubmed PMID: 7791180.
• Aboutalebi A, Kearney DL, Metry DW. " Flesh-colored, rubbery nodules in a young girl. " Pediatr Dermatol. 2010 May ; 27 (3) : 299-300.
  Pubmed PMID: 20609150.
• Lu CW, Lin JH, Rajawat YS, Jerng H, Rami TG, Sanchez X, DeFreitas G, Carabello B, DeMayo F, Kearney DL, Miller G, Li H, Pfaffinger PJ, Bowles NE, Khoury DS, Towbin JA. " Functional and clinical characterization of a mutation in KCNJ2 associated with Andersen-Tawil syndrome. " J. Med. Genet.. 2006 Aug ; 43 (8) : 653-9.
  Pubmed PMID: 16571646.
• Chen-An Lee T, Kim ES, Ferrell LB, Brandt ML, Minifee PK, Midgen C, Domingo RP, Kearney DL. " Gastric duplication cysts of the pancreas: clinical presentation and surgical management. " Eur J Pediatr Surg. 2011 Dec ; 21 (6) : 402-4.
  Pubmed PMID: 21901665.
• Murray JC, Singh RR, Brandt ML, Kearney DL, Ogden AK. " Granulomatous submandibular lymphadenitis caused by Salmonella species in a healthy child. " Clin. Infect. Dis.. 1994 Dec ; 19 (6) : 1175-6.
  Pubmed PMID: 7888569.
• Dearlove J, Kearney D. " How good is general practice developmental screening? " BMJ. 1990 May 5; 300 (6733) : 1177-80.
  Pubmed PMID: 1693300.
• Mullins CE, O'Laughlin MP, Vick GW, Mayer DC, Myers TJ, Kearney DL, Schatz RA, Palmaz JC. " Implantation of balloon-expandable intravascular grafts by catheterization in pulmonary arteries and systemic veins. " Circulation. 1988 Jan ; 77 (1) : 188-99.
  Pubmed PMID: 3335067.
• Garson A, Smith RT, Moak JP, Kearney DL, Hawkins EP, Titus JL, Cooley DA, Ott DA. " Incessant ventricular tachycardia in infants: myocardial hamartomas and surgical cure. " J. Am. Coll. Cardiol.. 1987 Sep ; 10 (3) : 619-26.
  Pubmed PMID: 3624668.
• Stephens EH, Kearney DL, Grande-Allen KJ. " Insight into pathologic abnormalities in congenital semilunar valve disease based on advances in understanding normal valve microstructure and extracellular matrix. " Cardiovasc. Pathol.. 2012 Jan ; 21 (1) : 46-58.
  Pubmed PMID: 21349746.
• Lapointe A, Parke RB, Kearney DL, Morriss MC, Krance RA, Friedman EM. " Laryngectomy for fungal abscesses of the larynx. " Otolaryngol Head Neck Surg. 2004 Dec ; 131 (6) : 1007-8.
  Pubmed PMID: 15577806.
• Perry JC, Kearney DL, Friedman RA, Moak JP, Garson A. " Late ventricular arrhythmia and sudden death following direct-current catheter ablation of the atrioventricular junction. " Am. J. Cardiol.. 1992 Sep 15; 70 (7) : 765-8.
  Pubmed PMID: 1519527.
• Fenrich AL, Friedman RA, Cecchin FC, Kearney D. " Left-sided atrioventricular nodal ablation using the transseptal approach: clinico-histopathologic correlation. " J. Cardiovasc. Electrophysiol.. 1998 Jul ; 9 (7) : 757-60.
  Pubmed PMID: 9684723.
• Kertesz NJ, Towbin JA, Clunie S, Fenrich AL, Friedman RA, Kearney DL, Dreyer WJ, Price JF, Radovancevic B, Denfield SW. " Long-term follow-up of arrhythmias in pediatric orthotopic heart transplant recipients: incidence and correlation with rejection. " J. Heart Lung Transplant.. 2003 Aug ; 22 (8) : 889-93.
