Research

Publications

Master
Content

Han SJ, Begum K, Foulds CL, Hamilton RA, Bailey S, Malovannaya A, Chan D, Qin J, O’Malley BW. The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. Mol Pharmacol. 2016 Jan;89(1):14-26.

Selected as Journal Highlights.

Han SJ, Jung SY, Wu SP, Hawkins SM, Park MJ, Kyo S, Qin J, Lydon JP, Tsai SY, Tsai MJ, DeMayo FJ, O'Malley BW. Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis. Cell. 2015 Nov 5;163(4):960-74.

Highlighted in Nature Reviews Immunology: Reproductive immunology: Evading immunosurveillance in endometriosis p729 | doi:10.1038/nri3942.

Comments in Le Quotidien Du Medecin (France) Lundi 9 novembre 2015-n09448.

Editor’s Choice Science Signaling. 17 Nov 2015:Vol. 8, Issue 403, pp. ec338 DOI: 10.1126/scisignal.aad8685.

Highlighted in Endometriosis News. Endometriosis Study Links Estrogen Receptor to Disease Onset, Progression.

Recommended by Faculty of 1000.

Highlighted in J Mol Endocrinol. 2016 Aug;57(2):F23-27

Ye X, Han SJ, Tsai SY, DeMayo FJ, Xu J, Tsai M-J and O'Malley BW. 2005 Roles of steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF) 2 in androgen receptor activity in mice. PNAS 102:9487-9492

Han SJ, Jeong J, DeMayo FJ, Xu J, Tsai SY, Tsai M-J and O’Malley BW. 2005 Dynamic cell type specificity of SRC-1 coactivator in modulating uterine progesterone receptor function in mice. Mol Cell Biol 25:8150-8165.

Han SJ, DeMayo FJ, Xu J, Tsai SY, Tsai M-J and O’Malley BW. 2006 Steroid receptor coactivators SRC-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor. Mol Endocrinol. 20: 45-55. Selected as “Cover Story”

Han SJ, Jung SY, Malovannaya A, Kim T, Ranz BR, Qin J, O’Malley BW. 2006 A Scoring system for the Follow up Study of Nuclear Receptor Coactivator Complexes. Nuclear Receptor Signaling 4 :e014.

Han SJ, Tsai SY, Tsai M-J, and O'Malley BW. 2007 Distinct Temporal and Spatial Activities of RU486 on PR Function in Reproductive Organs of Ovariectomized Mice. Endocrinol 144(5): 2471-2486

Jeong JW, Lee KY, Han SJ, Aronow BJ, Lydon JP, O'Malley BW, DeMayo FJ. 2007 The p160 Steroid Receptor Coactivator 2, SRC-2, regulates murine endometrial function and regulates progesterone independent and dependent gene expression. Endocrinol 148(9):4238-50

Han SJ, DeMayo FJ and O’Malley BW. 2007 Dynamic Regulation of Progesterone Receptor Activity in Female Reproductive Tissues. Ernst Schering Found Symp Proc. Vol. 2007/1:25-43

Han SJ, Lonard DM and O’Malley BW. 2009 Multi-modulation of nuclear receptor coactivators through posttranslational modifications. Trends in Endocrinology and Metabolism 20(1):8-15

Han SJ, O’Malley BW, and DeMayo FJ, 2009 An Estrogen Receptor Alpha Activity Indicator Model in Mice. Genesis 00:1-10.

Zhang L, Zhang B, Han SJ, Shore AN, Rosen JM, DeMayo FJ, Xin L., 2012 Targeting CreER(T2) expression to keratin 8-expressing murine simple epithelia using bacterial artificial chromosome transgenesis. Transgenic Res. 21(5):1117-23

Han SJ, Hawkins SM, Begum K, Jung YS, Kovanci E, Qin J, Lydon JP, DeMayo FJ and O’Malley BW, A novel isoform of Steroid Receptor Coactivator-1 is critical for endometriosis progression. 2012 Nature Medicine 18(7): 1102-11

Reviewed by Faculty of 1000.

Comment in: Dyson, M.T. & Bulun, S.E. Cutting SRC-1 down to size in endometriosis. Nat Med 18, 1016-1018 (2012).

Comment in: Maduro, M.R. Understanding the Pathogenesis Progression of Endometriosis, SAGE.

Comments in: Haas, M.J., Fragmentary progress in endometriosis. Science-Business eXchange 5, 8-10

Liu S, Han SJ and Smith CL, Cooperative Activation of Gene Expression by Agonists and Antagonists Mediated by Estrogen Receptor Heteroligand Dimer Complexes. 2013 Molecular Pharmacology. 83 (5):1066-77

Han SJ, O’Malley BW, The Dynamics of Nuclear Receptors and Nuclear Receptor Coregulators in the Pathogenesis of Endometriosis. 2014 Human Reproduction Update. 20(4):467-84

Selected as “Key Scientific Article” by Global Medical Discovery

Han SJ, Begum K, Foulds CL, Hamilton RA, Bailey S, Malovannaya A, Chan D, Qin J amd O’Malley BW. (2015) The Dual ERa Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. Molecular Pharmacology. 2015 Oct 20. pii: mol.115.100925.

Han SJ, Jung SY , Wu S, Hawkins SM, Park MJ, Kyo S, Qin J, Lydon JP, Tsai SY, Tsai M-J, DeMayo FJ, O'Malley BW. (2015) Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis. Cell. 2015 Nov 5;163(4):960-974.