Anne E Anderson, M.D.

Associate Professor

(832) 824-3976

Email

annea@bcm.edu

Positions

Associate Professor: Pediatrics-Neurology
Baylor College of Medicine
Houston, TX, US

Addresses

Jan and Duncan Neurological Research Institute (Office): Suite 1225
Houston, TX, 77030
United States
Phone: (832) 824-3976
annea@bcm.edu

Texas Children's Hospital, Clinical Care Center (Clinic): 6701 Fannin St
Ste 1250
Houston, TX, 77030
United States
Phone: (832) 822-1750

Professional Interests

Signal transduction mechanisms in epilepsy
Potassium channels
MAPK

Websites

VIICTR Publications List

Selected Publications

Anderson AE, Hrachovy RA, Antalffy BA, Armstrong DL, Swann JW. " A chronic focal epilepsy with mossy fiber sprouting follows recurrent seizures induced by intrahippocampal tetanus toxin injection in infant rats. " Neuroscience. 1999 ; 92 (1) : 73-82.
Pubmed PMID: 10392831.
Shibata R, Misonou H, Campomanes CR, Anderson AE, Schrader LA, Doliveira LC, Carroll KI, Sweatt JD, Rhodes KJ, Trimmer JS. " A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. " J. Biol. Chem.. 2003 Sep 19; 278 (38) : 36445-54.
Pubmed PMID: 12829703.
Bernard C, Anderson A, Becker A, Poolos NP, Beck H, Johnston D. " Acquired dendritic channelopathy in temporal lobe epilepsy. " Science. 2004 Jul 23; 305 (5683) : 532-5.
Pubmed PMID: 15273397.
Lugo JN, Barnwell LF, Ren Y, Lee WL, Johnston LD, Kim R, Hrachovy RA, Sweatt JD, Anderson AE. " Altered phosphorylation and localization of the A-type channel, Kv4.2 in status epilepticus. " J. Neurochem.. 2008 Aug ; 106 (4) : 1929-40.
Pubmed PMID: 18513371.
Bealer SL, Little JG, Metcalf CS, Brewster AL, Anderson AE. " Autonomic and cellular mechanisms mediating detrimental cardiac effects of status epilepticus. " Epilepsy Res.. 2010 Sep ; 91 (1) : 66-73.
Pubmed PMID: 20650612.
Varga AW, Yuan LL, Anderson AE, Schrader LA, Wu GY, Gatchel JR, Johnston D, Sweatt JD. " Calcium-calmodulin-dependent kinase II modulates Kv4.2 channel expression and upregulates neuronal A-type potassium currents. " J. Neurosci.. 2004 Apr 7; 24 (14) : 3643-54.
Pubmed PMID: 15071113.
Anderson A, Oviedo M, Adcock LM, Yamashita Y, Louis PT, Goddard-Finegold J. " Cytochrome oxidase is decreased in piglet hippocampus following hypoxia-ischemia. " Metab Brain Dis. 1997 Mar ; 12 (1) : 61-8.
Pubmed PMID: 9101538.
Harbour DV, Anderson AE, Farrington J, Wassef A, Smith E, Meyer MJ. " Decreased mononuclear leukocyte TSH responsiveness in patients with major depressive disorder. " Biol. Psychiatry. 1988 ; 23 (8) : 797-806.
Kazdoba TM, Sunnen CN, Crowell B, Lee GH, Anderson AE, D'Arcangelo G. " Development and characterization of NEX-Pten, a novel forebrain excitatory neuron-specific knockout mouse " Dev. Neurosci.. 2012 ; 34 (41308) : 198-209.
Pubmed PMID: 22572802.
Miller CL, Landry SH, Smith KE, Wildin SR, Anderson AE, Swank PR. " Developmental change in the neuropsychological functioning of very low birth weight infants. " Child Neuropsychol.. 1995 ; 1 : 224-36.
Marcelin B, Lugo JN, Brewster AL, Liu Z, Lewis AS, McClelland S, Chetkovich DM, Baram TZ, Anderson AE, Becker A, Esclapez M, Bernard C. " Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites " J. Biol. Chem.. 2012 May 18; 287 (21) : 17656-61.
Pubmed PMID: 22511771.
Schrader LA, Birnbaum SG, Nadin BM, Ren Y, Bui D, Anderson AE, Sweatt JD. " ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunit. " Am. J. Physiol., Cell Physiol.. 2006 Mar ; 290 (3) : C852-61.
Pubmed PMID: 16251476.
Krueger DA, Wilfong AA, Holland-Bouley K, Anderson AE, Agricola K, Tudor C, Mays M, Lopez CM, Kim MO, Franz DN. " Everolimus treatment of refractory epilepsy in tuberous sclerosis complex. " Ann. Neurol. 2013 ; 74 (5) : 679-87.
Staley KJ, Anderson AE. " Hyperactive interneurons impair learning in a neurofibromatosis model. " Nat. Neurosci.. 2009 Jan ; 12 (1) : 8-10.
Pubmed PMID: 19107143.
Anderson AE, Hrachovy RA, Swann JW. " Increased susceptibility to tetanus toxin-induced seizures in immature rats. " Epilepsy Res.. 1997 Mar ; 26 (3) : 433-42.
Pubmed PMID: 9127724.
Sunnen CN, Brewster AL, Lugo JN, Vanegas F, Turcios E, Mukhi S, Parghi D, D'Arcangelo G, Anderson AE. " Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice. " Epilepsia. 2011 Nov ; 52 (11) : 2065-75.
Pubmed PMID: 21973019.
Varga AW, Anderson AE, Adams JP, Vogel H, Sweatt JD. " Input-specific immunolocalization of differentially phosphorylated Kv4.2 in the mouse brain. " Learn. Mem.. 2000 ; 7 (5) : 321-32.
Pubmed PMID: 11040264.
Rashid S, Lee I, Anderson AE, Hrachovy RA, Swann JW. " Insights into the tetanus toxin model of early-onset epilepsy from long-term video monitoring during anticonvulsant therapy. " Brain Res. Dev. Brain Res.. 1999 Dec 10; 118 (41276) : 221-5.
Pubmed PMID: 10611523.
Smith KE, Denson SE, Swank PR, Miller-Loncar CL, Anderson AE, Landry SH. " Is severity of respiratory disease associated with differences in neurodevelopmental patterns in preterm infants?. " Dev. Neuropsych.. 1998 ; 16 (1) : 59-77.
