David Mansouri, Ph.D., M.S.
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David Mansouri, Ph.D., M.S.
Assistant Professor
Positions
- Assistant Professor
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Physical Medicine & Rehabilitation
Baylor College of Medicine
Houston, TX US
Education
- Ph.D. from Baylor College of Medicine
- Houston, Texas United States
- M.S. from Johns Hopkins University
- Baltimore, Maryland United States
- B.S. from University of Houston
- Houston, Texas United States
Professional Statement
Dr. Mansouri has a long-standing interest in the pathogenesis, prevention, and treatment of device-associated infections with a concentration in the development of novel means to avert these infections, which remain a medical challenge and can lead to excessive morbidity, undue mortality, and increased healthcare costs. Dr. Mansouri is also interested in new classes of small antimicrobial agents with novel non-traditional mechanisms of action that could evade resistance pathways.Websites
Selected Publications
- Mansouri MD, Hull RA, Stager CE, Cadle RM, Darouiche RO "In vitro activity and durability of a combination of an antibiofilm and an antibiotic against vascular catheter colonization." Antimicrob Agents Chemother. 2013;57(1):621-625. Pubmed PMID: 23114776
- Mansouri MD, Opperman TJ, Williams JD, Stager C, Darouiche RO "In vitro potency and in vivo efficacy of a novel bis-indole antimicrobial compound in reducing catheter colonization." Antimicrob Agents Chemother. 2012;56(4):2201-2204. Pubmed PMID: 22271864
- Mansouri MD, Cadle RM, Agbahiwe SO, Musher DM "Impact of an antibiotic restriction program on antibiotic utilization in the treatment of community-acquired pneumonia in a Veterans Affairs Medical Center." Infection. 2011;39(1):53-58. Pubmed PMID: 21318422
- Mansouri MD, Awan L, Darouiche RO "In vitro efficacy of antimicrobial-treated drainage catheters in preventing bacterial colonization in biological fluids." Infect Control Hosp Epidemiol. 2011;32(7):731-732. Pubmed PMID: 21666409
- Mansouri MD, Ramanathan V, Al-Sharif AH, Darouiche RO "Efficacy of trypsin in enhancing assessment of bacterial colonisation of vascular catheters." J Hosp Infect. 2010;76(4):328-331. Pubmed PMID: 20880606
- Mansouri MD, Boone TB, Darouiche RO "Comparative assessment of antimicrobial activities of antibiotic-treated penile prostheses." Eur Urol. 2009;56(6):1039-1045. Pubmed PMID: 19135292
- Ramanathan V, Riosa S, Al-Sharif AH, Mansouri MD, Tranchina A, Kayyal T, Abreo AP, Aslam S, Nassar G, Darouiche RO "Characteristics of biofilm on tunneled cuffed hemodialysis catheters in the presence and absence of clinical infection." Am J Kidney Dis. 2012;60(6):976-982. Pubmed PMID: 22795945
- Viola GM, Mansouri MD, Nasir N Jr, Darouiche RO "Incubation alone is adequate as a culturing technique for cardiac rhythm management devices." J Clin Microbiol. 2009;47(12):4168-4170. Pubmed PMID: 19846629
- Narasimhan S, Aslam S, Lin PH, Bechara CF, Mansouri MD, Darouiche RO "Bacterial translocation across ePTFE vascular graft surfaces." J Infect. 2010;60(6):486-490. Pubmed PMID: 20362612
- Hernandez MD, Mansouri MD, Aslam S, Zeluff B, Darouiche RO "Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices." Infect Control Hosp Epidemiol. 2009;30(2):190-192. Pubmed PMID: 19090771
- Darouiche RO, Mansouri MD, Gawande PV, Madhyastha S "Antimicrobial and antibiofilm efficacy of triclosan and DispersinB combination." J Antimicrob Chemother. 2009;64(1):88-93. Pubmed PMID: 19447791
- Darouiche RO, Mansouri MD, Schneidkraut MJ "Comparative efficacies of telavancin and vancomycin in preventing device-associated colonization and infection by Staphylococcus aureus in rabbits." Antimicrob Agents Chemother. 2009;53(6):2626-2628. Pubmed PMID: 19364874
- Mansouri MD, Darouiche RO "In-vitro activity and in-vivo efficacy of catheters impregnated with chloroxylenol and thymol against uropathogens." Clin Microbiol Infect. 2008;14(2):190-192. Pubmed PMID: 18042195
- Darouiche RO, Mansouri MD, Gawande PV, Madhyastha S "Efficacy of combination of chlorhexidine and protamine sulphate against device-associated pathogens." J Antimicrob Chemother. 2008;61(3):651-657. Pubmed PMID: 18258612
- Mansouri MD, Darouiche RO "In vitro antimicrobial activity of N-acetylcysteine against bacteria colonising central venous catheters." Int J Antimicrob Agents. 2007;29(4):474-476. Pubmed PMID: 17293092
