The Global TB Program has focused on the seamless integration of TB and HIV care and treatment across our network of African partner sites and expanded efforts to support the eight clinical centers of excellence located in seven countries (BIPAI). The TB Program has also conducted trainings, improved standardization, and enhanced the existing Electronic Medical Records (EMR) system to effectively capture outcome data regarding TB and other common HIV-comorbidities.
In collaboration with colleagues from IUATLD, McGill University, and the Cochrane Collaboration, the Global TB Program partners to conduct systematic reviews and meta-analyze data to generate evidence informing international and WHO policy regarding the care and treatment of children battling TB. Examples of this work include the following publications:
Mandalakas A, Detjen A, Hesseling A, Benedetti A, Menzies D. Interferon-Gamma Release Assays for the detection of Mycobacterium tuberculosis infection in children: a systematic review and meta-analysis. International Journal of Tuberculosis and Lung Disease. 2011 Aug; 15(8):1018-32.
Detjen AK, DiNardo AR, Leyden J, Steingart KR, Menzies D, Schiller I, Dendukuri N, Mandalakas AM. Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in children: a systematic review and meta-analysis. The Lancet Respiratory Medicine. 2015 Mar 23. PubMed PMID: 25812968
DiNardo AR, Detjen A, Ustero P, Ngo K, Bacha J, Mandalakas AM. Culture is an imperfect and heterogeneous reference standard in pediatric tuberculosis. Tuberculosis. 2016 Sep 28. PMID: 27727131
Partnering with institutions to provide linkage of new and established researchers, the Global TB Program has successfully attracted a new cadre of investigators to collaborate in TB-related research and expand capacity at our existing and newly established research centers. Learn more about the Global TB Program’s research.