Amos Solomon Gaikwad, M.S., Ph.D.

Assistant Professor

(832) 824-4814

Positions

Assistant Professor: Pediatrics-Hema & Oncology
Baylor College of Medicine
Houston, TX, US

Instructor: Pediatrics
Hematology Oncology
Baylor College of Medicine
Houston, Texas, United States

Instructor: Molecular Therapeutics
Cancer Medicine
M D Anderson Cancer Center
Houston, Texas, United States

Postdoctoral Associate: Pharmacology
Baylor College of Medicine
Houston, Texas, United States

Member: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Addresses

Texas Children's Hosptial (Office): Feigin Building
Suite 1130
Houston, TX, 77030
United States
Phone: (832) 824-4814
axgaikwa@txch.org

Education

MS from Pune University: 04/1986 - Pune, Maharashtra, India

Ph.D. from Indian Institute Of Science: 01/1991 - Bangalore, India

Websites

VIICTR Publications List

Selected Publications

Nussenzveig RH, Lingam HB, Gaikwad A, Zhu Q, Jing N, Prchal JT. " A novel mutation of the cytochrome-b5 reductase gene in an Indian patient: the molecular basis of type I methemoglobinemia. " Haematologica. 2006 Nov ; 91 (11) : 1542-5.
Pubmed PMID: 17082011.
Xu ZX, Liang J, Haridas V, Gaikwad A, Connolly FP, Mills GB, Gutterman JU. " A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase. " Cell Death Differ.. 2007 Nov ; 14 (11) : 1948-57.
Pubmed PMID: 17690712.
Zhang C, Li B, Gaikwad AS, Haridas V, Xu Z, Gutterman JU, Duvic M. " Avicin D selectively induces apoptosis and downregulates p-STAT-3, bcl-2, and survivin in cutaneous T-cell lymphoma cells. " J. Invest. Dermatol.. 2008 Nov ; 128 (11) : 2728-35.
Pubmed PMID: 18496567.
Zhang C, Li B, Gaikwad AS, Haridas V, Xu Z, Gutterman JU, Duvic M.. " Avicin D selectively induces apoptosis and downregulates p-STAT-3, bcl-2, and survivin in cutaneous T-cell lymphoma cells. " J Invest Dermatol. 2008 Nov ; 128 (11) : 2728-35.
Pubmed PMID: 18496567.
Allen CE, Li L, Peters TL, Leung HC, Yu A, Man TK, Gurusiddappa S, Phillips MT, Hicks MJ, Gaikwad A, Merad M, McClain KL. " Cell-specific gene expression in Langerhans cell histiocytosis lesions reveals a distinct profile compared with epidermal Langerhans cells. " J. Immunol.. 2010 Apr 15; 184 (8) : 4557-67.
Pubmed PMID: 20220088.
Gaikwad A, Bonifant CL, Cubbage M, Goltsova T, Mudannayake M, Ringrose J, Punia J, Lopez-Terrada D, Sheehan AM.. " Detection of Lymphoid and Myeloid Lineages in Infantile B Acute Lymphoblastic Leukemia with Mixed Lineage Leukemia Rearrangement by Use of Flow Cytometry and Cytogenetics. " Clin Lymphoma Myeloma Leuk. 2014 Sep 14; Suppl; S2-5.
Pubmed PMID: 25486951.
Long DJ, Iskander K, Gaikwad A, Arin M, Roop DR, Knox R, Barrios R, Jaiswal AK. " Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity. " J. Biol. Chem.. 2002 Nov 29; 277 (48) : 46131-9.
Pubmed PMID: 12351651.
Gutterman JU, Lai HT, Yang P, Haridas V, Gaikwad A, Marcus S. " Effects of the tumor inhibitory triterpenoid avicin G on cell integrity, cytokinesis, and protein ubiquitination in fission yeast. " Proc. Natl. Acad. Sci. U.S.A.. 2005 Sep 6; 102 (36) : 12771-6.
Pubmed PMID: 16118282.
Gaikwad AS, Donohue RE, Elghetany MT, Sheehan AM, Lu XY, Gramatges MM, McClain KL, Mistretta TA, Punia JN, Moore TJ, Goltsova T, Cubbage M, Curry CV.. " Expression of CD25 is a specific and relatively sensitive marker for the Philadelphia chromosome (BCR-ABL1) translocation in pediatric B acute lymphoblastic leukemia. " Int J Clin Exp Pathol. 2014 Aug 15; 7 (9) : 6225-30..
Pubmed PMID: 25337274.
Gaikwad A, Verstovsek S, Yoon D, Chang KT, Manshouri T, Nussenzveig R, Cortes J, Vainchenker W, Prchal JT. " Imatinib effect on growth and signal transduction in polycythemia vera. " Exp. Hematol.. 2007 Jun ; 35 (6) : 931-8.
Pubmed PMID: 17533047.
