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research › ... › current-projects
… We are studying how infections affect the quiescence, epigenetic programming, and differentiation of hematopoietic stem cells and their progeny. Our … We are studying how the differential responses of hematopoietic stem cells to inflammation contribute to clonal competition and emergence of leukemia. These studies provide …
research › ... › publications
… of S. pombe proteins required for mating and morphogenesis. Cell, 79: 131-141. PMID 7923372 Zheng, Z., Cheng, C-M, Fu, X-R, Chen, L-Y, Xu, L., Terrillon, … C., 2012. CHMP6 and VPS4A mediate recycling of Ras to the plasma membrane to promote growth factor signaling. …
research › ... › projects
… The following are projects that Dr. Yang and his lab members are involved in: … MAPK4 biology in human diseases, including cancers, remain largely unknown. We discovered that MAPK4 activates the … to promote cancer initiation, progression, and the development of therapy-resistance. We are now pioneering the …
research › ... › publications
… Han D, Wang W, Jeon JH, Shen T, Huang X, Yi P, Dong B, … . Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy. … . 2023 Aug;21(8):e3002227. Singh R, Meng H, Shen T, Lumahan LEV, Nguyen S, Shen H, Dasgupta S, Qin L, …
research › ... › staff-scientists
… Zechiedrich Lab Staff Scientists …
research › ... › undergraduate-students
… We have hosted fantastic undergraduate students from many different disciplines and institutions. … to publishing a paper on their own original work. They all contributed their unique talents toward the success of our laboratory and we're proud of their many subsequent accomplishments and accolades. …
research › ... › visiting-professors
… Zechiedrich Lab Visiting Professors …
research › ... › awards
… Supercoiled Minicircle DNA For Gene Therapy Applications … Patent number: 20130316449 Abstract: The present invention relates to nucleic acid molecule compositions comprising minivectors encoding a nucleic acid … As A Tool For DNA Repair, Alteration And Replacement …
research › ... › projects
… New Methods for Large-Scale Computer Simulation - R01GM127628 … June 1, 2018 - Feb. 28, 2022 National Institute of General Medical Sciences (NIGMS) $336,813 … Enhancing Vaccine Design Against Influenza H1N1 Virus … for Bird-to-Human Transmission of Avian H5N1 Influenza A Virus …