Cristian Lasagna-Reeves

Associate Professor

Email

cristian.lasagna-reeves@bcm.edu

Positions

Associate Professor: Neurology
Baylor College of Medicine

Addresses

One Baylor Plaza (Lab): 344EB
Houston, TX, 77030
United States

Education

Postdoctoral Fellowship at Baylor College of Medicine: 01/2017 - Houston, Texas, United States

PhD from University of Texas Medical Branch: 12/2010 - Galveston, Texas, United States

MS from University of Chile: 12/2007 - Santiago, Chile

BS from University of Chile: 12/2006 - Santiago, Chile

Honors & Awards

Emerging Leaders in Health and Medicine Scholar.: National Academy of Medicine (03/2025 - 03/2028)

Dr. Mel Perelman Fellowship for Alzheimer’s Research.: Alzheimer’s Association. (09/2024)

Rainwater Prize for Innovative Early-Career Scientist.: Rainwater Charitable Foundation. (03/2024)

Inge Grundke-Iqbal Award for Alzheimer’s Research.: Alzheimer’s Association. (07/2023)

August M. Watanabe Translational Research Scholar.: Indiana CTSI. (07/2019)

Postdoc Dean’s Award of Excellence.: Baylor College of Medicine. (09/2015)

Jen Chieh and Katherinen Huang Scholarship Award for Excellence in Neuroscience.: University of Texas Medical Branch. (07/2010)

Dr. and Mrs. Seymour Fisher Academic Excellence Award in Neuroscience.: University of Texas Medical Branch. (03/2010)

Professional Statement

The central focus of my research program is to understand the role of tau in Alzheimer’s disease (AD) and other neurodegenerative tauopathies, with particular emphasis on the mechanisms underlying tau aggregation and propagation, as well as the contributions of vascular damage and neuroinflammation to the synaptotoxicity associated with tau pathology. To investigate these mechanisms, my laboratory employs a wide range of approaches, including in vitro aggregation assays, cellular disease models, Drosophila screens, genetic interaction studies in mice, behavioral analyses, human neuropathological investigations and bioinformatics.

Websites

Lasagna-Reeves Lab

Selected Publications

Jury-Garfe N, Chimal-Juárez E, Patel H, Martinez-Pinto J, Vanderbosch K, Mardones MD, Perkins A, Prisco GVD, Marambio Y, Vidal R, Atwood BK, Lasagna-Reeves CA.. " 1. Tau depletion diminishes vascular amyloid-related deficits in a mouse model of cerebral amyloid angiopathy. " Alzheimers Dement. 2025 May 21; 21 (5)
Pubmed PMID: 40346706.
Jury-Garfe N, Redding-Ochoa J, You Y, Martínez P, Karahan H, Chimal-Juárez E, Johnson TS, Zhang J, Resnick S, Kim J, Troncoso JC, Lasagna-Reeves CA.. " 2. Enhanced microglial dynamics and a paucity of tau seeding in the amyloid plaque microenvironment contribute to cognitive resilience in Alzheimer's disease. " Acta Neuropathol.. 2024 Aug 5; 148 (1)
Pubmed PMID: 39102080.
Lee-Gosselin A, Jury-Garfe N, You Y, Dabin L, Soni D, Dutta S, Rochet JC, Kim J, Oblak AL, Lasagna-Reeves CA.. " 3. TREM2-Deficient Microglia Attenuate Tau Spreading In Vivo. " Cells. 2023 Jun 10; 12 (12)
Pubmed PMID: 37371067.
Martinez P, Patel H, You Y, Jury N, Perkins A, Lee-Gosselin A, Taylor X, You Y, Viana Di Prisco G, Huang X, Dutta S, Wijeratne AB, Redding-Ochoa J, Shahid SS, Codocedo JF, Min S, McKinzie DL, Rochet JC, Zhang J, Atwood BK, Troncoso J, Lasagna-Reeves CA.. " 4. Bassoon contributes to tau-seed propagation and neurotoxicity. " Nat Neurosci.. 2022 Dec ; 25 (12)
Pubmed PMID: 36344699.
Cisternas P, Taylor X, Martinez P, Maldonado O, Jury N, Lasagna-Reeves CA.. " 5. The reduction of astrocytic tau prevents amyloid-β-induced synaptotoxicity. " Brain Commun.. 2022 Sep 19; 17 (1)
Pubmed PMID: 36196088.