  Pubmed PMID: 12909469.
• Gajarski RJ, Smith EO, Denfield SW, Rosenblatt HM, Kearney D, Frazier OH, Radovancevic B, Price JK, Kertesz NJ, Towbin JA. " Long-term results of triple-drug-based immunosuppression in nonneonatal pediatric heart transplant recipients. " Transplantation. 1998 Jun 15; 65 (11) : 1470-6.
  Pubmed PMID: 9645805.
• Kearney D, Cahill RA, O'Brien E, Kirwan WO, Redmond HP. " Influence of delays on perforation risk in adults with acute appendicitis. " Dis. Colon Rectum. 2008 Dec ; 51 (12) : 1823-7.
  Pubmed PMID: 18584252.
• Kannankeril PJ, Mitchell BM, Goonasekera SA, Chelu MG, Zhang W, Sood S, Kearney DL, Danila CI, De Biasi M, Wehrens XH, Pautler RG, Roden DM, Taffet GE, Dirksen RT, Anderson ME, Hamilton SL. " Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. " Proc. Natl. Acad. Sci. U.S.A.. 2006 Aug 8; 103 (32) : 12179-84.
  Pubmed PMID: 16873551.
• Purevjav E, Arimura T, Augustin S, Huby AC, Takagi K, Nunoda S, Kearney DL, Taylor MD, Terasaki F, Bos JM, Ommen SR, Shibata H, Takahashi M, Itoh-Satoh M, McKenna WJ, Murphy RT, Labeit S, Yamanaka Y, Machida N, Park JE, Alexander PM, Weintraub RG, Kitaura. " Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations. " Hum. Mol. Genet.. 2012 May 1; 21 (9) : 2039-53.
  Pubmed PMID: 22286171.
• Zaidi S, Elidemir O, Heinle JS, McKenzie ED, Schecter MG, Kaplan SL, Dishop MK, Kearney DL, Mallory GB. " Mycobacterium abscessus in cystic fibrosis lung transplant recipients: report of 2 cases and risk for recurrence. " Transpl Infect Dis. 2009 Jun ; 11 (3) : 243-8.
  Pubmed PMID: 19298240.
• Purevjav E, Nelson DP, Varela JJ, Jimenez S, Kearney DL, Sanchez XV, DeFreitas G, Carabello B, Taylor MD, Vatta M, Shearer WT, Towbin JA, Bowles NE. " Myocardial Fas ligand expression increases susceptibility to AZT-induced cardiomyopathy. " Cardiovasc. Toxicol.. 2007 ; 7 (4) : 255-63.
  Pubmed PMID: 17943461.
• Breinholt JP, Vallejo JG, Gates CM, Clunie SK, Kearney DL, Dreyer WJ, Towbin JA, Bowles NE. " Myocardial pro-inflammatory cytokine expression and cellular rejection in pediatric heart transplant recipients. " J. Heart Lung Transplant.. 2008 Mar ; 27 (3) : 317-24.
  Pubmed PMID: 18342755.
• Purevjav E, Varela J, Morgado M, Kearney DL, Li H, Taylor MD, Arimura T, Moncman CL, McKenna W, Murphy RT, Labeit S, Vatta M, Bowles NE, Kimura A, Boriek AM, Towbin JA. " Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis. " J. Am. Coll. Cardiol.. 2010 Oct 26; 56 (18) : 1493-502.
  Pubmed PMID: 20951326.
• Louis PT, Bricker JT, Frazier OH, Duncan M, Towbin JA, Gelb BD, Macris MA, Radovencavic B, Kearney D, Igo S. " Nonpulsatile total left ventricular support in pediatric patients. " Crit. Care Med.. 1992 May ; 20 (5) : 704-7.
  Pubmed PMID: 1572197.