Gaikwad A, Nussenzveig R, Liu E, Gottshalk S, Chang K, Prchal JT. " In vitro expansion of erythroid progenitors from polycythemia vera patients leads to decrease in JAK2 V617F allele. " Exp. Hematol.. 2007 Apr ; 35 (4) : 587-95.
Pubmed PMID: 17379069.
Gaikwad A, Long DJ, Stringer JL, Jaiswal AK. " In vivo role of NAD(P)H:quinone oxidoreductase 1 (NQO1) in the regulation of intracellular redox state and accumulation of abdominal adipose tissue. " J. Biol. Chem.. 2001 Jun 22; 276 (25) : 22559-64.
Pubmed PMID: 11309386.
Iskander K, Gaikwad A, Paquet M, Long DJ, Brayton C, Barrios R, Jaiswal AK. " Lower induction of p53 and decreased apoptosis in NQO1-null mice lead to increased sensitivity to chemical-induced skin carcinogenesis. " Cancer Res.. 2005 Mar 15; 65 (6) : 2054-8.
Pubmed PMID: 15781611.
Agarwal N, Kutlar F, Mojica-Henshaw MP, Ou CN, Gaikwad A, Reading NS, Bailey L, Kutlar A, Prchal JT. " Missense mutation of the last nucleotide of exon 1 (G->C) of beta globin gene not only leads to undetectable mutant peptide and transcript but also interferes with the expression of wild allele. " Haematologica. 2007 Dec ; 92 (12) : 1715-6.
Pubmed PMID: 18056002.
Nussenzveig RH, Swierczek SI, Jelinek J, Gaikwad A, Liu E, Verstovsek S, Prchal JF, Prchal JT. " Polycythemia vera is not initiated by JAK2V617F mutation. " Exp. Hematol.. 2007 Jan ; 35 (1) : 32-8.
Pubmed PMID: 17198871.
Quintás-Cardama A, Manshouri T, Estrov Z, Harris D, Zhang Y, Gaikwad A, Kantarjian HM, Verstovsek S. " Preclinical characterization of atiprimod, a novel JAK2 AND JAK3 inhibitor. " Invest New Drugs. 2011 Oct ; 29 (5) : 818-26.
Pubmed PMID: 20372971.
Stringer JL, Gaikwad A, Gonzales BN, Long DJ, Marks LM, Jaiswal AK. " Presence and induction of the enzyme NAD(P)H: quinone oxidoreductase 1 in the central nervous system. " J. Comp. Neurol.. 2004 Apr 5; 471 (3) : 289-97.
Pubmed PMID: 14991562.
Gaikwad A, Rye CL, Devidas M, Heerema NA, Carroll AJ, Izraeli S, Plon SE, Basso G, Pession A, Rabin KR. " Prevalence and clinical correlates of JAK2 mutations in Down syndrome acute lymphoblastic leukaemia. " Br. J. Haematol.. 2009 Mar ; 144 (6) : 930-2.
Pubmed PMID: 19120350.
Gaikwad A, Rye CL, Devidas M, Heerema NA, Carroll AJ, Izraeli S, Plon SE, Basso G, Pession A, Rabin KR.. " Prevalence and clinical correlates of JAK2 mutations in Down syndrome acute lymphoblastic leukaemia. " Br J Haematol. 2009 Mar ; 144 (6) : 930-2.
Pubmed PMID: 19120350.
Gaikwad A, Prchal JT. " Study of two tyrosine kinase inhibitors on growth and signal transduction in polycythemia vera. " Exp. Hematol.. 2007 Nov ; 35 (11) : 1647-56.
Pubmed PMID: 17976517.
Manshouri T, Quintás-Cardama A, Nussenzveig RH, Gaikwad A, Estrov Z, Prchal J, Cortes JE, Kantarjian HM, Verstovsek S. " The JAK kinase inhibitor CP-690,550 suppresses the growth of human polycythemia vera cells carrying the JAK2V617F mutation. " Cancer Sci.. 2008 Jun ; 99 (6) : 1265-73.
Pubmed PMID: 18482053.
Gaikwad AS, Cumsky MG. " The use of chemical cross-linking to identify proteins that interact with a mitochondrial presequence. " J. Biol. Chem.. 1994 Mar 4; 269 (9) : 6437-43.
Pubmed PMID: 8119994.
Haridas V, Hanausek M, Nishimura G, Soehnge H, Gaikwad A, Narog M, Spears E, Zoltaszek R, Walaszek Z, Gutterman JU. " Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery. " J. Clin. Invest.. 2004 Jan ; 113 (1) : 65-73.
Pubmed PMID: 14702110.
Gaikwad A, Poblenz A, Haridas V, Zhang C, Duvic M, Gutterman J. " Triterpenoid electrophiles (avicins) suppress heat shock protein-70 and x-linked inhibitor of apoptosis proteins in malignant cells by activation of ubiquitin machinery: implications for proapoptotic activity. " Clin. Cancer Res.. 2005 Mar 1; 11 (5) : 1953-62.
Pubmed PMID: 15756021.

Skills

Flow Cytometry