2018

Hsu JI, Dayaram T, Tovy A, De Braekeleer E, Jeong M, Wang F, Zhang J, Heffernan TP, Gera S, Kovacs JJ, Marszalek JR, Bristow C, Yan Y, Garcia-Manero G, Kantarjian H, Vassiliou G, Futreal PA, Donehower LA, Takahashi K, Goodell MA. PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy. Cell Stem Cell. 2018;23(5):700-13 e6. View in PubMed

Brunetti L, Gundry MC, Sorcini D, Guzman AG, Huang YH, Ramabadran R, Gionfriddo I, Mezzasoma F, Milano F, Nabet B, Buckley DL, Kornblau SM, Lin CY, Sportoletti P, Martelli MP, Falini B, Goodell MA. Mutant NPM1 Maintains the Leukemic State through HOX Expression. Cancer Cell. 2018;34(3):499-512 e9. View in PubMed

Su J, Huang YH, Cui X, Wang X, Zhang X, Lei Y, Xu J, Lin X, Chen K, Lv J, Goodell MA, Li W. Homeobox oncogene activation by pan-cancer DNA hypermethylation. Genome Biol. 2018;19(1):108. View in PubMed

Gu T, Lin X, Cullen SM, Luo M, Jeong M, Estecio M, Shen J, Hardikar S, Sun D, Su J, Rux D, Guzman A, Lee M, Qi LS, Chen JJ, Kyba M, Huang Y, Chen T, Li W, Goodell MA. DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells. Genome Biol. 2018;19(1):88. View in PubMed

Brunetti L, Gundry MC, Kitano A, Nakada D, Goodell MA. Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9. J Vis Exp. 2018(134). View in PubMed

Jeong M, Park HJ, Celik H, Ostrander EL, Reyes JM, Guzman A, Rodriguez B, Lei Y, Lee Y, Ding L, Guryanova OA, Li W, Goodell MA, Challen GA. Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo. Cell Rep. 2018;23(1):1-10. View in PubMed

Tan Q, Brunetti L, Rousseaux MWC, Lu HC, Wan YW, Revelli JP, Liu Z, Goodell MA, Zoghbi HY. Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma. Proc Natl Acad Sci U S A. 2018;115(7):E1511-E9. View in PubMed

Jeong M, Park HJ, Celik H, Ostrander EL, Reyes JM, Guzman A, Rodriguez B, Lei Y, Lee Y, Ding L, Guryanova OA, Li W, Goodell MA, Challen GA. Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo. Cell Rep. 2018;23(1):1-10. View in PubMed

Brunetti L, Gundry MC, Kitano A, Nakada D, Goodell MA. Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9. J Vis Exp. 2018(134). View in PubMed

2017

Huang YH, Su J, Lei Y, Brunetti L, Gundry MC, Zhang X, Jeong M, Li W, Goodell MA. DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A. Genome Biol. 2017;18(1):176. View in PubMed

Lei Y, Zhang X, Su J, Jeong M, Gundry MC, Huang YH, Zhou Y, Li W, Goodell MA. Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein. Nat Commun. 2017;8:1602. View in PubMed

Brunetti L, Gundry MC, Goodell MA. DNMT3A in Leukemia. Cold Spring Harb Perspect Med. 2017;7(2). View in PubMed

Jeong M, Guzman AG, Goodell MA. Genome-Wide Analysis of DNA Methylation in Hematopoietic Cells: DNA Methylation Analysis by WGBS. Methods Mol Biol. 2017;1633:137-49. View in PubMed

2016

Gundry MC, Brunetti L, Lin A, Mayle AE, Kitano A, Wagner D, Hsu JI, Hoegenauer KA, Rooney CM, Goodell MA, Nakada D. Highly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9. Cell Rep. 2016;17(5):1453-61. View in PubMed

Jeong M, Goodell MA. Noncoding Regulatory RNAs in Hematopoiesis. Curr Top Dev Biol. 2016;118:245-70. View in PubMed

