Christopher Michael Grochowski

Assistant Professor

Email

christopher.grochowski@bcm.edu

Positions

Assistant Professor: HGSC: Faculty
Baylor College of Medicine
Houston, TX US

Education

BS from American University: 05/2011 - Washington, District of Columbia United States; Biology, Religious Studies

MS from Rowan University: 05/2014 - Stratford, New Jersey United States; Biomedical Science

PhD from Baylor College of Medicine: 01/2022 - Houston, Texas United States

Postdoctoral Training at Baylor College of Medicine: 07/2023 - Houston, Texas United States

Professional Interests

Complex genomic rearrangements (CGRs)
Copy number variation (CNV)
Genomic optical mapping and long-read sequencing technologies
Genomic disorders
Chromothripsis, chromoanasynthesis, and chromoplexy

Professional Statement

Christopher M. Grochowski is an Assistant Professor at the Human Genome Sequencing Center (HGSC) at Baylor College of Medicine, where he joined the faculty in 2023. His research is dedicated to understanding the genetic and genomic underpinnings of human disease, with a particular emphasis on complex genomic rearrangements (CGRs), copy number variation (CNV), and somatic mosaicism.

Trained in the laboratory of Dr. James R. Lupski, Dr. Grochowski has worked on the integration of cutting-edge technologies — including genomic optical mapping, long-read sequencing (PacBio and Oxford Nanopore), and droplet digital PCR — with classical cytogenetic and molecular methods to resolve structural variants to nucleotide-level resolution. His work has highlights the mechanisms driving chromothripsis, chromoanasynthesis, and chromoplexy events, and has advanced our understanding of mutational processes including FoSTeS/MMBIR, NAHR, NHEJ, and AAMR.