Alli Antar, Ph.D.

Assistant Professor

Email

antar@bcm.edu

Positions

Assistant Professor: Pediatrics
Nutrition
Baylor College of Medicine
Houston, Texas, United States

Member: Inclusion and Excellence Council
Baylor College of Medicine
Houston, Texas, United States

Member: Cardiovascular Research Institute
Baylor College of Medicine
Houston, Texas, United States

Member: Center for Research in Obesity and Nutrition
Baylor College of Medicine
Houston, Texas, United States

Member: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Member: Digestive Diseases Center
Texas Medical Center
Houston, Texas, United States

Member: Houston Nutrition Obesity Research Center
Houston, Texas, United States

Education

PhD from Vanderbilt University: Nashville, Tennessee, United States; Molecular Physiology and Biophysics

Postdoctoral Fellowship at Baylor College Of Medicine: Houston, Texas, United States; Pediatric Gastroenterology, Hepatology, and Nutrition

BS from Sewanee: The University of the South: Sewanee, Tennessee, United States; Chemistry

Honors & Awards

ENDO2012 Outstanding Abstract Award: Endocrine Society

AHA Postdoctoral Fellowship Award: Grant # 10POST3850002; American Heart Association

ENDO2010 Presidential Poster Competition Award: American Heart Association

CNRC-NICHD Postdoctoral Training Grant Award: Grant # T32HD007445; National Institutes of Health

BCM-NIDDK Pediatric Gastroenterology Postdoctoral Training Grant Award: Grant # T32DK007664; National Institutes of Health

VUMC-CHHD Reproductive Biology Pre-doctoral Training Grant Award: Grant # T32HD007043; National Institutes of Health

Student Stipend Award: Lupus Foundation of America, Nashville (Mid-South) Chapter

Professional Statement

My lab seeks to address links between alterations in nutrient metabolism and health. We apply a variety of molecular biology, cell culture, and in vivo metabolic phenotyping techniques and use transgenic mice to study obesity and associated pathologies, such as dyslipidemia, insulin resistance, and nonalcoholic fatty liver disease. We have three physiological areas of interest: 1.) adipocyte metabolism and consequent effects on adipose tissue function, 2.) hepatocyte metabolism and development of chronic liver disease, and 3.) immunometabolism and its impact on inflammation in metabolic tissues. The aim of our research is to identify new prevention and treatment strategies for patients at risk for type 2 diabetes and cardiovascular disease.

