Email

pati@bcm.edu

Positions

Professor

Pediatrics-Oncology
Baylor College of Medicine
Houston, TX, US

Member

Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Education

Postdoctoral Fellowship at Baylor College Of Medicine

01/2001 - Houston, Texas, United States

PhD from University Of Calgary

01/1995 - Calgary, Canada

MSc from University Of Buckingham

01/1988 - Buckingham, United Kingdom

Professional Interests

• Role of Chromosomal Cohesion and Separation in Aneuploidy and Tumorigenesis

Websites

Selected Publications

• Zhang N, Kuznetsov SG, Sharan SK, Li K, Rao PH, Pati D. " A handcuff model for the cohesin complex. " J. Cell Biol.. 2008 Dec 15; 183 (6) : 1019-31.
  Pubmed PMID: 19075111.
• Meyer R, Fofanov V, Panigrahi A, Merchant F, Zhang N, Pati D. " Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers. " Clin. Cancer Res.. 2009 Apr 15; 15 (8) : 2703-10.
  Pubmed PMID: 19351757.
• Zhang N, Scorsone K, Ge G, Kaffes CC, Dobrolecki LE, Mukherjee M, Lewis MT, Berg S, Stephan CC and Pati D.. " Identification and characterization of Separase Inhibitors (Sepins) for Cancer Therapy " J. Biomolecular Screening. 2014 ; 19 (6) : 878-889.
  Pubmed PMID: 24525869.
• Zhang N, Ge G, Meyer R, Sethi S, Basu D, Pradhan S, Zhao YJ, Li XN, Cai WW, El-Naggar AK, Baladandayuthapani V, Kittrell FS, Rao PH, Medina D, Pati D. " Overexpression of Separase induces aneuploidy and mammary tumorigenesis. " Proc. Natl. Acad. Sci. U.S.A.. 2008 Sep 2; 105 (35) : 13033-8.
  Pubmed PMID: 18728194.
• Zhang N, Ge G, Meyer R, Sethi S, Basu D, Pradhan S, Zhao YJ, Li XN, Cai WW, El-Naggar AK, Baladandayuthapani V, Kittrell FS, Rao PH, Medina D, Pati D.. " Overexpression of Separase induces aneuploidy and mammary tumorigenesis " PNAS. 2008 Sep 2; 105 (35) : 13033-8.
• Mukherjee, M, Ge, G., Zhang N, Edwards D, Sumazin, P., Sharan, S, Rao PH, Medina D, Pati D. " MMTV-Espl1 Transgenic Mice Develop Aneuploid, Estrogen Receptor Alpha (ERα)-Positive Mammary Adenocarcinomas " Oncogene. 2014 ; 48 (33) : 5511-22.
  Pubmed PMID: 4032816.
• Panigrahi AK, Pati D. " Higher-order orchestration of hematopoiesis: Is cohesin a new player? " Exp. Hematol.. 2012 Dec ; 40 (12) : 967-73.
  Pubmed PMID: 23022223.
• Panigrahi AK, Zhang N, Otta SK, Pati D. " A cohesin-RAD21 interactome. " Biochem. J.. 2012 Mar 15; 442 (3) : 661-70.
  Pubmed PMID: 22145905.
• Horton TM, Pati D, Plon SE, Thompson PA, Bomgaars LR, Adamson PC, Ingle AM, Wright J, Brockman AH, Paton M, Blaney SM. " A phase 1 study of the proteasome inhibitor bortezomib in pediatric patients with refractory leukemia: a Children's Oncology Group study. " Clin. Cancer Res.. 2007 Mar 1; 13 (5) : 1516-22.
  Pubmed PMID: 17332297.
• Panigrahi AK, Zhang N, Mao Q, Pati D. " Calpain-1 cleaves rad21 to promote sister chromatid separation. " Mol. Cell. Biol.. 2011 Nov ; 31 (21) : 4335-47.
  Pubmed PMID: 21876002.
• Lu XY, Lu Y, Zhao YJ, Jaeweon K, Kang J, Xiao-Nan L, Ge G, Meyer R, Perlaky L, Hicks J, Chintagumpala M, Cai WW, Ladanyi M, Gorlick R, Lau CC, Pati D, Sheldon M, Rao PH. " Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma. " Mol. Cancer Res.. 2008 Jun ; 6 (6) : 937-46.
  Pubmed PMID: 18567798.
• Basu D, Zhang N, Panigrahi AK, Horton TM, Pati D. " Development and validation of a fluorogenic assay to measure separase enzyme activity. " Anal. Biochem.. 2009 Sep 15; 392 (2) : 133-8.
  Pubmed PMID: 19497291.
