Balasubramanium Vijayalakshmi Ayyar, Ph.D.

Senior Staff Scientist

(713) 798-6388

Email

bayyar@bcm.edu

Positions

Senior Staff Scientist: Virol & Micro
Baylor College of Medicine
Houston, Texas, United States

Addresses

BCM-Jewish Institute for Research (Lab): Room: 903D
Houston, TX, 77030
United States

Education

BSc from Govt. Motilal Vigyan Mahavidyalaya (MVM): Bhopal, Madhya Pradesh, India

MSc from Barkatullah University: Bhopal, Madhya Pradesh, India

Fellowship at High Security Animal Disease Laboratory: Bhopal, Madhya Pradesh, India

PhD from Dublin City University: Dublin, Dublin, Ireland

Post-Doctoral Fellowship at Biomedical Diagnostics Institute (BDI), Dublin City University: Dublin, Dublin, Ireland

Selected Publications

Stephen Hearty, Paul J Conroy, B Vijayalakshmi Ayyar, Barry Byrne, Richard O’Kennedy. " Surface plasmon resonance for vaccine design and efficacy studies: recent applications and future trends " Expert Rev Vaccines. 2010 Jun ; 9 (6) : 645-664.
Pubmed PMID: 20518719.
B Vijayalakshmi Ayyar, Stephen Hearty, Richard O’Kennedy. " Highly sensitive recombinant antibodies capable of reliably differentiating heart-type fatty acid binding protein from noncardiac isoforms " Anal Biochem. 2010 Dec ; 15 (2) : 165-171.
Pubmed PMID: 20696127.
B Vijayalakshmi Ayyar, Sushrut Arora, Caroline Murphy, Richard O’Kennedy. " Affinity chromatography as a tool for antibody purification " Methods. 2012 Feb ; 56 (2) : 116-129.
Pubmed PMID: 22033471.
B Vijayalakshmi Ayyar, Stephen Hearty, Richard O’Kennedy. " Facile domain rearrangement abrogates expression recalcitrance in a rabbit scFv. " Appl Microbiol Biotechnol. 2015 ; 99 (6) : 2693-2703.
Pubmed PMID: 25535092.
B. Vijayalakshmi Ayyar, K. Roger Aoki and M. Zouhair Atassi. " The C-Terminal Heavy-Chain Domain of Botulinum Neurotoxin A Is Not the Only Site That Binds Neurons, as the N-Terminal Heavy-Chain Domain Also Plays a Very Active Role in Toxin-Cell Binding and Interactions " Infect Immun.. 2015 Apr ; 83 (4) : 1465-1476.
Pubmed PMID: 25624352.
Sushrut Arora, B. Vijayalakshmi Ayyar, Richard O’Kennedy. " Affinity chromatography for antibody purification. " Methods Mol Biol.. 2014 ; 1129 : 497-516.
Pubmed PMID: 24648096.
B. Vijayalakshmi Ayyar, Rajeev B. Tajhya, Christine Beeton and M. Zouhair Atassi. " Antigenic sites on the HN domain of botulinum neurotoxin A stimulate protective antibody responses against active toxin " Sci Rep. 2015 Oct 28; 5 : 15776.
Pubmed PMID: 26508475.
B. Vijayalakshmi Ayyar and M. Zouhair Atassi. " Effects of membrane properties on the binding activities of the H N and H C heavy-chain domains of botulinum neurotoxin A " Biochim Biophys Acta. 2016 Dec ; 1864 (12) : 1678-1685.
Pubmed PMID: 27596061.
B Vijayalakshmi Ayyar, Sushrut Arora, Richard O’Kennedy. " Coming-of-Age of Antibodies in Cancer Therapeutics " Trends Pharmacol Sci. 2016 ; 37 (12) : 1009-1028.
Pubmed PMID: 27745709.
Sushrut Arora, Vikas Saxena, B. Vijayalakshmi Ayyar. " Affinity chromatography: A versatile technique for antibody purification. " Methods. 2017 ; 116 : 84-94.
Pubmed PMID: 28012937.
B Vijayalakshmi Ayyar, Sushrut Arora, Shiva Shankar Ravi. " Optimizing antibody expression: The nuts and bolts. " Methods. 2017 ; 116 : 51-62.
Pubmed PMID: 28163103.