Lubin FD, Johnston LD, Sweatt JD, Anderson AE. " Kainate mediates nuclear factor-kappa B activation in hippocampus via phosphatidylinositol-3 kinase and extracellular signal-regulated protein kinase. " Neuroscience. 2005 ; 133 (4) : 969-81.
Pubmed PMID: 15916859.
Schrader LA, Ren Y, Cheng F, Bui D, Sweatt JD, Anderson AE. " Kv4.2 is a locus for PKC and ERK/MAPK cross-talk. " Biochem. J.. 2009 Feb 1; 417 (3) : 705-15.
Pubmed PMID: 18795890.
Barnwell LF, Lugo JN, Lee WL, Willis SE, Gertz SJ, Hrachovy RA, Anderson AE. " Kv4.2 knockout mice demonstrate increased susceptibility to convulsant stimulation. " Epilepsia. 2009 Jul ; 50 (7) : 1741-51.
Pubmed PMID: 19453702.
Lugo JN, Brewster AL, Spencer CM, Anderson AE. " Kv4.2 knockout mice have hippocampal-dependent learning and memory deficits. " Learn. Mem.. 2012 ; 19 (5) : 182-9.
Pubmed PMID: 22505720.
Anderson AE, Adams JP, Qian Y, Cook RG, Pfaffinger PJ, Sweatt JD. " Kv4.2 phosphorylation by cyclic AMP-dependent protein kinase. " J. Biol. Chem.. 2000 Feb 25; 275 (8) : 5337-46.
Pubmed PMID: 10681507.
Dineley KT, Weeber EJ, Atkins C, Adams JP, Anderson AE, Sweatt JD. " Leitmotifs in the biochemistry of LTP induction: amplification, integration and coordination. " J. Neurochem.. 2001 May ; 77 (4) : 961-71.
Pubmed PMID: 11359861.
Heilstedt HA, Burgess DL, Anderson AE, Chedrawi A, Tharp B, Lee O, Kashork CD, Starkey DE, Wu YQ, Noebels JL, Shaffer LG, Shapira SK. " Loss of the potassium channel beta-subunit gene, KCNAB2, is associated with epilepsy in patients with 1p36 deletion syndrome. " Epilepsia. 2001 Sep ; 42 (9) : 1103-11.
Pubmed PMID: 11580756.
Anderson A, Swank P, Wildin S, Landry S, Smith K. " Modeling analysis of change in neurologic abnormalities in children born prematurely: a novel approach. " J. Child Neurol.. 1999 Aug ; 14 (8) : 502-8.
Pubmed PMID: 10456759.
Lubin FD, Ren Y, Xu X, Anderson AE. " Nuclear factor-kappa B regulates seizure threshold and gene transcription following convulsant stimulation. " J. Neurochem.. 2007 Nov ; 103 (4) : 1381-95.
Pubmed PMID: 17727632.
Schrader LA, Anderson AE, Mayne A, Pfaffinger PJ, Sweatt JD. " PKA modulation of Kv4.2-encoded A-type potassium channels requires formation of a supramolecular complex. " J. Neurosci.. 2002 Dec 1; 22 (23) : 10123-33.
Pubmed PMID: 12451113.
Wildin SR, Anderson AE, Woodside M, Swank P, Smith K, Denson S, Landry S. " Prediction of 12-month neurodevelopmental outcome from a 6-month neurologic examination in premature infants. " Clin. Pediatr.. 1995 ; 34 (6) : 290-9.
Jung S, Jones TD, Lugo JN, Sheerin AH, Miller JW, D'Ambrosio R, Anderson AE, Poolos NP. " Progressive dendritic HCN channelopathy during epileptogenesis in the rat pilocarpine model of epilepsy. " J. Neurosci.. 2007 Nov 21; 27 (47) : 13012-21.
Pubmed PMID: 18032674.
Brewster AL, Lugo JN, Patil VV, Lee WL, Qian Y, Vanegas F, Anderson AE. " Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage. " PLoS ONE. 2013 ; 8 (3) : e57808.
Pubmed PMID: 23536771.
Ljungberg MC, Sunnen CN, Lugo JN, Anderson AE, D'Arcangelo G. " Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia. " Dis Model Mech. 2009 ; 2 (2) : 389-98.
Pubmed PMID: 19470613.
Hawasli AH, Koovakkattu D, Hayashi K, Anderson AE, Powell CM, Sinton CM, Bibb JA, Cooper DC. " Regulation of hippocampal and behavioral excitability by cyclin-dependent kinase 5. " PLoS ONE. 2009 ; 4 (6) : e5808.
Pubmed PMID: 19529798.
Misonou H, Mohapatra DP, Park EW, Leung V, Zhen D, Misonou K, Anderson AE, Trimmer JS. " Regulation of ion channel localization and phosphorylation by neuronal activity. " Nat. Neurosci.. 2004 Jul ; 7 (7) : 711-8.
Pubmed PMID: 15195093.
Ren Y, Barnwell LF, Alexander JC, Lubin FD, Adelman JP, Pfaffinger PJ, Schrader LA, Anderson AE. " Regulation of surface localization of the small conductance Ca2+-activated potassium channel, Sk2, through direct phosphorylation by cAMP-dependent protein kinase. " J. Biol. Chem.. 2006 Apr 28; 281 (17) : 11769-79.
Pubmed PMID: 16513649.
Shah MM, Anderson AE, Leung V, Lin X, Johnston D. " Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons. " Neuron. 2004 Oct 28; 44 (3) : 495-508.
Pubmed PMID: 15504329.
Anderson AE, Wildin SR, Woodside M, Swank PR, Smith KE, Denson SE, Miller CL, Butler IJ, Landry SH. " Severity of medical and neurologic complications as a determinant of neurodevelopmental outcome at 6 and 12 months in very low birth weight infants. " J. Child Neurol.. 1996 May ; 11 (3) : 215-9.
Pubmed PMID: 8734026.
Birnbaum SG, Varga AW, Yuan LL, Anderson AE, Sweatt JD, Schrader LA. " Structure and function of Kv4-family transient potassium channels. " Physiol. Rev.. 2004 Jul ; 84 (3) : 803-33.
Pubmed PMID: 15269337.
Adams JP, Anderson AE, Varga AW, Dineley KT, Cook RG, Pfaffinger PJ, Sweatt JD. " The A-type potassium channel Kv4.2 is a substrate for the mitogen-activated protein kinase ERK. " J. Neurochem.. 2000 Dec ; 75 (6) : 2277-87.
Pubmed PMID: 11080179.
Schrader LA, Anderson AE, Varga AW, Levy M, Sweatt JD. " The other half of Hebb: K+ channels and the regulation of neuronal excitability in the hippocampus. " Mol. Neurobiol.. 2002 Feb ; 25 (1) : 51-66.
Pubmed PMID: 11890457.