Karlstaedt A, Zhang X, Vitrac H, Harmancey R, Vasquez H, Wang JH, Goodell MA, Taegtmeyer H. Oncometabolite d-2-hydroxyglutarate impairs alpha-ketoglutarate dehydrogenase and contractile function in rodent heart. Proc Natl Acad Sci U S A. 2016;113(37):10436-41. View in PubMed

Zhang X, Su J, Jeong M, Ko M, Huang Y, Park HJ, Guzman A, Lei Y, Huang YH, Rao A, Li W, Goodell MA. DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells. Nat Genet. 2016;48(9):1014-23. View in PubMed

Rau RE, Rodriguez BA, Luo M, Jeong M, Rosen A, Rogers JH, Campbell CT, Daigle SR, Deng L, Song Y, Sweet S, Chevassut T, Andreeff M, Kornblau SM, Li W, Goodell MA. DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia. Blood. 2016;128(7):971-81. View in PubMed

Yang L, Rodriguez B, Mayle A, Park HJ, Lin X, Luo M, Jeong M, Curry CV, Kim SB, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, Gottgens B, Lee JS, Rau R, Li W, Goodell MA. DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias. Cancer Cell. 2016;30(2):363-5. View in PubMed

Eckstein OS, Wang L, Punia JN, Kornblau SM, Andreeff M, Wheeler DA, Goodell MA, Rau RE. Mixed-phenotype acute leukemia (MPAL) exhibits frequent mutations in DNMT3A and activated signaling genes. Exp Hematol. 2016;44(8):740-4. View in PubMed

2015

Goodell, MA and Rando, TA (2015) Stem Cells and Healthy Aging. Science, 350: 1199-1204. View in PubMed

Artandi, SE, Blau, HM, de Haan, G, Geiger, H, Goodell, MA, Jones, L, Levine, RL, Muñoz-Cánoves, P, Rodewald, HR, Wagers, A, Wang, ZQ and Y. Yamashita (2015) Stem Cells and Aging: What's Next? Cell Stem Cell Jun 4; 16(6):578-81. View in PubMed

An J, González-Avalos E, Chawla A, Jeong M, López-Moyado IF, Li W, Goodell MA, Chavez L, Ko M, Rao A. Acute loss of TET function results in aggressive myeloid cancer in mice. Nat Commun. 2015 Nov 26;6:10071. View in PubMed

Gibson, BW, Boles, NC, Souroullas, GP, Herron, AJ, Fraley, JK, Schwiebert, RS, Sharp, JJ and MA Goodell (2015) Comparison of Cesium-137 and X-ray Irradiators by Using Bone Marrow Transplant Reconstitution in C57BL/6J Mice. Comp Med 65:165-172. View in PubMed

Wang J, Wegener, JE, Huang, TW, Sripathy, S, De Jesus-Cortes, H, Xu P, Tran, S, Knobbe, W, Leko, V, Britt, J, Starwalt, R, McDaniel L, Ward, CS, Parra D, Newcomb, B, Lao, U, Nourigat, C, Flowers, DA, Cullen, S, Jorstad, NL, Yang, Y, Glaskova, L, Vigneau, S, Kozlitina, J, Yetman, MJ, Jankowsky, JL, Reichardt, SD, Reichardt, HM, Gärtner, J, Bartolomei, MS, Fang, M, Loeb, K, Keene, CD, Bernstein, I, Goodell, MA, Brat, DJ, Huppke P, Neul, JL, Bedalov, A and AA Pieper (2015) Wild-type Microglia do not Reverse Pathology in Mouse Models of Rett Syndrome. Nature 521:7552. View in PubMed

King, KY, Matatall, KA, Shen, CC, Goodell, MA, Swierczek, SI and JT Prchal (2015) Comparative Long-term Effects of Interferon a and Hydroxyurea on Human Hematopoietic Progenitor Cells. Exp Hematol 2015 Jun 11. View in PubMed