• Sen P, Yang Y, Navarro C, Silva I, Szafranski P, Kolodziejska KE, Dharmadhikari AV, Mostafa H, Kozakewich H, Kearney D, Cahill JB, Whitt M, Bilic M, Margraf L, Charles A, Goldblatt J, Gibson K, Lantz PE, Garvin AJ, Petty J, Kiblawi Z, Zuppan C, McConkie-R. " Novel FOXF1 Mutations in Sporadic and Familial Cases of Alveolar Capillary Dysplasia with Misaligned Pulmonary Veins Imply a Role for its DNA Binding Domain. " Hum. Mutat.. 2013 Jun ; 34 (6) : 801-11.
  Pubmed PMID: 23505205.
• Kearney DL, Titus JL, Hawkins EP, Ott DA, Garson A. " Pathologic features of myocardial hamartomas causing childhood tachyarrhythmias. " Circulation. 1987 Apr ; 75 (4) : 705-10.
  Pubmed PMID: 3829332.
• Friedman RA, Kearney DL, Moak JP, Fenrich AL, Perry JC. " Persistence of ventricular arrhythmia after resolution of occult myocarditis in children and young adults. " J. Am. Coll. Cardiol.. 1994 Sep ; 24 (3) : 780-3.
  Pubmed PMID: 8077553.
• Kearney DL, Perez-Atayde AR, Easley KA, Bowles NE, Bricker JT, Colan SD, Kaplan S, Lai WW, Lipshultz SE, Moodie DS, Sopko G, Starc TJ, Towbin JA. " Postmortem cardiomegaly and echocardiographic measurements of left ventricular size and function in children infected with the human immunodeficiency virus. The Prospective P2C2 HIV Multicenter Study. " Cardiovasc. Pathol.. ; 12 (3) : 140-8.
  Pubmed PMID: 12763553.
• Nowlen TT, Ayres NA, Kearney DL, Nihill MR, Grifka RG. " Premature closure of the foramen ovale associated with aortic stenosis, left ventricular dilation with thrombus, and early mortality. " Am. J. Cardiol.. 2000 May 1; 85 (9) : 1159-61, A9.
  Pubmed PMID: 10781774.
• Kim JJ, Kearney DL, Grifka RG, McKenzie ED, Mott AR. " Pulmonary venous stenosis as an associated manifestation of left-sided obstructive lesions in an infant with partial atrioventricular canal defect. " Pediatr Cardiol. ; 26 (4) : 449-51.
  Pubmed PMID: 16374697.
• Carlson P, Jefferies JL, Kearney D, Russell H. " Refractory dilated cardiomyopathy associated with metastatic neuroblastoma. " Pediatr Blood Cancer. 2010 Oct ; 55 (4) : 736-8.
  Pubmed PMID: 20589652.
• Arora G, Fraser CD, Kearney DL, Vincent JA. " Severe supravalvar aortic stenosis in familial homozygous hypercholesterolemia. " Pediatr Cardiol. ; 27 (2) : 282-5.
  Pubmed PMID: 16261269.
• McMahon CJ, Thompson KS, Kearney DL, Nihill MR. " Subclavian steal syndrome in anomalous connection of the left subclavian artery to the pulmonary artery in d-transposition of the great arteries. " Pediatr Cardiol. ; 22 (1) : 60-2.
  Pubmed PMID: 11123131.
• Rivenes SM, Kearney DL, Smith EO, Towbin JA, Denfield SW. " Sudden death and cardiovascular collapse in children with restrictive cardiomyopathy. " Circulation. 2000 Aug 22; 102 (8) : 876-82.
  Pubmed PMID: 10952956.
• Garson A, Gillette PC, Titus JL, Hawkins E, Kearney D, Ott D, Cooley DA, McNamara DG. " Surgical treatment of ventricular tachycardia in infants. " N. Engl. J. Med.. 1984 May 31; 310 (22) : 1443-5.
  Pubmed PMID: 6717523.
• Kearney D, Fitzgerald D. " The anti-thrombotic effects of statins. " J. Am. Coll. Cardiol.. 1999 Apr ; 33 (5) : 1305-7.
  Pubmed PMID: 10193731.
