Positions
- Assistant Professor
-
Pediatrics
Nutrition
Baylor College of Medicine
Houston, Texas United States
- Member
-
Digestive Disease Center
Texas Medical Center
Houston, Texas United States
- Member
-
Center for Research in Obesity and Nutrition
Baylor College of Medicine
Houston, Texas United States
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
- Member
-
Inclusion and Excellence Council
Baylor College of Medicine
Houston, Texas United States
Addresses
- Office (Office)
-
Children's Nutrition Research Center, Room 6070
1100 Bates Street
Houston, TX 77030
United States
- Lab (Lab)
-
Children's Nutrition Research Center, Room 6012
1100 Bates Street
Houston, TX 77030
United States
Education
- PhD from Vanderbilt University
- Nashville, TN United States
- Molecular Physiology and Biophysics
- Postdoctoral Fellowship at Baylor College Of Medicine
- Houston, TX United States
- Pediatric Gastroenterology, Hepatology, and Nutrition
Honors & Awards
- ENDO2010 Presidential Poster Competition Award
- Endocrine Society (06/2010)
- ENDO2012 Outstanding Abstract Award
- Endocrine Society (06/2012)
- AHA Postdoctoral Fellowship Award
- 10POST3850002
- American Heart Association (07/2010 - 06/2012)
Professional Statement
I am the Principal Investigator of a lab that seeks to address links between alterations in nutrient metabolism and health. My research background includes studies of thymocyte development in mice and atherosclerosis in mouse models of metabolic syndrome. Currently, my lab applies a variety of molecular biology, cell culture, and in vivo metabolic phenotyping techniques using transgenic mice to study obesity and associated pathologies, such as dyslipidemia, insulin resistance, and nonalcoholic fatty liver disease. We have three physiological areas of interest: 1.) adipocyte metabolism and consequent effects on adipose tissue function, 2.) hepatocyte metabolism and development of chronic liver disease, and 3.) immunometabolism and its impact on inflammation in metabolic tissues. The aim of our research is to identify new prevention and treatment strategies for patients at risk for type 2 diabetes and cardiovascular disease.As a person with West Asian heritage and as a new mom, I am fully committed to promoting diversity, equity, and inclusion in scientific research.
Websites
Selected Publications
- Wooton-Kee CR*, Robertson M, Zhou Y, Dong B, Sun Z, Kim KH, Liu H, Xu Y, Putluri N, Saha P, Coarfa C, Moore DD*, Nuotio-Antar AM*. *co-corresponding authors "Metabolic dysregulation in the Atp7b -/- Wilson's disease mouse model." Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):2076-2083. Pubmed PMID: 31924743
- Couturier J, Nuotio-Antar AM, Agarwal N, Wilkerson GK, Saha P, Kulkarni V, Lakhashe SK, Esquivel J, Nehete PN, Ruprecht RM, Sastry KJ, Meyer JM, Hill LR, Lake JE, Balasubramanyam A, Lewis DE "Lymphocytes upregulate CD36 in adipose tissue and liver." Adipocyte. 2019 Dec;8(1):154-163. Pubmed PMID: 31035848
- Mo Q, Salley J, Roshan T, Baer LA, May FJ, Jaehnig EJ, Lehnig AC, Guo X, Tong Q, Nuotio-Antar AM, Shamsi F, Tseng YH, Stanford KI, Chen MH "Identification and characterization of a supraclavicular brown adipose tissue in mice." JCI Insight. 2017 Jun 2;2(11):pii: 93166. Pubmed PMID: 28570265
- Nuotio-Antar AM, Poungvarin N, Li M, Schupp M, Mohammad M, Gerard S, Zou F, Chan L "FABP4-Cre Mediated Expression of Constitutively Active ChREBP Protects Against Obesity, Fatty Liver, and Insulin Resistance.." Endocrinology. 2015 Nov;156(11):4020-32. Pubmed PMID: 26248218
- Witte N, Muenzner M, Rietscher J, Knauer M, Heidenreich S, Nuotio-Antar AM, Graef FA, Fedders R, Tolkachov A, Goehring I, Schupp M "The glucose sensor ChREBP links de-novo lipogenesis to PPARγ activity and adipocyte differentiation.." Endocrinology. 2015 Nov;156(11):4008-19. Pubmed PMID: 26181104
- Mehta P, Nuotio-Antar AM, Smith CW "γδ T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice." J Leukoc Biol. 2015 Jan;97(1):121-34. Pubmed PMID: 25395302
- Huang L, Belousova T, Pan JS, Du J, Ju H, Lu L, Zhang P, Truong LD, Nuotio-Antar A, Sheikh-Hamad D "AKI after conditional and kidney-specific knockdown of stanniocalcin-1." J Am Soc Nephrol. 2014 Oct;25(10):2303-15. Pubmed PMID: 24700878
- Lin L*, Nuotio-Antar AM*, Ma X, Liu F, Fiorotto ML, Sun Y. *co-first authors "Ghrelin receptor regulates appetite and satiety during aging in mice by regulating meal frequency and portion size but not total food intake." J Nutr. 2014 Sep;144(9):1349-55. Pubmed PMID: 24991043
- Li MV, Chen W, Harmancey RN, Nuotio-Antar AM, Imamura M, Saha P, Taegtmeyer H, Chan L "Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP)." Biochem Biophys Res Commun. 2010 May 7;395(3):395-400. Pubmed PMID: 20382127
- Nuotio-Antar AM, Hachey DL, Hasty AH "Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice." Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1517-28. Pubmed PMID: 17878220
- Nuotio-Antar AM, Hasty AH, Kovacs WJ "Quantitation and cellular localization of 11beta-HSD1 expression in murine thymus." J Steroid Biochem Mol Biol. 2006 May;99(2):93-9. Pubmed PMID: 16621520
- Gruen ML, Saraswathi V, Nuotio-Antar AM, Plummer MR, Coenen KR, Hasty AH "Plasma insulin levels predict atherosclerotic lesion burden in obese hyperlipidemic mice." Atherosclerosis. 2006 May;186(1):54-64. Pubmed PMID: 16102772
Memberships
- American Association for the Advancement of Science
- American Diabetes Association
- American Heart Association
- American Physiological Society
- American Society for Nutrition
- The Endocrine Society
- The Obesity Society
- Sigma Xi
- (05/2007)
Funding
- Cooperative Agreement - #3092-51000-060-03S (04/01/2014 - 03/31/2019) Grant funding from USDA/ARS
- Grant funding from USDA/ARS
- Career Development Award - #18CDA34110137 (07/01/2018 - 06/30/2022) Grant funding from AHA
- Grant funding from American Heart Association
- Cooperative Agreement - #3092-51000-064-05S (04/01/2019 - 03/31/2024) Grant funding from USDA/ARS
- Grant funding from USDA/ARS
- Pediatric Pilot Award (07/01/2022 - 06/30/2023) Texas Children's Hospital
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