Luo, M, Jeong, M, Sun, D, Park, HJ, Xia, Z, Rodriguez, B, Yang, L, Zhang, X, Darlington, GJ, Li, W and MA Goodell (2015) Long Non-coding RNAs Control Hematopoietic Progenitor Cell Function. Cell Stem Cell 16:1-13. View in PubMed

Mayle A, Yang L, Rodriguez B, Zhou T, Chang E, Curry CV, Challen GA, Li W, Wheeler D, Rebel VI, Goodell MA. Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation. Blood. 2015 Jan 22;125(4):629-638. View in PubMed

Cullen SM, Goodell MA. Dynamic DNA methylation discovered during HSC differentiation. Cell Cycle. 2015;14(5):693-4. View in PubMed

Goodell MA, Nguyen H, Shroyer N. Somatic stem cell heterogeneity: diversity in the blood, skin and intestinal stem cell compartments. Nat Rev Mol Cell Biol. 2015;16(5):299-309. View in PubMed

Goodell M. Introduction to a review series on hematopoietic stem cells. Blood. 2015;125(17):2587. View in PubMed

Yang L, Rau R, Goodell MA. DNMT3A in haematological malignancies. Nat Rev Cancer. 2015;15(3):152-65. View in PubMed

2014

Cullen S, Mayle A, Rossi L, Goodell MA. Hematopoietic Stem Cell Development: An epigenetic journey. Current Topics in Developmental Biology. 2014 107:39-75 View in: Pubmed

Challen GA, Sun D, Mayle A, Jeong M, Luo M, Rodriguez B, Mallaney C, Celik H, Yang L, Xia Z, Cullen S, Berg J, Zheng Y, Darlington GJ, Li W, Goodell MA. Dnmt3a and dnmt3b have overlapping and distinct functions in hematopoietic stem cells. Cell Stem Cell. 2014 Sep 4; 15(3):350-64.View in: PubMed

Jeong M, Goodell MA. New answers to old questions from genome-wide maps of DNA methylation in hematopoietic cells. Exp Hematol. 2014 Aug; 42(8):609-17.View in: PubMed

Goodell MA. A gallon of sweat to make a pint of blood. J Exp Med. 2014 Jun 30; 211(7):1271-2.View in: PubMed

Rodgers JT, King KY, Brett JO, Cromie MJ, Charville GW, Maguire KK, Brunson C, Mastey N, Liu L, Tsai CR, Goodell MA, Rando TA. mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert). Nature. 2014 Jun 19; 510(7505):393-6.View in: PubMed

Sun D, Luo M, Jeong M, Rodriguez B, Xia Z, Hannah R, Wang H, Le T, Faull KF, Chen R, Gu H, Bock C, Meissner A, Göttgens B, Darlington GJ, Li W, Goodell MA. Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal. Cell Stem Cell. 2014 May 1; 14(5):673-88.View in: PubMed

Sun D, Xi Y, Rodriguez B, Park HJ, Tong P, Meong M, Goodell MA, Li W. MOABS: model based analysis of bisulfite sequencing data. Genome Biol. 2014; 15(2):R38.View in: PubMed

Cullen SM, Mayle A, Rossi L, Goodell MA. Hematopoietic stem cell development: an epigenetic journey. Curr Top Dev Biol. 2014; 107:39-75.View in: PubMed

Jeong M, Sun D, Luo M, Huang Y, Challen GA, Rodriguez B, Zhang X, Chavez L, Wang H, Hannah R, Kim SB, Yang L, Ko M, Chen R, Göttgens B, Lee JS, Gunaratne P, Godley LA, Darlington GJ, Rao A, Li W, Goodell MA. Large conserved domains of low DNA methylation maintained by Dnmt3a. Nat Genet. 2014 Jan; 46(1):17-23.View in: PubMed

