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… Regulation of Hematopoietic Stem Cells and Development of … little is known about the factors or mechanisms that regulate them. We are using HSCs as a paradigm to understand the general mechanisms governing adult stem cells, and how … DNMT3A is mutated in about 20 percent of hematologic malignancies, and is emerging as one of …
research › ... › activities
… “All work and no play makes Jack a dull boy All work and no play makes Jack a dull boy All work and no play makes Jack a dull boy...” ( The Shining , reference). One needs to get out of the lab to be fulfilled and … Tom Cooper Lab Activities …
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… The William's lab isn't currently recruiting for positions at this time. … We have opportunities for graduate students to join the lab and participate in our research. Contact Matthew McGinley at matthew.mcginley@bcm.edu to … Open Positions … Graduate Students …
research › ... › projects
… the anteroposterior embryonic axis are required for extension of that axis, but how is this coordination achieved at the molecular level? We are working to identify ‘molecular translators’ that allow complex spatial cues to be interpreted by an embryo’s … Asymmetry along the head-tail axis is required for its extension. Such asymmetry is apparent within zebrafish embryo …
research › ... › publications
… Alaniz Emig A, Williams MLK. Generation of Naïve Blastoderm Explants from Zebrafish … cell polarity signaling cooperate to regulate zebrafish convergence and extension gastrulation movements. Elife. … 2020 Apr 22;9. doi: 10.7554/eLife.54445. PubMed PMID: 32319426; PubMed Central PMCID: PMC7250581. View article Williams …
research › ... › lab-members
… Postdoctoral Fellow (2016-2023) Current position: Senior Scientist, Nitto BioPharma, Inc. … Graduate Student (2014-2020) Postdoctoral Fellow (2021-2023) Current position: Postdoctoral Fellow, Baylor College of Medicine … Graduate Student (2016-2019) Postdoctoral Fellow (2020) Current …
research › ... › projects
… The Notch signaling pathway plays important roles in animal embryonic development and adult maintenance. We and others have shown that … in flies and mammals. Notably, we have found that in some contexts, the Notch pathway is sensitive to the gene dosage … is an autosomal dominant disorder characterized by a congenital cholangiopathy of variable severity accompanied by …
research › ... › research-areas
… Our laboratory uses genetic, cell biological, and biochemical approaches to explore the pathogenesis of polyglutamine neurodegenerative diseases, the function of Math1 in … ataxias (SCAs) are dominantly inherited neurodegenerative disorders characterized by a progressive loss of …
research › ... › current-projects
… receptors as key survival factors in prostate cancer Cellular senescence and prostate cancer Cellular senescence and benign prostatic hyperplasia (BPH) Mouse models of prostate cancer Mechanisms of Cytokine Induced Lower … Ittmann Lab Current Projects …