Darryl L. Hadsell, Ph.D.

Associate Professor

(713) 798-7043

Email

dhadsell@bcm.edu

Positions

Associate Professor: Pediatrics-Nutrition
Baylor College of Medicine
Houston, TX, US

Assistant Professor: Department of Molecular and Cellular Biology
Baylor College of Medicine
Houston, Texas, United States

Member: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Addresses

CNRC (Office): Children's Nutrition Research Center
Room: CNRC-10072
Houston, TX, 77030
United States
https://www.bcm.edu/departments/pediatrics/sections-divisions-centers/childrens-nutrition-research-center

Education

MS from South Dakota State University, 1987: Brookings, South Dakota, United States; Dairy Science

PhD from Pennsylvania State University, 1991: University Park, Pennsylvania, United States; Animal Science

Postdoctoral Fellowship at Baylor College Of Medicine, 1995: Houston, Texas, United States; Department of Molecular and Cellular Biology

Professional Interests

Lactation Biology, Mammalian Genomics

Professional Statement

As a researcher with over 20 years of experience in lactation biology, I have conducted studies on a variety of aspects of mammary gland development and lactation in multiple species. This includes early work on the nutrition of lactating dairy cows, Post-doctoral work on the application of molecular biology and transgenic approaches to mammary development and lactation in mice, an analysis of growth factor signaling mechanisms in the mammary gland, to more recent forward genetic approaches to identifying and mapping regions within the mouse genome that drive variation in mammary gland development and lactation-related traits. Through collaborative work with clinicians, I have also contributed to the development of a novel approach employing the purification of RNA from fresh milk to measure the activity of mammary epithelial gene expression networks in breastfeeding women.

Websites

VIICTR Publications List

Selected Publications

Hadsell DL, Hadsell LA, Rijnkels M, Carcamo-Bahena Y, Wei J, Williamson P, Grusak MA. " In silico mapping of quantitative trait loci (QTL) regulating the milk ionome in mice identifies a milk iron locus on chromosome 1 " Mamm Genome. 2018 Oct ; 10 (29(9-10)) : 632-655.
Pubmed PMID: 30073618.
Hadsell DL, Hadsell LA, Olea W, Rijnkels M, Creighton CJ, Smyth I, Short KM, Cox LL, Cox TC. " In-silico QTL mapping of postpubertal mammary ductal development in the mouse uncovers potential human breast cancer risk loci. " Mamm Genome. 2015 Feb ; 26 (1) : 57-79.
Pubmed PMID: 25552398.
Hadsell DL, Wei J, Olea W, Hadsell LA, Renwick A, Thomson PC, Shariflou M, Williamson P. " In silico QTL mapping of maternal nurturing ability with the mouse diversity panel. " Physiol. Genomics. 2012 Aug 17; 44 (16) : 787-98.
Pubmed PMID: 22759921.
Hadsell DL, Olea W, Wei J, Fiorotto ML, Matsunami RK, Engler DA, Collier RJ. " Developmental regulation of mitochondrial biogenesis and function in the mouse mammary gland during a prolonged lactation cycle. " Physiol. Genomics. 2011 Mar 29; 43 (6) : 271-85.
Pubmed PMID: 21189371.
Alex AP, Collier JL, Hadsell DL, Collier RJ.. " Milk yield differences between 1× and 4× milking are associated with changes in mammary mitochondrial number and milk protein gene expression, but not mammary cell apoptosis or SOCS gene expression. " J Dairy Sci. 2015 ; 98 (7) : 4439-48.
Pubmed PMID: 25981061.
Maningat PD, Sen P, Rijnkels M, Sunehag AL, Hadsell DL, Bray M, Haymond MW. " Gene expression in the human mammary epithelium during lactation: the milk fat globule transcriptome. " Physiol. Genomics. 2009 Mar 3; 37 (1) : 41630.
Pubmed PMID: 19018045.
Mohammad MA, Hadsell DL, Haymond MW. " Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans. " Am. J. Physiol. Endocrinol. Metab.. 2012 Aug ; 303 (3) : E365-76.
Pubmed PMID: 22649065.
Hadsell DL, Parlow AF, Torres D, George J, Olea W. " Enhancement of maternal lactation performance during prolonged lactation in the mouse by mouse GH and long-R3-IGF-I is linked to changes in mammary signaling and gene expression. " J. Endocrinol.. 2008 Jul ; 198 (1) : 61-70.
Pubmed PMID: 18577570.
Hadsell DL, Bonnette S, George J, Torres D, Klimentidis Y, Klementidis Y, Gao S, Haney PM, Summy-Long J, Soloff MS, Parlow AF, Sirito M, Sawadogo M. " Diminished milk synthesis in upstream stimulatory factor 2 null mice is associated with decreased circulating oxytocin and decreased mammary gland expression of eukaryotic initiation factors 4E and 4G. " Mol. Endocrinol.. 2003 Nov ; 17 (11) : 2251-67.
Pubmed PMID: 12907752.

Memberships

American Dairy Science Association

The International Society for Research on Human Milk and Lactation