2013

Kim SJ, Zhao H, Hardikar S, Singh AK, Goodell MA, Chen T. A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells. Blood. 2013 Dec 12; 122(25):4086-9.View in: PubMed

Goodell MA. Parental permissions: H19 and keeping the stem cell progeny under control. Cell Stem Cell. 2013 Aug 1; 13(2):137-8.View in: PubMed

Shi FT, Kim H, Lu W, He Q, Liu D, Goodell MA, Wan M, Songyang Z. Ten-eleven translocation 1 (Tet1) is regulated by O-linked N-acetylglucosamine transferase (Ogt) for target gene repression in mouse embryonic stem cells. J Biol Chem. 2013 Jul 19; 288(29):20776-84.View in: PubMed

Cullen SM, Goodell MA. Rising from the crypt: decreasing DNA methylation during differentiation of the small intestine. Genome Biol. 2013; 14(5):116.View in: PubMed

Goodell MA, Godley LA. Perspectives and future directions for epigenetics in hematology. Blood. 2013 Jun 27; 121(26):5131-7.View in: PubMed

Kahle JJ, Souroullas GP, Yu P, Zohren F, Lee Y, Shaw CA, Zoghbi HY, Goodell MA. Ataxin1L is a regulator of HSC function highlighting the utility of cross-tissue comparisons for gene discovery. PLoS Genet. 2013 Mar; 9(3):e1003359.View in: PubMed

Ergen AV, Jeong M, Lin KK, Challen GA, Goodell MA. Isolation and characterization of mouse side population cells. Methods Mol Biol. 2013; 946:151-62.View in: PubMed

Rossi L, Lemoli RM, Goodell MA. Gpr171, a putative P2Y-like receptor, negatively regulates myeloid differentiation in murine hematopoietic progenitors. Exp Hematol. 2013 Jan; 41(1):102-12.View in: PubMed

2012

Rossi L, Lin KK, Boles NC, Jeong M, Yang L, King KY, Mayle A, Goodell MA. Less is More: unveiling the functional core of hematopoietic stem cells through knockout mice. Cell Stem Cell. 2012 Sep 7;11(3):302-17. [Pubmed]

Mayle A, Luo M, Jeong M, Goodell MA. Flow cytometry analysis of murine hematopoietic stem cells. Cytometry A. 2012. [Pubmed]

Li J, Harris RA, Cheung SW, Coarfa C, Jeong M, Goodell MA, White LD, Patel A, Kang SH, Shaw C, Chinault AC, Gambin T, Gambin A, Lupski JR, Milosavljevic A. Plos Genetics. 2012. 8(5):e1002692. [Pubmed]

James RA, Rao MM, Chen ES, Goodell MA, Shaw CA. The hematopoietic expression viewer: expanding mobile apps as a scientific tool. Bioinformatics. 2012 28(14):1941-2. [Pubmed]

Zohren F, Souroullas GP, Luo M, Gerdemann U, Imperato MR, Wilson NK, Gottgens B, Lukov GL, Goodell MA. The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors. Nature Immunology. 2012 13(8):761-9. [Pubmed]

Ergen AV, Boles NC, Goodell MA. Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing. Blood. 2012 Mar 15;119(11):2500-9. [Pubmed]

2011

Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS, Bock C, Vasanthakumar A, Gu H, Xi Y, Liang S, Lu Y, Darlington GJ, Meissner A, Issa JP, Godley LA, Li W, Goodell MA. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet. 2011 Dec 4;44(1):23-31.[Pubmed]

Berg JS, Lin KK, Sonnet C, Boles NC, Weksberg DC, Nguyen H, Holt LJ, Rickwood D, Daly RJ,Goodell MA. Imprinted genes that regulate early mammalian growth are coexpressed in somatic stem cells. PLoS One. 2011;6(10):e26410. [Pubmed]