• Eliseeva E, Pati D, Diccinanni MB, Yu AL, Mohsin SK, Margolin JF, Plon SE. " Expression and localization of the CDC34 ubiquitin-conjugating enzyme in pediatric acute lymphoblastic leukemia. " Cell Growth Differ.. 2001 Aug ; 12 (8) : 427-33.
  Pubmed PMID: 11504708.
• Zhang N, Pati D. " Handcuff for sisters: a new model for sister chromatid cohesion. " Cell Cycle. 2009 Feb 1; 8 (3) : 399-402.
  Pubmed PMID: 19177018.
• Pati D, Haddad BR, Haegele A, Thompson H, Kittrell FS, Shepard A, Montagna C, Zhang N, Ge G, Otta SK, McCarthy M, Ullrich RL, Medina D. " Hormone-induced chromosomal instability in p53-null mammary epithelium. " Cancer Res.. 2004 Aug 15; 64 (16) : 5608-16.
  Pubmed PMID: 15313898.
• Pati D, Meistrich ML, Plon SE. " Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. " Mol. Cell. Biol.. 1999 Jul ; 19 (7) : 5001-13.
  Pubmed PMID: 10373550.
• Zhang N, Panigrahi AK, Mao Q, Pati D. " Interaction of Sororin Protein with Polo-like Kinase 1 Mediates Resolution of Chromosomal Arm Cohesion. " J. Biol. Chem.. 2011 Dec 2; 286 (48) : 41826-37.
  Pubmed PMID: 21987589.
• Pati D, Habibi HR. " Involvement of protein kinase C and arachidonic acid pathways in the gonadotropin-releasing hormone regulation of oocyte meiosis and follicular steroidogenesis in the goldfish ovary. " Biol. Reprod.. 2002 Mar ; 66 (3) : 813-22.
  Pubmed PMID: 11870090.
• Pati D, Zhang N, Plon SE. " Linking sister chromatid cohesion and apoptosis: role of Rad21. " Mol. Cell. Biol.. 2002 Dec ; 22 (23) : 8267-77.
  Pubmed PMID: 12417729.
• Pati D. " Oncogenic activity of separase. " Cell Cycle. 2008 Nov 15; 7 (22) : 3481-2.
  Pubmed PMID: 19001849.
• Horton TM, Jenkins G, Pati D, Zhang L, Dolan ME, Ribes-Zamora A, Bertuch AA, Blaney SM, Delaney SL, Hegde M, Berg SL. " Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity. " Mol. Cancer Ther.. 2009 Aug ; 8 (8) : 2232-42.
  Pubmed PMID: 19671751.
• Kuznetsov S, Pellegrini M, Shuda K, Fernandez-Capetillo O, Liu Y, Martin BK, Burkett S, Southon E, Pati D, Tessarollo L, West SC, Donovan PJ, Nussenzweig A, Sharan SK. " RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. " J. Cell Biol.. 2007 Feb 26; 176 (5) : 581-92.
  Pubmed PMID: 17312021.
• Pati D, Keller C, Groudine M, Plon SE. " Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA. " Mol. Cell. Biol.. 1997 Jun ; 17 (6) : 3037-46.
  Pubmed PMID: 9154802.
• Panigrahi AK, Pati D. " Road to the crossroads of life and death: linking sister chromatid cohesion and separation to aneuploidy, apoptosis and cancer. " Crit. Rev. Oncol. Hematol.. 2009 Dec ; 72 (3) : 181-93.
  Pubmed PMID: 19162508.
• Mukherjee M, Ge G, Zhang N, Huang E, Nakamura LV, Minor M, Fofanov V, Rao PH, Herron A, Pati D. " Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice. " PLoS ONE. 2011 ; 6 (7) : e22167.
  Pubmed PMID: 21799785.
• Zhang N, Pati D. " Sororin is a master regulator of sister chromatid cohesion and separation. " Cell Cycle. 2012 Jun 1; 11 (11) : 2073-83.
  Pubmed PMID: 22580470.

Show 22 more publications

Intellectual Property

SEPARASE INHIBITORS AND USES THEREOF

Product Patent #PCT/US2014/061353 (Pending)

In some embodiments, the present disclosure pertains to compositions with compounds that inhibit Separase activity. In additional embodiments, the present disclosure pertains to methods of treating a tumor in a subject by administering one or more compositions of the present disclosure to the subject.

Co Inventors: Nenggang Zhang