Clavia
Middle Name
Ruth
Wooton-Kee, Ph.D.
Middle Name
Ruth
Picture
Positions
- Assistant Professor
-
Mol and Cell Biology-Dmoore
Baylor College of Medicine
Houston, TX US
- Faculty Senator
-
Baylor College of Medicine
Houston, Texas
Addresses
- BCM-Alkek Graduate School (Lab)
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Room: BCMN-N610
Houston, TX 77030
United States
Education
- BSc from Union College
- 05/1996 - Barbourville, Kentucky United States
- Biology and Chemistry
- MS from University of Louisville, School of Medicine
- 12/1999 - Louisville, Kentucky United States
- Biochemistry
- PhD from University of Kentucky, College of Medicine
- 12/2008 - Lexington, Kentucky United States
- Toxicology
Websites
Selected Publications
- "Metabolic dysregulation in the Atp7b -/- Wilson's disease mouse model.." 2020 January ; : Pubmed PMID: 31924743
- Clavia Ruth Wooton-Kee, Ajay K. Jain, Martin Wagner, Michael A. Grusak, Milton J. Finegold, Svetlana Lutsenko, David D. Moore "Elevated copper impairs hepatic nuclear receptor function in Wilson's disease.." Journal of Clinical Investigation. 2015 September 1; 125 (9): 3449-60. Pubmed PMID: 4588285
- "Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing.." : Pubmed PMID: 30170115
- Wagner M, Choi S, Panzitt K, Mamrosh JL, Lee JM, Zaufel A, Xiao R, Wooton-Kee R, Ståhlman M, Newgard CB, Borén J, Moore DD "Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism.." Hepatology. 2015 August 12; : Pubmed PMID: 26267291
- Coy DJ, Wooton-Kee CR, Yan B, Sabeva NS, Su K, Graf GA, Vore M "ABCG5/ABCG8-independent biliary cholesterol excretion in lactating rats.." Am J Physiol Gastrointestinal Liver Physiol. 2010 April 22; 299 (1): 228-235. Pubmed PMID: 20413720
- Antony Athippozhy, Huang L, Wooton-Kee CR, Zhao T, Jungsuwadee P, Stromberg AJ, and Vore, M "Differential gene expression in liver and small intestine from lactating rats compared to age-matched virgin controls detects increased mRNA of cholesterol biosynthetic genes." BMC Genomics. 2011 February 3; 12 (95): Pubmed PMID: 3045338
- Wooton-Kee, C.R., Coy, D.J., Athippozhy, A.T., Jones, B.R., Zhao, T., and Vore, M "Mechanisms for increased expression of cholesterol 7 -hydroxylase (Cyp7A1) in lactating rats." Hepatology. 2010 January ; 51 (1): 277-285. Pubmed PMID: 2799537
- Wooton-Kee, C.R., Cohen, D.E., and Vore, M. "Increased cholesterol 7alpha-hydroxylase expression and size of the bile acid pool in the lactating rat." Am J Physiol Gastrointest Liver Physiol. 2008 February 21; 294 : 1009-1016. Pubmed PMID: 2408447
- Wood, M., Ananthanarayanan, M., Jones, B., Wooton-Kee, R., Hoffman, T., Suchy, F.J., and Vore, M "Hormonal regulation of hepatic organic anion transporting polypeptides.." Molecular Pharmacology. 2005 July ; 68 (1): 218-225. Pubmed PMID: 1463998
- Wooton-Kee, C.R., Boyanovsky, B.B., Nasser, M.S., de Villiers, W.J.S., and Webb, N.R. "Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation.." Arteriosclerosis, Thrombosis, and Vascular Bi. 2004 24 (4): 762-767.
- Tabb, A.L., Utsugi, T., Wooten-Kee, C.R., Sasaki, T., Edling, S.A., Gump, W., Kikuchi,Y., Ellis, S.R. "Genes encoding ribosomal proteins Rps0A/B of Saccharomyces cerevisiae interact with TOM1 mutants defective in ribosome synthesis." Genetics. 2001 157 (3): 1107-1116.
- Wooton-Kee, C.R., Clark, B.J. "Steroidogenic factor-1 influences protein-deoxyribonucleic acid interactions within the cyclic adenosine 3,5-monophosphate-responsive regions of the murine steroidogenic acute regulatory protein gene." Endocrinology. 2000 141 (4): 1345-1355.
- "Constitutive Androstane Receptor Differentially Regulates Bile Acid Homeostasis in Mouse Models of Intrahepatic Cholestasis.." : Pubmed PMID: 30620001
- "Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis.." : Pubmed PMID: 29718219
- "Targeted inactivation of copper transporter Atp7b in hepatocytes causes liver steatosis and obesity in mice.." : Pubmed PMID: 28428350
Funding
- Nuclear Receptors as Novel Therapeutic Targets for Wilson's Disease - #1K01DK111716-01 (02/17/2017 - 01/31/2022) Grant funding from NIH/NIDDK
- NIH K01 Career Development Award
- Excessive Copper Levels Disrupt Hepatic Nuclear Receptor Function - #F32 DK089689-01A1 (10/01/2010 - 10/31/2012) Grant funding from NIH/NIDDK
- Ruth L. Kirschstein National Research Service Award for Individual Postdoctoral Fellow - F32 Award
- Copper Disruption of Nuclear Receptors and Zinc Therapy - #P30 DK056338 (02/28/2014 - 02/28/2015) Grant funding from Texas Medical Center Digestive Diseases Center, NIH/NIDDK
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