Challen GA, Goodell MA. [Editorial] Bridge over troubled stem cells. Mol Ther. 2011 Oct;19(10):1756-8. [Pubmed]

Lin KK, Rossi L, Boles NC, Hall BE, George TC, Goodell MA. CD81 is essential for reentry of hematopoietic stem cells to quiescence following stress-induced proliferation via deactivation of the Akt pathway. PLoS Biol. 2011 Sep;9(9):e1001148. [Pubmed]

King KY, Goodell MA. Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response. Nat Rev Immunol. 2011 Sept 9. [Pubmed]

Souroullas GP, Goodell MA. A new allele of Lyl1 confirms its important role in hematopoietic stem cell function. Genesis. 2011 Jun;49(6):441-8. [Pubmed]

King KY, Baldridge MT, Weksberg DC, Chambers SM, Lukov GL, Wu S, Boles NC, Jung SY, Qin J, Liu D, Songyang Z, Eissa NT, Taylor GA, Goodell MA. Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. Blood 2011 Aug 11; 118(6):1525-33. [Pubmed]

Liao J, Hammerick KE, Challen GA, Goodell MA, Kasper FK, Mikos AG. Investigating the role of hematopoietic stem and progenitor cells in regulating the osteogenic differentiation of mesenchymal stem cells in vitro. J Orthop Res. 2011 Oct;29(10):1544-53. [Pubmed]

Rossi L, Ergen AV, Goodell MA. TIMP-1 deficiency subverts cell-cycle dynamics in murine long-term HSCs. Blood. 2011 Jun 16;117(24):6479-88. [Pubmed]

Boles NC, Lin KK, Lukov GL, Bowman TV, Baldridge MT, Goodell MA. CD48 on hematopoietic progenitors regulates stem cells and suppresses tumor formation. Blood. 2011 Jul 7;118(1):80-7.[Pubmed]

Rossi L, Challen GA, Sirin O, Lin KK, Goodell MA. Hematopoietic stem cell characterization and isolation. Methods Mol Biol. 2011;750:47-59. [Pubmed]

Lin KK, Goodell MA. Detection of hematopoietic stem cells by flow cytometry. Methods Cell Biol. 2011;103:21-30. [Pubmed]

King KY, Goodell MA. [Editorial] Direct conversion of skin cells into blood: alchemy or science? Molecular Therapy. 2011. Feb;19(2):227-8. [Pubmed]

King KY, Lew JD, Ha NP, Lin JS, Ma X, Graviss EA, Goodell MA. Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans. PLoS One. 2011 Jan;6(1):e16317. [Pubmed]

Baldridge MT, King KY, Goodell MA. [Review] Inflammatory signals regulate hematopoietic stem cells. Trends in Immunology. 2011 Jan;32(2):57-65. [Pubmed]

2010

Sirin O, Lukov G, Mao R, Conneely O, Goodell MA. The Orphan Nuclear Receptor Nurr1 Restricts the Proliferation of Hematopoietic Stem Cells. Nature Cell Biology. 2010 Dec;12(12):1213-9.[Pubmed]

Lukov GL, Rossi L, Souroullas GP, Mao R, Goodell MA. LYL1 degradation by the proteasome is directed by a N-terminal PEST rich site in a phosphorylation-independent manner. PLoS One. 2010 Sept 10;5(9). [Pubmed]

Lukov GL, Rossi L, Souroullas GP, Mao R, Goodell MA. The expansion of T-cells and hematopoietic progenitors as a result of overexpression of the lymphoblastic leukemia gene, Lyl1 can support leukemia formation. Leuk Res. 2010 Aug 10. [Pubmed]

Baldridge MT, King KY, Boles NC, Weksberg DC, Goodell MA. Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature. 2010 Jun 10;465(7299):793-7. [Pubmed]

Challen GA, Boles NC, Chambers SM, Goodell MA. Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1. Cell Stem Cell. 2010 Mar 5;6(3):265-278. [PubMed]