- Cadle RM, Mansouri MD, Logan N, Kudva DR, Musher DM "Association of proton-pump inhibitors with outcomes in Clostridium difficile colitis." Am J Health Syst Pharm. 2007;64(22):2359-2363. Pubmed PMID: 17989446
- Cadle RM, Mansouri MD, Darouiche RO "Vancomycin-induced elevation of liver enzyme levels." Ann Pharmacother. 2006;40(6):1186-1189. Pubmed PMID: 16720708
- Darouiche RO, Mansouri MD, Zakarevicz D, Alsharif A, Landon GC "In vivo efficacy of antimicrobial-coated devices." J Bone Joint Surg Am. 2007;89(4):792-797. Pubmed PMID: 17403802
- Darouiche RO, Mansouri MD, Kojic EM "Antifungal activity of antimicrobial-impregnated devices." Clin Microbiol Infect. 2006;12(4):397-399. Pubmed PMID: 16524420
- Darouiche RO, Mansouri MD "Dalbavancin compared with vancomycin for prevention of Staphylococcus aureus colonization of devices in vivo." J Infect. 2005;50(3):206-209. Pubmed PMID: 15780414
- Darouiche RO, Berger DH, Khardori N, Robertson CS, Wall MJ Jr, Metzler MH, Shah S, Mansouri MD, Cerra-Stewart C, Versalovic J, Reardon MJ, Raad II "Comparison of antimicrobial impregnation with tunneling of long-term central venous catheters: a randomized controlled trial." Ann Surg. 2005;242(2):193-200. Pubmed PMID: 16041209
- Darouiche RO, Mansouri MD "In vitro activity and in vivo efficacy of antimicrobial-coated vascular grafts." Ann Vasc Surg. 2004;18(4):497-501. Pubmed PMID: 15156366
- Darouiche RO, Mansouri MD, Raad II "Efficacy of antimicrobial-impregnated silicone sections from penile implants in preventing device colonization in an animal model." Urology. 2002;59(2):303-307. Pubmed PMID: 11834416
- Darouiche RO, Fowler VG Jr, Adal K, Kielhofner M, Mansouri D, Reller LB "Antimicrobial activity of prosthetic heart valve sewing cuffs coated with minocycline and rifampin." Antimicrob Agents Chemother. 2002;46(2):543-545. Pubmed PMID: 11796374
- Darouiche RO, Netscher DT, Mansouri MD, Meade R "Activity of antimicrobial-impregnated silicone tissue expanders." Ann Plast Surg. 2002;49(6):567-571. Pubmed PMID: 12461436
- Darouiche RO, Meade R, Mansouri MD, Netscher DT "In vivo efficacy of antimicrobe-impregnated saline-filled silicone implants." Plast Reconstr Surg. 2002;109(4):1352-1357. Pubmed PMID: 11964990
- Darouiche RO, Mansouri MD, Meade R "In-vitro and in-vivo activity of antimicrobial-coated prosthetic heart valve sewing cuffs." J Heart Valve Dis. 2002;11(1):99-104. Pubmed PMID: 11843512
- Darouiche RO, Meade R, Mansouri M, Raad II "In vivo efficacy of antimicrobial-coated fabric from prosthetic heart valve sewing rings." J Heart Valve Dis. 1998;7(6):639-646. Pubmed PMID: 9870198
- Darouiche RO, Farmer J, Chaput C, Mansouri M, Saleh G, Landon GC "Anti-infective efficacy of antiseptic-coated intramedullary nails." 1998;80(9):1336-1340. Pubmed PMID: 9759819
- Darouiche RO, Green G, Mansouri MD "Antimicrobial activity of antiseptic-coated orthopaedic devices." Int J Antimicrob Agents. 1998;10(1):83-86. Pubmed PMID: 9624548
- Raad II, Darouiche RO, Hachem R, Abi-Said D, Safar H, Darnule T, Mansouri M, Morck D "Antimicrobial durability and rare ultrastructural colonization of indwelling central catheters coated with minocycline and rifampin." Crit Care Med. 1998;26(2):219-224. Pubmed PMID: 9468157
- Kil KS, Darouiche RO, Hull RA, Mansouri MD, Musher DM "Identification of a Klebsiella pneumoniae strain associated with nosocomial urinary tract infection." J Clin Microbiol. 1997;35(9):2370-2374. Pubmed PMID: 9276418
- Raad I, Darouiche R, Hachem R, Mansouri M, Bodey GP "The broad-spectrum activity and efficacy of catheters coated with minocycline and rifampin." J Infect Dis. 1996;173(2):418-424. Pubmed PMID: 8568304
- Giulian D, Corpuz M, Chapman S, Mansouri M, Robertson C "Reactive mononuclear phagocytes release neurotoxins after ischemic and traumatic injury to the central nervous system." J Neurosci Res. 1993;36(6):681-693. Pubmed PMID: 8145296
Funding
- Assessment of Catheter-Related Bloodstream Infections Grant funding from National Institutes of Health
- A Novel Bis-Indole Compound against Catheter Colonization Grant funding from National Institutes of Health
- Antibiofilm/Antimicrobial Combination for Infections Associated with Vascular catheters Grant funding from National Institutes of Health
- Rapid Biomarker-Based Diagnosis and Monitoring of UTI in SCI Veterans Grant funding from Department of Veterans Affairs
Intellectual Property
- Method Patent #9,956,319 (Approved)
- Method Patent #8,062,691 (Approved)
- Method Patent #7,238,363 (Approved)
- Method Patent #6,589,591 (Approved)
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