Websites

My Publications

Selected Publications

Zhang J, Zhao Y, Pulivendala G, Zhang Q, Rui L, Gao J, Wang H, Zhang G, Nuotio-Antar A, Tong X, Yin L. " The Non-Canonical ChREBPα Activity Suppresses the Activation of Hepatic Stellate Cells and Liver Fibrosis by Antagonizing TGF-β-E2F1 Axis " Adv Sci. 2025 Jun 23; e15032.
Pubmed PMID: 40548862.
Starr CR, Zhylkibayev A, Gorbatyuk O, Nuotio-Antar AM, Mobley J, Grant MB, Gorbatyuk M. " Glucose-Sensing Carbohydrate Response Element-Binding Protein in the Pathogenesis of Diabetic Retinopathy " Cells. 2025 Jan 13; 14 (2) : 107.
Pubmed PMID: 39851533.
Zhang D, Zhao Y, Zhang G, Lank D, Cooke S, Wang S, Nuotio-Antar A, Tong X, Yin L. " Suppression of hepatic ChREBP⍺-CYP2C50 axis-driven fatty acid oxidation sensitizes mice to diet-induced MASLD/MASH " Mol Metab. 2024 Jul ; 85 : 101957.
Pubmed PMID: 38740087.
Taylor BC, Steinthal LH, Dias M, Yalamanchili HK, Ochsner SA, Zapata GE, Mehta NR, McKenna NJ, Young NL, Nuotio-Antar AM. " Histone proteoform analysis reveals epigenetic changes in adult mouse brown adipose tissue in response to cold stress " Epigenetics Chromatin. 2024 Apr 27; 17 (1) : 12.
Pubmed PMID: 38678237.
Masschelin PM, Saha P, Ochsner SA, Cox AR, Kim KH, Felix JB, Sharp R, Li X, Tan L, Park JH, Wang L, Putluri V, Lorenzi PL, Nuotio-Antar AM, Sun Z, Kaipparettu BA, Putluri N, Moore DD, Summers SA, McKenna NJ, Hartig SM. " Vitamin B2 enables regulation of fasting glucose availability " eLife. 2023 Jul 7; 12 : e84077.
Pubmed PMID: 37417957.
Wooton-Kee CR, Robertson M, Zhou Y, Dong B, Sun Z, Kim KH, Liu H, Xu Y, Putluri N, Saha P, Coarfa C, Moore DD, Nuotio-Antar AM. " Metabolic dysregulation in the Atp7b -/- Wilson's disease mouse model " Proc Natl Acad Sci U S A. 2020 Jan 28; 117 (4) : 2076-2083.
Pubmed PMID: 31924743.
Couturier J, Nuotio-Antar AM, Agarwal N, Wilkerson GK, Saha P, Kulkarni V, Lakhashe SK, Esquivel J, Nehete PN, Ruprecht RM, Sastry KJ, Meyer JM, Hill LR, Lake JE, Balasubramanyam A, Lewis DE. " Lymphocytes upregulate CD36 in adipose tissue and liver " Adipocyte. 2019 Dec ; 8 (1) : 154-163.
Pubmed PMID: 31035848.
Mo Q, Salley J, Roshan T, Baer LA, May FJ, Jaehnig EJ, Lehnig AC, Guo X, Tong Q, Nuotio-Antar AM, Shamsi F, Tseng YH, Stanford KI, Chen MH. " Identification and characterization of a supraclavicular brown adipose tissue in mice " JCI Insight. 2017 Jun 2; 2 (11) : pii: 93166.
Pubmed PMID: 28570265.
Nuotio-Antar AM, Poungvarin N, Li M, Schupp M, Mohammad M, Gerard S, Zou F, Chan L. " FABP4-Cre Mediated Expression of Constitutively Active ChREBP Protects Against Obesity, Fatty Liver, and Insulin Resistance " Endocrinology. 2015 Nov ; 156 (11) : 4020-32.
Pubmed PMID: 26248218.
Witte N, Muenzner M, Rietscher J, Knauer M, Heidenreich S, Nuotio-Antar AM, Graef FA, Fedders R, Tolkachov A, Goehring I, Schupp M. " The glucose sensor ChREBP links de-novo lipogenesis to PPARγ activity and adipocyte differentiation " Endocrinology. 2015 Nov ; 156 (11) : 4008-19.
Pubmed PMID: 26181104.
Mehta P, Nuotio-Antar AM, Smith CW. " γδ T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice " J Leukoc Biol. 2015 Jan ; 97 (1) : 121-34.
Pubmed PMID: 25395302.
Huang L, Belousova T, Pan JS, Du J, Ju H, Lu L, Zhang P, Truong LD, Nuotio-Antar A, Sheikh-Hamad D. " AKI after conditional and kidney-specific knockdown of stanniocalcin-1 " J Am Soc Nephrol. 2014 Oct ; 25 (10) : 2303-15.
Pubmed PMID: 24700878.
Lin L*, Nuotio-Antar AM*, Ma X, Liu F, Fiorotto ML, Sun Y. " Ghrelin receptor regulates appetite and satiety during aging in mice by regulating meal frequency and portion size but not total food intake " J Nutr. 2014 Sep ; 144 (9) : 1349-55.
Pubmed PMID: 24991043.
Li MV, Chen W, Harmancey RN, Nuotio-Antar AM, Imamura M, Saha P, Taegtmeyer H, Chan L. " Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP) " Biochem Biophys Res Commun. 2010 May 7; 395 (3) : 395-400.
Pubmed PMID: 20382127.
Nuotio-Antar AM, Hachey DL, Hasty AH. " Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice " Am J Physiol Endocrinol Metab. 2007 Dec ; 293 (6) : E1517-28.
Pubmed PMID: 17878220.
Nuotio-Antar AM, Hasty AH, Kovacs WJ. " Quantitation and cellular localization of 11beta-HSD1 expression in murine thymus " J Steroid Biochem Mol Biol. 2006 May ; 99 (2-3) : 93-9.
Pubmed PMID: 16621520.
Gruen ML, Saraswathi V, Nuotio-Antar AM, Plummer MR, Coenen KR, Hasty AH. " Plasma insulin levels predict atherosclerotic lesion burden in obese hyperlipidemic mice " Atherosclerosis. 2006 May ; 186 (1) : 54-64.
Pubmed PMID: 16102772.

Funding

Cooperative Agreement #3092-10700-069-001S: (04/01/2024 - 03/31/2029); Grant funding from USDA/ARS

Pediatric Pilot Award: (07/01/2022 - 06/30/2024); Texas Children's Hospital

Cooperative Agreement #3092-51000-064-005-S: (04/01/2019 - 03/31/2024); Grant funding from USDA/ARS

Career Development Award and COVID Relief Supplement #18CDA34110137: (07/01/2018 - 06/30/2022); Grant funding from American Heart Association

Cooperative Agreement #3092-51000-065-30S: (04/01/2014 - 03/31/2019); Grant funding from USDA/ARS