• Bowles NE, Kearney DL, Ni J, Perez-Atayde AR, Kline MW, Bricker JT, Ayres NA, Lipshultz SE, Shearer WT, Towbin JA. " The detection of viral genomes by polymerase chain reaction in the myocardium of pediatric patients with advanced HIV disease. " J. Am. Coll. Cardiol.. 1999 Sep ; 34 (3) : 857-65.
  Pubmed PMID: 10483970.
• Kearney DL. " The pathological spectrum of left-ventricular hypoplasia. " Semin Cardiothorac Vasc Anesth. 2013 Jun ; 17 (2) : 105-16.
  Pubmed PMID: 23657433.
• Miller RG, Robie DK, Davis SL, Cooley DA, Klish WJ, Skolkin MD, Kearney DL, Jaksic T. " Survival after aberrant right subclavian artery-esophageal fistula: case report and literature review. " J. Vasc. Surg.. 1996 Aug ; 24 (2) : 271-5.
  Pubmed PMID: 8752039.
• Jeewa A, Dreyer WJ, Kearney DL, Denfield SW. " The presentation and diagnosis of coronary allograft vasculopathy in pediatric heart transplant recipients. " Congenit Heart Dis. 2012 Jul ; 7 (4) : 302-11.
  Pubmed PMID: 22497818.
• Muscal E, Edwards RM, Kearney DL, Hicks JM, Myones BL, Teruya J. " Thrombotic Microangiopathic Hemolytic Anemia With Reduction of ADAMTS13 Activity: Initial Manifestation of Childhood-Onset Systemic Lupus Erythematosus. " Am. J. Clin. Pathol.. 2011 Mar ; 135 (3) : 406-16.
  Pubmed PMID: 21350095.
• Gajarski RJ, Kearney DL, Price JK, Denfield SW. " Update on pediatric heart transplantation. Long-term complications. " Tex Heart Inst J. 1997 ; 24 (4) : 260-8.
  Pubmed PMID: 9456478.
• Kertesz NJ, Denfield SW, Kearney DL, Towbin JA, Price JK, Gajarski RJ. " Usefulness of routine surveillance biopsies in children more than one year after orthotopic heart transplantation. " Am. J. Cardiol.. 2001 Mar 1; 87 (5) : 667-8, A11.
  Pubmed PMID: 11230863.
• Pass AK, McLin VA, Rushton JR, Kearney DL, Hastings CA, Margolin JF. " Vanishing bile duct syndrome and Hodgkin disease: a case series and review of the literature. " J. Pediatr. Hematol. Oncol.. 2008 Dec ; 30 (12) : 976-80.
  Pubmed PMID: 19131796.
• Moulik M, Breinholt JP, Dreyer WJ, Kearney DL, Price JF, Clunie SK, Moffett BS, Kim JJ, Rossano JW, Jefferies JL, Bowles KR, O'Brian Smith E, Bowles NE, Denfield SW, Towbin JA. " Viral endomyocardial infection is an independent predictor and potentially treatable risk factor for graft loss and coronary vasculopathy in pediatric cardiac transplant recipients. " J. Am. Coll. Cardiol.. 2010 Aug 10; 56 (7) : 582-92.
  Pubmed PMID: 20688214.
• Breinholt JP, Moulik M, Dreyer WJ, Denfield SW, Kim JJ, Jefferies JL, Rossano JW, Gates CM, Clunie SK, Bowles KR, Kearney DL, Bowles NE, Towbin JA. " Viral epidemiologic shift in inflammatory heart disease: the increasing involvement of parvovirus B19 in the myocardium of pediatric cardiac transplant patients. " J. Heart Lung Transplant.. 2010 Jul ; 29 (7) : 739-46.
  Pubmed PMID: 20456978.
• Ni J, Bowles NE, Kim YH, Demmler G, Kearney D, Bricker JT, Towbin JA. " Viral infection of the myocardium in endocardial fibroelastosis. Molecular evidence for the role of mumps virus as an etiologic agent. " Circulation. 1997 Jan 7; 95 (1) : 133-9.
  Pubmed PMID: 8994428.

Show 64 more publications