Funding

SLEEP MODULATION OF EPILEPTIC ACTIVITY IN IMMATURE BRAIN #K08NS001836: (04/01/1996 - 03/31/2001); NIH/NINDS

THE MAPK CASCADE IN EPILEPSY #K02NS002231: (09/30/2000 - 08/31/2005); NIH/NINDS

Ion Channel Remodeling in Epilepsy #R01NS039943: (05/01/2004 - 04/30/2012); NIH/NINDS

ION CHANNEL REGULATION OF EXCITABILITY IN IMMATURE BRAIN #R01NS049427: (12/05/2005 - 11/30/2011); NIH/NINDS

Signaling pathway dysregulation in epilepsy #R01NS081053: (09/01/2013 - 08/30/2017); NIH/NINDS

Everolimus (RAD001) Therapy of Epilepsy in Patients with Tuberous #NA: (01/01/2011 - 12/12/2012); Novartis; Sponsored by Novartis to enroll 20 children (10 at each center)

Gene Expression Profiles of Normal and Abnormal Neurons in Cortical Dysplasia #NA: $50,000.00 (07/01/2007 - 06/30/2011); Vivian L Smith Foundation

Evaluation of Novel Therapeutics and Seizure/EEG #FIRE Initiative (Integrative Res: (05/01/2013 - 04/30/2014); Foundation for Angelman Syndrome Therapeutics (FAST)

Activity-dependent Ion Channel Regulation: A Candidate Mechanism in Developmental Epilepsy #NA: (10/01/2005 - 09/30/2007); Partnership for Pediatric Epilepsy Research/Epilepsy Foundation

Generation and characterization of mouse models of cortical dysplasia #Subcontract with Rutgers Univers: (02/01/2008 - 12/31/2010); Citizens United for a Research in Epilepsy (CURE)